Treatment of Depressive Symptoms in Human Immunodeficiency Virus–Positive Patients
Abstract
BACKGROUND: This randomized clinical trial compared 16-week interventions with interpersonal psychotherapy, cognitive behavioral therapy, supportive psychotherapy, and supportive psychotherapy with imipramine for human immunodeficiency virus (HIV)-positive patients with depressive symptoms. METHODS: Subjects (N = 101; 85 male, 16 female) with known HIV seropositivity for at least 6 months were randomized to 16 weeks of treatment. Inclusion criteria were 24-item Hamilton Depression Rating Scale score of 15 or higher, clinical judgment of depression, and physical health sufficient to attend outpatient sessions. Therapists were trained in manualized therapies specific for HIV-positive patients. Treatment adherence was monitored. RESULTS: Subjects randomized to interpersonal psychotherapy (n = 24) and supportive psychotherapy with imipramine (n = 26) had significantly greater improvement on depressive measures than those receiving supportive psychotherapy (n = 24) or cognitive behavioral therapy (n = 27). Similar results appeared in the completer subsample. CONCLUSIONS: Depressive symptoms appear treatable in HIV-positive patients. Interpersonal psychotherapy may have particular advantages as a psychotherapy for patients who have experienced the significant life events of HIV infection.
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Interpersonal therapy has been shown to be effective for treating depressive symptoms in HIV-positive patients.
“In addition, interpersonal therapy has been shown to be effective for treating depressive symptoms in HIV-positive patients (Markowitz et al , 1998), which is important given the high prevalence of HIV infection in this region of Africa.”
From Group interpersonal psychotherapy for depression in rural Uganda: 6-month outcomes: Randomised controlled trial (2006) · cites this paper as Markowitz et al, 1998
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Miller, M. D., Cornes, C. L., Frank, E., Ehrenpreis, L., Silberman, R. L., Schlernitzauer, M., Tracey, B., Richards, V. J., Wolfson, L., Zaltman, J., et al. (2001) · PubMed Central · Cited by 33 · see citing works
- Authors
- Markowitz, J. C., Kocsis, J. H., Fishman, B., Spielman, L. A., Jacobsberg, L. B., Frances, A. J., Klerman, G. L., & Perry, S. W.
- Affiliations
- Cornell University (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1998-05-01
- Volume
- 55
- Issue
- 5
- Pages
- 452
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1976615687
- Cited by
- 268
- References
- 16
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 15 · 2022: 16 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 13 · 2012: 14
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- New York Community Trust
- National Institutes of Health (5r01mh046250-05)
- College of Veterinary Medicine, Cornell University
- National Institute of Mental Health (MH-46250)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- HIV, depressive symptoms, depression treatment, interpersonal psychotherapy, cognitive behavioral therapy, supportive therapy, imipramine, psychotherapy, antidepressant augmentation, medication adherence
- MeSH terms
- Adult, Ambulatory Care, Combined Modality Therapy, Depressive Disorder, Female, HIV Seropositivity, Humans, Imipramine, Life Change Events, Male, Psychiatric Status Rating Scales, Psychotherapy, Risk Factors, Comorbidity, Cognitive Behavioral Therapy, Treatment Outcome, CD4 Lymphocyte Count
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