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Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status
Abstract
We previously reported a prospective follow-up study of 101 young adult males whose conditions had been diagnosed as hyperactivity in childhood. Compared with controls, probands had significantly higher rates of attention-deficit, antisocial, and drug use disorders at follow-up (mean age, 18 years). The present study was an attempt to replicate these findings on an independent sample of 94 hyperactive boys who were seen at the same clinic, compared with 78 normal controls. Assessments were made by clinicians who were blind to group membership. Information was obtained for 90% of the original cohort. As in the previous study, significantly more probands than controls were given ongoing diagnoses of attention-deficit disorder (43% vs 4%), antisocial disorders (32% vs 8%), and drug use disorders (10% vs 1%). Furthermore, the absolute rates of these disorders were comparable for corresponding groups across studies, and the adjusted odds ratios did not differ significantly. As previously, there was no increased risk for affective disorders in the grown hyperactive children. The present study provides a powerful replication of the nature of the young adult outcome of childhood hyperactivity.
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“Separate categories for Alcohol and Non-Alcohol SUD were included since our late adolescent and adult follow-ups showed that, compared to controls, probands were at significantly increased risk for Non-Alcohol SUD, but not for Alcohol SUD (3–6).”
From Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. (2008) · cites this paper as [4]
In the citing paper
“Numerous studies have shown that childhood attention deficit hyperactivity disorder (ADHD) is significantly associated with adolescent and adult substance use disorders (SUD) (1–8).”
From Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. (2008) · cites this paper as [4]
In the citing paper
“It is not surprising that age at initiation was significantly associated with both SUD and antisocial personality disorder since follow-ups of this sample consistently showed substantial comorbidity between SUD and antisocial disorder (3–6).”
From Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. (2008) · cites this paper as [4]
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“…letztlich jedoch um keine „reine“ Störung des Kindesalters oder Heranwachsenden handelt, sondern sich durchaus auch im Erwachsenenalter symptomatisch darstellen kann, haben wir neueren Studienergebnissen zu verdanken (Barkley et al., 1998, Mannuzza et al., 1991, 1993, 1998, Wender et al., 1995).”
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“Introduction Attention Deficit Hyperactivity Disorder (ADHD) is a highly prevalent chronic childhood disease which persists into adulthood for approximately half of affected children.(1-5) In the United States, 8 to 13 percent of all children aged 5 to 17 years suffered from ADHD in 2008.”
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“Although 50 percent of ADHD children will no longer meet criteria for the disorder by adolescence, the persistence of the disorder in other children significantly increases their risk for antisocial and substance use disorders (Gittelman et al. 1985; Mannuzza et al. 1991; Weiss et al. 1985).”
BackgroundDonnelly, S. L., Wolpert, C. M., Menold, M. M., Bass, M. P., Gilbert, J. R., Cuccaro, M. L., Delong, G. R., & Pericak-Vance, M. A. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20000612)96:3
Metadata
- Authors
- Mannuzza, S.
- Affiliations
- Long Island Jewish Medical Center (US)
- Corresponding author
- Mannuzza, Salvatore
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1991-01-01
- Volume
- 48
- Issue
- 1
- Pages
- 77
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2108483316
- Cited by
- 549
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 12 · 2014: 16 · 2013: 18 · 2012: 21
- FWCI
- 14.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-18579, R01MH018579, MH30906)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- hyperactive children, adult outcomes, attention deficit disorder, antisocial personality disorder, drug use disorders, mood disorders, replication study, young men, long-term follow-up
- MeSH terms
- Adolescent, Age Factors, Alcoholism, Antisocial Personality Disorder, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Child, Child Behavior Disorders, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Male, Psychiatric Status Rating Scales, Psychometrics, Regression Analysis, Comorbidity, Prevalence, Substance-Related Disorders
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