Cited by 549Attention Deficit Hyperactivity DisorderChild and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual Offending

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Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status

Mannuzza, Salvatore·1991·Archives of General Psychiatry

DOI 10.1001/archpsyc.1991.01810250079012

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Abstract

We previously reported a prospective follow-up study of 101 young adult males whose conditions had been diagnosed as hyperactivity in childhood. Compared with controls, probands had significantly higher rates of attention-deficit, antisocial, and drug use disorders at follow-up (mean age, 18 years). The present study was an attempt to replicate these findings on an independent sample of 94 hyperactive boys who were seen at the same clinic, compared with 78 normal controls. Assessments were made by clinicians who were blind to group membership. Information was obtained for 90% of the original cohort. As in the previous study, significantly more probands than controls were given ongoing diagnoses of attention-deficit disorder (43% vs 4%), antisocial disorders (32% vs 8%), and drug use disorders (10% vs 1%). Furthermore, the absolute rates of these disorders were comparable for corresponding groups across studies, and the adjusted odds ratios did not differ significantly. As previously, there was no increased risk for affective disorders in the grown hyperactive children. The present study provides a powerful replication of the nature of the young adult outcome of childhood hyperactivity.

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Hyperactive Boys Almost Grown Up: I. Psychiatric Status
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Biederman, J., Petty, C. R., Monuteaux, M. C., Mick, E. O., Clarke, A., Haagen, K. T., & Faraone, S. V. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.02040.x · Cited by 19
“Follow-up studies have documented a higher than expected risk for PSUD in adults with ADHD (Hechtman & Weiss, 1986; Mannuzza et al., 1991).”
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Unlocking the potential of patients with ADHD: A model for clinical practice.
Monastra, V. J. (2008) · American Psychological Association eBooks · doi:10.1037/11665-000 · Cited by 21
A natural history of hyperactivity and conduct problems: self-reported outcome
Danckaerts, M., Heptinstall, E., Chadwick, O., & Taylor, E. (2000) · European Child and Adolescent Psychiatry · doi:10.1007/s007870050113 · Cited by 18
The Psychobiology of Oppositional Defiant Disorder and Conduct Disorder
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Differences Between Juvenile Offenders With and Without AD(H)D in Recidivism Rates and Risk and Protective Factors for Recidivism
van der Put, C. E., Asscher, J., & Stams, G. (2016) · Journal of Attention Disorders · doi:10.1177/1087054712466140 · Cited by 17
“In addition, other studies have found that children with ADHD without CD symptoms were much more likely to be diagnosed with an ASP disorder than children without ADHD (Gittelman et al., 1985; Mannuzza et al, 1991).”
BackgroundResult
The Predictive Utility of Conduct Disorder Symptoms in Preschool Children: A 3-Year Follow-Up Study
Rolon‐Arroyo, B., Arnold, D. H., & Harvey, E. A. (2013) · Child Psychiatry & Human Development · doi:10.1007/s10578-013-0404-8 · Cited by 17
“Prospectively, about a third of school-age boys diagnosed with ADHD progress to CD [30, 31].”
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ADHD matures: time for practitioners to do the same?
Bolea-Alamanac, B. M., Adamou, M., Arif, M., Asherson, P. J., Gudjonsson, G. H., Müller, U., Nutt, D., Pitts, M. E., Thome, J., & Young, S. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111410898 · Cited by 15
Attention Deficit Hyperactivity Disorder and Substance Use Disorders
Szobot, C. M., & Bukstein, O. G. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2007.11.003 · Cited by 28
“These factors include the presence of comorbid disruptive behavior disorders (DBDs) (e.g., oppositional defiant disorder and CD; August et al. 2006; Barkley et al. 1990; Biederman et al. 1997; Katusic et al. 2005; Mannuzza et al. 1991; McGough et al. 2005) and comorbid bipolar disorder (Biederman et al.”
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Personality Comorbidity in Adolescent Females with ADHD
Burket, R., Sajid, M. W., Wasiak, M., & Myers, W. (2005) · Journal of Psychiatric Practice · doi:10.1097/00131746-200503000-00009 · Cited by 17
Nosology, Neurobiology, and Clinical Patterns of ADHD in Adults
Hunt, R. D. (1997) · Psychiatric Annals · doi:10.3928/0048-5713-19970801-10 · Cited by 17
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Childhood Attention Deficit Hyperactivity Disorder, Substance Use, and Adult Functioning Among Incarcerated Women
Hennessey, K. A., Stein, M. D., Rosengard, C., Rose, J. S., & Clarke, J. G. (2009) · Journal of Attention Disorders · doi:10.1177/1087054709347185 · Cited by 15
“It is commonly cited that 30% to 50% of children with ADHD will be impaired by symptoms of ADHD as adults (Cantwell, 1985; Hill & Schoener, 1996; Mannuzza et al., 1991; Weiss et al., 1985).”
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Developmental evaluation of children born to mothers occupationally exposed to waste anesthetic gases
Ratzon, N. Z., Ornoy, A., Pardo, A., Rachel, M., & HATCH, M. C. (2004) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20044 · Cited by 17
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Externalizing disorders and substance use: empirically derived subtypes in a population-based sample of adults
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“Although the lacking association of ADHD and illicit drug use found in the current study differs from some studies [39, 40], it is explainable by other research showing that the relation between ADHD and substance use disappeared when the high overlap between ADHD and CD was taken into account [3].”
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Gender differences in children's problem behaviours in competitive play with friends.
Ensor, R., Hart, M., Jacobs, L., & Hughes, C. (2011) · British Journal of Developmental Psychology · doi:10.1111/j.2044-835x.2010.02016.x · Cited by 14
Substance Use Among Young Offenders: Thrills, Bad Feelings, or Bad Behavior?
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“Longitudinal studies (Boyle et al., 1993; Lynskey and Fergusson, 1995; Mannuzza et al., 1991) generally indicate that although ADHD behaviors are a risk factor for conduct problems, which in turn are a risk factor for PSU, in the absence of conduct problems ADHD behaviors do not increase the risk of PSU.”
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Diagnostic and Treatment Issues in Comorbid Substance Abuse and Adult Attention-Deficit Hyperactivity Disorder
Levin, F., & Evans, S. (2001) · Psychiatric Annals · doi:10.3928/0048-5713-20010501-08 · Cited by 14
Attention deficit hyperactivity disorder in adults - experience of the first National Health Service clinic in the United Kingdom
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Substance Abuse among Adolescents with Chronic Mental Illnesses: A Pilot Study of Descriptive and Differentiating Features*
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The Dopamine D2 Receptor Gene (DRD2) and Neuropsychiatric Disorders
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The Adult ADHD Quality of Life Questionnaire (AAQoL)
Gjervan, B., & Nordahl, H. (2010) · Nordic Psychology · doi:10.1027/1901-2276/a000003 · Cited by 13
Methylphenidate and Attentional Training
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“The manifestation of ADHD throughout the lifespan evolves such that there is symptomatic improvement in 30–40% of children from late adolescence onwards (Mannuzza et al. 1991).”
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Causes of violence in children
Withecomb, J. (1997) · Journal of Mental Health · doi:10.1080/09638239718536 · Cited by 13

Authors: Mannuzza, S.
Affiliations: Long Island Jewish Medical Center (US)
Corresponding author: Mannuzza, Salvatore
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1991-01-01
Volume: 48
Issue: 1
Pages: 77
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.1991.01810250079012
OpenAlex: W2108483316
Cited by: 549
References: 0
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 12 · 2014: 16 · 2013: 18 · 2012: 21
FWCI: 14.99
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH-18579, R01MH018579, MH30906)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: hyperactive children, adult outcomes, attention deficit disorder, antisocial personality disorder, drug use disorders, mood disorders, replication study, young men, long-term follow-up
MeSH terms: Adolescent, Age Factors, Alcoholism, Antisocial Personality Disorder, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Child, Child Behavior Disorders, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Male, Psychiatric Status Rating Scales, Psychometrics, Regression Analysis, Comorbidity, Prevalence, Substance-Related Disorders

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Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status

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