The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Outcomes of Mild Cognitive Impairment by Definition: A Population Study
Open accessAbstract
BACKGROUND: Mild cognitive impairment (MCI) has been defined in several ways. OBJECTIVE: To determine the 1-year outcomes of MCI by different definitions at the population level. DESIGN: Inception cohort with 1-year follow-up. Participants were classified as having MCI using the following definitions operationalized for this study: amnestic MCI by Mayo criteria, expanded MCI by International Working Group criteria, Clinical Dementia Rating (CDR) = 0.5, and a purely cognitive classification into amnestic and nonamnestic MCI. SETTING: General community. PARTICIPANTS: Stratified random population-based sample of 1982 individuals 65 years and older. MAIN OUTCOME MEASURES: For each MCI definition, there were 3 possible outcomes: worsening (progression to dementia [CDR ≥ 1] or severe cognitive impairment), improvement (reversion to CDR = 0 or normal cognition), and stability (unchanged CDR or cognitive status). RESULTS: Regardless of MCI definition, over 1 year, a small proportion of participants progressed to CDR > 1 (range, 0%-3%) or severe cognitive impairment (0%-20%) at rates higher than their cognitively normal peers. Somewhat larger proportions of participants improved or reverted to normal (6%-53%). Most participants remained stable (29%-92%). Where definitions focused on memory impairment and on multiple cognitive domains, higher proportions progressed and lower proportions reverted on the CDR. CONCLUSIONS: As ascertained by several operational definitions, MCI is a heterogeneous entity at the population level but progresses to dementia at rates higher than in normal elderly individuals. Proportions of participants progressing to dementia are lower and proportions reverting to normal are higher than in clinical populations. Memory impairments and impairments in multiple domains lead to greater progression and lesser improvement. Research criteria may benefit from validation at the community level before incorporation into clinical practice.
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Cites
The Clinical Dementia Rating (CDR): Current version and scoring rules
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Mild Cognitive Impairment: Clinical Characterization and Outcome
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“Although longer prospective studies usually report annual progression rates averaged over multiple years,(5,8,12,14) the annual rate changes over time.(12) Repeated assessments of this cohort over a longer follow-up period will clarify these patterns and identify the profiles of individuals whose mild impairments are…”
Mild Cognitive Impairment: Ten Years Later
Petersen, R. C., Roberts, R. O., Knopman, D. S., Boeve, B. F., Geda, Y. E., Ivnik, R. J., Smith, G. E., & Jack, C. R. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.266 · Cited by 1,447
Self-citationQuantification of Five Neuropsychological Approaches to Defining Mild Cognitive Impairment
Jak, A. J., Bondi, M. W., Delano-Wood, L., Wierenga, C., Corey-Bloom, J., Salmon, D. P., & Delis, D. C. (2009) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31819431d5 · Cited by 823
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2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
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Sachdev, P. S., Lipnicki, D. M., Kochan, N. A., Crawford, J. D., Thalamuthu, A., Andrews, G., Brayne, C., Matthews, F. E., Stephan, B. C. M., Lipton, R. B., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0142388 · Cited by 380
Self-citationKoepsell, T. D., & Monsell, S. E. (2012) · Neurology · doi:10.1212/wnl.0b013e31826e26b7 · Cited by 369
Edmonds, E. C., Delano‐Wood, L., Clark, L. R., Jak, A. J., Nation, D. A., McDonald, C. R., Libon, D. J., Au, R., Galasko, D., Salmon, D. P., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.03.005 · Cited by 256
Metadata
- Authors
- Ganguli, M., Snitz, B. E., Saxton, J. A., Chang, C.-C. H., Lee, C.-W., Vander Bilt, J., Hughes, T. F., Loewenstein, D. A., Unverzagt, F. W., & Petersen, R. C.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2011-06-01
- Volume
- 68
- Issue
- 6
- Pages
- 761-7
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W1999429226
- Cited by
- 285
- References
- 7
- FWCI
- 16.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Ganguli, M., Snitz, B. E., Saxton, J. A., Chang, C.-C. H., Lee, C.-W., Vander Bilt, J., Hughes, T. F., Loewenstein, D. A., Unverzagt, F. W., & Petersen, R. C. (2011). Outcomes of Mild Cognitive Impairment by Definition: A Population Study. Archives of Neurology. https://doi.org/10.1001/archneurol.2011.101
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