Mechanisms of interhemispheric transfer and patterns of cognitive function in acallosal patients of normal intelligence
Abstract
We investigated interhemispheric transfer and cognitive function in two boys with normal intelligence in whom agenesis of the corpus callosum was identified following minor head trauma. In patient 1, magnetic resonance imaging scan showed agenesis of the corpus callosum and absent anterior commissure. Results of visual interhemispheric transfer tasks suggested degradation in transfer of information to the left hemisphere. Results of a tactile interhemispheric transfer task suggested degradation of access to the right hemisphere. In patient 2, magnetic resonance imaging scan showed agenesis of the corpus callosum and enlarged anterior commissure. Results for both visual and tactile interhemispheric transfer tasks were normal. Dichotic listening tests showed a slight left ear advantage in both patients. These results support the hypothesis that hypertrophy of the anterior commissure is an important mechanism of functional compensation in agenesis of the corpus callosum. However, the relative subtlety of deficits in patient 1 and results of dichotic listening tests support use of other mechanisms as well. No consistent pattern of cognitive deficits was observed.
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Several cognitive and social deficits observed in autism have also been described in individuals with agenesis of the corpus callosum.
“Several cognitive and social deficits observed in autism have also been described in individuals with agenesis of the CC, although not all individuals with these deficits meet full DSM-IV-TR criteria for autistic disorder.”
From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [60]
The results are consistent with evidence from investigations of individuals with agenesis of the corpus callosum.
“Results reported here are consistent with evidence from investigations examining individuals with agenesis of the CC, pointing to the role that this structure plays in complex brain functions.”
From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [60]
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- Authors
- Fischer, M., Ryan, S. B., & Dobyns, W. B.
- Affiliations
- Medical College of Wisconsin (US)
- Indiana University (US)
- ORCID
- Dobyns, W. B.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1992-03-01
- Volume
- 49
- Issue
- 3
- Pages
- 271-277
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W1981298313
- Cited by
- 110
- References
- 26
- Citations by year
- 2024: 5 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 2 · 2019: 7 · 2018: 7 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
- Keywords
- agenesis of the corpus callosum, interhemispheric transfer, functional compensation, dichotic listening, hemispheric lateralization, cognitive function, normal intelligence, head trauma
- MeSH terms
- Auditory Perception, Brain, Child, Cognition, Corpus Callosum, Humans, Intelligence, Functional Laterality, Male, Neuropsychological Tests, Touch, Visual Perception, Agenesis of Corpus Callosum
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