Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications

Tests for comparing elements of a correlation matrix

Steiger, J. H. (1980) · Psychological Bulletin · doi:10.1037/0033-2909.87.2.245 · Cited by 4,621 · cited 1× · see citing works

Huntington's disease

Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,623 · see citing works

Neuropathological Classification of Huntingtonʼs Disease

Vonsattel, J., Myers, R. H., STEVENS, T. J., Ferrante, R. J., Bird, E. D., & Richardson, E. P. (1985) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198511000-00003 · Cited by 2,598 · see citing works

Regional Development of the Brain in Early Life

(1968) · Archives of Disease in Childhood · doi:10.1136/adc.43.229.388 · Cited by 2,107 · see citing works

Iron, brain ageing and neurodegenerative disorders

Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., & Crichton, R. R. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1537 · Cited by 1,801 · see citing works

The effect of age on the non-haemin iron in the human brain

Hallgren, B., & Sourander, P. (1958) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1958.tb12607.x · Cited by 1,427 · see citing works

Huntington Disease

Vonsattel, J. P., & DiFiglia, M. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199805000-00001 · Cited by 1,305 · see citing works

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

Gauthier, L. R., Charrin, B. C., Borrell-Pagès, M., Dompierre, J. P., Rangone, H., Cordelières, F. P., De Mey, J., MacDonald, M. E., Leßmann, V., Humbert, S., et al. (2004) · Cell · doi:10.1016/j.cell.2004.06.018 · Cited by 1,178 · see citing works

Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial

Ritchie, C. W., Bush, A. I., Mackinnon, A., Macfarlane, S., Mastwyk, M., MacGregor, L., Kiers, L., Cherny, R., Li, Q.-X., Tammer, A., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.12.1685 · Cited by 988 · see citing works

Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease

Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works

Intramuscular desferrioxamine in patients with Alzheimer's disease

MCLACHLAN, D. (1991) · The Lancet · doi:10.1016/0140-6736(91)92978-b · Cited by 764 · see citing works

LINGO-1 negatively regulates myelination by oligodendrocytes

Mi, S., Miller, R. H., Lee, X., Scott, M. L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1460 · Cited by 628 · see citing works

Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo

Kaur, D., Yantiri, F., Rajagopalan, S., Kumar, J., Mo, J. Q., Boonplueang, R., Viswanath, V., Jacobs, R., Yang, L., Beal, M. F., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00126-0 · Cited by 620 · see citing works

Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain

Sapp, E., Kegel, K. B., D, N. A. M., Hashikawa, T., Uchiyama, Y., Tohyama, K., Bhide, P. G., Vonsattel, J., & DiFiglia, M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.2.161 · Cited by 537 · see citing works

Evidence for more widespread cerebral pathology in early HD

Rosas, H. D., Koroshetz, W. J., Chen, Y. I., Skeuse, C., Vangel, M. G., Cudkowicz, M., Caplan, K., MAREK, K. L., Seidman, L. J., Makris, N., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000065888.88988.6e · Cited by 499 · see citing works

The regional distribution and cellular localization of iron in the rat brain

Hill, J. M., & Switzer, R. C. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90046-0 · Cited by 486 · see citing works

Huntingtin and the molecular pathogenesis of Huntington's disease

Landles, C., & Bates, G. P. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400250 · Cited by 485 · see citing works

Microglial activation correlates with severity in Huntington disease: A clinical and PET study

Pavese, N., Gerhard, A., Tai, Y. F., Ho, A. K., Turkheimer, F., Barker, R. A., Brooks, D. J., & Piccini, P. (2006) · Neurology · doi:10.1212/01.wnl.0000222734.56412.17 · Cited by 462 · see citing works

The Selection of Variates for Use in Prediction with Some Comments on the General Problem of Nuisance Parameters

Hotelling, H. (1940) · The Annals of Mathematical Statistics · doi:10.1214/aoms/1177731867 · Cited by 436 · see citing works

Morphometric Demonstration of Atrophic Changes in the Cerebral Cortex, White Matter, and Neostriatum in Huntington's Disease

de la Monte, S. M., Vonsattel, J., & Richardson, E. P. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198809000-00003 · Cited by 434 · see citing works

Cytological and quantitative characteristics of four cerebral commissures in the rhesus monkey

LaMantia, A., & RAKIC, P. T. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902910404 · Cited by 420 · see citing works

Heterogeneous age-related breakdown of white matter structural integrity: Implications for cortical “disconnection” in aging and Alzheimer's disease.

Bartzokis, G., Sultzer, D., Lu, P. H., Nuechterlein, K. H., Mintz, J., & Cummings, J. L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.005 · Cited by 363 · see citing works

Clinical Neurology of Aging

(2010) · Oxford University Press eBooks · doi:10.1093/med/9780195369298.001.0001 · Cited by 360 · see citing works

Brain-Derived Neurotrophic Factor Regulates the Onset and Severity of Motor Dysfunction Associated with Enkephalinergic Neuronal Degeneration in Huntington's Disease

Canals, J. M., Pineda, J. R., Torres-Peraza, J. F., Bosch, M., Martín‐Ibáñez, R., Muñoz, M. T., Mengod, G., Ernfors, P., & Alberch, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1197-04.2004 · Cited by 345 · see citing works

Neurobiological Bases of Age-Related Cognitive Decline in the Rhesus Monkey

Peters, A., Rosene, D. L., Moss, M. B., Kemper, T. L., Abraham, C. R., Tigges, J., & Albert, M. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199608000-00001 · Cited by 344 · see citing works

Brain ferritin iron may influence age- and gender-related risks of neurodegeneration

Bartzokis, G., Tishler, T. A., Lu, P. H., Villablanca, P. J., Altshuler, L. L., Carter, M., Huang, D., Edwards, N. J., & Mintz, J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.02.005 · Cited by 343 · see citing works

Iron misregulation in the brain: a primary cause of neurodegenerative disorders

Ke, Y., & Qian, Z. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00353-3 · Cited by 339 · see citing works

A laminar analysis of the number of neurons, glia, and synapses in the visual cortex (area 17) of adult macaque monkeys

OʼKusky, J. R., & Colonnier, M. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902100307 · Cited by 327 · see citing works

Study of the localization of iron, ferritin, and hemosiderin in Alzheimer’s disease hippocampus by analytical microscopy at the subcellular level

Quintana, C., Bellefqih, S., Laval, J. Y., Guerquin‐Kern, J., Wu, T., Ávila, J., Ferrer, I., Arranz, R., & Patiño, C. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.11.001 · Cited by 297 · see citing works

Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia

Dexter, D. T., Jenner, P. G., Schapira, A. H. V., & MARSDEN, C. D. (1992) · Annals of Neurology · doi:10.1002/ana.410320716 · Cited by 292 · see citing works

Clinical Neurology of Aging

Poser, C. M. (1995) · JAMA · doi:10.1001/jama.1995.03520280102058 · Cited by 284 · see citing works

The distribution of structural neuropathology in pre-clinical Huntington's disease

Thieben, M. J. (2002) · Brain · doi:10.1093/brain/awf179 · Cited by 270 · see citing works

Decreased Neuronal and Increased Oligodendroglial Densities in Huntington's Disease Caudate Nucleus

Myers, R. H., Vonsattel, J. P., Paskevich, P. A., Kiely, D. K., Stevens, T. J., Cupples, L. A., Richardson, E. P., & Bird, E. D. (1991) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199111000-00005 · Cited by 239 · see citing works

Brain Structure in Preclinical Huntington’s Disease

Paulsen, J. S., Magnotta, V. A., Mikos, A., Paulson, H. L., Penziner, E., Andreasen, N. C., & Nopoulos, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.003 · Cited by 235 · see citing works

In Vivo Evaluation of Brain Iron in Alzheimer Disease Using Magnetic Resonance Imaging

Bartzokis, G., Sultzer, D. L., Cummings, J. L., Holt, L. E., Hance, D. B., Henderson, V. W., & Mintz, J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.47 · Cited by 235 · see citing works

Ironing Iron Out in Parkinson's Disease and Other Neurodegenerative Diseases with Iron Chelators: A Lesson from 6‐Hydroxydopamine and Iron Chelators, Desferal and VK‐28

YOUDIM, M. B. H., STEPHENSON, G., & SHACHAR, D. B. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.025 · Cited by 233 · see citing works

Role of Iron in Neurodegenerative Disorders

Berg, D., & Youdim, M. B. H. (2006) · Topics in Magnetic Resonance Imaging · doi:10.1097/01.rmr.0000245461.90406.ad · Cited by 227 · see citing works

Histochemical Distribution of Non-Haem Iron in the Human Brain

Morris, C. M., Candy, J., Oakley, A. E., Bloxham, C. A., & Edwardson, J. A. (1992) · Cells Tissues Organs · doi:10.1159/000147312 · Cited by 218 · see citing works

Cellular management of iron in the brain

Connor, J. R., & Menzies, S. L. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00206-h · Cited by 213 · see citing works

MRI evaluation of brain iron in earlier- and later-onset Parkinson’s disease and normal subjects

Bartzokis, G., Cummings, J. L., Markham, C. H., Marmarelis, P. Z., Treciokas, L. J., Tishler, T. A., Marder, S. R., & Mintz, J. (1999) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(98)00155-6 · Cited by 212 · see citing works

Morphometric analysis of the prefrontal cortex in Huntington's disease

Sotrel, A., Paskevich, P. A., Kiely, D. K., Bird, E. D., Williams, R. S., & Myers, R. H. (1991) · Neurology · doi:10.1212/wnl.41.7.1117 · Cited by 204 · see citing works

Current Status of Metals as Therapeutic Targets in Alzheimer's Disease

Finefrock, A. E., Bush, A. I., & Doraiswamy, P. M. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51368.x · Cited by 203 · see citing works

Cerebral structure on MRI, part II: Specific changes in Alzheimer's and Huntington's diseases

Jernigan, T. L., Salmon, D. P., Butters, N., & Hesselink, J. R. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90211-4 · Cited by 198 · see citing works

Clioquinol down-regulates mutant huntingtin expression <i>in vitro</i> and mitigates pathology in a Huntington's disease mouse model

Nguyen, T., Hamby, A., & Massa, S. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502177102 · Cited by 194 · see citing works

Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases

Bartzokis, G., Tishler, T. A., Shin, I., Lu, P. H., & Cummings, J. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.019 · Cited by 184 · see citing works

Increased basal ganglia iron levels in Huntington disease

Bartzokis, G., Cummings, J., Perlman, S., Hance, D. B., & Mintz, J. (1999) · Archives of Neurology · doi:10.1001/archneur.56.5.569 · Cited by 183 · see citing works

MR evaluation of age-related increase of brain iron in young adult and older normal males

Bartzokis, G., Beckson, M., Hance, D. B., Marx, P., Foster, J., & Marder, S. R. (1997) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(96)00234-2 · Cited by 181 · see citing works

Schizophrenia: breakdown in the well-regulated lifelong process of brain development and maturation

Bartzokis, G. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00364-0 · Cited by 179 · see citing works

Iron regulation in the brain: Histochemical, biochemical, and molecular considerations

Connor, J. R., & Benkovic, S. A. (1992) · Annals of Neurology · doi:10.1002/ana.410320710 · Cited by 178 · see citing works

The relation between brain iron and NMR relaxation times: An in vitro study

Vymazal, J., Brooks, R. A., Baumgarner, C. D., Tran, V., Katz, D., Bulte, J. W. M., Bauminger, E. R., & Chiro, G. D. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350108 · Cited by 172 · see citing works

Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores

Bartzokis, G., Aravagiri, M., Oldendorf, W. H., Mintz, J., & Marder, S. R. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290406 · Cited by 172 · see citing works

Frontal lobe volume in patients with Huntington's disease

Aylward, E., Anderson, N. B., Bylsma, F., Wagster, M. V., Barta, P. E., Sherr, M., Feeney, J., Davis, A., Rosenblatt, A., Pearlson, G. D., et al. (1998) · Neurology · doi:10.1212/wnl.50.1.252 · Cited by 170 · see citing works

Quantitative neuropathological changes in presymptomatic Huntington's disease

Gómez‐Tortosa, E., MacDonald, M. E., Friend, J. C., Taylor, S. A., Weiler, L., Cupples, L. A., Srinidhi, J., Gusella, J. F., Bird, E. D., Vonsattel, J., et al. (2001) · Annals of Neurology · doi:10.1002/1531-8249(200101)49:1 · Cited by 170 · see citing works

In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease

Fennema‐Notestine, C., Archibald, S. L., Jacobson, M. W., Corey‐Bloom, J., Paulsen, J. S., Peavy, G. M., Gamst, A. C., Hamilton, J. M., Salmon, D. P., & Jernigan, T. L. (2004) · Neurology · doi:10.1212/01.wnl.0000138434.68093.67 · Cited by 166 · see citing works

Metals in our minds: therapeutic implications for neurodegenerative disorders

Doraiswamy, P. M., & Finefrock, A. E. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00809-9 · Cited by 161 · see citing works

Cellular iron status influences the functional relationship between microglia and oligodendrocytes

Zhang, X., Surguladze, N., Slagle‐Webb, B., Cozzi, A., & Connor, J. R. (2006) · Glia · doi:10.1002/glia.20416 · Cited by 160 · see citing works

MR of human postmortem brain tissue: correlative study between T2 and assays of iron and ferritin in Parkinson and Huntington disease.

Chen, J. C., Hardy, P., Kucharczyk, W., Clauberg, M., Joshi, J. G., Vourlas, A., Dhar, M. S., & Henkelman, R. M. (1993) · PubMed Central · Cited by 156 · see citing works

Regional white matter change in pre-symptomatic Huntington's disease: A diffusion tensor imaging study

Reading, S. A. J., Yassa, M. A., Bakker, A., Dziorny, A. C., Gourley, L. M., Yallapragada, V., Rosenblatt, A., Margolis, R. L., Aylward, E., Brandt, J., et al. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.05.011 · Cited by 151 · see citing works

Development and maturation of central nervous system myelin: Comparison of immunohistochemical localization of proteolipid protein and basic protein in myelin and oligodendrocytes

Hartman, B. K., Agrawal, H. C., Agrawal, D., & Kalmbach, S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.13.4217 · Cited by 151 · see citing works

Oligodendrocytes, their Progenitors and other Neuroglial Cells in the Aging Primate Cerebral Cortex

Peters, A. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh060 · Cited by 147 · see citing works

In vivo MR evaluation of age-related increases in brain iron.

Bartzokis, G., Mintz, J., Sultzer, D. L., Marx, P., Herzberg, J., Phelan, C., & Marder, S. R. (1994) · PubMed Central · Cited by 140 · see citing works

In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI

Bartzokis, G., Sultzer, D. L., Mintz, J., Holt, L. E., Marx, P., Phelan, C., & Marder, S. R. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90047-7 · Cited by 137 · see citing works

Effects of brain‐derived neurotrophic factor (BDNF) on glial cells and serotonergic neurones during development

Djalali, S., Höltje, M., Große, G., Rothe, T., Stroh, T., Große, J., Deng, D. R., Hellweg, R., Grantyn, R., Hörtnagl, H., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02911.x · Cited by 130 · see citing works

Apolipoprotein E Genotype and Age-Related Myelin Breakdown in Healthy Individuals

Bartzokis, G., Lu, P. H., Geschwind, D. H., Edwards, N. J., Mintz, J., & Cummings, J. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.63 · Cited by 128 · see citing works

The topographic distribution of brain atrophy in Huntington's disease and progressive supranuclear palsy

Mann, D., Oliver, R., & Snowden, J. S. (1993) · Acta Neuropathologica · doi:10.1007/bf00230496 · Cited by 127 · see citing works

Nuclear magnetic resonance relaxation in experimental brain edema: Effects of water concentration, protein concentration, and temperature

Kamman, R. L., Go, K. G., Brouwer, W., & Berendsen, H. J. C. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910060304 · Cited by 117 · see citing works

Nicotine's oxidative and antioxidant properties in CNS

Newman, M. B., Arendash, G. W., Shytle, R. D., Bickford, P. C., Tighe, T., & Sanberg, P. R. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02135-5 · Cited by 116 · see citing works

Huntington Disease: Volumetric, Diffusion-weighted, and Magnetization Transfer MR Imaging of Brain

Mascalchi, M., Lolli, F., Nave, R. D., Tessa, C., Petralli, R., Gavazzi, C., Politi, L. S., Macucci, M., Filippi, M., & Piacentini, S. (2004) · Radiology · doi:10.1148/radiol.2322030820 · Cited by 114 · see citing works

Regionally Specific Effects of BDNF on Oligodendrocytes

Du, Y., Fischer, T. Z., Lee, L. N., Lercher, L. D., & Dreyfus, C. F. (2003) · Developmental Neuroscience · doi:10.1159/000072261 · Cited by 113 · see citing works

Huntington and its Role in Neuronal Degeneration

Li, S., & Li, X. (2004) · The Neuroscientist · doi:10.1177/1073858404266777 · Cited by 111 · see citing works

Iron in Brain Function and Dysfunction with Emphasis on Parkinson’s Disease

Youdim, M. B. H., Ben‐Shachar, D., & Riederer, P. F. (2008) · European Neurology · doi:10.1159/000116719 · Cited by 106 · see citing works

Hepatic hemosiderosis in non‐human primates: Quantification of liver iron using different field strengths

Bulte, J. W. M., Miller, G., Vymazal, J., Brooks, R. A., & Frank, J. A. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370409 · Cited by 97 · see citing works

Quadratic trajectories of brain myelin content: unifying construct for neuropsychiatric disorders

Bartzokis, G. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.001 · Cited by 92 · see citing works

Iron‐enriched oligodendrocytes: A reexamination of their spatial distribution

LeVine, S. M., & Macklin, W. B. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490260415 · Cited by 91 · see citing works

BDNF overexpression produces a long‐term increase in myelin formation in the peripheral nervous system

Tolwani, R. J., Cosgaya, J. M., Varma, S., Jacob, R., Kuo, L. E., & Shooter, E. M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20181 · Cited by 89 · see citing works

Magnetic resonance imaging of brain iron in health and disease

Vymazal, J., Brooks, R. A., Patronas, N. J., Hájek, M., Bulte, J. W. M., & Chiro, G. D. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00204-f · Cited by 88 · see citing works

A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated τ of Alzheimer’s disease

Shin, R., Kruck, T. P. A., Murayama, H., & Kitamoto, T. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03893-3 · Cited by 88 · see citing works

The quantitative Relation Between T1‐Weighted and T2‐Weighted MRI of Normal gray Matter and iron concentration

Vymazal, J., Hájek, M., Patronas, N., Giedd, J. N., Bulte, J. W. M., Baumgarner, C. D., Tran, V., & Brooks, R. A. (1995) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880050514 · Cited by 87 · see citing works

T1 and T2 of ferritin solutions: Effect of loading factor

Vymazal, J., Zak, O., Bulte, J. W. M., Aisen, P., & Brooks, R. A. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910360111 · Cited by 84 · see citing works

Differential Expression of Normal and Mutant Huntington's Disease Gene Alleles

Persichetti, F., Carlée, L., Faber, P. W., McNeil, S. M., Ambrose, C. M., Srinidhi, J., Anderson, M., Barnes, G. T., Gusella, J. F., & MacDonald, M. E. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0018 · Cited by 82 · see citing works

Quantifying Age-Related Myelin Breakdown with MRI: Novel Therapeutic Targets for Preventing Cognitive Decline and Alzheimer's Disease

Bartzokis, G., Lu, P. H., & Mintz, J. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6s604 · Cited by 78 · see citing works

Electron Microscopic Immunocytochemical Localization of Myelin Proteolipid Protein and Myelin Basic Protein to Oligodendrocytes in Rat Brain During Myelination

Schwob, V. S., Clark, H. B., Agrawal, D., & Agrawal, H. C. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb04024.x · Cited by 63 · see citing works

The Role of Metal Ions in Oxidative Processes and Aging

Floyd, R. A., & Carney, J. M. (1993) · Toxicology and Industrial Health · doi:10.1177/0748233793009001-214 · Cited by 58 · see citing works

Postnatal changes in the number of astrocytes, oligodendrocytes, and microglia in the visual cortex (area 17) of the macaque monkey: A stereological analysis in normal and monocularly deprived animals

OʼKusky, J. R., & Colonnier, M. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902100309 · Cited by 57 · see citing works

Brain Myelination in Prevalent Neuropsychiatric Developmental Disorders: Primary and Comorbid Addiction

Flaherty, L. T. (2013) · Routledge eBooks · doi:10.4324/9780203780589-9 · Cited by 49 · see citing works

Basics of Magnetic Resonance Imaging

Oldendorf, W. H., & Oldendorf, W. H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-2081-4 · Cited by 45 · see citing works

Nocturnal TSH Surge and TRH Test Response in the Evaluation of Thyroid Axis in Hypothalamic Pituitary Disorders in Childhood

Gruñeiro‐Papendieck, L., Chiesa, A. E., Martínez, A. S., Heinrich, J. J., & Bergadá, C. (1998) · Hormone Research in Paediatrics · doi:10.1159/000023286 · Cited by 42 · see citing works

Ferritin levels in microglia depend upon activation: Modulation by reactive oxygen species

Mehlhase, J., Gieche, J., Widmer, R., & Grune, T. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.04.012 · Cited by 37 · see citing works

The distribution of iron in the brain: A phylogenetic analysis using iron histochemistry

Erb, G. L., Osterbur, D., & LeVine, S. M. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(96)00020-x · Cited by 35 · see citing works

Effects of diet and development upon the uptake and distribution of cerebral iron

Dwork, A. J. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00207-i · Cited by 35 · see citing works

Regional studies of myelin proteins in human brain and spinal cord

Trotter, J. L., Wegescheide, C. L., & Garvey, W. F. (1984) · Neurochemical Research · doi:10.1007/bf00967665 · Cited by 15 · see citing works

Age-Related Changes in Frontal and Temporal Lobe Volumes in Men: A Magnetic Resonance Imaging Study

Bartzokis, G., Beckson, M., Lu, P. H., Nuechterlein, K. H., Edwards, N., & Mintz, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.461 · Cited by 14 · see citing works

Gradual inhibition of inducible nitric oxide synthase but not of interleukin-1β production in rat microglial cells of endotoxin- treated mixed glial cell cultures

(1996) · Pure Amsterdam UMC · doi:10.1002/(sici)1098-1136(199606)17:2

The role of iron in brain ageing and neurodegenerative disorders

Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works

Oligodendrocytes and myelination: The role of iron

Todorich, B., Pasquini, J. M., Garcia, C. I., Paez, P. M., & Connor, J. R. (2008) · Glia · doi:10.1002/glia.20784 · Cited by 615 · see citing works

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

Belaidi, A. A., & Bush, A. I. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13425 · Cited by 580 · see citing works

Alzheimer's disease as homeostatic responses to age-related myelin breakdown

Bartzokis, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.007 · Cited by 546 · see citing works

MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping

Bilgic, B., Pfefferbaum, A., Rohlfing, T., Sullivan, E. V., & Adalsteinsson, E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.077 · Cited by 499 · see citing works

Biological metals and metal-targeting compounds in major neurodegenerative diseases

Barnham, K. J., & Bush, A. I. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00138a · Cited by 497 · see citing works

The life, death, and replacement of oligodendrocytes in the adult CNS

McTigue, D. M., & Tripathi, R. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05570.x · Cited by 455 · see citing works

A delicate balance: Iron metabolism and diseases of the brain

Hare, D. J., Ayton, S., Bush, A. I., & Lei, P. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00034 · Cited by 444 · see citing works

Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

Boudreau, R. L., McBride, J. L., Martins, I., Shen, S., Xing, Y., Carter, B. J., & Davidson, B. L. (2009) · Molecular Therapy · doi:10.1038/mt.2009.17 · Cited by 339 · see citing works

Integrated Laplacian‐based phase unwrapping and background phase removal for quantitative susceptibility mapping

Li, W., Avram, A., Wu, B. H., Xiao, X., & Liu, C. (2013) · NMR in Biomedicine · doi:10.1002/nbm.3056 · Cited by 311 · see citing works

Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer’s Disease Detected in vivo with Magnetic Resonance Imaging

Raven, E. P., Lu, P. H., Tishler, T. A., Heydari, P., & Bartzokis, G. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130209 · Cited by 270 · see citing works

The transition metals copper and iron in neurodegenerative diseases

Rivera-Mancía, S., Pérez‐Neri, I., Rı́os, C., Tristán-López, L. A., Rivera-Espinosa, L., & Montes, S. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.04.010 · Cited by 243 · see citing works

Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA)

Kruer, M. C., Paisán‐Ruiz, C., Boddaert, N., Yoon, M. Y., Hama, H., Gregory, A., Malandrini, A., Woltjer, R. L., Münnich, A., Gobin, S., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22122 · Cited by 239 · see citing works

Striatal and white matter predictors of estimated diagnosis for Huntington disease

Paulsen, J. S., Nopoulos, P., Aylward, E., Ross, C. A., Johnson, H. J., Magnotta, V. A., Juhl, A., Pierson, R. K., Mills, J. A., Langbehn, D. R., et al. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.04.003 · Cited by 223 · see citing works

PGC-1α, mitochondrial dysfunction, and Huntington's disease

Johri, A., Chandra, A., & Beal, M. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.016 · Cited by 223 · see citing works

Diffusion tensor imaging of deep gray matter brain structures: Effects of age and iron concentration

Pfefferbaum, A., Elfar Adalsteinsson, A., Torsten Rohlfing, B., & Sullivan, E. V. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.013 · Cited by 192 · see citing works

Mutant Huntingtin Downregulates Myelin Regulatory Factor-Mediated Myelin Gene Expression and Affects Mature Oligodendrocytes

Huang, B., Wei, W., Wang, G., Gaertig, M. A., Feng, Y., Wang, W., Li, X., & Li, S. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.026 · Cited by 181 · see citing works

Iron dysregulation in movement disorders

Dušek, P., Jankovic, J. J., & Le, W. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.054 · Cited by 172 · see citing works

Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases

Hammond, K. E., Lupo, J., Xu, D., Metcalf, M., Kelley, D. A. C., Pelletier, D., Chang, S. M., Mukherjee, P., Vigneron, D. B., & Nelson, S. J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.037 · Cited by 166 · see citing works

MRI estimates of brain iron concentration in normal aging: Comparison of field-dependent (FDRI) and phase (SWI) methods

Pfefferbaum, A., Elfar Adalsteinsson, A., Torsten Rohlfing, B., & Sullivan, E. V. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.006 · Cited by 165 · see citing works

Development of biomarkers for Huntington's disease

Weir, D. W., Sturrock, A., & Leavitt, B. R. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70070-9 · Cited by 159 · see citing works

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

Ettle, B., Schlachetzki, J. C. M., & Winkler, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9205-3 · Cited by 160 · see citing works

Alterations in Brain Transition Metals in Huntington Disease

Rosas, H. D., Chen, Y. I., Doros, G. D., Salat, D. H., Chen, N., Kwong, K. K., Bush, A. I., Fox, J. H., & Hersch, S. M. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.2945 · Cited by 160 · see citing works

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders

Mena, N. P., Urrutia, P. J., Lourido, F., Carrasco, C. M., & Núñez, M. T. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.02.001 · Cited by 154 · see citing works

Interleukin-17A: The Key Cytokine in Neurodegenerative Diseases

Chen, J., Liu, X., & Zhong, Y. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.566922 · Cited by 154 · see citing works

Cerebral cortex structure in prodromal Huntington disease

Nopoulos, P., Aylward, E., Ross, C. A., Johnson, H. J., Magnotta, V. A., Juhl, A. R., Pierson, R. K., Mills, J. A., Langbehn, D. R., & Paulsen, J. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.07.014 · Cited by 151 · see citing works

Role and mechanism of ferroptosis in neurological diseases

Ou, M., Jiang, Y., Ji, Y., Zhou, Q., Du, Z., Zhu, H., & Zhou, Z. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101502 · Cited by 148 · see citing works

Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease

Bergen, J. M. G. V., Hua, J., Unschuld, P. G., Lim, I. A. L., Jones, C. K., Margolis, R. L., Ross, C. A., van Zijl, P. C. M., & Li, X. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4617 · Cited by 140 · see citing works

Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions

Popescu, B. F. G., Frischer, J. M., Webb, S. M., Tham, M., Adiele, R. C., Robinson, C. A., Fitz‐Gibbon, P. D., Weigand, S. D., Metz, I., Nehzati, S., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1696-8 · Cited by 138 · see citing works

Oligodendrocytes and Alzheimer's disease

Cai, Z., & Xiao, M. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1025778 · Cited by 133 · see citing works

Peroxisome-Proliferator-Activated Receptor Gamma Coactivator 1 Contributes to Dysmyelination in Experimental Models of Huntington's Disease

Xiang, Z., Valenza, M., Cui, L., Leoni, V., Jeong, H.-K., Brilli, E., Zhang, J., Peng, Q., Duan, W., Reeves, S. A., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1291-11.2011 · Cited by 132 · see citing works

Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer’s Disease

Du, L., Zhao, Z., Cui, A., Zhu, Y., Zhang, L., Liu, J., Shi, S., Fu, C., Han, X., Gao, W., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00194 · Cited by 129 · see citing works

Longitudinal diffusion tensor imaging in Huntington's Disease

Weaver, K. E., Richards, T. L., Liang, O., Laurino, M., Samii, A., & Aylward, E. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2008.12.026 · Cited by 125 · see citing works

Iron dysregulation in Huntington's disease

Müller, M., & Leavitt, B. R. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12739 · Cited by 122 · see citing works

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease

Bardile, C. F., Garcia‐Miralles, M., Caron, N. S., Rayan, N. A., Langley, S. R., Harmston, N., Rondelli, A. M., Teo, R. T. Y., Waltl, S., Anderson, L. M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818042116 · Cited by 119 · see citing works

Role of iron in neurodegenerative diseases

Li, K., & Reichmann, H. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1508-7 · Cited by 118 · see citing works

24S-hydroxycholesterol in plasma: A marker of cholesterol turnover in neurodegenerative diseases

Leoni, V., & Caccia, C. (2012) · Biochimie · doi:10.1016/j.biochi.2012.09.025 · Cited by 114 · see citing works

The Emerging Roles of Ferroptosis in Huntington’s Disease

Mi, Y., Gao, X., Xu, H., Cui, Y., Zhang, Y., & Gou, X. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8518-6 · Cited by 113 · see citing works

New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases

Scarian, E., Viola, C., Dragoni, F., Gerlando, R. D., Rizzo, B., Diamanti, L., Gagliardi, S., Bordoni, M., & Pansarasa, O. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052698 · Cited by 115 · see citing works

Contrasting gray and white matter changes in preclinical Huntington disease

Stoffers, D., Sheldon, S. S., Kuperman, J. M., Goldstein, J. L., Corey‐Bloom, J., & Aron, A. R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d8c20a · Cited by 106 · see citing works

Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging

Bartzokis, G., Lu, P. H., Tingus, K., Peters, D. G., Amar, C. P., Tishler, T. A., Finn, J. P., Villablanca, P. J., Altshuler, L. L., Mintz, J., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.22 · Cited by 104 · see citing works

Iron accumulation in the basal ganglia in Huntington's disease: cross-sectional data from the IMAGE-HD study

D, J. F. D., Ng, A., Poudel, G. R., Stout, J. C., Churchyard, A., Chua, P. M.-L., Egan, G. F., & Georgiou‐Karistianis, N. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-310183 · Cited by 99 · see citing works

Diffusion Tensor Imaging in Huntington’s disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits

Bohanna, I., Georgiou‐Karistianis, N., Sritharan, A., Asadi, H., Johnston, L. A., Churchyard, A., & Egan, G. F. (2011) · Brain Imaging and Behavior · doi:10.1007/s11682-011-9121-8 · Cited by 94 · see citing works

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

Jin, J., Peng, Q., Hou, Z., Jiang, M., Wang, X., Langseth, A. J., Tao, M., Barker, P. B., Mori, S., Bergles, D. E., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv016 · Cited by 93 · see citing works

Evidence for altered cholesterol metabolism in <scp>H</scp>untington's disease <i>post mortem</i> brain tissue

Kreilaus, F., Spiro, A. S., McLean, C. A., Garner, B., & Jenner, A. M. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12286 · Cited by 92 · see citing works

Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice

Park, H., Cho, B., Kim, H., Saito, T., Saido, T. C., Won, K.-J., & Kim, J. (2023) · Nature Communications · doi:10.1038/s41467-023-36519-8 · Cited by 92 · see citing works

CSF T-Tau/Aβ42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease

Bendlin, B. B., Carlsson, C. M., Johnson, S. C., Zetterberg, H., Blennow, K., Willette, A. A., Okonkwo, O. C., Sodhi, A., Ries, M. L., Birdsill, A. C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037720 · Cited by 91 · see citing works

Multi-Modal Neuroimaging in Premanifest and Early Huntington’s Disease: 18 Month Longitudinal Data from the IMAGE-HD Study

D, J. F. D., Egan, G. F., Gray, M. A., Poudel, G. R., Churchyard, A., Chua, P. M.-L., Stout, J. C., & Georgiou‐Karistianis, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074131 · Cited by 90 · see citing works

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

Teo, R. T. Y., Hong, X., Yu-Taeger, L., Huang, Y., Tan, L. J., Xie, Y., To, X. V., Guo, L. T., Rajendran, R., Novati, A., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw122 · Cited by 87 · see citing works

Aging in deep gray matter and white matter revealed by diffusional kurtosis imaging

Gong, N.-J., Wong, C.-S., Chan, C.-C., Leung, L.-M., & Chu, Y.-C. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.011 · Cited by 82 · see citing works

A Critical Review of White Matter Changes in Huntington’s Disease

Casella, C., Lipp, I., Rosser, A., Jones, D. K., & Metzler‐Baddeley, C. (2020) · Movement Disorders · doi:10.1002/mds.28109 · Cited by 78 · see citing works

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

Arteaga-Bracho, E. E., Gulinello, M. E., Winchester, M. L., Pichamoorthy, N., Petronglo, J. R., Zambrano, A. D., Inocencio, J. F., Jesus, C. D. D., Louie, J. O., Gökhan, Ş., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.09.006 · Cited by 81 · see citing works

Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Toonen, L. J. A., Overzier, M., Evers, M. M., León, L. G., van der Zeeuw, S. A. J., Mei, H., Kiełbasa, S. M., Goeman, J. J., Hettne, K. M., Magnússon, Ó. Þ., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0261-9 · Cited by 80 · see citing works

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging

Xu, J., Marzetti, E., Seo, A. Y., Kim, J., Prolla, T. A., & Leeuwenburgh, C. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.04.007 · Cited by 77 · see citing works

Major Superficial White Matter Abnormalities in Huntington's Disease

Phillips, O. R., Joshi, S. H., Squitieri, F., Sánchez‐Castañeda, C., Narr, K. L., Shattuck, D. W., Caltagirone, C., Sabatini, U., & Paola, M. D. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00197 · Cited by 76 · see citing works

Disease‐modifying effects of ganglioside GM1 in Huntington's disease models

Alpaugh, M., Galleguillos, D., Forero, J. P., Morales, L. C., Lackey, S. W. K., Kar, P., Pardo, A. D., Holt, A., Kerr, B. J., Todd, K. G., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707763 · Cited by 73 · see citing works

Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications

Paul, B. D., & Snyder, S. H. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00068 · Cited by 75 · see citing works

Myelin Breakdown in Human Huntington’s Disease: Multi-Modal Evidence from Diffusion MRI and Quantitative Magnetization Transfer

Bourbon‐Teles, J., Bells, S., Jones, D. K., Coulthard, E. J., Rosser, A., & Metzler‐Baddeley, C. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.042 · Cited by 74 · see citing works

Seeking huntington disease biomarkers by multimodal, cross‐sectional basal ganglia imaging

Sánchez‐Castañeda, C., Cherubini, A., Elifani, F., Péran, P., Orobello, S., Capelli, G., Sabatini, U., & Squitieri, F. (2012) · Human Brain Mapping · doi:10.1002/hbm.22019 · Cited by 73 · see citing works

Time-efficient, high-resolution, whole brain three-dimensional macromolecular proton fraction mapping

Yarnykh, V. L. (2015) · Magnetic Resonance in Medicine · doi:10.1002/mrm.25811 · Cited by 70 · see citing works

Oligodendroglia and neurotrophic factors in neurodegeneration

Bankston, A. N., Mandler, M. D., & Feng, Y. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1321-3 · Cited by 70 · see citing works

Multimodal MRI Analysis of the Corpus Callosum Reveals White Matter Differences in Presymptomatic and Early Huntington's Disease

Paola, M. D., Eileen Luders, A., Cherubini, A., Sánchez‐Castañeda, C., Thompson, P. M., Toga, A. W., Caltagirone, C., Orobello, S., Elifani, F., Squitieri, F., et al. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr360 · Cited by 68 · see citing works

Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis

Ismail, N., Kureishy, N., Church, S. J., Scholefield, M., Unwin, R. D., Xu, J., Patassini, S., & Cooper, G. J. S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.052 · Cited by 67 · see citing works

Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment

Blockx, I., Groof, G. D., Verhoye, M., Audekerke, J. V., Raber, K. A., Poot, D. H. J., Sijbers, J., Osmand, A. P., von Hörsten, S., & der Linden, A. V. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.062 · Cited by 66 · see citing works

Hydroxamate, a Key Pharmacophore Exhibiting a Wide Range of Biological Activities

Bertrand, S., Hélesbeux, J., Larcher, G., & Duval, O. (2013) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/13895575113139990007 · Cited by 66 · see citing works

Altered brain iron content and deposition rate in Huntington’s disease as indicated by quantitative susceptibility MRI

Chen, L., Hua, J., Ross, C. A., Cai, S., van Zijl, P. C. M., & Li, X. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24358 · Cited by 64 · see citing works

Elevated brain iron is independent from atrophy in Huntington's Disease

Dumas, E. M., Versluis, M. J., van den Bogaard, S. J. A., van Osch, M. J. P., Hart, E. P., van Roon‐Mom, W., van Buchem, M. A., WEBB, A. G., van der Grond, J., & Roos, R. A. C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.056 · Cited by 62 · see citing works

Tractography of the Corpus Callosum in Huntington’s Disease

Phillips, O. R., Sánchez‐Castañeda, C., Elifani, F., Maglione, V., Pardo, A. D., Caltagirone, C., Squitieri, F., Sabatini, U., & Paola, M. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073280 · Cited by 58 · see citing works

Comparison of Histological Techniques to Visualize Iron in Paraffin-embedded Brain Tissue of Patients with Alzheimer’s Disease

van Duijn, S., Nabuurs, R. J. A., van Duinen, S. G., & Natté, R. (2013) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155413501325 · Cited by 61 · see citing works

Neuroglialpharmacology: white matter pathophysiologies and psychiatric treatments

Bartzokis, G. (2011) · Frontiers in bioscience · doi:10.2741/3881 · Cited by 60 · see citing works

Gene therapy for Huntington's disease

Ramaswamy, S., & Kordower, J. H. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.030 · Cited by 57 · see citing works

Focal dystonia and the Sensory-Motor Integrative Loop for Enacting (SMILE)

Perruchoud, D., Murray, M. M., Lefebvre, J., & Ionta, S. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00458 · Cited by 56 · see citing works

Iron and Alzheimer’s Disease: From Pathology to Imaging

Tran, D. Q., DiGiacomo, P., Born, D. E., Georgiadis, M., & Zeineh, M. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.838692 · Cited by 57 · see citing works

Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease

Rosas, H. D., Wilkens, P. J., Salat, D. H., Mercaldo, N. D., Vangel, M. G., Yendiki, A., & Hersch, S. M. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.01.029 · Cited by 54 · see citing works

Metal and complementary molecular bioimaging in Alzheimer's disease

Braidy, N., Poljak, A., Marjo, C. E., Rutlidge, H., Rich, A. M., Jayasena, T., Inestrosa, N. C., & Sachdev, P. S. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00138 · Cited by 53 · see citing works

Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/2 Mouse Model of HD

Rattray, I., Smith, E. J., Gale, R., Matsumoto, K., Bates, G. P., & Modo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060012 · Cited by 52 · see citing works

Deep White Matter in Huntington's Disease

Phillips, O. R., Squitieri, F., Sánchez‐Castañeda, C., Elifani, F., Caltagirone, C., Sabatini, U., & Paola, M. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109676 · Cited by 52 · see citing works

Ferroptosis: underlying mechanisms and involvement in neurodegenerative diseases

Wang, Y., Li, H., He, Q., Zou, R., Cai, J., & Zhang, L. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01902-9 · Cited by 53 · see citing works

Multimodal imaging biomarkers in premanifest and early Huntington's disease: 30-month IMAGE-HD data

Domínguez, J. F., Stout, J. C., Poudel, G. R., Churchyard, A., Chua, P. M.-L., Egan, G. F., & Georgiou‐Karistianis, N. (2015) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.156588 · Cited by 51 · see citing works

[Iron deficiency and overload. Implications in oxidative stress and cardiovascular health].

Toxqui, L., Piero, A. D., Courtois, V., Bastida, S., Sánchez-Muniz, F. J., & Vaquero, M. P. (2010) · PubMed · doi:10.3305/nh.2010.25.3.4583 · Cited by 50 · see citing works

Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model

Cheng, Y., Peng, Q., Hou, Z., Aggarwal, M., Zhang, J., Mori, S., Ross, C. A., & Duan, W. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.022 · Cited by 50 · see citing works

Overdosing on iron: Elevated iron and degenerative brain disorders

D’Mello, S. R., & Kindy, M. S. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220953065 · Cited by 49 · see citing works

MRI measures of corpus callosum iron and myelin in early Huntington's disease

Paola, M. D., Phillips, O. R., Sánchez‐Castañeda, C., Pardo, A. D., Maglione, V., Caltagirone, C., Sabatini, U., & Squitieri, F. (2013) · Human Brain Mapping · doi:10.1002/hbm.22391 · Cited by 49 · see citing works

Reactive Species in Huntington Disease: Are They Really the Radicals You Want to Catch?

Bono-Yagüe, J., Gómez-Escribano, A. P., Millán, J. M., & Vázquez‐Manrique, R. P. (2020) · Antioxidants · doi:10.3390/antiox9070577 · Cited by 49 · see citing works

Free radical biology in neurological manifestations: mechanisms to therapeutics interventions

Tripathi, R. S., Gupta, R. V., Sahu, M., Srivastava, D., Das, A., Ambasta, R. K., & Kumar, P. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16693-2 · Cited by 52 · see citing works

The role of iron in gray matter degeneration in Huntington's disease: A magnetic resonance imaging study

Sánchez‐Castañeda, C., Squitieri, F., Paola, M. D., Dayan, M., Petrollini, M., & Sabatini, U. (2014) · Human Brain Mapping · doi:10.1002/hbm.22612 · Cited by 46 · see citing works

Diffusion Tensor Imaging in Preclinical Huntington’s Disease

Magnotta, V. A., Kim, J., Koscik, T. R., Beglinger, L. J., Espinso, D., Langbehn, D. R., Nopoulos, P., & Paulsen, J. S. (2008) · Brain Imaging and Behavior · doi:10.1007/s11682-008-9051-2 · Cited by 46 · see citing works

Brain, blood, and iron: Perspectives on the roles of erythrocytes and iron in neurodegeneration

Prohaska, R., Sibon, O. C. M., Rudnicki, D. D., Danek, A., Hayflick, S. J., Verhaag, E. M., Vonk, J. J., Margolis, R. L., & Walker, R. H. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.006 · Cited by 45 · see citing works

Combining atlas-based parcellation of regional brain data acquired across scanners at 1.5T and 3.0T field strengths

Pfefferbaum, A., Torsten Rohlfing, B., Rosenbloom, M. J., & Sullivan, E. V. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.092 · Cited by 45 · see citing works

Phenolic Compounds of Therapeutic Interest in Neuroprotection

Nájera-Maldonado, J. M., Salazar, R., Fitz, P. Á., Quiroz, M. E. A., Flores‐Alfaro, E., Hernández‐Sotelo, D., Espinoza-Rojo, M., & Ramı́rez, M. (2024) · Journal of Xenobiotics · doi:10.3390/jox14010014 · Cited by 49 · see citing works

Widespread Decreases in Cerebral Copper Are Common to Parkinson's Disease Dementia and Alzheimer's Disease Dementia

Scholefield, M., Church, S. J., Xu, J., Patassini, S., Roncaroli, F., Hooper, N. M., Unwin, R. D., & Cooper, G. J. S. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.641222 · Cited by 44 · see citing works

Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington’s Disease

Simmons, D. A. (2017) · Journal of Huntington s Disease · doi:10.3233/jhd-170275 · Cited by 41 · see citing works

Cell Rearrangement and Oxidant/Antioxidant Imbalance in Huntington’s Disease

D’Egidio, F., Castelli, V., Cimini, A., & d’Angelo, M. (2023) · Antioxidants · doi:10.3390/antiox12030571 · Cited by 41 · see citing works

MRI T2 Hypointensities in basal ganglia of premanifest Huntington's disease

Jurgens, C. K., Jasinschi, R., Ekin, A., Witjes‐Ané, M. W., van der Grond, J., Middelkoop, H. A. M., & Roos, R. A. C. (2010) · PLoS Currents · doi:10.1371/currents.rrn1173 · Cited by 42 · see citing works

The Corticospinal Tract in Huntington's Disease

Phillips, O. R., Squitieri, F., Sánchez‐Castañeda, C., Elifani, F., Griguoli, A. M., Maglione, V., Caltagirone, C., Sabatini, U., & Paola, M. D. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu065 · Cited by 41 · see citing works

Relationship between aging and T1 relaxation time in deep gray matter: A voxel‐based analysis

Okubo, G., Okada, T., Yamamoto, A., Fushimi, Y., Okada, T., Murata, K., & Togashi, K. (2017) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25590 · Cited by 42 · see citing works

Detection of axonal degeneration in a mouse model of Huntington’s disease: comparison between diffusion tensor imaging and anomalous diffusion metrics

Gatto, R. G., Ye, A. Q., Colon-Perez, L., Mareci, T. H., Lysakowski, A., Price, S. D., Brady, S. T., Karaman, M., Morfini, G., & Magin, R. L. (2019) · Magnetic Resonance Materials in Physics, Biology and Medicine · doi:10.1007/s10334-019-00742-6 · Cited by 42 · see citing works

Myelin injury in the central nervous system and Alzheimer's disease.

Wang, S.-S., Zhang, Z., Zhu, T., Chu, S.-F., He, W.-B., & Chen, N.-H. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.05.003 · Cited by 40 · see citing works

Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study

Johnson, E. B., Parker, C. S., Scahill, R. I., Gregory, S., Papoutsi, M., Zeun, P., Osborne‐Crowley, K., Lowe, J., Nair, A., Estevez‐Fraga, C., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103266 · Cited by 39 · see citing works

Effects of aging and calorie restriction on white matter in rhesus macaques

Bendlin, B. B., Canu, E., Willette, A. A., Kastman, E. K., McLaren, D. G., Kosmatka, K. J., Xu, G., Field, A. S., Colman, R. J., Coe, C. L., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.008 · Cited by 41 · see citing works

MRI measures of corpus callosum iron and myelin in early Huntington's disease

Paola, M. D., Phillips, O. R., Sánchez‐Castañeda, C., Pardo, A. D., Maglione, V., Caltagirone, C., Sabatini, U., & Squitieri, F. (2013) · Human Brain Mapping · doi:10.1002/hbm.22391 · Cited by 49 · see citing works

Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study

Johnson, E. B., Parker, C. S., Scahill, R. I., Gregory, S., Papoutsi, M., Zeun, P., Osborne‐Crowley, K., Lowe, J., Nair, A., Estevez‐Fraga, C., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103266 · Cited by 39 · see citing works

MRI imaging of myelin and iron in Huntington’s Disease

Athertya, J., Lo, J. S.-I., Shin, S. H., Bagga, K., Ma, Y., Tang, H., Bydder, G. M., Corey‐Bloom, J., & Du, J. (2025) · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · doi:10.58530/2025/2983

G06 Iron defect is implicated in white matter changes in Huntington disease

Paola, M. D., Phillips, O., Sánchez‐Castañeda, C., Pardo, A. D., Maglione, V., Caltagirone, C., Sabatini, U., & Squitieri, F. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303524.86

7T MRI Reveals Abnormal Iron Deposition and Microstructure in Premanifest and Manifest Huntington’s Disease

Yao, J., Morrison, M. A., Jakary, A., Avadiappan, S., Glueck, J., Driscoll, T., Geschwind, M., Nelson, A., Xu, D., Hess, C. P., et al. (2024) · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · doi:10.58530/2023/0574