Cited by 830Fetal and Pediatric Neurological DisordersAdvanced Neuroimaging Techniques and ApplicationsGenetics and Neurodevelopmental Disorders

Agenesis of the corpus callosum: Genetic, developmental and functional aspects of connectivity

Paul, Lynn K., Brown, Warren S., Adolphs, Ralph, Tyszka, J. Michael, Richards, Linda J., Mukherjee, Pratik, Sherr, Elliott H.·2007·Nature Reviews Neuroscience

Abstract

Agenesis of the corpus callosum (AgCC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1:4000 individuals. Genetics, animal models and detailed structural neuroimaging are now providing insights into the developmental and molecular bases of AgCC. Studies using neuropsychological, electroencephalogram and functional MRI approaches are examining the resulting impairments in emotional and social functioning, and have begun to explore the functional neuroanatomy underlying impaired higher-order cognition. The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism.

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  • The corpus callosum provides integrated inter-hemispheric communication between homotopic and heterotopic cortical regions.

    “The CC provides integrated inter-hemispheric communication between homotopic and heterotopic cortical regions (50).”

    From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [50]

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Research works printed but not linked: 4

  1. [4]4. Sperry, R. W. in The Neurosciences (eds. Schmitt, F. O. & Worden, F. G.) 5-19 (MIT Press, Cambridge, MA, 1974).
  2. [119]119. Barbaresi, W. J. Autism - A review of the state of the science for pediatric primary health care clinicians. Archives of Pediatrics & Adolescent Medicine 160, 1167-1175 (2006).
  3. [136]136. Hetts, S. W., Sherr, E. H., Gobuty, S., Chao, S. & Barkovich, A. J. Anomalies of the corpus callosum: MR analysis of the phenotypic spectrum. American Journal of Roentgenology 187 (2006).
  4. [137]137. Rauch, R. A. & Jinkins, J. R. in Callosal Agenesis: A Natural Split Brain? (eds. Lassonde, M. & Jeeves, M. A.) 83-95 (Plenum Press, New York, 1994).

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Authors
Paul, L. K., Brown, W. S., Adolphs, R., Tyszka, J. M., Richards, L. J., Mukherjee, P., & Sherr, E. H.
Affiliations
  • California Institute of Technology (US)
  • The University of Queensland (AU)
  • University of California, San Francisco (US)
Corresponding author
  • Paul, Lynn K.
  • Sherr, Elliott H.
Venue
Nature Reviews Neuroscience
Published
2007-04
Volume
8
Issue
4
Pages
287-299
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2137538651
Cited by
830
References
149
Citations by year
2026: 22 · 2025: 39 · 2024: 42 · 2023: 54 · 2022: 44 · 2021: 58 · 2020: 43 · 2019: 60 · 2018: 50 · 2017: 49 · 2016: 45 · 2015: 44 · 2014: 51 · 2013: 48 · 2012: 50
FWCI
4.72
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS058721)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
agenesis of the corpus callosum, corpus callosum development, interhemispheric connectivity, genetic basis, animal models, neuropsychological deficits, social-emotional functioning, higher-order cognition, schizophrenia, autism spectrum disorder, neurodevelopmental disorders, functional neuroanatomy
MeSH terms
Mental Disorders, Child Behavior, Developmental Disabilities, Child, Preschool, Corpus Callosum, Female, Humans, Infant, Infant, Newborn, Neuropsychological Tests, Pregnancy

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