Cited by 178Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedical Imaging Techniques and Applications

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Topography of Cross-sectional and Longitudinal Glucose Metabolic Deficits in Alzheimer's Disease: Pathophysiologic Implications

Smith, Gwenn S.·1992·Archives of Neurology

DOI 10.1001/archneur.1992.00530350056020

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Abstract

Positron emission tomographic studies of cerebral glucose metabolism have shown high diagnostic specificity in distinguishing among the degenerative dementias and differentiating between Alzheimer's disease (AD) and normal aging. The current investigation was undertaken to characterize the regional glucose metabolic deficits in AD, using cross-sectional and longitudinal study designs. All subjects met the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for AD (n = 45) or were normal (n = 20), and the AD subjects were subdivided into incipient and mild AD and moderate plus moderately severe subgroups based on the Global Deterioration Scale. The subjects underwent a non-contrast computed tomographic scan and a positron emission tomographic (PETT VI) scan. The AD subjects (n = 14) and normal control subjects (n = 15) received evaluations 2 to 3 years after baseline study. The brain regions that show glucose metabolic deficits cross-sectionally (temporal and parietal association areas, with lesser degrees of deficit in subcortical gray matter structures), over the stages of AD, also show further deficits longitudinally within the same AD subjects. The reduction in glucose metabolism is greater than would be expected from the degree of brain atrophy. The glucose metabolic deficits are discussed in the context of neuropathologic findings and neurotransmitter deficits in AD.

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Authors: Smith, G. S.
Corresponding author: Smith, Gwenn S.
ORCID: Smith, Gwenn S.
Venue: Archives of Neurology
Publisher: American Medical Association (AMA)
Published: 1992-11-01
Volume: 49
Issue: 11
Pages: 1142
ISSN: 0003-9942 (ISSN-L)
DOI: 10.1001/archneur.1992.00530350056020
OpenAlex: W2113406852
Cited by: 178
References: 67
Citations by year: 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 2 · 2012: 8
FWCI: 4.66
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (1P30-AG08051, P30AG008051)
National Institute of Mental Health (1 ROI MH 43965-04)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords: Alzheimer's disease, brain glucose metabolism, longitudinal metabolic changes, temporal lobe, parietal association areas, subcortical gray matter, brain atrophy, disease stage, neuropathology, neurotransmitter deficits, dementia diagnosis
MeSH terms: Aged, Alzheimer Disease, Analysis of Variance, Cerebral Cortex, Cross-Sectional Studies, Female, Glucose, Humans, Longitudinal Studies, Male, Middle Aged, Tomography, Emission-Computed, Tomography, X-Ray Computed

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Topography of Cross-sectional and Longitudinal Glucose Metabolic Deficits in Alzheimer's Disease: Pathophysiologic Implications

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