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Cited by 137Retinal Diseases and TreatmentsAntioxidant Activity and Oxidative StressRetinal Imaging and Analysis

Neovascular age-related macular degeneration and its relationship to antioxidant intake

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Snellen, E.L.M., Verbeek, A.L.M., Van Den Hoogen, G.W.P., Cruysberg, J.R.M., Hoyng, C.B.·2002·Acta Ophthalmologica Scandinavica
DOI 10.1034/j.1600-0420.2002.800404.x
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Abstract

PURPOSE: Experimental and epidemiological studies suggest that low antioxidant intake may be associated with the occurrence of neovascular age-related macular degeneration (AMD). METHODS: We investigated this hypothesis further with a case-control study involving 72 case and 66 control patients attending the Ophthalmology Department of the University Hospital in Nijmegen. Data were collected by interview on antioxidant intake (i.e. in fruit and vegetables), cigarette smoking, sunlight exposure and familial predisposition. Antioxidant intake was calculated according to the method described in the Framingham Eye Study. Logistic regression analysis was used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: The prevalence rate of AMD in patients with low antioxidant intake and low lutein intake (dichotomized at the median value) was about twice as high as that in patients with high intake: OR = 1.7, 95% CI (0.8-3.7), and OR = 2.4, 95% CI (1.1-5.1). Further specification of intake data into quartiles of antioxidant intake and lutein/zeaxanthine intake showed a clear dose-response relationship. CONCLUSION: The effect of dietary antioxidants upon macular health warrants preventive studies.

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  • Results from observational studies that assessed the effect of dietary antioxidants on risk for age-related macular degeneration have been inconsistent.

    “Results from observational studies that assessed the effect of dietary antioxidants on risk for age-related macular degeneration have been inconsistent.90–95”

    From Age-related macular degeneration (2008) · cites this paper as [91]

  • Some case-control studies have found evidence of decreasing risk of neovascular age-related macular degeneration among individuals who reported the highest intake of dietary lutein and zeaxanthin.

    “Some case-control studies have found evidence of decreasing risk of neovascular age-related macular degeneration among individuals who reported the highest intake of dietary lutein and zeaxanthin, the major macular carotenoids98 that are found mostly in green leafy vegetables such as spinach, collard greens, and kale.90,91,99,100”

    From Age-related macular degeneration (2008) · cites this paper as [91]

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  1. Rothman KJ & Greenland S (1998): Modern Epidemiology, 2nd edn. Philadelphia: Lip- pincott-Raven. Chapter

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Authors
Snellen, E. L. M., Verbeek, A. L. M., Van Den Hoogen, G. W. P., Cruysberg, J. R. M., & Hoyng, C. B.
Corresponding author
Verbeek, A.L.M.
ORCID
Venue
Acta Ophthalmologica Scandinavica
Publisher
Wiley
Published
2002-08
Volume
80
Issue
4
Pages
368-371
ISSN
  • 1395-3907 (ISSN-L)
  • 1600-0420
DOI
10.1034/j.1600-0420.2002.800404.x
OpenAlex
W2005354516
Cited by
137
References
27
Citations by year
2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 8 · 2013: 10 · 2012: 11
FWCI
6.91
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 19 d)
Locations
  • Acta Ophthalmologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords
neovascular age-related macular degeneration, dietary antioxidants, lutein, zeaxanthin, fruit and vegetable intake, cigarette smoking, sun exposure, familial predisposition, dose-response relationship, disease prevention
MeSH terms
Aged, Antioxidants, Diet, Feeding Behavior, Female, Humans, Macular Degeneration, Male, Middle Aged, Risk Factors, Lutein, Prevalence, Odds Ratio, Case-Control Studies, beta Carotene, Xanthophylls, Zeaxanthins

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