Hypotheses to explain the association between vigorous physical activity and amyotrophic lateral sclerosis
Abstract
Many epidemiologic studies indicate a relation between vigorous physical activity and amyotrophic lateral sclerosis. Physical activity itself is unlikely to cause amyotrophic lateral sclerosis, but could it modify the effects of other etiologic factors such as neurotoxins? Vigorous physical activity could potentiate the effect of a toxin to motor neurons by any of several mechanisms, especially if the toxin's effects were mediated through excitation. Exercise could alter the extent of exposure or could influence the distribution, metabolism or potency of an excitotoxin. Future epidemiologic studies of amyotrophic lateral sclerosis should include sufficient detail about vigorous physical exercise to explore this relationship further.
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Longstreth and colleagues hypothesized that the effect of toxins on motor neurons could be potentiated by vigorous physical activity.
“Harwood and colleagues proposed that such a susceptibility could be reflected in a specific physical constitution with a relatively larger fraction of type 1 muscle fibers (Harwood et al., 2009) and Longstreth and colleagues hypothesized that the effect of toxins on motor neurons could be potentiated by vigorous physical activity (Longstreth, Nelson, Koepsell, & van Belle, 1991).”
From Prevalence of potential sports‐associated risk factors in Swiss amyotrophic lateral sclerosis patients (2017) · cites this paper as Longstreth et al., 1991
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- Authors
- Longstreth, W. T., Nelson, L. M., Koepsell, T. D., & Van Belle, G.
- Affiliations
- University of Washington (US)
- Corresponding author
- Longstreth, W.T.
- ORCID
- Nelson, L.M.
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 1991-02
- Volume
- 34
- Issue
- 2
- Pages
- 144-148
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2028345225
- Cited by
- 51
- References
- 50
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 4
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Keywords
- amyotrophic lateral sclerosis, high-intensity exercise, physical activity, neurotoxins, excitotoxins, motor neurons, etiology
- MeSH terms
- Amyotrophic Lateral Sclerosis, Physical Exertion, Humans, Leisure Activities, Motor Neurons, Sports
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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