Cited by 79Dementia and Cognitive Impairment ResearchMedical Imaging Techniques and ApplicationsAging and Gerontology Research

Positron emission tomography studies of normal aging: A replication of PET III and 18-FDG using PET VI and 11-CDG

de Leon, Mony J., George, Ajax E., Tomanelli, Joseph, Christman, David, Kluger, Alan, Miller, Jeffrey, Ferris, Steven H., Fowler, Joanna +4 more·1987·Neurobiology of Aging

Abstract

Using PET VI and 11-CDG we replicated our earlier PET III and 18-FDG normal aging findings. Examination of young and old normal volunteers revealed the absence of any absolute regional age-related changes in glucose utilization. For the combined sample (N = 81) we did find evidence to suggest a relative hypofrontal change with increasing age. A strong relationship between age and ventricular size (CT) was also found. These findings suggest the preserved glucose metabolism of the resting aging brain in the presence of structural atrophic changes.

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Crossref · 10.1016/0197-4580(87)90070-4

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Authors
de Leon, M. J., George, A. E., Tomanelli, J., Christman, D., Kluger, A., Miller, J., Ferris, S. H., Fowler, J., Brodie, J. D., van Gelder, P., Klinger, A., & Wolf, A. P.
Affiliations
  • NYU Langone Health (US)
  • Brookhaven National Laboratory (US)
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
1987-07
Volume
8
Issue
4
Pages
319-323
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2009904690
Cited by
79
References
14
Citations by year
2026: 1 · 2022: 2 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH36969)
  • National Institute of Neurological Disorders and Stroke (NS 15636)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
Keywords
normal aging, brain glucose metabolism, regional cerebral glucose utilization, frontal lobe hypometabolism, brain atrophy, ventriculomegaly, replication study
MeSH terms
Adult, Aged, Aging, Atrophy, Brain, Deoxyglucose, Glucose, Humans, Middle Aged, Tomography, Emission-Computed, Cerebral Ventriculography, Fluorodeoxyglucose F18

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