Cited by 549Attention Deficit Hyperactivity DisorderChild and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual Offending

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Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status

Mannuzza, Salvatore·1991·Archives of General Psychiatry

DOI 10.1001/archpsyc.1991.01810250079012

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Abstract

We previously reported a prospective follow-up study of 101 young adult males whose conditions had been diagnosed as hyperactivity in childhood. Compared with controls, probands had significantly higher rates of attention-deficit, antisocial, and drug use disorders at follow-up (mean age, 18 years). The present study was an attempt to replicate these findings on an independent sample of 94 hyperactive boys who were seen at the same clinic, compared with 78 normal controls. Assessments were made by clinicians who were blind to group membership. Information was obtained for 90% of the original cohort. As in the previous study, significantly more probands than controls were given ongoing diagnoses of attention-deficit disorder (43% vs 4%), antisocial disorders (32% vs 8%), and drug use disorders (10% vs 1%). Furthermore, the absolute rates of these disorders were comparable for corresponding groups across studies, and the adjusted odds ratios did not differ significantly. As previously, there was no increased risk for affective disorders in the grown hyperactive children. The present study provides a powerful replication of the nature of the young adult outcome of childhood hyperactivity.

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Hyperactive Boys Almost Grown Up: I. Psychiatric Status
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Familial risk analyses of attention deficit hyperactivity disorder and substance use disorders
Biederman, J., Petty, C. R., Wilens, T. E., Fraire, M. G., Purcell, C. A., Mick, E., Monuteaux, M. C., & Faraone, S. V. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030419 · Cited by 114
Attention‐Deficit Hyperactivity Disorder and Substance Abuse: Relationships and Implications for Treatment
Levin, F., & Kleber, H. (1995) · Harvard Review of Psychiatry · doi:10.3109/10673229509017144 · Cited by 114
Diagnostic stability in adolescents followed up 2 years after hospitalization.
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Presentation of unrecognized attention deficit hyperactivity disorder in college students.
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Interactive effects of attention deficit hyperactivity disorder and conduct disorder on early adolescent substance use.
Molina, B. S. G., Smith, B. H., & Pelham, W. E. (1999) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.13.4.348 · Cited by 116
Pathways From ADHD to Early Drug Use
Chilcoat, H. D., & Breslau, N. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199911000-00008 · Cited by 105
Neuropsychological performance of a sample of adults with ADHD, developmental reading disorder, and controls
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Attention deficit hyperactivity disorder in childhood among adults with major depression
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Age-dependent expression of attention-deficit/hyperactivity disorder symptoms
Mick, E. O., Faraone, S. V., & Biederman, J. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.01.003 · Cited by 119
Attention-deficit/hyperactivity disorder: An overview of the etiology and a review of the literature relating to the correlates and lifecourse outcomes for men and women
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Young adult mental status of hyperactive boys and their brothers: a prospective follow-up study.
Mannuzza, S., Klein, R., & Addalli, K. A. (1991) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1016/s0890-8567(10)80009-7 · Cited by 105
Self-citation
Adult ADHD and Substance Abuse: Diagnostic and Treatment Issues
Kalbag, A. S., & Levin, F. R. (2005) · Substance Use & Misuse · doi:10.1080/10826080500294858 · Cited by 104
“Given the negative effect that ADHD has on an individual’s social and occupational functioning (Mannuzza et al., 1991, 1993, 1997; Mannuzza and Klein, 2000; Weiss et al., 1999; Murphy et al., 2002), and the worse response that those who have substance use disorders and comorbid ADHD have in…”
Background
Further validation of social impairment as a predictor of substance use disorders: findings from a sample of siblings of boys with and without ADHD.
Greene, R. W., Biederman, J., Faraone, S., Wilens, T., Mick, E., & Blier, H. K. (1999) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp280307 · Cited by 104
Substance Abuse in Patients with Attention-Deficit Hyperactivity Disorder: Therapeutic Implications
Schubiner, H. (2005) · CNS Drugs · doi:10.2165/00023210-200519080-00001 · Cited by 104
Bupropion Treatment for Cocaine Abuse and Adult Attention-Deficit/Hyperactivity Disorder
Levin, F. R., Evans, S. M., McDowell, D. M., Brooks, D. J., & Nunes, E. (2002) · Journal of Addictive Diseases · doi:10.1300/j069v21n02_01 · Cited by 102
“21(2) 2002  2002 by The Haworth Press, Inc.”
MethodResult
Factor Structure and Criterion Validity of Secondary School Teacher Ratings of ADHD and ODD
Molina, B. S. G., Smith, B. H., & Pelham, W. E. (2001) · Research on Child and Adolescent Psychopathology · doi:10.1023/a:1005203629968 · Cited by 99
Stopping and changing in adults with ADHD
BEKKER, E. M., OVERTOOM, C. C., KENEMANS, J. L., KOOIJ, J. J., DE NOORD, I., BUITELAAR, J. K., & VERBATEN, M. N. (2005) · Psychological Medicine · doi:10.1017/s0033291704003459 · Cited by 101
“Although traditionally considered a childhood disorder, it has become clear that approximately 30–66% of the patients do not outgrow their problems (Weiss et al. 1985; Mannuzza et al. 1991; Barkley et al. 2002; Pary et al. 2002).”
An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adults
Wilens, T. E., Morrison, N. R., & Prince, J. B. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.137 · Cited by 117
Untreated ADHD in Adults: Are There Sex Differences in Symptoms, Comorbidity, and Impairment?
Rasmussen, K., & Levander, S. (2009) · Journal of Attention Disorders · doi:10.1177/1087054708314621 · Cited by 100
“Higher frequency of ADHD among substance abusers has been found (Carroll & Rounsaville, 1993), as well as higher risk for substance abuse in ADHD (Biederman et al., 1997; Mannuzza et al., 1991).”
Background
Attention deficit hyperactivity disorder and borderline personality disorder
Davids, E., & Gastpar, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.04.033 · Cited by 101
Lack of gender effects on subtype outcomes in adults with attention–deficit/hyperactivity disorder
Grevet, E., Bau, C. H. D., Salgado, C. A., Fischer, A. G., Kalil, K., Victor, M., Garcia, C. R., Sousa, N., Rohde, L., & Belmonte-de-Abreu, P. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-0639-5 · Cited by 99
A qualitative review of issues arising in the use of psychostimulant medications in patients with ADHD and co‑morbid substance use disorders
Kollins, S. H. (2008) · Current Medical Research and Opinion · doi:10.1185/030079908x280707 · Cited by 97
Attention Deficit Hyperactivity Disorder Across the Lifespan: The Child, Adolescent, and Adult
Greydanus, D. E., Pratt, H. D., & Patel, D. R. (2007) · Disease-a-Month · doi:10.1016/j.disamonth.2007.01.001 · Cited by 98
The development of ADHD boys: A 12-year follow-up.
Claude, D., & Firestone, P. (1995) · Canadian Journal of Behavioural Science/Revue canadienne des sciences du comportement · doi:10.1037/0008-400x.27.2.226 · Cited by 97
Assessing ADHD and Comorbid Disorders in Children: The Child Behavior Checklist and the Devereux Scales of Mental Disorders
Eiraldi, R., Power, T. J., Karustis, J. L., & Goldstein, S. (2000) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp2901_2 · Cited by 96
“Up to 70% of children with ADHD continue to meet diagnostic criteria into adolescence (Gittelman, Mannuzza, Shenker, & Bonagura, 1985; Klein & Mannuzza, 1991), and at least 50% meet diagnostic criteria into young adulthood (Mannuzza et al., 1991).”
Background
Attention Deficit Disorders and Sleep/Arousal Disturbance
BROWN, T. E., & McMULLEN, W. J. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05784.x · Cited by 95

Authors: Mannuzza, S.
Affiliations: Long Island Jewish Medical Center (US)
Corresponding author: Mannuzza, Salvatore
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1991-01-01
Volume: 48
Issue: 1
Pages: 77
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.1991.01810250079012
OpenAlex: W2108483316
Cited by: 549
References: 0
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 12 · 2014: 16 · 2013: 18 · 2012: 21
FWCI: 14.99
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH-18579, R01MH018579, MH30906)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: hyperactive children, adult outcomes, attention deficit disorder, antisocial personality disorder, drug use disorders, mood disorders, replication study, young men, long-term follow-up
MeSH terms: Adolescent, Age Factors, Alcoholism, Antisocial Personality Disorder, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Child, Child Behavior Disorders, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Male, Psychiatric Status Rating Scales, Psychometrics, Regression Analysis, Comorbidity, Prevalence, Substance-Related Disorders

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Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status

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