Cognitive and psychosocial deficits in agenesis of the corpus callosum with normal intelligence
Abstract
Cognitive disabilities in agenesis of the corpus callosum (ACC) have been described in scattered reports, but few complete case descriptions are available. Consequent psychosocial disabilities in ACC have received little attention. We expected that ACC would be manifest in deficits specific to complex reasoning, concept formation, and problem solving. We also expected that these cognitive problems would be particularly evident in difficulties interpreting and understanding social situations, and in abnormal self-perception. Methods. Cognitive and psychosocial deficits were studied in two adolescents with ACC and normal IQ using a battery of cognitive and psychological tests. Results. Test results indicated poor interhemispheric integration of complex material. Performance on tests of reasoning, and concept formation were clearly below expectations based on IQ. Significantly poor performance was also found on tests of social insight, proverb interpretation, social logic, self-perception, and interpretation of ambiguous stimuli. Gross behavioural disorder or psychopathology were not found. Conclusions. ACC results in disabilities in social cognition that appear to be secondary to deficits in complex cognitive operations such as reasoning, concept formation, and problem solving. It is suggested that these cognitive deficits may be related to diminished interhemispheric transfer of complex information.
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The results are consistent with evidence from investigations of individuals with agenesis of the corpus callosum.
“Results reported here are consistent with evidence from investigations examining individuals with agenesis of the CC, pointing to the role that this structure plays in complex brain functions.”
From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [62]
Several cognitive and social deficits observed in autism have also been described in individuals with agenesis of the corpus callosum.
“Several cognitive and social deficits observed in autism have also been described in individuals with agenesis of the CC, although not all individuals with these deficits meet full DSM-IV-TR criteria for autistic disorder.”
From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [62]
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- Authors
- Brown, W. S., & Paul, L. K.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Cognitive Neuropsychiatry
- Publisher
- Informa UK Limited
- Published
- 2000-05
- Volume
- 5
- Issue
- 2
- Pages
- 135-157
- ISSN
- 1354-6805 (ISSN-L)
- 1464-0619
- OpenAlex
- W2141044575
- Cited by
- 117
- References
- 65
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 10 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 1 · 2014: 7 · 2013: 8 · 2012: 10
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cognitive Neuropsychiatry (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
- Keywords
- agenesis of the corpus callosum, social cognition, hemispheric integration, reasoning, concept formation, problem solving, self-perception, social insight, adolescents, normal intelligence, interhemispheric transfer
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