Iron drives T helper cell pathogenicity by promoting RNA-binding protein PCBP1-mediated proinflammatory cytokine production
Open accessAbstract
Iron deposition is frequently observed in human autoinflammatory diseases, but its functional significance is largely unknown. Here we showed that iron promoted proinflammatory cytokine expression in T cells, including GM-CSF and IL-2, via regulating the stability of an RNA-binding protein PCBP1. Iron depletion or Pcbp1 deficiency in T cells inhibited GM-CSF production by attenuating Csf2 3' untranslated region (UTR) activity and messenger RNA stability. Pcbp1 deficiency or iron uptake blockade in autoreactive T cells abolished their capacity to induce experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis. Mechanistically, intracellular iron protected PCBP1 protein from caspase-mediated proteolysis, and PCBP1 promoted messenger RNA stability of Csf2 and Il2 by recognizing UC-rich elements in the 3' UTRs. Our study suggests that iron accumulation can precipitate autoimmune diseases by promoting proinflammatory cytokine production. RNA-binding protein-mediated iron sensing may represent a simple yet effective means to adjust the inflammatory response to tissue homeostatic alterations.
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Iron protects PCBP1, an RNA binding protein which stabilizes GMCSF mRNA, from caspase-mediated proteolysis, leading to enhanced GMCSF production when iron levels are high within the T cell to drive inflammation.
“It was demonstrated that iron protects PCBP1 (Poly(RC)-binding protein 1), an RNA binding protein which stabilizes GMCSF mRNA, from caspase-mediated proteolysis thus leading to enhanced GMCSF production when iron levels are high within the T cell to drive inflammation (Wang et al., 2018).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Wang et al., 2018
Iron directly participates in inflammatory responses by promoting proinflammatory cytokine production in T helper cells via poly(rC)-binding protein 1.
“In a recent investigation it could be demonstrated that iron was able to directly participate in inflammatory responses by promoting proinflammatory cytokine production in T helper cells via poly(rC)-binding protein 1 [133].”
From Iron in immune cell function and host defense (2021) · cites this paper as [133]
Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889 · see citing works
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
Open source clustering software
de Hoon, M., Imoto, S., Nolan, J., & Miyano, S. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth078 · Cited by 3,043 · see citing works
Java Treeview—extensible visualization of microarray data
Saldanha, A. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth349 · Cited by 2,991 · see citing works
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.016 · Cited by 2,204 · see citing works
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.031 · Cited by 2,132 · see citing works
Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)
Van Nostrand, E. L., Pratt, G. A., Shishkin, A. A., Gelboin-Burkhart, C., Fang, M. Y., Sundararaman, B., Blue, S. M., Nguyen, T. B., Surka, C., Elkins, K., et al. (2016) · Nature Methods · doi:10.1038/nmeth.3810 · Cited by 1,397 · see citing works
HITS-CLIP yields genome-wide insights into brain alternative RNA processing
Licatalosi, D. D., Mele, A., Fak, J. J., Ule, J., Kayikci, M., Chi, S. W., Clark, T. A., Schweitzer, A. C., Blume, J. E., Wang, X., et al. (2008) · Nature · doi:10.1038/nature07488 · Cited by 1,352 · see citing works
Ganz, T., & Nemeth, E. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.01.014 · Cited by 1,282 · see citing works
Homeostasis, Inflammation, and Disease Susceptibility
Kotas, M. E., & Medzhitov, R. (2015) · Cell · doi:10.1016/j.cell.2015.02.010 · Cited by 1,213 · see citing works
Codarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., & Becher, B. (2011) · Nature Immunology · doi:10.1038/ni.2027 · Cited by 1,191 · see citing works
The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
Baltz, A. G., Munschauer, M., Schwanhäußer, B., Vasile, A. I., Murakawa, Y., Schueler, M., Youngs, N., Penfold-Brown, D., Drew, K., Milek, M., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.021 · Cited by 1,175 · see citing works
El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.-X., Dittel, B. N., & Rostami, A. (2011) · Nature Immunology · doi:10.1038/ni.2031 · Cited by 1,071 · see citing works
Fan, X. C., & Steitz, J. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3448 · Cited by 866 · see citing works
Bettelli, E., Pagany, M., Weiner, H. L., Linington, C., Sobel, R. A., & Kuchroo, V. K. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021603 · Cited by 828 · see citing works
Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR
Lebedeva, S., Jens, M., Theil, K., Schwanhäusser, B., Selbach, M., Landthaler, M., & Rajewsky, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.008 · Cited by 716 · see citing works
Mukherjee, N., Corcoran, D. L., Nusbaum, J. D., Reid, D. W., Georgiev, S., Hafner, M., Ascano, M., Tuschl, T., Ohler, U., & Keene, J. D. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.007 · Cited by 654 · see citing works
A cytosolic iron chaperone that delivers iron to ferritin
Shi, H., Bencze, K. Z., Stemmler, T. L., & Philpott, C. C. (2008) · Science · doi:10.1126/science.1157643 · Cited by 536 · see citing works
Iron and neurodegeneration in the multiple sclerosis brain
Hametner, S., Wimmer, I., Haider, L., Pfeifenbring, S., Brück, W., & Lassmann, H. (2013) · Annals of Neurology · doi:10.1002/ana.23974 · Cited by 519 · see citing works
Identification of a target RNA motif for RNA-binding protein HuR
de Silanes, I. L., Zhan, M., Lal, A., Yang, X., & Gorospe, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306453101 · Cited by 502 · see citing works
Carballo, E., Lai, W. S., & Blackshear, P. J. (2000) · Blood · doi:10.1182/blood.v95.6.1891 · Cited by 442 · see citing works
Flügel, A., Berkowicz, T., Ritter, T., Labeur, M. S., Jenne, D. E., Li, Z., Ellwart, J. W., Willem, M., Lassmann, H., & Wekerle, H. (2001) · Immunity · doi:10.1016/s1074-7613(01)00143-1 · Cited by 431 · see citing works
Control of alternative RNA splicing and gene expression by eukaryotic riboswitches
Cheah, M. T., Wachter, A., Sudarsan, N., & Breaker, R. R. (2007) · Nature · doi:10.1038/nature05769 · Cited by 430 · see citing works
Post-transcriptional control of cytokine production
Anderson, P. (2008) · Nature Immunology · doi:10.1038/ni1584 · Cited by 422 · see citing works
Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges
Lovci, M. T., Ghanem, D., Marr, H., Arnold, J., Gee, S., Parra, M., Liang, T. Y., Stark, T. J., Gehman, L. T., Hoon, S., et al. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2699 · Cited by 385 · see citing works
GM-CSF in inflammation and autoimmunity
Hamilton, J. A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02260-3 · Cited by 373 · see citing works
Haider, L., Simeonidou, C., Steinberger, G., Hametner, S., Grigoriadis, N., Deretzi, G., Kovács, G., Kutzelnigg, A., Lassmann, H., & Frischer, J. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-307712 · Cited by 347 · see citing works
PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data
Corcoran, D. L., Georgiev, S., Mukherjee, N., Gottwein, E., Skalsky, R. L., Keene, J. D., & Ohler, U. (2011) · Genome biology · doi:10.1186/gb-2011-12-8-r79 · Cited by 339 · see citing works
Identification of HuR as a protein implicated in AUUUA‐mediated mRNA decay
Myer, V. E., Fan, X. C., & Steitz, J. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.2130 · Cited by 302 · see citing works
Chaudhury, A., Chander, P. N., & Howe, P. H. (2010) · RNA · doi:10.1261/rna.2254110 · Cited by 292 · see citing works
Localizing CNS immune surveillance: Meningeal APCs activate T cells during EAE
Kivisäkk, P., Imitola, J., Rasmussen, S., Elyaman, W., Zhu, B., Ransohoff, R., & Khoury, S. J. (2009) · Annals of Neurology · doi:10.1002/ana.21379 · Cited by 281 · see citing works
Raven, E. P., Lu, P. H., Tishler, T. A., Heydari, P., & Bartzokis, G. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130209 · Cited by 270 · see citing works
Campbell, I. K., Rich, M. J., Bischof, R. J., Dunn, A. R., Grail, D., & Hamilton, J. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3639 · Cited by 233 · see citing works
Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2
Nandal, A., Ruiz, J. C., Subramanian, P., Ghimire-Rijal, S., Sinnamon, R. A., Stemmler, T. L., Bruick, R. K., & Philpott, C. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.015 · Cited by 204 · see citing works
Iron Is a Sensitive Biomarker for Inflammation in Multiple Sclerosis Lesions
Mehta, V. B., Pei, W., Yang, G., Li, S., Swamy, E., Boster, A. L., Schmalbrock, P., & Pitt, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057573 · Cited by 202 · see citing works
Iron deposits surrounding multiple sclerosis plaques.
Craelius, W., Mw, M., Luessenhop, C. P., Sugar, A. W., & Mihalakis, I. (1982) · PubMed · Cited by 197 · see citing works
Identification of an mRNP Complex Regulating Tumorigenesis at the Translational Elongation Step
Hussey, G. S., Chaudhury, A., Dawson, A. E., Lindner, D. J., Knudsen, C. R., Wilce, M. C. J., Merrick, W. C., & Howe, P. H. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.003 · Cited by 193 · see citing works
Increased basal ganglia iron levels in Huntington disease
Bartzokis, G., Cummings, J., Perlman, S., Hance, D. B., & Mintz, J. (1999) · Archives of Neurology · doi:10.1001/archneur.56.5.569 · Cited by 183 · see citing works
Eberhard, Y., McDermott, S., Wang, X., Gronda, M., Venugopal, A. L., Wood, T. E., Hurren, R., Datti, A., Batey, R. A., Wrana, J. L., et al. (2009) · Blood · doi:10.1182/blood-2009-03-209965 · Cited by 183 · see citing works
Levine, S. M., & Chakrabarty, A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.021 · Cited by 183 · see citing works
Bandukwala, H. S., Gagnon, J. D., Togher, S., Greenbaum, J., Lamperti, E. D., Parr, N. J., Molesworth, A. M. H., Smithers, N. N., Lee, K. C., Witherington, J. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212264109 · Cited by 182 · see citing works
Post-transcriptional coordination of immunological responses by RNA-binding proteins
Kafasla, P., Skliris, A., & Kontoyiannis, D. L. (2014) · Nature Immunology · doi:10.1038/ni.2884 · Cited by 177 · see citing works
PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis
Ryu, M., Zhang, D., Protchenko, O. V., Shakoury‐Elizeh, M., & Philpott, C. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90519 · Cited by 169 · see citing works
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewalPreprint
Zhao, Z., Zuber, J. A., Díaz-Flores, E., Lintault, L., Kogan, S. C., Shannon, K., & Lowe, S. W. (2010) · Genes & Development · doi:10.1101/gad.1940710 · Cited by 167 · see citing works
CLIP: Crosslinking and ImmunoPrecipitation of In Vivo RNA Targets of RNA-Binding Proteins
Jensen, K. B., & Darnell, R. B. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-475-3_6 · Cited by 143 · see citing works
Shen, Z.-J., Esnault, S. J., & Malter, J. S. (2005) · Nature Immunology · doi:10.1038/ni1266 · Cited by 127 · see citing works
Genome-wide technology for determining RNA stability in mammalian cells
Tani, H., & Akimitsu, N. (2012) · RNA Biology · doi:10.4161/rna.22036 · Cited by 120 · see citing works
Transferrin receptor 1 is differentially required in lymphocyte development
Ned, R. M., Swat, W., & Andrews, N. C. (2003) · Blood · doi:10.1182/blood-2003-04-1086 · Cited by 120 · see citing works
Chen, R., Bélanger, S., Frederick, M. A., Li, B., Johnston, R. J., Xiao, N., Liu, Y., Sharma, S., Peters, B., Rao, A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.08.002 · Cited by 117 · see citing works
Structure/Function Overview of Proteins Involved in Iron Storage and Transport
Sargent, P. J., Farnaud, S., & Evans, R. W. (2005) · Current Medicinal Chemistry · doi:10.2174/092986705774462969 · Cited by 103 · see citing works
Iwai, Y., Bickel, M., Pluznik, D. H., & Cohen, R. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55222-4 · Cited by 87 · see citing works
Zhou, X., You, F., Chen, H., & Jiang, Z. (2011) · Cell Research · doi:10.1038/cr.2011.184 · Cited by 85 · see citing works
Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice
Pedchenko, T. V., & LeVine, S. M. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00256-7 · Cited by 78 · see citing works
Iron-deficient mice fail to develop autoimmune encephalomyelitis
Grant, S. M., Wiesinger, J. A., Beard, J. L., & Cantorna, M. T. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.8.2635 · Cited by 78 · see citing works
Iron homoeostasis in rheumatic disease
Baker, J. F., & Ghio, A. J. (2009) · Rheumatology · doi:10.1093/rheumatology/kep221 · Cited by 68 · see citing works
Chang, X., Li, B., & Rao, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422490112 · Cited by 63 · see citing works
Iron chelation and multiple sclerosis
Weigel, K. J., Lynch, S. G., & LeVine, S. M. (2014) · ASN NEURO · doi:10.1042/an20130037 · Cited by 63 · see citing works
Iron regulation of ferritin gene expression
Munro, H. N. (1990) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240440205 · Cited by 58 · see citing works
Ho, J. J. D., Robb, G. B., Tai, S. C., Turgeon, P. J., Mawji, I. A., Man, H. S. J., & Marsden, P. A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01257-12 · Cited by 58 · see citing works
A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis.
Sg, L., Fonseca, T., & Sm, L. (2000) · PubMed · Cited by 57 · see citing works
Poly (C)-Binding Protein 1 Regulates p63 Expression through mRNA Stability
Cho, S.-J., Jung, Y.-S., & Chen, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071724 · Cited by 50 · see citing works
αCP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation
Ji, X., Wan, J., Vishnu, M. R., Xing, Y., & Liebhaber, S. A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01380-12 · Cited by 45 · see citing works
Kemp, J. D., Thorson, J., McAlmont, T. H., Horowitz, M. C., Cowdery, J. S., & Ballas, Z. K. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.8.2422 · Cited by 35 · see citing works
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Galy, B., Conrad, M., & Muckenthaler, M. U. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00648-1 · Cited by 806 · see citing works
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Chapman, N. M., Boothby, M. R., & Chi, H. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0203-y · Cited by 749 · see citing works
The Role of Iron Regulation in Immunometabolism and Immune-Related Disease
Cronin, S. J. F., Woolf, C. J., Weiss, G., & Penninger, J. M. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00116 · Cited by 299 · see citing works
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Ni, S., Yuan, Y., Kuang, Y., & Li, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.816282 · Cited by 266 · see citing works
Hsieh, C., Hsieh, H.-C., Shih, F.-H., Wang, P., Yang, L., Shieh, D.-B., & Wang, Y. (2021) · Theranostics · doi:10.7150/thno.57803 · Cited by 260 · see citing works
Hochrein, S. M., Wu, H., Eckstein, M., Arrigoni, L., Herman, J. S., Schumacher, F., Gerecke, C., Rosenfeldt, M. T., Grün, D., Kleuser, B., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.02.015 · Cited by 244 · see citing works
The role of iron homeostasis in remodeling immune function and regulating inflammatory disease
Mu, Q., Chen, L., Gao, X., Shen, S., Sheng, W., Min, J., & Wang, F. (2021) · 中国科学通报:英文版 · doi:10.1016/j.scib.2021.02.010 · Cited by 226 · see citing works
Cancer the‘RBP’eutics–RNA-binding proteins as therapeutic targets for cancer
Mohibi, S., Chen, X., & Zhang, J. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.07.001 · Cited by 200 · see citing works
Iron in immune cell function and host defense
Haschka, D., Hoffmann, A., & Weiss, G. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.12.005 · Cited by 188 · see citing works
Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis
Luoqian, J., Yang, W., Ding, X., Tuo, Q., Xiang, Z., Zheng, Z., Guo, Y., Li, L., Guan, P., Ayton, S., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00883-0 · Cited by 189 · see citing works
Iron in the Tumor Microenvironment-Connecting the Dots
Pfeifhofer-Obermair, C., Tymoszuk, P., Petzer, V., Weiss, G., & Nairz, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00549 · Cited by 151 · see citing works
Transcriptomic and clonal characterization of T cells in the human central nervous system
Pappalardo, J. L., Zhang, L., Pecsok, M. K., Perlman, K., Zografou, C., Raddassi, K., Abulaban, A. A., Krishnaswamy, S., Antel, J. P., van Dijk, D., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb8786 · Cited by 132 · see citing works
Ironing out mechanisms of iron homeostasis and disorders of iron deficiency
Koleini, N., Shapiro, J. S., Geier, J., & Ardehali, H. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148671 · Cited by 145 · see citing works
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Frost, J. N., Tan, T. K., Abbas, M., Wideman, S. K., Bonadonna, M., Stoffel, N. U., Wray, K., Kronsteiner, B., Smits, G. P., Campagna, D. R., et al. (2020) · Med · doi:10.1016/j.medj.2020.10.004 · Cited by 125 · see citing works
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Heintzman, D. R., Fisher, E. L., & Rathmell, J. C. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00833-2 · Cited by 119 · see citing works
Li, S., & Huang, Y. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02669-8 · Cited by 119 · see citing works
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Majumder, M., Chakraborty, P., Mohan, S., Mehrotra, S., & Palanisamy, V. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114442 · Cited by 114 · see citing works
Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus
Voss, K., Sewell, A. E., Krystofiak, E., Gibson-Corley, K. N., Young, A., Basham, J. H., Sugiura, A., Arner, E. N., Beavers, W. N., Kunkle, D. E., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.abq0178 · Cited by 113 · see citing works
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Wang, S., He, X.-Y., Wu, Q., Jiang, L., Chen, L., Yu, Y., Zhang, P., Huang, X., Wang, J., Ju, Z., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.224899 · Cited by 99 · see citing works
Metabolic waypoints during T cell differentiation
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Gao, X., Song, Y., Wu, J., Lu, S., Min, X., Liu, L., Hu, L., Zheng, M., Du, P., Yu, Y., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci152345 · Cited by 94 · see citing works
Liu, Y., Luo, X., Chen, Y., Dang, J., Zeng, D., Guo, X., Weng, W., Zhao, J., Shi, X., Chen, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.103008 · Cited by 91 · see citing works
Wang, Y., Fu, Z., Li, X., Liang, Y., Pei, S., Hao, S., Zhu, Q., Yu, T., Pei, Y., Yuan, J., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.02.003 · Cited by 84 · see citing works
He, Y., Zhou, X., Chang, C. H., Chen, G., Liu, W., Li, G., Fan, X., Sun, M., Miao, C., Huang, Q., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.01.021 · Cited by 79 · see citing works
Gut microbiota bridges the iron homeostasis and host health
Xiao, L., Tang, R., Wang, J., Wan, D., Yin, Y., & Xie, L. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2302-5 · Cited by 70 · see citing works
Armitage, A. E., & Moretti, D. (2019) · Pharmaceuticals · doi:10.3390/ph12020059 · Cited by 71 · see citing works
Yarosz, E. L., Ye, C., Kumar, A., Black, C., Choi, E., Seo, Y. A., & Chang, C. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901399 · Cited by 63 · see citing works
Sun, J., Zhang, N.-P., Xu, R., Zhang, G.-C., Liu, Z.-Y., Abuduwaili, W., Wang, F., Yu, X.-N., Shi, X., Song, G.-Q., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03034-7 · Cited by 59 · see citing works
Wang, H., Zhang, R., Shen, J., Jin, Y., Chang, C., Hong, M.-J., Guo, S., & He, D. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03148-z · Cited by 60 · see citing works
Analysis of Iron and Iron-Interacting Protein Dynamics During T-Cell Activation
Teh, M. R., Frost, J. N., Armitage, A. E., & Drakesmith, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714613 · Cited by 52 · see citing works
Ansa-Addo, E. A., Huang, H., Riesenberg, B., Iamsawat, S., Borucki, D. M., Nelson, M. H., Nam, J. H., Chung, D., Paulos, C. M., Liu, B., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz3865 · Cited by 52 · see citing works
Liu, S., Liu, J., Yang, X., Jiang, M., Wang, Q., Zhang, L., Ma, Y., Shen, Z., Tian, Z., & Cao, X. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2108276118 · Cited by 48 · see citing works
The role of iron metabolism in the pathogenesis and treatment of multiple sclerosis
Duarte-Silva, E., Meuth, S. G., & Peixoto, C. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1137635 · Cited by 46 · see citing works
Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications
Cheng, Z., Chu, H., Zhu, Q., & Yang, L. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1090338 · Cited by 45 · see citing works
Microbiota-assisted iron uptake promotes immune tolerance in the intestine
Zhu, L., Li, G., Liang, Z., Qi, T., Deng, K., Yu, J., Peng, Y., Zheng, J., Song, Y., & Chang, X. (2023) · Nature Communications · doi:10.1038/s41467-023-38444-2 · Cited by 46 · see citing works
Vinchi, F. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8167 · Cited by 43 · see citing works
Metabolic rewiring and communication in cancer immunity
Chapman, N. M., & Chi, H. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.02.001 · Cited by 43 · see citing works
Sun, F., Cui, L., Qian, J., Li, M., Chen, L., Chen, C., Li, D., Wang, S., & Du, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097836 · Cited by 40 · see citing works
Hurrell, B. P., Sakano, Y., Shen, S. M.-C., Helou, D. G., Li, M., Shafiei-Jahani, P., Kazemi, M. H., Sakano, K., Li, X., Quach, C., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk4728 · Cited by 42 · see citing works
Targeting ferroptosis in autoimmune diseases: Mechanisms and therapeutic prospects.
Zheng, Y., Yan, F., He, S., & Luo, L.-X. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103640 · Cited by 42 · see citing works
Frost, J. N., & Drakesmith, H. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01193-y · Cited by 40 · see citing works
Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy
Lai, Y., Zhao, S., Chen, B., Huang, Y., Guo, C., Li, M., Ye, B., Wang, S., Zhang, H., & Yang, N. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.999 · Cited by 36 · see citing works
The Potential Role of Ferroptosis in Systemic Lupus Erythematosus
Chen, Q., Wang, J., Xiang, M., Wang, Y., Zhang, Z., Liang, J. F., & Xu, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.855622 · Cited by 38 · see citing works
Regulation of iron homeostasis: Lessons from mouse models
Altamura, S., Marques, O., Colucci, S., Mertens, C., Alikhanyan, K., & Muckenthaler, M. U. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100872 · Cited by 35 · see citing works
Nutrition impact on ILC3 maintenance and function centers on a cell-intrinsic CD71–iron axis
Xiong, L., Helm, E. Y., Dean, J. W., Sun, N., Jimenez, F. R., & Zhou, L. (2023) · Nature Immunology · doi:10.1038/s41590-023-01612-z · Cited by 35 · see citing works
Ferroptosis of T cell in inflammation and tumour immunity
Xia, X., Wu, H., Chen, Y., Peng, H., & Wang, S. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70253 · Cited by 32 · see citing works
Chen, J., Martindale, J., Abdelmohsen, K., Kumar, G., Fortina, P., Gorospe, M., Rostami, A., & Yu, S.-G. (2020) · Journal of Immunology · doi:10.4049/jimmunol.1900769 · Cited by 29 · see citing works
Liu, S., Dong, Z., Tang, W., Zhou, J. W., Guo, L., Gong, C., Liu, G., Wan, D., & Yin, Y. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2298-1 · Cited by 33 · see citing works
Iron in multiple sclerosis – Neuropathology, immunology, and real-world considerations
Zierfuss, B., Wang, Z., Jackson, A. N., Moezzi, D., & Yong, V. W. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.104934 · Cited by 34 · see citing works
Effects of Iron Status on Adaptive Immunity and Vaccine Efficacy: A Review
Stoffel, N. U., & Drakesmith, H. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100238 · Cited by 38 · see citing works
Iron Metabolism: State of the Art in Hypoxic Cancer Cell Biology
Liu, S., Cao, X., Wang, D., & Zhu, H. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109199 · Cited by 31 · see citing works
Post‐transcriptional control of immune responses and its potential application
Yoshinaga, M., & Takeuchi, O. (2019) · Clinical & Translational Immunology · doi:10.1002/cti2.1063 · Cited by 32 · see citing works
Cheng, Z., Chu, H., Seki, E., Lin, R., & Yang, L. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1431921 · Cited by 30 · see citing works
Luo, Y., Zhang, Y., Pang, S., Min, J., Wang, T., Wu, D., Lin, C., Xiao, Z., Xiang, Q., Li, Q., et al. (2023) · Molecular Carcinogenesis · doi:10.1002/mc.23533 · Cited by 30 · see citing works
Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections
Abuga, K. M., Nairz, M., MacLennan, C. A., & Atkinson, S. H. (2023) · Wellcome Open Research · doi:10.12688/wellcomeopenres.18829.1 · Cited by 29 · see citing works
Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell
Li, L., Xia, Y., Yuan, S., Li, F., Xie, X., Luo, Y. M., Yang, X., & He, R. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma0821-015r · Cited by 29 · see citing works
Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation
Rossatti, P., Redpath, G., Ziegler, L., Samson, G. P. B., Clamagirand, C. D., Legler, D. F., & Rossy, J. (2022) · BMC Biology · doi:10.1186/s12915-022-01386-0 · Cited by 29 · see citing works
Ferritin heavy chain supports stability and function of the regulatory T cell lineage
Wu, Q., Carlos, A. R., Braza, F., Bergman, M., Kitoko, J. Z., Bastos-Amador, P., Cuadrado, E., Martins, R., de Oliveira, B. S. P., Martins, V. C., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00064-x · Cited by 29 · see citing works
RNATACs: Multispecific small molecules targeting RNA by induced proximity
Song, Y., Cui, J., Zhu, J., Kim, B., Kuo, M.-L., & Potts, P. R. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.05.006 · Cited by 28 · see citing works
KH-Domain Poly(C)-Binding Proteins as Versatile Regulators of Multiple Biological Processes
Nazarov, I. B., Bakhmet, E. I., & Tomilin, A. N. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919030039 · Cited by 28 · see citing works
Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells
Shetty, A., Bhosale, S. D., Tripathi, S. K., Buchacher, T., Biradar, R., Rasool, O., Moulder, R., Galande, S., & Lahesmaa, R. (2021) · ACS Omega · doi:10.1021/acsomega.1c03681 · Cited by 25 · see citing works
Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases
Fan, J., Jiang, T., & He, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1120519 · Cited by 27 · see citing works
Kumar, A., Ye, C., Nkansah, A., Decoville, T., Fogo, G. M., Sajjakulnukit, P., Reynolds, M. B., Zhang, L., Quaye, O., Seo, Y. A., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2318420121 · Cited by 26 · see citing works
A double-edged sword with a therapeutic target: iron and ferroptosis in immune regulation
Ni, S., Yuan, Y., Song, S., & Li, X. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac071 · Cited by 24 · see citing works
Zheng, Y., Zhou, Z. Y., Wei, R., Chu, X., Zhang, H., Fan, T. T., Zheng, B. J., Li, C., & He, J. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03552-y · Cited by 23 · see citing works
A closer look at the role of iron in glioblastoma
Shenoy, G., & Connor, J. R. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad136 · Cited by 22 · see citing works
Huang, N. J., Wei, Y., Cheng, Y., Wang, X., Wang, Q., Chen, D., & Li, W. (2022) · Genes & Genomics · doi:10.1007/s13258-021-01205-w · Cited by 21 · see citing works
Gao, X., Song, Y., Du, P., Yang, S. C., Cui, H., Lu, S., Hu, L., Liu, L., Jia, S., & Zhao, M. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108578 · Cited by 22 · see citing works
Morel, L. M., & Scindia, Y. M. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110181 · Cited by 21 · see citing works
Qian, X., Zhou, Q., Ouyang, Y., Wu, X., Sun, X. L., Wang, S., Duan, Y., Hu, Z., Hou, Y., Wang, Z., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412473122 · Cited by 22 · see citing works
Zhang, W., Zhang, S., Guan, W. X., Huang, Z., Kong, J., Huang, C., Wang, H., & Yang, S. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00930 · Cited by 21 · see citing works
Aba, Ü., Maslak, İ. C., İpşir, C., Pehlivan, D., Warnock, N. I., Tumes, D. J., Cildir, G., & Erman, B. (2024) · Journal of Clinical Immunology · doi:10.1007/s10875-024-01658-0 · Cited by 20 · see citing works
Immunological pathogenesis and treatment progress of adenovirus pneumonia in children
Liang, Y., Wei, J., Shen, J., Liang, Z., Ma, X., Du, Y., Qian, W., Dong, H., Huang, P., Chen, A., et al. (2025) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-024-01836-1 · Cited by 20 · see citing works
The RNA regulatory programs that govern lymphocyte development and function
Díaz‐Muñoz, M. D., & Osma-García, I. C. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1683 · Cited by 20 · see citing works
Inflammasome activation occurs in CD4+ and CD8+ T cells during graft-versus-host disease
Talley, S., Rademacher, D. J., & Campbell, E. M. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06138-8 · Cited by 20 · see citing works
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells
Teh, M. R., Gudgeon, N. H., Frost, J. N., Sinclair, L. V., Smith, A., Millington, C. L., Kronsteiner, B., Roberts, J., Marzullo, B. P., Murray, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60204-7 · Cited by 20 · see citing works
Kane, H., LaMarche, N. M., Scannail, A. N., Garza, A., Koay, H., Azad, A. I., Kunkemoeller, B. H., Stevens, B., Brenner, M. B., & Lynch, L. (2022) · eLife · doi:10.7554/elife.76586 · Cited by 19 · see citing works
Cellular iron governs the host response to malaria
Wideman, S. K., Frost, J. N., Richter, F. C., Naylor, C., Lopes, J. M., Viveiros, N., Teh, M. R., Preston, A. E., White, N., Yusuf, S., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011679 · Cited by 18 · see citing works
Liu, Y., Chen, H., Hao, J., Li, Z., Hou, T., & Hao, H. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.47766 · Cited by 19 · see citing works
Mei, W., Wei, M., Tang, C., Li, W., Ye, B., Xin, S., Ma, W., & Ye, L. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07559-3 · Cited by 20 · see citing works
Adaptive immunity and vaccination – iron in the spotlight
Preston, A. E., Drakesmith, H., & Frost, J. N. (2021) · Immunotherapy Advances · doi:10.1093/immadv/ltab007 · Cited by 20 · see citing works
Poly(rC)-binding proteins as pleiotropic regulators in hematopoiesis and hematological malignancy
Zhao, H., Wei, Z., Shen, G., Chen, Y., Hao, X., Li, S., & Wang, R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1045797 · Cited by 17 · see citing works
Lu, Y., Xi, J., Zhang, Y., Chen, W., Zhang, F., Li, C., & Wang, Z. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00703 · Cited by 16 · see citing works
Ionic Regulation of T-Cell Function and Anti-Tumour Immunity
Ginefra, P., Hope, H. C., Spagna, M., Zecchillo, A., & Vannini, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413668 · Cited by 17 · see citing works
Sundeep, D., Varadharaj, E. K., Umadevi, K., & Jhansi, R. (2023) · ECS Advances · doi:10.1149/2754-2734/acb832 · Cited by 17 · see citing works
Insufficient Iron Improves Pristane-Induced Lupus by Promoting Treg Cell Expansion
Gao, X., Song, Y., Lu, S., Hu, L., Zheng, M., Jia, S., & Zhao, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.799331 · Cited by 15 · see citing works
Yabe‐Wada, T., Philpott, C. C., & Onai, N. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12794 · Cited by 15 · see citing works
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*
Chen, H., Hsu, M., & Lio, C. J. (2021) · Immunological Reviews · doi:10.1111/imr.13045 · Cited by 17 · see citing works
Biocompatibility study of Fe-doped zirconia-toughened alumina ceramic for artificial joints
Jing, P. P., Gong, Y. L., Xiang, Y., Li, Y. X., Li, Q., Su, Y., & Leng, Y. X. (2024) · Ceramics International · doi:10.1016/j.ceramint.2024.03.134 · Cited by 14 · see citing works
Yusufujiang, A., Zeng, S., Chen, Y., Jing, S., Yang, L., & Li, H. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.884837 · Cited by 13 · see citing works
Iron Boosts Antitumor Type 1 T-cell Responses and Anti-PD1 Immunotherapy
Porte, S., Audemard‐Verger, A., Wu, C., Durand, A., Level, T., Giraud, L., Lombès, A., Germain, M., Pierre, R., Saintpierre, B., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0739 · Cited by 14 · see citing works
Iron capture through CD71 drives perinatal and tumor-associated Treg expansion
Pacella, I., Grimaldos, A. P., Rossi, A., Tucci, G., Zagaglioni, M., Potenza, E., Pinna, V., Rotella, I., Cammarata, I., Cancila, V., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.167967 · Cited by 14 · see citing works
Ferroptosis contributes to immunosuppression
He, N., Yuan, D., Luo, M., Xu, Q., Wen, Z., Wang, Z., Zhao, J., & Liu, Y. (2024) · Frontiers of Medicine · doi:10.1007/s11684-024-1080-8 · Cited by 13 · see citing works
Liang, S., Ma, H., Liu, Y., Hai, L., Tian, Y., Sun, Y., & Wang, Z. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113846 · Cited by 12 · see citing works
Labile iron accumulation augments T follicular helper cell differentiation
Scindia, Y. M., Mehrad, B., & Morel, L. M. (2022) · Journal of Clinical Investigation · doi:10.1172/jci159472 · Cited by 12 · see citing works
Yang, X., Yabe‐Wada, T., Han, J., Saito, F., Ogasawara, C., Yamada, S., & Onai, N. (2023) · International Immunology · doi:10.1093/intimm/dxad003 · Cited by 12 · see citing works
Cao, X., Li, P., Song, X., Shi, L., Qin, L., Chen, D., Chu, T., & Cheng, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-12594-7 · Cited by 10 · see citing works
Comparison of iron-reduced and iron-supplemented semisynthetic diets in T cell transfer colitis
Markota, A., Metzger, R., Heiseke, A. F., Jandl, L., Dursun, E., Eisenächer, K., Reindl, W., Haller, D., & Krug, A. B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218332 · Cited by 9 · see citing works
- Authors
- Wang, Z., Yin, W., Zhu, L., Li, J., Yao, Y., Chen, F., Sun, M., Zhang, J., Shen, N., Song, Y., & Chang, X.
- Affiliations
- Shanghai Jiao Tong University (CN)
- University of California San Diego (US)
- Corresponding author
- Chang, Xing
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 49
- Issue
- 1
- Pages
- 80-92.e7
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2810518168
- Cited by
- 156
- References
- 66
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 28 · 2023: 26 · 2022: 31 · 2021: 20 · 2020: 13 · 2019: 8 · 2018: 1
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- MOST (31370858, 81671552)
- NSFC (13PJ1409300)
- SMSTC
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- iron accumulation, T helper cells, PCBP1, RNA-binding proteins, inflammatory cytokines, GM-CSF, interleukin-2, mRNA stability, 3' untranslated region, experimental autoimmune encephalomyelitis, multiple sclerosis, autoinflammatory disease, iron sensing, autoreactive T cells
- MeSH terms
- Iron Deficiencies, Animals, Binding Sites, Carrier Proteins, Cell Line, DNA-Binding Proteins, Encephalomyelitis, Autoimmune, Experimental, Female, T-Lymphocytes, Helper-Inducer, Humans, Iron, Multiple Sclerosis, Receptors, Transferrin, RNA Processing, Post-Transcriptional, RNA, Messenger, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Cytokines, RNA-Binding Proteins, 3' Untranslated Regions, RNA Stability, RNA, Small Interfering, Mice
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