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Cited by 186Schizophrenia research and treatmentMental Health and PsychiatryMemory and Neural Mechanisms

The Hippocampus and Parahippocampus in Schizophrenic, Suicide, and Control Brains

Altshuler, Lori L.·1990·Archives of General Psychiatry
DOI 10.1001/archpsyc.1990.01810230045008
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Abstract

Recent postmortem studies in schizophrenia have shown abnormalities in medial temporal lobe structures, including the hippocampus and parahippocampus. We tried to replicate previous studies and to explore the specificity of this finding to schizophrenia. The anterior hippocampus and parahippocampal cortex were evaluated for area and shape in postmortem tissue from 12 schizophrenic, 17 nonschizophrenic suicide, and 10 nonpsychiatric control brains. No significant differences were found in hippocampal area, but the parahippocampal cortex was significantly smaller in the schizophrenic group than in the control group. When parahippocampi from right and left sides were analyzed separately, both the suicide and schizophrenic groups had smaller parahippocampi on the right side than did the controls [corrected]. The suicide group exhibited greater parahippocampal areas in the left than in the right tissue samples within the group, while such a difference did not exist in the schizophrenic or control groups. This study demonstrated changes in temporal lobe structures in both schizophrenic and nonschizophrenic suicide groups.

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Crossref · 10.1001/archpsyc.1990.01810230045008

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  • Suicide decedents have smaller gray matter volume in the dlPFC and hippocampus.

    “Suicide decedents have smaller gray matter volume in the dlPFC (68) and hippocampus (69, 70), perhaps related to impaired decision making and learning/memory functions, respectively.”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [69]

  • Low brain BDNF in the hippocampus of suicide decedents may underlie its smaller size in suicide decedents and attempters and fewer mature granule neurons in its dentate gyrus.

    “Low brain BDNF in the hippocampus of suicide decedents (180) may underlie its smaller size in suicide decedents (69) and attempters (194) and fewer mature granule neurons in its dentate gyrus (70).”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [69]

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Authors
Altshuler, L. L.
Affiliations
National Institute of Mental Health (US)
Corresponding author
Altshuler, Lori L.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1990-11-01
Volume
47
Issue
11
Pages
1029
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1990.01810230045008
OpenAlex
W2068971099
Cited by
186
References
58
Citations by year
2026: 1 · 2025: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
10.70
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
hippocampus, parahippocampal cortex, schizophrenia, suicide, medial temporal lobe, brain structure, laterality, postmortem brain
MeSH terms
Adult, Anthropometry, Computers, Female, Hippocampus, Humans, Male, Middle Aged, Schizophrenia, Schizophrenic Psychology, Suicide, Temporal Lobe, Wounds and Injuries

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