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Cited by 286Retinal Diseases and TreatmentsAntioxidant Activity and Oxidative StressRetinal Imaging and Analysis

Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey

Marse-Perlman, Julie A., Fisher, Alicia I., Klein, Ronald, Palta, Mari, Block, Gladys, Millen, Amy E., Wright, Jacqueline D.·2001·American Journal of Epidemiology
DOI 10.1093/aje/153.5.424
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Abstract

Relations of the carotenoids lutein and zeaxanthin in the diet and serum to photographic evidence of early and late age-related maculopathy (ARM) among persons over age 40 years (n = 8,222) were examined. Inverse relations of these carotenoids in the diet or serum to any form of ARM were not observed overall. There was a direct relation of dietary levels to one type of early ARM (soft drusen). However, relations differed by age and race. In the youngest age groups who were at risk for developing early (ages 40-59 years) or late (ages 60-79 years) ARM, higher levels of lutein and zeaxanthin in the diet were related to lower odds for pigmentary abnormalities, one sign of early ARM (odds ratio among persons in high vs. low quintiles = 0.1, 95 percent confidence interval: 0.1, 0.3) and of late ARM (odds ratio = 0.1, 95 percent confidence interval: 0.0, 0.9) after adjustment for age, gender, alcohol use, hypertension, smoking, and body mass index. Relations of these carotenoids to ARM may be influenced by age and race and require further evaluation in separate populations and in prospective studies.

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  • Population-based studies have shown inconsistent associations of dietary levels of lutein and zeaxanthin with age-related macular degeneration.

    “Population-based studies have shown in consistent associations of dietary levels of these compounds with age-related macular degeneration.94,96,102,103”

    From Age-related macular degeneration (2008) · cites this paper as [102]

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Authors
Marse-Perlman, J. A., Fisher, A. I., Klein, R., Palta, M., Block, G., Millen, A. E., & Wright, J. D.
Affiliations
University of Wisconsin–Madison (US)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2001-03-01
Volume
153
Issue
5
Pages
424-432
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/153.5.424
OpenAlex
W2125586768
Cited by
286
References
45
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 16 · 2016: 11 · 2015: 12 · 2014: 9 · 2013: 13 · 2012: 21
FWCI
14.40
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ey011722-03)
  • National Eye Institute (EY 11722)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords
lutein, zeaxanthin, carotenoids, age-related maculopathy, dietary intake, serum carotenoids, soft drusen, pigmentary abnormalities, age differences, racial differences, older adults, NHANES III
MeSH terms
Adult, Age Factors, Aged, Aged, 80 and over, Diet, Female, Humans, Macular Degeneration, Male, Middle Aged, Nutrition Surveys, Risk Factors, United States, Lutein, Odds Ratio, beta Carotene, Xanthophylls, Zeaxanthins

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