The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Frontal-Subcortical Circuits and Human Behavior
Abstract
OBJECTIVE: This synthetic review was performed to demonstrate the utility of frontal-subcortical circuits in the explanation of a wide range of human behavioral disorders. DATA SOURCES: Reports of patients with degenerative disorders or focal lesions involving frontal lobe or linked subcortical structures were chosen from the English literature. Individual case reports and group investigations from peer-reviewed journals were evaluated. STUDY SELECTION: Studies were included if they described patient behavior in detail or reported pertinent neuropsy-chological findings and had compelling evidence of a disorder affecting frontal-subcortical circuits. DATA EXTRACTION: Information was used if the report from which it was taken met study selection criteria. DATA SYNTHESIS: Five parallel segregated circuits link the frontal lobe and subcortical structures. Clinical syndromes observed with frontal lobe injury are recapitulated with lesions of subcortical member structures of the circuits. Each prefrontal circuit has a signature behavioral syndrome: executive function deficits occur with lesions of the dorsolateral prefrontal circuit, disinhibition with lesions of the orbitofrontal circuit, and apathy with injury to the anterior cingulate circuit. Depression, mania, and obsessive-compulsive disorder may also be mediated by frontal-subcotical circuits. Movement disorders identify involvement of the basal ganglia component of frontal-subcortical circuits. CONCLUSIONS: Frontal-subcortical circuits mediate many aspects of human behavior.
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“The dorsolateral prefrontal circuit underlies executive function, which includes the control of attention, as well as the sustained organization of behavior to solve complex problems (Cummings, 1993; Stuss and Alexander, 2000).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Cummings, 1993
Citations
Cites
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
Alexander, G. E., & Crutcher, M. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90107-l · Cited by 4,131
Primate models of movement disorders of basal ganglia origin
DeLong, M. R. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90110-v · Cited by 3,824
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990) · PubMed · Cited by 2,422
Neuropathological Classification of Huntingtonʼs Disease
VONSATTEL, J.-P., MYERS, R. H., STEVENS, T. J., FERRANTE, R. J., BIRD, E. D., & RICHARDSON, E. P. (1985) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-198511000-00003 · Cited by 2,227
Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes
MILNER, B. (1963) · Archives of Neurology · doi:10.1001/archneur.1963.00460070100010 · Cited by 2,217
Neurotransmitters and neuromodulators in the basal ganglia
Graybiel, A. M. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90104-i · Cited by 1,576
Differential behavioral effects in frontal lobe disease
Benton, A. (1968) · Neuropsychologia · doi:10.1016/0028-3932(68)90038-9 · Cited by 1,575
Reliability, validity, and clinical correlates of apathy in Parkinson's disease
STARKSTEIN, S. E., Mayberg, H. S., Preziosi, T. J., Andrezejewski, P., Leiguarda, R. C., & Robinson, R. G. (1992) · Journal of Neuropsychiatry · doi:10.1176/jnp.4.2.134 · Cited by 1,224
Depression and Parkinson's disease: a review
Cummings, J. L. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.4.443 · Cited by 1,116
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Holroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027
The FAB: A frontal assessment battery at bedside
Dubois, B., Slachevsky, A., Litvan, I., & Pillon, B. (2000) · Neurology · doi:10.1212/wnl.55.11.1621 · Cited by 3,913
Executive Function and the Frontal Lobes: A Meta-Analytic Review
Alvarez, J. A., & Emory, E. (2006) · Neuropsychology Review · doi:10.1007/s11065-006-9002-x · Cited by 1,981
Basal ganglia and cerebellar loops: motor and cognitive circuits
Middleton, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00040-5 · Cited by 1,940
Nigg, J. T. (2000) · Psychological Bulletin · doi:10.1037/0033-2909.126.2.220 · Cited by 1,941
Metadata
- Authors
- Cummings, J. L.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Cummings, J. L.
- ORCID
- Cummings, J. L.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1993-08-01
- Volume
- 50
- Issue
- 8
- Pages
- 873-880
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2038012828
- Cited by
- 2,262
- References
- 68
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 38 · 2023: 40 · 2022: 33 · 2021: 50 · 2020: 60 · 2019: 53 · 2018: 66 · 2017: 58 · 2016: 57 · 2015: 71 · 2014: 82 · 2013: 88 · 2012: 86
- FWCI
- 27.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- frontal-subcortical circuits, frontal lobe lesions, subcortical lesions, executive dysfunction, disinhibition, apathy, depression, mania, obsessive-compulsive disorder, basal ganglia, movement disorders, behavioral disorders, neuropsychology
- MeSH terms
- Behavior, Brain Diseases, Frontal Lobe, Humans, Neural Pathways
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