Cited by 183Genetic Neurodegenerative DiseasesNeurological diseases and metabolismIron Metabolism and Disorders

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Increased Basal Ganglia Iron Levels in Huntington Disease

Bartzokis, George, Cummings, Jeffrey, Perlman, Susan, Hance, Darwood B., Mintz, Jim·1999·Archives of Neurology

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Abstract

OBJECTIVE: To quantify in vivo brain ferritin iron levels in patients with Huntington disease (HD) and normal control subjects. DESIGN AND SUBJECTS: A magnetic resonance imaging method that can quantify ferritin iron levels with specificity in vivo was employed to study 11 patients with HD and a matched group of 27 normal controls. Three basal ganglia structures (caudate, putamen, and globus pallidus) and 1 comparison region (frontal lobe white matter) were evaluated. RESULTS: Basal ganglia iron levels were significantly increased (P<.002) in patients with HD, and this increase occurred early in the disease process. This was not a generalized phenomenon, as white matter iron levels were lower in patients with HD. CONCLUSIONS: The data suggest that increased iron levels may be related to the pattern of neurotoxicity observed in HD. Reducing the oxidative stress associated with increased iron levels may offer novel ways to delay the rate of progression and possibly defer the onset of HD.

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“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Untitled work
(1976) · Medical Entomology and Zoology · Cited by 8,899
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
The effect of age on the non-haemin iron in the human brain
Hallgren, B., & Sourander, P. (1958) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1958.tb12607.x · Cited by 1,427
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
Smith, M. A., Harris, P. L. R., Sayre, L. M., & Perry, G. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9866 · Cited by 1,365
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
Beal, M. F., Brouillet, E., Jenkins, B. G., Ferrante, R. J., Kowall, N. W., Miller, J., Storey, E., Srivastava, R., Rosen, B. R., & Hyman, B. T. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04181.1993 · Cited by 1,026
Psychological Statistics.
Katz, L., & McNemar, Q. (1963) · Journal of the American Statistical Association · doi:10.2307/2283304 · Cited by 991
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410514 · Cited by 885
Intramuscular desferrioxamine in patients with Alzheimer's disease
MCLACHLAN, D. (1991) · The Lancet · doi:10.1016/0140-6736(91)92978-b · Cited by 764

Show all 49 references

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Authors: Bartzokis, G., Cummings, J., Perlman, S., Hance, D. B., & Mintz, J.
Affiliations: Central Arkansas Veterans Healthcare System (US)
University of California, Los Angeles (US)
ORCID: Cummings, Jeffrey
Mintz, Jim
Venue: Archives of Neurology
Publisher: American Medical Association (AMA)
Published: 1999-05-01
Volume: 56
Issue: 5
Pages: 569
ISSN: 0003-9942 (ISSN-L)
DOI: 10.1001/archneur.56.5.569
OpenAlex: W2008362268
Cited by: 183
References: 49
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 13 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 12 · 2014: 11 · 2013: 8 · 2012: 12
FWCI: 1.55
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: Huntington's disease, basal ganglia, brain iron, ferritin, caudate nucleus, putamen, globus pallidus, oxidative stress, neurotoxicity, disease progression
MeSH terms: Adult, Aged, Basal Ganglia, Female, Ferritins, Humans, Huntington Disease, Male, Middle Aged, Neurotoxins, Oxidative Stress, Disease Progression

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Increased Basal Ganglia Iron Levels in Huntington Disease

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