18Fluorodeoxyglucose Positron Emission Tomography Studies in Presumed Alzheimer Cases, Including 13 Serial Scans
Open accessAbstract
Positron emission tomographic (PET) data on local cerebral metabolic rates for glucose (LCMR) are reported for 32 regions of interest (ROI)s in cross-sectional studies on 57 patients with clinically diagnosed Alzheimer's disease (AD) and 20 neurologically normal controls, and in serial studies on 13 of the AD cases, including a familial, young-onset case where the diagnosis has been confirmed at autopsy. Extensive psychological testing was done on all the AD cases. Almost all cortical regions showed a significant decline in LCMR with age in the control subjects. There were the expected cortical metabolic deficits in AD and the serial studies showed a general increase in such deficits over time in 12 of the 13 cases. The regions showing the greatest declines with time in serial studies are the same as those showing the most severe deficiencies in cross-sectional studies. The young-onset case did not show a greater rate of metabolic decline than many of the older cases studied. Results on individual psychological tests tended to correlate with metabolic rates in multiple, rather than single, cortical regions, suggesting intact neuronal networks are required for good performance. The correlations with cortical metabolic activity found were of a sign indicating that the higher the metabolic rates and the better the left:right asymmetry index, the better was the performance.
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PET reveals abnormally low prefrontal and whole-brain glucose metabolism in more severely affected Alzheimer's disease patients.
“abnormally low prefrontal and whole-brain levels in more severely affected patients”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [9]
PET reveals characteristic abnormalities in patients with probable and definite Alzheimer's disease, including abnormally low parietal, temporal, and posterior cingulate glucose metabolism.
“When used to measure cerebral glucose metabolism, PET reveals characteristic abnormalities in patients with probable and definite Alzheimer's disease, including abnormally low parietal, temporal, and posterior cingulate levels”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [9]
PET reveals a progressive decline in glucose metabolism levels over time in Alzheimer's disease.
“and a progressive decline in these levels over time.”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [9]
The observation of metabolic reductions is consistent with reports that reductions in regional glucose metabolism increase as Alzheimer's disease progresses from a presymptomatic stage to mild symptoms and then to increasingly severe stages.
“This observation is consistent with reports that reductions in regional glucose metabolism increase as Alzheimer's disease progresses from a presymptomatic stage to one characterized by mild symptoms, and ultimately to increasingly severe stages.[9][10][11][12][13]”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [9]
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- Authors
- McGeer, E. G., Peppard, R. P., McGeer, P. L., Tuokko, H., Crockett, D., Parks, R., Akiyama, H., Calne, D. B., Beattie, B. L., & Harrop, R.
- Affiliations
- University of British Columbia (CA)
- Simon Fraser University (CA)
- Corresponding author
- McGeer, E.G.
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 1990-02
- Volume
- 17
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W2411997763
- Cited by
- 76
- References
- 30
- Citations by year
- 2018: 2 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer Society
- Medical Research Council Canada
- Medical Research Council
- Alzheimer Society of B.C.
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, 18F-FDG PET, early-onset Alzheimer's disease, familial Alzheimer's disease, neuropsychological performance, hemispheric lateralization, age-related metabolic decline
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebral Cortex, Deoxy Sugars, Deoxyglucose, Female, Fluorine Radioisotopes, Humans, Male, Middle Aged, Psychological Tests, Tomography, Emission-Computed, Fluorodeoxyglucose F18
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