Normally occurring environmental and behavioral influences on gene activity: From central dogma to probabilistic epigenesis

Gottlieb, Gilbert

doi:10.1037/0033-295x.105.4.792-802

Cited by 489Epigenetics and DNA MethylationPhilosophy and History of ScienceBirth, Development, and Health

Normally occurring environmental and behavioral influences on gene activity: From central dogma to probabilistic epigenesis

Gottlieb, Gilbert·1998·Psychological Review

DOI 10.1037/0033-295x.105.4.792-802

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Abstract

The central dogma of molecular biology holds that "information" flows from the genes to the structure of the proteins that the genes bring about through the formula DNA-->RNA-->Protein. In this view, a set of master genes activates the DNA necessary to produce the appropriate proteins that the organism needs during development. In contrast to this view, probabilistic epigenesis holds that necessarily there are signals from the internal and external environment that activate DNA to produce the appropriate proteins. To support this view, a substantial body of evidence is reviewed showing that external environmental influences on gene activation are normally occurring events in a large variety of organisms, including humans. This demonstrates how genes and environments work together to produce functional organisms, thus extending the author's model of probabilistic epigenesis.

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Authors: Gottlieb, G.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Gottlieb, Gilbert
Venue: Psychological Review
Publisher: American Psychological Association (APA)
Published: 1998
Volume: 105
Issue: 4
Pages: 792-802
ISSN: 0033-295X (ISSN-L)
1939-1471
DOI: 10.1037/0033-295x.105.4.792-802
OpenAlex: W2018492820
Cited by: 489
References: 84
Citations by year: 2026: 9 · 2025: 5 · 2024: 12 · 2023: 20 · 2022: 13 · 2021: 7 · 2020: 40 · 2019: 11 · 2018: 11 · 2017: 23 · 2016: 11 · 2015: 28 · 2014: 20 · 2013: 30 · 2012: 20
FWCI: 2.79
Type: journal article
Language: en
Open access: closed
Locations: Psychological Review (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH-52429, P50MH052429)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: central dogma, gene-environment interaction, environmental influences on gene expression, epigenetic regulation, organismal development
MeSH terms: Behavior, DNA, Environment, Humans, RNA, Messenger, Twins

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Normally occurring environmental and behavioral influences on gene activity: From central dogma to probabilistic epigenesis

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