Cited by 2,262Neural and Behavioral Psychology StudiesHistorical and Modern Theater StudiesDeep Brain Stimulation and Movement Disorders

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Frontal-Subcortical Circuits and Human Behavior

Cummings, J. L.·1993·Archives of Neurology

DOI 10.1001/archneur.1993.00540080076020

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Abstract

OBJECTIVE: This synthetic review was performed to demonstrate the utility of frontal-subcortical circuits in the explanation of a wide range of human behavioral disorders. DATA SOURCES: Reports of patients with degenerative disorders or focal lesions involving frontal lobe or linked subcortical structures were chosen from the English literature. Individual case reports and group investigations from peer-reviewed journals were evaluated. STUDY SELECTION: Studies were included if they described patient behavior in detail or reported pertinent neuropsy-chological findings and had compelling evidence of a disorder affecting frontal-subcortical circuits. DATA EXTRACTION: Information was used if the report from which it was taken met study selection criteria. DATA SYNTHESIS: Five parallel segregated circuits link the frontal lobe and subcortical structures. Clinical syndromes observed with frontal lobe injury are recapitulated with lesions of subcortical member structures of the circuits. Each prefrontal circuit has a signature behavioral syndrome: executive function deficits occur with lesions of the dorsolateral prefrontal circuit, disinhibition with lesions of the orbitofrontal circuit, and apathy with injury to the anterior cingulate circuit. Depression, mania, and obsessive-compulsive disorder may also be mediated by frontal-subcotical circuits. Movement disorders identify involvement of the basal ganglia component of frontal-subcortical circuits. CONCLUSIONS: Frontal-subcortical circuits mediate many aspects of human behavior.

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Authors: Cummings, J. L.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Cummings, J. L.
ORCID: Cummings, J. L.
Venue: Archives of Neurology
Publisher: American Medical Association (AMA)
Published: 1993-08-01
Volume: 50
Issue: 8
Pages: 873-880
ISSN: 0003-9942 (ISSN-L)
DOI: 10.1001/archneur.1993.00540080076020
OpenAlex: W2038012828
Cited by: 2,262
References: 68
Citations by year: 2026: 16 · 2025: 25 · 2024: 38 · 2023: 40 · 2022: 33 · 2021: 50 · 2020: 60 · 2019: 53 · 2018: 66 · 2017: 58 · 2016: 57 · 2015: 71 · 2014: 82 · 2013: 88 · 2012: 86
FWCI: 27.23
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: frontal-subcortical circuits, frontal lobe lesions, subcortical lesions, executive dysfunction, disinhibition, apathy, depression, mania, obsessive-compulsive disorder, basal ganglia, movement disorders, behavioral disorders, neuropsychology
MeSH terms: Behavior, Brain Diseases, Frontal Lobe, Humans, Neural Pathways

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Frontal-Subcortical Circuits and Human Behavior

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