Molecular genetics research in ADHD: Ethical considerations concerning patients' benefit and resource allocation
Open accessAbstract
Immense resource allocations have led to great data output in genetic research. Concerning ADHD resources spent on genetic research are less than those spent on clinical research. But there are successful efforts made to increase support for molecular genetics research in ADHD. Concerning genetics no evidence based conclusive results have significant impact on prevention, diagnosis or treatment yet. With regard to ethical aspects like the patients' benefit and limited resources the question arises if it is indicated to think about a new balance of resource allocation between molecular genetics and non‐genetics research in ADHD. An ethical reflection was performed focusing on recent genetic studies and reviews based on a selective literature search. There are plausible reasons why genetic research results in ADHD are somehow disappointing for clinical practice so far. Researchers try to overcome these gaps systematically, without knowing what the potential future benefits for the patients might be. Non‐genetic diagnostic/therapeutic research may lead to clinically relevant findings within a shorter period of time. On the other hand, non‐genetic research in ADHD may be nurtured by genetic approaches. But, with the latter there exist significant risks of harm like stigmatization and concerns regarding data protection. Isolated speeding up resources of genetic research in ADHD seems questionable from an ethical point of view. There is a need to find a new balance of resource allocation between genetic and non‐genetic research in ADHD, probably by integrating genetics more systematically into clinical research. A transdisciplinary debate is recommended. © 2012 Wiley Periodicals, Inc.
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ADHD is usually accompanied by other comorbid conditions, and patients with ADHD are frequently diagnosed with another neuropsychiatric condition, which can mask ADHD.
“ADHD disorder is usually accompanied by other comorbid conditions. In fact, patients with ADHD are frequently diagnosed with another neuropsychiatric conditions, which can mask ADHD [71].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [71]
In “A Brief Summary on ADHD” (page unavailable), the paper says comorbidities such as depression, anxiety, and conduct disorder are common in children with ADHD. It does not say that patients are frequently diagnosed with another condition or that such a diagnosis can mask ADHD, and its statement about comorbidity is limited to children. (LLM, conf=0.87)
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- Authors
- Rothenberger, L. G.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Rothenberger, Lillian Geza
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2012-10-22
- Volume
- 159B
- Issue
- 8
- Pages
- 885-895
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2004561340
- Cited by
- 8
- References
- 67
- Citations by year
- 2022: 1 · 2021: 5 · 2015: 1 · 2014: 1
- FWCI
- 0.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroethics, Human Enhancement, Biomedical Innovations
- Keywords
- attention deficit hyperactivity disorder, research ethics, resource allocation, patient benefit, genetic research funding, stigmatization, data protection, translational gap
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Health Priorities, Humans, Research, Genetic Predisposition to Disease, Ethics, Research, Diagnostic and Statistical Manual of Mental Disorders, Resource Allocation
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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