Agenesis of the corpus callosum: Genetic, developmental and functional aspects of connectivity
Abstract
Agenesis of the corpus callosum (AgCC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1:4000 individuals. Genetics, animal models and detailed structural neuroimaging are now providing insights into the developmental and molecular bases of AgCC. Studies using neuropsychological, electroencephalogram and functional MRI approaches are examining the resulting impairments in emotional and social functioning, and have begun to explore the functional neuroanatomy underlying impaired higher-order cognition. The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism.
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The corpus callosum provides integrated inter-hemispheric communication between homotopic and heterotopic cortical regions.
“The CC provides integrated inter-hemispheric communication between homotopic and heterotopic cortical regions (50).”
From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [50]
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- Authors
- Paul, L. K., Brown, W. S., Adolphs, R., Tyszka, J. M., Richards, L. J., Mukherjee, P., & Sherr, E. H.
- Affiliations
- California Institute of Technology (US)
- The University of Queensland (AU)
- University of California, San Francisco (US)
- Corresponding author
- Paul, Lynn K.
- Sherr, Elliott H.
- ORCID
- Venue
- Nature Reviews Neuroscience
- Published
- 2007-04
- Volume
- 8
- Issue
- 4
- Pages
- 287-299
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2137538651
- Cited by
- 830
- References
- 149
- Citations by year
- 2026: 22 · 2025: 39 · 2024: 42 · 2023: 54 · 2022: 44 · 2021: 58 · 2020: 43 · 2019: 60 · 2018: 50 · 2017: 49 · 2016: 45 · 2015: 44 · 2014: 51 · 2013: 48 · 2012: 50
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS058721)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- agenesis of the corpus callosum, corpus callosum development, interhemispheric connectivity, genetic basis, animal models, neuropsychological deficits, social-emotional functioning, higher-order cognition, schizophrenia, autism spectrum disorder, neurodevelopmental disorders, functional neuroanatomy
- MeSH terms
- Mental Disorders, Child Behavior, Developmental Disabilities, Child, Preschool, Corpus Callosum, Female, Humans, Infant, Infant, Newborn, Neuropsychological Tests, Pregnancy
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