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Cited by 204HIV/AIDS Research and InterventionsHIV Research and TreatmentStress Responses and Cortisol

Stress management interventions for HIV+ adults: A meta-analysis of randomized controlled trials, 1989 to 2006.

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Scott-Sheldon, Lori A. J., Kalichman, Seth C., Carey, Michael P., Fielder, Robyn L.·2008·Health Psychology
DOI 10.1037/0278-6133.27.2.129PMC PMC2409585
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Abstract

OBJECTIVE: Numerous studies document that stress accelerates disease processes in a variety of diseases including HIV. As a result, investigators have developed and evaluated interventions to reduce stress as a means to improve health among persons living with HIV. Therefore, the current meta-analysis examines the impact of stress-management interventions at improving psychological, immunological, hormonal, and other behavioral health outcomes among HIV+ adults. DESIGN: This meta-analytic review integrated the results of 35 randomized controlled trials examining the efficacy of 46 separate stress management interventions for HIV+ adults (N=3,077). MAIN OUTCOME MEASURES: Effect sizes were calculated for stress processes (coping and social support), psychological/psychosocial (anxiety, depression, distress, and quality of life), immunological (CD4+ counts and viral load), hormonal (cortisol, dehydroepiandrosterone sulfate [DHEA-S], cortisol/DHEA-S ratio, and testosterone) and other behavioral health outcomes (fatigue). RESULTS: Compared to controls, stress-management interventions reduce anxiety, depression, distress, and fatigue and improve quality of life (d+s=0.16 to 0.38). Stress-management interventions do not appear to improve CD4+ counts, viral load, or hormonal outcomes compared with controls. CONCLUSION: Overall, stress-management interventions for HIV+ adults significantly improve mental health and quality of life but do not alter immunological or hormonal processes. The absence of immunological or hormonal benefits may reflect the studies' limited assessment period (measured typically within 1-week postintervention), participants' advanced stage of HIV (HIV+ status known for an average of 5 years), and/or sample characteristics (predominately male and White participants). Future research might test these hypotheses and refine our understanding of stress processes and their amelioration.

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  • An established evidence base exists for cognitive behavioral stress management (CBSM) to address stress among individuals living with HIV and improve immune functioning.

    “An established evidence base exists for cognitive behavioral stress management (CBSM) to address stress among individuals living with HIV and improve immune functioning (Antoni, 2003; Brown & Vanable, 2008; Scott-Sheldon, Kalichman, Carey, & Fielder, 2008)”

    From The Application of Mindfulness for Individuals Living with HIV in South Africa: a Hybrid Effectiveness-Implementation Pilot Study (2018) · cites this paper as Scott-Sheldon, Kalichman, Carey, & Fielder, 2008

    The Discussion reports that stress-management interventions reduced emotional distress in adults living with HIV, supporting the stress-related part of the claim. But the Discussion and Conclusion explicitly state that the meta-analysis found no evidence of improved immune functioning. The paper evaluates stress-management interventions broadly, including CBSM, rather than establishing an immune benefit for CBSM. (LLM, conf=0.89)

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Research works printed but not linked: 8

  1. Antoni MH. Cognitive-behavioral intervention for persons with HIV. In: Spira JL, editor. Group Therapy for Medically Ill Patients. Guilford Press; New York: 1997. pp. 55–91. [LaPerriere et al., 1990] [Google Scholar]
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Authors
Scott-Sheldon, L. A. J., Kalichman, S. C., Carey, M. P., & Fielder, R. L.
Affiliations
  • University of Connecticut (US)
  • Syracuse University (US)
ORCID
Venue
Health Psychology
Publisher
American Psychological Association (APA)
Published
2008
Volume
27
Issue
2
Pages
129-139
ISSN
  • 0278-6133 (ISSN-L)
  • 1930-7810
DOI
10.1037/0278-6133.27.2.129
PMC
PMC2409585
OpenAlex
W2024424432
Cited by
204
References
80
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 45 · 2016: 9 · 2015: 5 · 2014: 6 · 2013: 14 · 2012: 26
FWCI
2.44
Type
journal article
Language
en
Open access
Locations
  • Health Psychology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (R01-MH71164, R01-MH068171)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
stress management interventions, HIV, people living with HIV, coping, social support, anxiety, depression, psychological distress, quality of life, fatigue, CD4 count, viral load, cortisol, dehydroepiandrosterone sulfate, testosterone, immunological outcomes
MeSH terms
Adaptation, Psychological, Arousal, Behavior Therapy, HIV Seropositivity, Hydrocortisone, Pyridines, Stress, Psychological, Testosterone, Randomized Controlled Trials as Topic, CD4 Lymphocyte Count, Dehydroepiandrosterone Sulfate, Viral Load

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