Positron emission tomography studies of normal aging: A replication of PET III and 18-FDG using PET VI and 11-CDG
Abstract
Using PET VI and 11-CDG we replicated our earlier PET III and 18-FDG normal aging findings. Examination of young and old normal volunteers revealed the absence of any absolute regional age-related changes in glucose utilization. For the combined sample (N = 81) we did find evidence to suggest a relative hypofrontal change with increasing age. A strong relationship between age and ventricular size (CT) was also found. These findings suggest the preserved glucose metabolism of the resting aging brain in the presence of structural atrophic changes.
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Neuropsychological studies and neuroimaging studies have often suggested that DFL changes underlie age-associated deficits in working memory, psychomotor speed, and attention.
“Neuropsychological studies (see ref. 46 for review) and neuroimaging studies (47) have often suggested that DFL changes underlie age-associated deficits in working memory, psychomotor speed, and attention.”
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- Authors
- de Leon, M. J., George, A. E., Tomanelli, J., Christman, D., Kluger, A., Miller, J., Ferris, S. H., Fowler, J., Brodie, J. D., van Gelder, P., Klinger, A., & Wolf, A. P.
- Affiliations
- NYU Langone Health (US)
- Brookhaven National Laboratory (US)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1987-07
- Volume
- 8
- Issue
- 4
- Pages
- 319-323
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2009904690
- Cited by
- 79
- References
- 14
- Citations by year
- 2026: 1 · 2022: 2 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH36969)
- National Institute of Neurological Disorders and Stroke (NS 15636)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- normal aging, brain glucose metabolism, regional cerebral glucose utilization, frontal lobe hypometabolism, brain atrophy, ventriculomegaly, replication study
- MeSH terms
- Adult, Aged, Aging, Atrophy, Brain, Deoxyglucose, Glucose, Humans, Middle Aged, Tomography, Emission-Computed, Cerebral Ventriculography, Fluorodeoxyglucose F18
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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