EARLY MARKER FOR ALZHEIMER'S DISEASE: THE ATROPHIC HIPPOCAMPUS

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works

The Global Deterioration Scale for assessment of primary degenerative dementia

Reisberg, ‌., Ferris, S. H., de Leon, M. J., & Crook, T. H. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.9.1136 · Cited by 4,982 · see citing works

The prevalence of dementia: A quantitative integration of the literature

Jorm, A. F., Korten, A. E., & Henderson, A. S. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02906.x · Cited by 1,301 · see citing works

Perforant pathway changes and the memory impairment of Alzheimer's disease

Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., & Damasio, A. R. (1986) · Annals of Neurology · doi:10.1002/ana.410200406 · Cited by 672 · see citing works

A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA

Ball, M. J., Hachinski, V., Fox, A. J., Kirshen, A. J., Fisman, M., Blume, W. T., Kral, V. A., Fox, H., & Merskey, H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90965-1 · Cited by 427 · see citing works

ABNORMAL CORTISOL RESPONSE IN ALZHEIMER'S DISEASE LINKED TO HIPPOCAMPAL ATROPHY

de Leon, M. J., McRae, T., Tsai, J., GEORGE, A. E., MARCUS, D., Freedman, M. S., Wolf, A., & McEwen, B. S. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92855-3 · Cited by 198 · see citing works

CT diagnostic features of Alzheimer disease: importance of the choroidal/hippocampal fissure complex.

GEORGE, A. E., de Leon, M. J., Stylopoulos, L. A., Miller, J. D., Kluger, A., Smith, G. S., & Miller, D. C. (1990) · PubMed Central · Cited by 115 · see citing works

Mild cognitive impairment

Gauthier, S. G., Reisberg, ‌., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 3,920 · see citing works

Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates.

Scheltens, P., Leys, D., Barkhof, F., Huglo, D. G., Weinstein, H. C., Vermersch, P., Kuiper, M. A., Steinling, M., Wolters, E. C., & Valk, J. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.10.967 · Cited by 1,781 · see citing works

EEG dynamics in patients with Alzheimer's disease

Jeong, J. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.01.001 · Cited by 1,346 · see citing works

Structural Brain Changes in Aging: Courses, Causes and Cognitive Consequences

Fjell, A. M., & Walhovd, K. B. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.3.187 · Cited by 1,085 · see citing works

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

Jack, C. R., Lowe, V. J., Senjem, M. L., Weigand, S. D., Kemp, B. J., Shiung, M. M., Knopman, D. S., Boeve, B. F., Klunk, W. E., Mathis, C. A., et al. (2008) · Brain · doi:10.1093/brain/awm336 · Cited by 958 · see citing works

Brain glucose metabolism in the early and specific diagnosis of Alzheimer?s disease

Mosconi, L. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1762-7 · Cited by 900 · see citing works

Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome

Starkman, M. N., Gebarski, S. S., Berent, S., & Schteingart, D. E. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90079-f · Cited by 840 · see citing works

Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease

Chan, D., Fox, N. C., Scahill, R. I., Crum, W. R., Whitwell, J. L., Leschziner, G., Rossor, A. M., Stevens, J. M., Cipolotti, L., & Rossor, M. N. (2001) · Annals of Neurology · doi:10.1002/ana.92 · Cited by 749 · see citing works

One-Year Brain Atrophy Evident in Healthy Aging

Fjell, A. M., Walhovd, K. B., Fennema-Notestine, C., McEvoy, L. K., Hagler, D. J., Holland, D., Brewer, J. B., & Dale, A. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3252-09.2009 · Cited by 692 · see citing works

Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease

Jack, C. R., Petersen, R. C., Xu, Y., O'Brien, P. C., Smith, G. E., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1998) · Neurology · doi:10.1212/wnl.51.4.993 · Cited by 666 · see citing works

Prediction of cognitive decline in normal elderly subjects with 2-[ ¹⁸ F]fluoro-2-deoxy- <scp>d</scp> -glucose/positron-emission tomography (FDG/PET)

de Leon, M. J., Convit, A., Wolf, O. T., Tarshish, C. Y., DeSanti, S., Rusinek, H., Tsui, W., Kandil, E., Scherer, A. J., Roche, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191044198 · Cited by 629 · see citing works

Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline

Waldemar, G., Dubois, B., Emre, M., Georges, J., McKeith, I. G., Rossor, M. N., Scheltens, P., Tariska, P., & Winblad, B. G. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01605.x · Cited by 619 · see citing works

Hippocampal formation glucose metabolism and volume losses in MCI and AD

De Santi, S., de Leon, M. J., Rusinek, H., Convit, A., Tarshish, C. Y., Roche, A., Tsui, W. H., Kandil, E., Boppana, M., Daisley, K., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00230-5 · Cited by 548 · see citing works

Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: Interobserver reliability

Scheltens, P., Launer, L. J., Barkhof, F., Weinstein, H. C., & van Gool, W. A. (1995) · Journal of Neurology · doi:10.1007/bf00868807 · Cited by 470 · see citing works

Early diagnosis of alzheimer’s disease: contribution of structural neuroimaging

Chételat, G., & Baron, J. (2003) · NeuroImage · doi:10.1016/s1053-8119(02)00026-5 · Cited by 442 · see citing works

In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease

Kuhl, D. E., Minoshima, S., Fessler, J. A., Ficaro, E. P., Wieland, D. M., Koeppe, R. A., Frey, K. A., & Foster, N. L. (1996) · Annals of Neurology · doi:10.1002/ana.410400309 · Cited by 426 · see citing works

Neuroimaging and Early Diagnosis of Alzheimer Disease: A Look to the Future

Petrella, J. R., Coleman, R. E., & Doraiswamy, P. M. (2003) · Radiology · doi:10.1148/radiol.2262011600 · Cited by 427 · see citing works

Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease

De Leon, M. J., George, A. E., Golomb, J., Tarshish, C., Convit, A., Kluger, A., De Santi, S., Mc Rae, T., Ferris, S. H., Reisberg, B., et al. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00213-8 · Cited by 429 · see citing works

Specific Hippocampal Volume Reductions in Individuals at Risk for Alzheimer’s Disease

Convit, A., De Leon, M. J., Tarshish, C., De Santi, S., Tsui, W., Rusinek, H., & George, A. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00001-8 · Cited by 427 · see citing works

Memory and MRI-based hippocampal volumes in aging and AD

Petersen, R. C., Jack, C. R., Xu, Y.-C., Waring, S. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Tangalos, E. G., Boeve, B. F., & Kokmen, E. (2000) · Neurology · doi:10.1212/wnl.54.3.581 · Cited by 426 · see citing works

Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion

Scheltens, P., Fox, N. C., Barkhof, F., & DeCarli, C. S. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00002-9 · Cited by 410 · see citing works

Automatic Differentiation of Anatomical Patterns in the Human Brain: Validation with Studies of Degenerative Dementias

Good, C. D., Scahill, R. I., Fox, N. C., Ashburner, J., Friston, K. J., Chan, D., Crum, W. R., Rossor, M. N., & Frackowiak, R. S. J. (2002) · NeuroImage · doi:10.1006/nimg.2002.1202 · Cited by 410 · see citing works

Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer’s disease☆

Convit, A., de Asis, J., de Leon, M. J., Tarshish, C. Y., De Santi, S., & Rusinek, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00107-4 · Cited by 359 · see citing works

Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain

Liang, W. S., Dunckley, T. L., Beach, T. G., Grover, A., Mastroeni, D., Walker, D. G., Caselli, R. J., Kukull, W. A., McKeel, D. W., Morris, J. C., et al. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00208.2006 · Cited by 341 · see citing works

Hippocampal Atrophy in Normal Aging

Golomb, J. B. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540090066012 · Cited by 323 · see citing works

The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation.

de Leon, M. J., Golomb, J. B., GEORGE, A. E., Convit, A. J., Tarshish, C. Y., McRae, T., Santi, S. D., Smith, G. S., Ferris, S. H., & Noz, M. E. (1993) · PubMed Central · Cited by 322 · see citing works

The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer’s disease.

Reisberg, B., Prichep, L., Mosconi, L., John, E. R., Glodzik‐Sobanska, L., Boksay, I., Monteiro, I., Torossian, C., Vedvyas, A., Ashraf, N., et al. (2008) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2007.11.017 · Cited by 312 · see citing works

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Ramsey, K., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., et al. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00242.2007 · Cited by 309 · see citing works

Amygdalohippocampal MR volume measurements in the early stages of Alzheimer disease.

Lehéricy, S., Baulac, M., Jacques Chiras, C., Pierot, L., Martin-Duverneuil, N., Pillon, B., Deweer, B., Dubois, B., & Marsault, C. (1994) · PubMed Central · Cited by 308 · see citing works

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

Lewczuk, P., Riederer, P. F., O’Bryant, S. E., Verbeek, M. M., Dubois, B., Visser, P. J., Jellinger, K. A., Engelborghs, S., Ramı́rez, A., Parnetti, L., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1375556 · Cited by 308 · see citing works

Patterns of Motor Impairment in Normal Aging, Mild Cognitive Decline, and Early Alzheimer' Disease

Kluger, A., Gianutsos, J. G., Golomb, J. B., Ferris, S. H., GEORGE, A. E., Franssen, E., & Reisberg, ‌. (1997) · The Journals of Gerontology Series B · doi:10.1093/geronb/52b.1.p28 · Cited by 304 · see citing works

Regional Brain Atrophy Rate Predicts Future Cognitive Decline: 6-year Longitudinal MR Imaging Study of Normal Aging

Rusinek, H., De Santi, S., Frid, D., Tsui, W.-H., Tarshish, C. Y., Convit, A., & de Leon, M. J. (2003) · Radiology · doi:10.1148/radiol.2293021299 · Cited by 281 · see citing works

On the Involvement of Prefrontal Networks in Cognitive Ageing

Tisserand, D. J., & Jolles, J. (2003) · Cortex · doi:10.1016/s0010-9452(08)70880-3 · Cited by 253 · see citing works

Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment

de Leon, M. J., DeSanti, S., Zinkowski, R. P., Mehta, P. D., Praticò, D., Segal, S., Rusinek, H., Li, J., Tsui, W., Louis, L. A. S., et al. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.003 · Cited by 253 · see citing works

3D in vitro modeling of the central nervous system

Hopkins, A. M., DeSimone, E. K., Chwalek, K., & Kaplan, D. L. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.11.003 · Cited by 230 · see citing works

MRI and CSF studies in the early diagnosis of Alzheimer's disease

de Leon, M. J., DeSanti, S., Zinkowski, R. P., Mehta, P. D., Praticò, D., Segal, S., Clark, C. M., Kerkman, D. J., DeBernardis, J. F., Li, J., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01381.x · Cited by 221 · see citing works

Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease

Jobst, K. A., Smith, A. D., Szatmari, M., Esiri, M. M., Jaskowski, A., Hindley, N., McDonald, B., & Molyneux, A. J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92028-1 · Cited by 215 · see citing works

Low body weight in Alzheimer's disease is associated with mesial temporal cortex atrophy

Grundman, M., Corey‐Bloom, J., Jernigan, T. L., Archibald, S. L., & Thal, L. J. (1996) · Neurology · doi:10.1212/wnl.46.6.1585 · Cited by 211 · see citing works

Imaging the progression of Alzheimer pathology through the brain

Smith, A. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082107399 · Cited by 202 · see citing works

Imaging and CSF Studies in the Preclinical Diagnosis of Alzheimer's Disease

de Leon, M. J., Mosconi, L., Blennow, K., DeSanti, S., Zinkowski, R. P., Mehta, P. D., Praticò, D., Tsui, W., Louis, L. A. S., Sobanska, L., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.012 · Cited by 198 · see citing works

Hippocampal formation size in normal human aging: a correlate of delayed secondary memory performance.Preprint

Golomb, J. B., Kluger, A., de Leon, M. J., Ferris, S. H., Convit, A. J., Mittelman, M. S., Cohen, J., Rusinek, H., Santi, S. D., & GEORGE, A. E. (1994) · Learning & Memory · doi:10.1101/lm.1.1.45 · Cited by 198 · see citing works

Predicting Progression from Mild Cognitive Impairment to Alzheimer's Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification

Korolev, I. O., Symonds, L. L., Bozoki, A., & Initiative, A. D. N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0138866 · Cited by 192 · see citing works

Using visual rating to diagnose dementia: a critical evaluation of MRI atrophy scales

Harper, L., Barkhof, F., Fox, N. C., & Schott, J. M. (2015) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp-2014-310090 · Cited by 187 · see citing works

Topography of Cross-sectional and Longitudinal Glucose Metabolic Deficits in Alzheimer's Disease: Pathophysiologic Implications

Smith, G. S. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530350056020 · Cited by 178 · see citing works

Cortisol Reduces Hippocampal Glucose Metabolism in Normal Elderly, but Not in Alzheimer's Disease

de Leon, M. J., McRae, T., Rusinek, H., Convit, A. J., Santi, S. D., Tarshish, C. Y., Golomb, J. B., Volkow, N. D., Daisley, K., Orentreich∥, N., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4305 · Cited by 176 · see citing works

Association of atrophy of the medial temporal lobe with reduced blood flow in the posterior parietotemporal cortex in patients with a clinical and pathological diagnosis of Alzheimer's disease.

Jobst, K. A., Smith, A. D., Barker, C. S., Wear, A., King, E. M., Smith, A. D., Anslow, P., Molyneux, A., SHEPSTONE, B. J., & Soper, N. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.190 · Cited by 163 · see citing works

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

Protas, H. D., Chen, K., Langbaum, J. B. S., Fleisher, A. S., Alexander, G. E., Lee, W., Bandy, D., de Leon, M. J., Mosconi, L., Buckley, S., et al. (2013) · JAMA Neurology · doi:10.1001/2013.jamaneurol.286 · Cited by 161 · see citing works

Cerebrovascular Reactivity to Carbon Dioxide in Alzheimer's Disease

Glodzik, L., Randall, C., Rusinek, H., & de Leon, M. J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122011 · Cited by 137 · see citing works

Hippocampal atrophy in early Alzheimer's Disease: Anatomic specificity and validation

Convit, A., de Leon, M. D., Golomb, J., George, A., Tarshish, C., Bobinski, M., Tsui, W., Santi, S. D. D., Wegiel, J., & Wiśniewski, H. (2005) · Psychiatric quarterly · doi:10.1007/bf01064929 · Cited by 81 · see citing works

FreeSurfer ‐based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts

Sämann, P. G., Iglesias, J. E., Gutman, B. A., Grotegerd, D., Leenings, R., Flint, C., Dannlowski, U., Clarke‐Rubright, E. K., Morey, R. A., van Erp, T. G. M., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25326 · Cited by 135 · see citing works

Contribution of Structural Neuroimaging to the Early Diagnosis of Alzheimer’s Disease

de Leon, M. J., Convit, A. J., DeSanti, S., Carroll, R., GEORGE, A. E., Rusinek, H., Bobinski, M., Wı́sniewski, H. M., & Louis, L. A. S. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004900 · Cited by 135 · see citing works

In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease.

Pfefferbaum, A., Adalsteinsson, E., Spielman, D., Sullivan, E., & Lim, K. O. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.2.185 · Cited by 141 · see citing works

Tissue segmentation of the brain in Alzheimer disease.

Tanabe, J., Amend, D. L., Schuff, N. W., Sclafani, V. D., Ezekiel, F., Norman, D. M., Fein, G., & Weiner, M. W. (1997) · PubMed Central · Cited by 133 · see citing works

Brain imaging in the study of Alzheimer's disease

Reiman, E. M., & Jagust, W. J. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.075 · Cited by 134 · see citing works

Structural imaging biomarkers of Alzheimer's disease: predicting disease progression

Eskildsen, S. F., Coupé, P., Fonov, V., Pruessner, J. C., & Collins, D. L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.04.034 · Cited by 129 · see citing works

Poststroke Dementia: Influence of Hippocampal Atrophy

Cordoliani-Mackowiak, M.-A., Hénon, H., Pruvo, J.-P., Pasquier, F., & Leys, D. (2003) · Archives of Neurology · doi:10.1001/archneur.60.4.585 · Cited by 126 · see citing works

Mild cognitive impairment (MCI): a historical perspective

Reisberg, ‌., Ferris, S. H., Kluger, A., Franssen, E., Węgiel, J., & de Leon, M. J. (2007) · International Psychogeriatrics · doi:10.1017/s1041610207006394 · Cited by 120 · see citing works

EEG spectral analysis in vascular and Alzheimer dementia

Signorino, M., Pucci, E., Belardinelli, N., Nolfe, G., & Angeleri, F. (1995) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(94)00290-2 · Cited by 111 · see citing works

Mapping brain morphological and functional conversion patterns in amnestic MCI: a voxel-based MRI and FDG-PET study

Morbelli, S., Piccardo, A., Villavecchia, G., Dessì, B., Brugnolo, A., Piccini, A., Caroli, A., Frisoni, G., Rodriguez, G., & Nobili, F. (2009) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-009-1218-6 · Cited by 117 · see citing works

Characterizing the Preclinical Stages of Alzheimer's Disease and the Prospect of Presymptomatic Intervention

Caselli, R. J., & Reiman, E. M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129026 · Cited by 109 · see citing works

Corticosteroids, the Aging Brain and Cognition

McEwen, B. S., de Leon, M. J., LUPIEN, S. J., & Meaney, M. J. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00122-2 · Cited by 108 · see citing works

Does Alzheimer’s Disease Affect Hippocampal Asymmetry? Evidence from a Cross-Sectional and Longitudinal Volumetric MRI Study

Barnes, J., Scahill, R. I., Schott, J. M., Frost, C. D., Rossor, M. N., & Fox, N. C. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000084560 · Cited by 105 · see citing works

Chapter 26 Re-examination of the glucocorticoid hypothesis of stress and aging

McEwen, B. S. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)64585-9 · Cited by 104 · see citing works

β-Amyloid affects frontal and posterior brain networks in normal aging

Oh, H., Mormino, E. C., Madison, C. M., Hayenga, A. O., Smiljic, A., & Jagust, W. J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.027 · Cited by 103 · see citing works

Medial temporal atrophy and memory impairment in early stage of Alzheimer’s disease: an MRI volumetric and memory assessment study

Mizuno, K., Wakai, M., Takeda, A., & Sobue, G. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00289-0 · Cited by 103 · see citing works

Magnetization Transfer Ratio in Mild Cognitive Impairment and Dementia of Alzheimer's Type

Kabani, N. J., Sled, J. G., & Chertkow, H. M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0992 · Cited by 103 · see citing works

Hippocampal volume reduction and history of aggressive behaviour in patients with borderline personality disorder

Zetzsche, T., Preuss, U. W., Frodl, T., Schmitt, G., Seifert, D., Münchhausen, E., Tabrizi, S. D., Leinsinger, G. L., Born, C., Reiser, M. F., et al. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.05.010 · Cited by 102 · see citing works

Association of Dementia Severity With Cortical Gray Matter and Abnormal White Matter Volumes in Dementia of the Alzheimer Type

Stout, J. C., Jernigan, T. L., Archibald, S. L., & Salmon, D. P. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550080056013 · Cited by 101 · see citing works

Parallels Between Major Depressive Disorder and Alzheimer’s Disease: Role of Oxidative Stress and Genetic Vulnerability

Rodrigues, R., Petersen, R. B., & Perry, G. L. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0074-5 · Cited by 99 · see citing works

Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease

Tarawneh, R. M., Head, D. M., Allison, S. L., Buckles, V., Fagan, A. M., Ladenson, J. H., Morris, J. C., & Holtzman, D. M. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0202 · Cited by 96 · see citing works

Surgery and Brain Atrophy in Cognitively Normal Elderly Subjects and Subjects Diagnosed with Mild Cognitive Impairment

Kline, R., Pirraglia, E., Cheng, H. M., Santi, S. D., Li, Y., Haile, M. M., de Leon, M. J., & Bekker, A. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318246ec0b · Cited by 96 · see citing works

Correlation of Hippocampal Volume and Cognitive Performances in Patients with Either Mild Cognitive Impairment or Alzheimer's disease

Peng, G., Feng, Z., He, F., Chen, Z., Liu, X., Liu, P., & Luo, B. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12317 · Cited by 92 · see citing works

Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies

Mistur, R. L., Mosconi, L., Santi, S. D., Guzman, M., Li, Y., Tsui, W., & de Leon, M. J. (2009) · Journal of Clinical Neurology · doi:10.3988/jcn.2009.5.4.153 · Cited by 94 · see citing works

Neurological Changes Induced by Stress in Streptozotocin Diabetic Rats

Reagan, L. P., Magariños, A. M., & McEwen, B. S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07822.x · Cited by 88 · see citing works

Imaging is superior to cognitive testing for early diagnosis of Alzheimer’s disease

ZAMRINI, E. Y., Santi, S. D., & Tolar, M. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.009 · Cited by 88 · see citing works

In Vivo Structural Studies of the Hippocampus in Normal Aging and in Incipient Alzheimer's Diseasea

de Leon, M. J., Convit, A. J., GEORGE, A. E., Golomb, J. B., Santi, S. D., Tarshish, C. Y., Rusinek, H., Bobinski, M., INCE, C., MILLER, D., et al. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34395.x · Cited by 88 · see citing works

Lifestyle and Genetic Contributions to Cognitive Decline and Hippocampal Structure and Function in Healthy Aging

Woodard, J. L., Sugarman, M. A., Nielson, K. A., Smith, J. C., Seidenberg, M., Durgerian, S., Butts, A. M., Hantke, N. C., Lancaster, M. A., & Matthews, M. A. (2012) · Current Alzheimer Research · doi:10.2174/156720512800492477 · Cited by 88 · see citing works

Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimer’s Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach

Nie, X., Sun, Y., Wan, S., Zhao, H., Liu, R., Li, X., Wu, S., Nedelská, Z., Hort, J., Zhao, Q., et al. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00399 · Cited by 85 · see citing works

Use of structural imaging to study the progression of Alzheimer's disease

Smith, A. D., & Jobst, K. A. (1996) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011568 · Cited by 85 · see citing works

Hippocampal atrophy correlates with severe cognitive impairment in elderly patients with suspected normal pressure hydrocephalus.

Golomb, J. B., de Leon, M. J., GEORGE, A. E., Kluger, A., Convit, A. J., Rusinek, H., Santi, S. D., Litt, A. W., Foo, S. H., & Ferris, S. H. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.5.590 · Cited by 85 · see citing works

An Optimal Decisional Space for the Classification of Alzheimer's Disease and Mild Cognitive Impairment

Zhou, Q., Goryawala, M., Cabrerizo, M., Wang, J., Barker, W., Loewenstein, D., Duara, R., & Adjouadi, M. (2014) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2014.2310709 · Cited by 84 · see citing works

Atrophy rate in medial temporal lobe during progression of Alzheimer disease

Rusinek, H., Endo, Y., Santi, S. D., Frid, D., Tsui, W. H., Segal, S., Convit, A. J., & de Leon, M. J. (2004) · Neurology · doi:10.1212/01.wnl.0000148602.30175.ac · Cited by 83 · see citing works

Association of Gray Matter Atrophy with Age, β-Amyloid, and Cognition in Aging

Oh, H., Madison, C. M., Villeneuve, S., Markley, C., & Jagust, W. J. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht017 · Cited by 81 · see citing works

Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology

Liang, W. S., Dunckley, T. L., Beach, T. G., Grover, A., Mastroeni, D., Ramsey, K. M., Caselli, R. J., Kukull, W. A., McKeel, D. W., Morris, J. C., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.013 · Cited by 78 · see citing works

Medial temporal lobe atrophy in stroke patients: relation to pre-existing dementia

Hénon, H., Pasquier, F., Durieu, I., Pruvo, J., & Leys, D. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.5.641 · Cited by 79 · see citing works

Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly

Glodzik, L., Mosconi, L., Tsui, W., Santi, S. D., Zinkowski, R. P., Pirraglia, E., Rich, K. E., McHugh, P. F., Li, Y., Williams, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.012 · Cited by 78 · see citing works

Magnetic resonance imaging of Alzheimer’s disease

Lehéricy, S., Marjańska, M., Mesrob, L., Sarazin, M., & Kinkingnéhun, S. (2006) · European Radiology · doi:10.1007/s00330-006-0341-z · Cited by 73 · see citing works

Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer's disease as shown by MRI and PET.

Yamaguchi, S., Meguro, K., Itoh, M., Hayasaka, C., Shimada, M., Yamazaki, H., & Yamadori, A. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.6.596 · Cited by 77 · see citing works

Early diagnosis of dementia: neuroimaging

Scheltens, P. (1999) · Journal of Neurology · doi:10.1007/s004150050300 · Cited by 75 · see citing works

Age-related changes in brain: II. Positron emission tomography of frontal and temporal lobe glucose metabolism in normal subjects

De Santi, S., de Leon, M. J., Convit, A., Tarshish, C., Rusinek, H., Tsui, W. H., Sinaiko, E., Wang, G.-J., Bartlet, E., & Volkow, N. (1995) · Psychiatric Quarterly · doi:10.1007/bf02238755 · Cited by 74 · see citing works

Hippocampal Atrophy Disrupts Transfer Generalization in Nondemented Elderly

Myers, C. E., Kluger, A., Golomb, J. B., Ferris, S. H., de Leon, M. J., Schnirman, G. M., & Gluck, M. A. (2002) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198870201500206 · Cited by 74 · see citing works

Emerging β-amyloid pathology and accelerated cortical atrophy

Mattsson, N., Insel, P. S., Nosheny, R., Tosun, D., Trojanowski, J. Q., Shaw, L. M., Jack, C. R., Donohue, M. C., & Weiner, M. W. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.446 · Cited by 71 · see citing works

Dementia as a complication of schizophrenia

de Vries, P. J. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.5.588 · Cited by 69 · see citing works

Prediction of Cognitive Decline in Healthy Older Adults using fMRI

Woodard, J. L., Seidenberg, M., Nielson, K. A., Smith, J. C., Antuono, P., Durgerian, S., Guidotti, L. M., Zhang, Q., Butts, A. M., Hantke, N. C., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091693 · Cited by 67 · see citing works

Pathological Aging of the Brain

de Bastos-Leite, A. J., Scheltens, P., & Barkhof, F. (2004) · Topics in Magnetic Resonance Imaging · doi:10.1097/01.rmr.0000168070.90113.dc · Cited by 67 · see citing works

Influence of APOE Genotype on Hippocampal Atrophy over Time - An N=1925 Surface-Based ADNI Study

Li, B., Shi, J., Gutman, B. A., Baxter, L. C., Thompson, P. M., Caselli, R. J., Wang, Y., & Initiative, A. D. N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152901 · Cited by 63 · see citing works

Magnetic Resonance Imaging Improves Cerebrospinal Fluid Biomarkers in the Early Detection of Alzheimer's Disease

Bryś, M., Glodzik, L., Mosconi, L., Switalski, R., Santi, S. D., Pirraglia, E., Rich, K. E., Kim, B. C., Mehta, P. D., Zinkowski, R., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0968 · Cited by 61 · see citing works

MRI Temporal Lobe Volume Measures and Neuropsychologic Function in Alzheimer's Disease

Smith, C. D., Malcein, M., Meurer, K., Schmitt, F. A., Markesbery, W. R., & Pettigrew, L. C. (1999) · Journal of Neuroimaging · doi:10.1111/jon1999912 · Cited by 61 · see citing works

THE HIPPOCAMPUS IN AGING AND ALZHEIMER'S DISEASE

de Leon, M. J., Convit, A. J., DeSanti, S., Golomb, J. B., Tarshish, C. Y., Rusinek, H., Bobinski, M., Ince, C., Miller, D. C., Wı́sniewski, H. M., et al. (1995) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(25)00272-2 · Cited by 59 · see citing works

Morphometric Changes in the Episodic Memory Network and Tau Pathologic Features Correlate with Memory Performance in Patients with Mild Cognitive Impairment

Fjell, A. M., Walhovd, K. B., Amlien, I. K., Bjørnerud, A., Reinvang, I., Gjerstad, L., Cappelen, T., Willoch, F., Due‐Tønnessen, P., Grambaitė, R., et al. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1059 · Cited by 60 · see citing works

ALZHEIMER'S DISEASE AND THE HIPPOCAMPUS

Collerton, D., & FAIRBAIRN, A. F. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91055-4 · Cited by 2 · see citing works

ATROPHY OF THE HIPPOCAMPUS (CCT/MRI) AN EARLY FEATURE OF ALZHEIMER DISEASE?

Horn, R., Staab, B., Ostertun, B., Solymosi, L., & Möller, H. ‐. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199202001-00193 · Cited by 3 · see citing works

ABNORMAL CORTISOL RESPONSE IN ALZHEIMER'S DISEASE LINKED TO HIPPOCAMPAL ATROPHY

de Leon, M. J., McRae, T., Tsai, J., GEORGE, A. E., MARCUS, D., Freedman, M. S., Wolf, A., & McEwen, B. S. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92855-3 · Cited by 198 · see citing works

Hippocampal atrophy: An early brain marker for Alzheimer's disease (AD)

George, A. E. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90173-u · Cited by 1 · see citing works

MRI-BASED EARLY DETECTION OF ALZHEIMER’S DISEASE USING HIPPOCAMPAL ATROPHY ANALYSIS

Katiyar, A. (2025) · Journal of Applied Bioanalysis · doi:10.53555/jab.v11si1.395