Glutamate Transporters in Neurologic Disease

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062 · see citing works

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143 · see citing works

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

Rothstein, J. D., Dykes-Hoberg, M., Pardo, C. A., Bristol, L. A., Jin, L., Kuncl, R. W., Kanai, Y., Hediger, M. A., Wang, Y., Schielke, J. P., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80086-0 · Cited by 2,534 · see citing works

El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis

Brooks, B. R. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90191-0 · Cited by 2,144 · see citing works

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

Olney, J. (1969) · Science · doi:10.1126/science.164.3880.719 · Cited by 1,885 · see citing works

Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1

Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., et al. (1997) · Science · doi:10.1126/science.276.5319.1699 · Cited by 1,755 · see citing works

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80272-x · Cited by 1,341 · see citing works

Primary structure and functional characterization of a high-affinity glutamate transporter

Kanai, Y., & Hediger, M. A. (1992) · Nature · doi:10.1038/360467a0 · Cited by 1,339 · see citing works

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

Reaume, A. G., Elliott, J. L., Hoffman, E. K., Kowall, N. W., Ferrante, R. J., Siwek, D. F., Wilcox, H. M., Flood, D. G., Beal, M. F., Brown, R. H., et al. (1996) · Nature Genetics · doi:10.1038/ng0596-43 · Cited by 1,285 · see citing works

Cloning and expression of a rat brain L-glutamate transporter

Pines, G., Danbolt, N. C., Bjørås, M., Zhang, Y., Bendahan, A., Eide, L., Koepsell, H., Storm‐Mathisen, J., Seeberg, E. C., & Kanner, B. I. (1992) · Nature · doi:10.1038/360464a0 · Cited by 1,232 · see citing works

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

Storck, T., Schulte, S., Hofmann, K., & Stoffel, W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10955 · Cited by 1,185 · see citing works

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

Rothstein, J. D., Martin, L. J., & Kuncl, R. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205283262204 · Cited by 1,180 · see citing works

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaught, M. P., & Amara, S. G. (1995) · Nature · doi:10.1038/375599a0 · Cited by 1,132 · see citing works

The release and uptake of excitatory amino acids

Nicholls, D. G., & Attwell, D. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90129-v · Cited by 1,089 · see citing works

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

Lucas, D., & Newhouse, J. P. (1957) · Archives of Ophthalmology · doi:10.1001/archopht.1957.00940010205006 · Cited by 1,069 · see citing works

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

Arriza, J. L., Fairman, W. A., Wadiche, J. I., Murdoch, G., Kavanaugh, M. P., & Amara, S. G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05559.1994 · Cited by 998 · see citing works

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

Arriza, J. L., Eliasof, S. D., Kavanaugh, M. P., & Amara, S. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4155 · Cited by 914 · see citing works

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

Ripps, M. E., Huntley, G. W., Hof, P. R., Morrison, J., & Gordon, J. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.689 · Cited by 725 · see citing works

Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake

Szatkowski, M. S., Barbour, B., & Attwell, D. (1990) · Nature · doi:10.1038/348443a0 · Cited by 724 · see citing works

Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis

Lin, C.-L., Bristol, L. A., Jin, L., Dykes‐Hoberg, M., Crawford, T. O., Clawson, L., & Rothstein, J. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80997-6 · Cited by 672 · see citing works

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

Rothstein, J. D., Tsai, G. E., Kuncl, R. W., Clawson, L., Cornblath, D. R., Drachman, D. B., Pestronk, A., Stauch, B. L., & Coyle, J. T. (1990) · Annals of Neurology · doi:10.1002/ana.410280106 · Cited by 637 · see citing works

Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters

Hertz, L. (1979) · Progress in Neurobiology · doi:10.1016/0301-0082(79)90018-2 · Cited by 629 · see citing works

Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease

Masliah, E., Hansen, L., Alford, M., Deteresa, R., & Mallory, M. (1996) · Annals of Neurology · doi:10.1002/ana.410400512 · Cited by 476 · see citing works

Mechanism of Transport and Storage of Neurotransmitter

Kanner, B. I., & Schuldiner, S. (1987) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238709082546 · Cited by 470 · see citing works

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

Olney, J. W. (1971) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197101000-00008 · Cited by 416 · see citing works

Brain Damage in Infant Mice following Oral Intake of Glutamate, Aspartate or Cysteine

Olney, J. W., & Ho, O. L. (1970) · Nature · doi:10.1038/227609b0 · Cited by 385 · see citing works

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter

Trotti, D., Rolfs, A., Danbolt, N. C., Brown, R. H., & Hediger, M. A. (1999) · Nature Neuroscience · doi:10.1038/8091 · Cited by 373 · see citing works

Peroxynitrite Inhibits Glutamate Transporter Subtypes

Trotti, D., Rossi, D., Gjesdal, O., Levy, L. M., Racagni, G., Danbolt, N. C., & Volterra, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.5976 · Cited by 371 · see citing works

Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

Shank, R. P., Gardocki, J. F., Vaught, J. L., Davis, C. B., Schupsky, J. J., Raffa, R. B., Dodgson, S. J., Nortey, S. O., & Maryanoff, B. E. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02459.x · Cited by 345 · see citing works

Glutamate transporter EAAC‐1‐deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration

Peghini, P., Janzen, J., & Stoffel, W. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3822 · Cited by 343 · see citing works

Hypoxia—ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum

Martin, L. J., Brambrink, A. M., Lehmann, C. U., Portera‐Cailliau, C., Koehler, R. C., Rothstein, J. D., & Traystman, R. J. (1997) · Annals of Neurology · doi:10.1002/ana.410420310 · Cited by 271 · see citing works

The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1

Martin, D., Thompson, M. A., & Nadler, J. V. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90037-i · Cited by 259 · see citing works

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

Bristol, L. A., & Rothstein, J. D. (1996) · Annals of Neurology · doi:10.1002/ana.410390519 · Cited by 239 · see citing works

Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4

Furuta, A., Martin, L. J., Lin, C.-L. G., Dykes‐Hoberg, M., & Rothstein, J. D. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00252-2 · Cited by 235 · see citing works

THE TOXIC EFFECTS OF GLUTAMATE AND RELATED COMPOUNDS IN THE RETINA AND THE BRAIN

Olney, J. W. (1982) · Retina · doi:10.1097/00006982-198200000-00020 · Cited by 154 · see citing works

Modulation of non-vesicular glutamate release by pH

Billups, B., & Attwell, D. (1996) · Nature · doi:10.1038/379171a0 · Cited by 145 · see citing works

Expression of the glutamate transporters in human temporal lobe epilepsy

Tessler, S., Danbolt, N. C., Faull, R. L. M., Storm‐Mathisen, J., & Emson, P. C. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00301-7 · Cited by 112 · see citing works

Excitatory amino acids in amyotrophic lateral sclerosis: An update

Rothstein, J. D., Kuncl, R. W., Chaudhry, V., Clawson, L., Cornblath, D. R., Coyle, J. T., & Drachman, D. B. (1991) · Annals of Neurology · doi:10.1002/ana.410300223 · Cited by 96 · see citing works

Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity

Simantov, R., Crispino, M., Hoe, W., Broutman, G., Tocco, G., Rothstein, J. D., & Baudry, M. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00349-0 · Cited by 92 · see citing works

Chapter 19: Ultrastructural immunocytochemical observations on the localization, metabolism and transport of glutamate in normal and ischemic brain tissue

Storm‐Mathisen, J., Danbolt, N. C., Rothe, F., Torp, R., Zhang, N., Aas, J., Kanner, B. I., Langmoen, I. A., & Ottersen, O. P. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61753-7 · Cited by 83 · see citing works

Expression of glial glutamate transporters GLT-1 and GLAST is unchanged in the hippocampus in fully kindled rats

Akbar, M. T., Torp, R., Danbolt, N. C., Levy, L. M., Meldrum, B. S., & Ottersen, O. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00570-2 · Cited by 59 · see citing works

Expression of Two Glutamate Transporters, GLAST and EAAT4, in the Human Cerebellum: Their Correlation in Development and Neonatal Hypoxic-Ischemic Damage

Inage, Y. W., Itoh, M., Wada, K., & Takashima, S. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199806000-00003 · Cited by 57 · see citing works

Amino acids acting as transmitters in amyotrophic lateral sclerosis (ALS)

Niebrój-Dobosz, I., & Janik, P. (1999) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1999.tb00717.x · Cited by 55 · see citing works

Histidine 326 is critical for the function of GLT-1, a (Na+ + K+)-coupled glutamate transporter from rat brain.

Zhang, Y., Pines, G., & Kanner, B. I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32207-x · Cited by 51 · see citing works

Uptake of glutamate, not glutamine synthetase, regulates adaptation of mammalian cells to glutamine-free medium

McDermott, R. H., & Butler, M. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.1.51 · Cited by 49 · see citing works

Increased transcription of glutamate–aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure

Nonaka, M., Kohmura, E., Yamashita, T., Shimada, S., Tanaka, K., Yoshimine, T., Tohyama, M., & Hayakawa, T. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00361-6 · Cited by 43 · see citing works

Differential Expressions of Glycine Transporter 1 and Three Glutamate Transporter mRNA in the Hippocampus of Gerbils with Transient Forebrain Ischemia

Fujita, H. M., Sato, K., Wen, T., Peng, Y., & Sakanaka, M. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199906000-00003 · Cited by 40 · see citing works

Biological markers in the diagnosis and treatment of ALS

Kalra, S., Arnold, D. L., & Cashman, N. R. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00023-4 · Cited by 34 · see citing works

Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 999 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Kindling and status epilepticus models of epilepsy: rewiring the brain

Morimoto, K., Fahnestock, M. L., & Racine, R. J. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.009 · Cited by 840 · see citing works

Astrocyte dysfunction in neurological disorders: a molecular perspective

Seifert, G., Schilling, K., & Steinhäuser, C. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1870 · Cited by 798 · see citing works

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1

Allanbutterfield, D., Castegna, A., Lauderback, C. M., & Drake, J. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00340-2 · Cited by 715 · see citing works

Tau and tauopathies

Arendt, T., Stieler, J. T., & Holzer, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.018 · Cited by 609 · see citing works

Postmortem brain abnormalities of the glutamate neurotransmitter system in autism

Purcell, A. E., Jeon, O. H., Zimmerman, A. W., Blue, M. E., & Pevsner, J. (2001) · Neurology · doi:10.1212/wnl.57.9.1618 · Cited by 518 · see citing works

Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections

Danysz, W., & Parsons, C. G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02057.x · Cited by 500 · see citing works

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

Shin, J., Fang, Z.-H., Yu, Z.-X., Wang, C.-E., Li, S., & Li, X. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200508072 · Cited by 475 · see citing works

Non–cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

Ballas, N., Lioy, D. T., Grunseich, C., & Mandel, G. (2009) · Nature Neuroscience · doi:10.1038/nn.2275 · Cited by 466 · see citing works

The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

Lauderback, C. M., Hackett, J. M., Huang, F. F., Keller, J. N., Szweda, L. I., Markesbery, W. R., & Butterfield, D. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00451.x · Cited by 464 · see citing works

Mechanisms of methylmercury-induced neurotoxicity: Evidence from experimental studies

Farina, M., da Rocha, J. B. T., & Aschner, M. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.05.019 · Cited by 448 · see citing works

Huntington's disease: from pathology and genetics to potential therapies

Imarisio, S., Carmichael, J., Korolchuk, V., Chen, C.-W., Saiki, S., Rose, C., Krishna, G., Davies, J. E., Ttofi, E., Underwood, B. R., et al. (2008) · Biochemical Journal · doi:10.1042/bj20071619 · Cited by 409 · see citing works

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

Bradford, J. W., Shin, J., Redd, M. A., Wang, C.-E., Li, X.-J., & Li, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911503106 · Cited by 362 · see citing works

Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes

Tavares, R. G., Tasca, C. I., Santos, C. E. S., Alves, L. B., Porciúncula, L. O., Emanuelli, T., & Souza, D. O. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00133-4 · Cited by 320 · see citing works

Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH

Su, Z.-Z., Kang, D., Chen, Y., Pekarskaya, O., Chao, W., Volsky, D. J., & Fisher, P. B. (2002) · Oncogene · doi:10.1038/sj.onc.1205445 · Cited by 320 · see citing works

Stress as a neuroinflammatory condition in brain: Damaging and protective mechanisms

García‐Bueno, B., Caso, J. R., & Leza, J. C. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.04.001 · Cited by 280 · see citing works

Glial Cells and Neurotransmission

Auld, D. S., & Robitaille, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00607-x · Cited by 239 · see citing works

Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets

Rico, E. P., Rosemberg, D. B., Seibt, K. J., Capiotti, K. M., Silva, R. S. D., & Bonan, C. D. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.07.007 · Cited by 229 · see citing works

Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells

Graves, M. C., Fiala, M., Dinglasan, L. A. V., Liu, N., Sayre, J. W., Chiappelli, F., van Kooten, C., & Vinters, H. V. (2004) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820410020286 · Cited by 213 · see citing works

Riluzole Enhances Glutamate Uptake in Rat Astrocyte Cultures

Frizzo, M. E., Dall’Onder, L. P., Dalcin, K. B., & Souza, D. O. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000012717.37839.07 · Cited by 213 · see citing works

Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120

Wang, Z., Pekarskaya, O., Bencheikh, M., Chao, W., Gelbard, H. A., Ghorpade, A., Rothstein, J. D., & Volsky, D. J. (2003) · Virology · doi:10.1016/s0042-6822(03)00181-8 · Cited by 212 · see citing works

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

Neymotin, A., Calingasan, N. Y., Wille, E. J., Naseri, N., Petri, S., Damiano, M. G., Liby, K. T., Risingsong, R., Sporn, M. B., Beal, M. F., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.027 · Cited by 212 · see citing works

Glutamate–glutamine Cycling in the Epileptic Human Hippocampus

Petroff, O. A. C., Errante, L. D., Rothman, D. L., Kim, J., & Spencer, D. D. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.38901.x · Cited by 206 · see citing works

Drug repositioning and repurposing for Alzheimer disease

Ballard, C., Aarsland, D., Cummings, J., O’Brien, J., Mills, R., Molinuevo, J. L., Fladby, T., Williams, G., Doherty, P., Corbett, A., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0397-4 · Cited by 201 · see citing works

Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS

von Lewinski, F., & Keller, B. U. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.07.001 · Cited by 186 · see citing works

Microelectrode array studies of basal and potassium‐evoked release of l ‐glutamate in the anesthetized rat brain

Day, B. K., Pomerleau, F., Burmeister, J. J., Huettl, P. F., & Gerhardt, G. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03673.x · Cited by 174 · see citing works

Selective defect of in vivo glycolysis in early Huntington's disease striatum

Powers, W. J., Videen, T. O., Markham, J., McGee‐Minnich, L., Antenor‐Dorsey, J. A. V., Hershey, T. G., & Perlmutter, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609833104 · Cited by 174 · see citing works

Molecular targets in the treatment of anxiety

KENT, J. M., Mathew, S. J., & Gorman, J. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01672-4 · Cited by 167 · see citing works

Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: A decade of advance

Cherlyn, S. Y. T., Woon, P. S., Liu, J., Ong, W., Tsai, G., & Sim, K. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.002 · Cited by 165 · see citing works

Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat.

Martin, K. R. G., Levkovitch-Verbin, H., Valenta, D. F., Baumrind, L. A., Pease, M. E., & Quigley, H. A. (2002) · PubMed · Cited by 161 · see citing works

Cortical selective vulnerability in motor neuron disease: a morphometric study

Maekawa, S., Al‐Sarraj, S., Kibble, M., Landau, S., Parnavelas, J. G., Cotter, D., Everall, I., & Leigh, P. N. (2004) · Brain · doi:10.1093/brain/awh132 · Cited by 160 · see citing works

Glia in the pathogenesis of neurodegenerative diseases

Verkhratsky, A., Parpura, V., Pekna, M., Pekny, M., & Sofroniew, M. V. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140107 · Cited by 157 · see citing works

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

Divakaruni, A. S., Wallace, M., Buren, C., Martyniuk, K. M., Andreyev, A. Y., Li, E., Fields, J. A., Cordes, T., Reynolds, I. J., Bloodgood, B. L., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201612067 · Cited by 157 · see citing works

Synaptically induced sodium signals in hippocampal astrocytes in situ

Langer, J., & Rose, C. R. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.182279 · Cited by 155 · see citing works

Decreased Expression of Glutamate Transporters in Astrocytes after Human Traumatic Brain Injury

van Landeghem, F. K. H., Weiss, T., Oehmichen, M., & von Deimling, A. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.1518 · Cited by 151 · see citing works

Increased Expression of the Neuronal Glutamate Transporter (EAAT3/EAAC1) in Hippocampal and Neocortical Epilepsy

Crino, P. B., Jin, H., Shumate, M. D., Robinson, M. B., Coulter, D. A., & Brooks‐Kayal, A. R. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.35001.x · Cited by 148 · see citing works

Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport

Hurtado, O., Moro, M. Á., Cárdenas, A., Sánchez, V., Fernández-Tomé, P., Leza, J. C., Lorenzo, P. L., Secades, J. J., Lozano, R., Dávalos, A., et al. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.006 · Cited by 147 · see citing works

Altered expression of the glutamate transporter EAAT2b in neurological disease

Maragakis, N. J., Dykes‐Hoberg, M., & Rothstein, J. D. (2004) · Annals of Neurology · doi:10.1002/ana.20003 · Cited by 138 · see citing works

Rapid Trafficking of the Neuronal Glutamate Transporter, EAAC1

Fournier, K. M., González, M. I., & Robinson, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404032200 · Cited by 137 · see citing works

Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models

Cárdenas‐Rodríguez, N., Huerta-Gertrudis, B., Rivera-Espinosa, L., Montesinos-Correa, H., Bandala, C., Carmona‐Aparicio, L., & Coballase-Urrutía, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011455 · Cited by 135 · see citing works

Ischemic Preconditioning Reveals that GLT1/EAAT2 Glutamate Transporter is a Novel PPARγ Target Gene Involved in Neuroprotection

Romera, C., Hurtado, O., Mallolas, J., Pereira, M. P., Morales, J. R., Romera, A., Serena, J. L., Vivancos, J., Nombela, F., Lorenzo, P. L., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600438 · Cited by 133 · see citing works

The Puzzling Case of Hyperexcitability in Amyotrophic Lateral Sclerosis

Bae, J. S., Simon, N. G., Menon, P., Vucic, S., & Kiernan, M. C. (2013) · Journal of Clinical Neurology · doi:10.3988/jcn.2013.9.2.65 · Cited by 133 · see citing works

Impaired Glutamate Transport in a Mouse Model of Tau Pathology in Astrocytes

Dabir, D. V., Robinson, M. B., Swanson, E., Zhang, B., Trojanowski, J. Q., Lee, V. M. ‐., & Forman, M. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3861-05.2006 · Cited by 132 · see citing works

In VitroIschemic Tolerance Involves Upregulation of Glutamate Transport Partly Mediated by the TACE/ADAM17-Tumor Necrosis Factor-α Pathway

Romera, C., Hurtado, O., Botella, S. H., Lizasoaín, I., Cárdenas, A., Fernández-Tomé, P., Leza, J. C., Lorenzo, P. L., & Moro, M. Á. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1596-03.2004 · Cited by 128 · see citing works

Protective autoimmunity against the enemy within: fighting glutamate toxicity

Schwartz, M. H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00126-7 · Cited by 128 · see citing works

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

Malta, C. D., Fryer, J. D., Settembre, C., & Ballabio, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209577109 · Cited by 123 · see citing works

Patho-physiological and toxicological aspects of monosodium glutamate

Chakraborty, S. P. (2018) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2018.1528649 · Cited by 114 · see citing works

The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective

Mossink, B., Negwer, M., Schubert, D., & Nadif Kasri, N. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03714-5 · Cited by 114 · see citing works

Glial Tau Pathology in Tauopathies: Functional Consequences

Kahlson, M. A., & Colodner, K. J. (2015) · Journal of Experimental Neuroscience · doi:10.4137/jen.s25515 · Cited by 110 · see citing works

Gap Junction Intercellular Communication Mediated by Connexin43 in Astrocytes Is Essential for Their Resistance to Oxidative Stress

Le, H., Sin, W. C., Lozinsky, S., Bechberger, J. F., Vega, J. L., Guo, X., Sáez, J. C., & Naus, C. C. G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.508390 · Cited by 111 · see citing works

Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

Jaiswal, M. K., Zech, W., Goos, M., Leutbecher, C., Ferri, A., Zippelius, A., Carrı̀, M. T., Nau, R., & Keller, B. U. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-64 · Cited by 111 · see citing works

Ferrostatin-1 protects HT-22 cells from oxidative toxicity

Li, Q., Chu, J., Liu, C.-X., & Song, R. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266060 · Cited by 110 · see citing works

Research Applications of Magnetic Resonance Spectroscopy to Investigate Psychiatric Disorders

Dager, S. R., Corrigan, N. M., Richards, T. L., & Posse, S. (2008) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0b013e318181e0be · Cited by 107 · see citing works

Mutant huntingtin reduction in astrocytes slows disease progression in the bachd conditional huntington’s disease mouse model

Wood, T. E., Barry, J., Yang, Z., Cepeda, C., Levine, M. S., & Gray, M. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy363 · Cited by 109 · see citing works

Multiple pathways contribute to the pathogenesis of Huntington disease.

Li, S., & Li, X. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-19 · Cited by 109 · see citing works

Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders

Liu, B., Teschemacher, A. G., & Kasparov, S. (2017) · Glia · doi:10.1002/glia.23136 · Cited by 107 · see citing works

The endocannabinoid pathway in Huntington's disease: A comparison with other neurodegenerative diseases

Maccarrone, M., Battista, N., & Centonze, D. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.11.006 · Cited by 106 · see citing works

Evidence of alterations in brain structure and antioxidant status following ‘low-dose’ monosodium glutamate ingestion

Onaolapo, O. J., Onaolapo, A. Y., Akanmu, M. A., & Olayiwola, G. (2016) · Pathophysiology · doi:10.1016/j.pathophys.2016.05.001 · Cited by 103 · see citing works

Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity

Liang, J., Takeuchi, H., Doi, Y., Kawanokuchi, J., Sonobe, Y., Jin, S., Yawata, I., Li, H., Yasuoka, S., Mizuno, T., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.012 · Cited by 99 · see citing works

Molecular Abnormalities of the Glutamate Synapse in the Thalamus in Schizophrenia

Meador‐Woodruff, J. H., Clinton, S. M., Beneyto, M., & McCullumsmith, R. E. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.005 · Cited by 101 · see citing works

Molecular and cellular physiology of sodium-dependent glutamate transporters

Rose, C. R., Ziemens, D., Untiet, V., & Fahlke, C. M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.12.013 · Cited by 100 · see citing works

Role of astrocytes in manganese mediated neurotoxicity

Sidoryk‐Wȩgrzynowicz, M., & Aschner, M. (2013) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-14-23 · Cited by 98 · see citing works

Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection

Ganel, R., Ho, T. W., Maragakis, N. J., Jackson, M. T., Steiner, J. P., & Rothstein, J. D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.08.014 · Cited by 98 · see citing works

Cortical cultures coupled to Micro-Electrode Arrays: A novel approach to perform in vitro excitotoxicity testing

Frega, M., Pasquale, V., Tedesco, M., Marcoli, M., Contestabile, A., Nanni, M., Bonzano, L., Maura, G., & Chiappalone, M. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.08.001 · Cited by 93 · see citing works

Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration

Andrés‐Benito, P., Moreno, J. R., Aso, E., Povedano, M., & Ferrer, I. (2017) · Aging · doi:10.18632/aging.101195 · Cited by 89 · see citing works

Behavioral and neurochemical effects of proline

Wyse, Â. T. D. S., & Netto, C. A. (2011) · Metabolic Brain Disease · doi:10.1007/s11011-011-9246-x · Cited by 92 · see citing works

Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study

Wilson, H., Dervenoulas, G., Pagano, G., Tyacke, R. J., Polychronis, S., Myers, J., Gunn, R. N., Rabiner, E. A., Nutt, D., & Politis, M. (2019) · Brain · doi:10.1093/brain/awz260 · Cited by 93 · see citing works

Glutaminase in microglia: A novel regulator of neuroinflammation

Ding, L., Xu, X., Li, C., Wang, Y., Xia, X., & Zheng, J. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.038 · Cited by 88 · see citing works

Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice

Farina, M. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(03)00242-x · Cited by 88 · see citing works

Methylmercury Increases Glutamate Release from Brain Synaptosomes and Glutamate Uptake by Cortical Slices from Suckling Rat Pups: Modulatory Effect of Ebselen

Farina, M. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg058 · Cited by 88 · see citing works

Glutamate transporter expression and function in human glial progenitors

Maragakis, N. J., Dietrich, J., Wong, V., Xue, H., Mayer‐Pröschel, M., Rao, M. S., & Rothstein, J. D. (2003) · Glia · doi:10.1002/glia.10310 · Cited by 87 · see citing works

Neuronal and glial metabolite content of the epileptogenic human hippocampus

Petroff, O. A. C., Errante, L. D., Rothman, D. L., Kim, J., & Spencer, D. D. (2002) · Annals of Neurology · doi:10.1002/ana.10360 · Cited by 87 · see citing works

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection

Roman, J. Y. M., & González, C. C. (2024) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.46 · Cited by 90 · see citing works

Neuron-Glia Interactions as Therapeutic Targets in Neurodegeneration

Salmina, A. B. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0988 · Cited by 86 · see citing works

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons

Gupta, K., Hardingham, G. E., & Chandran, S. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.03.010 · Cited by 85 · see citing works

Necroptosis contributes to the NMDA-induced excitotoxicity in rat’s cultured cortical neurons

Li, Y., Yang, X., Ma, C., Qiao, J., & Zhang, C. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.037 · Cited by 82 · see citing works

Premature death of TDP ‐43 ( A 315 T ) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis

Esmaeili, M. A., Panahi, M., Yadav, S., Hennings, L. J., & Kiaei, M. (2013) · International Journal of Experimental Pathology · doi:10.1111/iep.12006 · Cited by 85 · see citing works

Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related Neurodegeneration

Arnold, F. J., Putka, A. F., Raychaudhuri, U., Hsu, S., Bedlack, R., Bennett, C. L., & Spada, A. R. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115587 · Cited by 84 · see citing works

Neurobiological evidence for thalamic, hippocampal and related glutamatergic abnormalities in bipolar disorder: a review and synthesis.

Ng, W., Lau, I.-Y., Graham, S., & Sim, K. (2009) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.001 · Cited by 77 · see citing works

Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington's disease

Sari, Y., Prieto, A. L., Barton, S. J., Miller, B., & Rebec, G. V. (2010) · Journal of Biomedical Science · doi:10.1186/1423-0127-17-62 · Cited by 84 · see citing works

An Insight into Cellular and Molecular Mechanisms Underlying the Pathogenesis of Neurodegeneration in Alzheimer’s Disease

Ratan, Y., Rajput, A., Maleysm, S., Pareek, A., Jain, V. K., Pareek, A., Kaur, R., & Singh, G. (2023) · Biomedicines · doi:10.3390/biomedicines11051398 · Cited by 87 · see citing works

Functional properties of multispecific amino acid transporters and their implications to transporter-mediated toxicity.

Kanai, Y., & Endou, H. (2003) · The Journal of Toxicological Sciences · doi:10.2131/jts.28.1 · Cited by 83 · see citing works

Characterization of astrocytes derived from human NTera‐2/D1 embryonal carcinoma cells

Sandhu, J. K., Sikorska, M., & Walker, P. R. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10236 · Cited by 82 · see citing works

Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model

Lee, W., Reyes, R. C., Gottipati, M. K., Lewis, K. C., Lesort, M. J., Parpura, V., & Gray, M. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.06.002 · Cited by 80 · see citing works

The dual face of glutamate: from a neurotoxin to a potential survival factor—metabolic implications in health and disease

Magi, S., Piccirillo, S., & Amoroso, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-3002-x · Cited by 79 · see citing works

Ontogenetic profile of glutamate uptake in brain structures slices from rats: sensitivity to guanosine

Thomazi, A. P. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.04.005 · Cited by 78 · see citing works

Decreased Glutamate/Glutamine Levels May Mediate Cytidine’s Efficacy in Treating Bipolar Depression: A Longitudinal Proton Magnetic Resonance Spectroscopy Study

Yoon, S. J., Lyoo, I. K., Haws, C. A., Kim, T. S., Cohen, B. M., & Renshaw, P. F. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.2 · Cited by 78 · see citing works

Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: Involvement of oxidative stress and glutamatergic system

Roos, D. H., Puntel, R. L., dos Santos, M. M., Souza, D. O., Farina, M., Nogueira, C. W., Aschner, M., Bürger, M. E., Barbosa, N. V., & da Rocha, J. B. T. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.12.020 · Cited by 75 · see citing works

Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage

van Putten, M. J. A. M., Fahlke, C. M., Kafitz, K. W., Hofmeijer, J., & Rose, C. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115679 · Cited by 73 · see citing works

Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS

Ghoddoussi, F., Galloway, M. P., Jambekar, A. A., Bame, M., Needleman, R. B., & Brusilow, W. S. A. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.11.013 · Cited by 73 · see citing works

Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity

Karus, C., Mondragão, M. A., Ziemens, D., & Rose, C. R. (2015) · Glia · doi:10.1002/glia.22793 · Cited by 72 · see citing works

Sodium signals in cerebellar Purkinje neurons and Bergmann glial cells evoked by glutamatergic synaptic transmission

Bennay, M., Langer, J., Meier, S. D., Kafitz, K. W., & Rose, C. R. (2008) · Glia · doi:10.1002/glia.20685 · Cited by 70 · see citing works

Protective effects of guanosine against sepsis-induced damage in rat brain and cognitive impairment

Petronilho, F. C., Pavei, S. R. P., Vuolo, F. S., Mina, F., Constantino, L. D. S., Comim, C. M., Quevedo, J., Souza, D. O., & Dal‐Pizzol, F. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.03.007 · Cited by 68 · see citing works

Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine

de Oliveira, D. L., Horn, J. F., Rodrigues, J. M., Frizzo, M. E., Moriguchi, E. H., Souza, D. O., & Wofchuk, S. T. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.033 · Cited by 67 · see citing works

Neuronal glutamate transporter EAAT4 is expressed in astrocytes

Hu, W., Walters, W. M., Xia, X., Karmally, S., & Bethea, J. R. (2003) · Glia · doi:10.1002/glia.10268 · Cited by 66 · see citing works

Effect of subacute and chronic immobilisation stress on the outcome of permanent focal cerebral ischaemia in rats

Madrigal, J. L. M., Caso, J. R., de Cristóbal, J., Cardenas, A. J., Leza, J. C., Lizasoaín, I., Lorenzo, P. L., & Moro, M. Á. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02892-0 · Cited by 65 · see citing works

Neuroprotective Drug Riluzole Amplifies the Heat Shock Factor 1 (HSF1)- and Glutamate Transporter 1 (GLT1)-dependent Cytoprotective Mechanisms for Neuronal Survival

Liu, A. Y. ‐., Mathur, R., Mei, N., Langhammer, C. G., Babiarz, B., & Firestein, B. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158220 · Cited by 65 · see citing works

Neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in Alzheimer's disease

Barrantes, F. J., Borroni, V., & Vallés, S. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.11.036 · Cited by 64 · see citing works

Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex

Gerkau, N. J., Rakers, C., Durry, S., Petzold, G. C., & Rose, C. R. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx280 · Cited by 65 · see citing works

Glutamate transporter and neurodegenerative disorders

Yan, Y. (2003) · Zhongguo linchuang yaolixue yu zhiliaoxue

Glutamate transporters, excitotoxicity, and human neurodegenerative disease

Dodd, P. R., & Scott, H. L. (2003)

Presynaptic Glutamate Transport in the Brain

Borisova, Т. (2013) · SpringerBriefs in neuroscience · doi:10.1007/978-1-4614-7759-4_1

Amyotrophic Lateral Sclerosis and Glutamate — Too Much of a Good Thing?

Choi, D. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205283262210 · Cited by 30 · see citing works

Glutamate transporters: Gene expression regulation and signaling properties

Olivares-Bañuelos, T. N., Chi-Castañeda, D., & Ortega, A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.032 · Cited by 32 · see citing works