Prenatal developmental disturbances in the limbic allocortex in schizophrenics
Abstract
Sixty-four autopsied brains of schizophrenic patients were neuropathologically examined and compared with 10 brains of non-schizophrenic controls. Clinical diagnoses were established retrospectively according to the Research Diagnostic Criteria and the International Classification of Diseases. We found: brains without deviations of the sulcogyral pattern of the temporal lobe or abnormal gross configuration (n = 22); brains with abnormal sulcogyral pattern of the temporal lobe or abnormal gross configuration (n = 42): with definite cytoarchitectonic abnormalities of the rostral entorhinal region in the parahippocampal gyrus and, in 16 cases only, in the ventral insular cortex (n = 20); with equivocal changes of the cytoarchitecture in these two regions (n = 22). Generally, these anatomical abnormalities were asymmetric. The histological findings in the two limbic regions consisted mainly of poorly developed structure in the upper layers, with a heterotopic displacement of single groups of nerve cells in the entorhinal region. Particularly, the disturbed structure of the second layer Pre-alpha in medial and central fields of the entorhinal region, situated in the parahippocampal gyrus (group 2a), suggests a disturbance of neuronal migration in a later phase of cortical development.
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In the medial temporal lobe, most abnormalities are found in superficial layers, such as atypical clustering of neurons in layer 2 of entorhinal cortex.
“In the medial temporal lobe, most abnormalities are again found in the superficial layers; such as atypical clustering of neurons in layer 2 of entorhinal cortex (Jakob and Beckmann, 1986; Arnold et al., 1991; Falkai et al., 2000)”
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- Authors
- Jakob, H., & Beckmann, H.
- Affiliations
- University of Würzburg (DE)
- Venue
- Journal of Neural Transmission
- Published
- 1986-09
- Volume
- 65
- Issue
- 3-4
- Pages
- 303-326
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2067646093
- Cited by
- 875
- References
- 0
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 18 · 2013: 6 · 2012: 9
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- schizophrenia, entorhinal cortex, parahippocampal gyrus, cytoarchitecture, neuronal migration, heterotopia, cortical development
- MeSH terms
- Adult, Aged, Female, Gestational Age, Humans, Limbic System, Male, Middle Aged, Retrospective Studies, Schizophrenia, Temporal Lobe
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