The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Basal Linear Deposit and Large Drusen Are Specific for Early Age-Related Maculopathy
Abstract
OBJECTIVE: To determine the distributions of basal laminar and basal linear deposits in Bruch membrane (BM) with respect to age and early age-related maculopathy (ARM). METHODS: The foveas of 41 human eyes (<60 years [n = 9]; > or =60 years [n = 32]), preserved no later than 3.5 hours post mortem, were examined using light and electron microscopy. Ten eyes met histopathologic criteria of the Alabama Age-related Macular Degeneration Grading System for early ARM. We calculated the specificity, sensitivity, and odds ratios for the association of basal laminar and basal linear deposits with early ARM. RESULTS: Both deposits occurred only in eyes older than 60 years. The highest specificities and sensitivities for early ARM were attained for eyes that had basal linear deposits or large (>125 microm) drusen, followed by eyes with any quantity of basal laminar deposits that also contained membranous debris. Eyes with ARM were 24 times more likely than age-matched control eyes to have basal linear deposits or large drusen (P = .002). CONCLUSIONS: Basal linear deposits and large drusen with membranous contents constitute different morphologic forms of the same ARM-associated lesion and may be significant for progression to late ARM.
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The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
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Oxidative damage and protection of the RPE
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Metadata
- Authors
- Curcio, C. A.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1999-03-01
- Volume
- 117
- Issue
- 3
- Pages
- 329
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W2077366389
- Cited by
- 386
- References
- 62
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Curcio, C. A. (1999). Basal Linear Deposit and Large Drusen Are Specific for Early Age-Related Maculopathy. Archives of Ophthalmology. https://doi.org/10.1001/archopht.117.3.329
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