The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Unitary Model of Schizophrenia: Bleuler's "Fragmented Phrene" as Schizencephaly
Abstract
inding a unifying concept behind the diversity of signs and symptoms in schizophrenia is a central challenge to contemporary research. A neo-Bleulerian unitary model is described, which defines the illness as a neurodevelopmentally derived "misconnection syndrome," involving connections between cortical regions and the cerebellum mediated through the thalamus (the cortico-cerebellar-thalamic-cortical circuit [CCTCC]). An abnormality in this circuitry, normally used to coordinate both motor and mental activity, leads to misconnections in many aspects of mental activity, or "cognitive dysmetria." As Bleuler originally proposed, "thought disorder" is the primary defining feature of schizophrenia, rather than the more obvious signs and symptoms such as delusions and hallucinations. Cognitive dysmetria, or a disorder in the CCTCC, may provide a heuristic theoretical framework for strategies to explore etiology, pathophysiology, intervention, or prevention.
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The cognitive neuropsychology of schizophrenia
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Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function
Middleton, F. A., & Strick, P. L. (1994) · Science · doi:10.1126/science.7939688 · Cited by 1,356
A functional neuroanatomy of hallucinations in schizophrenia
Silbersweig, D. A., Stern, E., Frith, C., Cahill, C., Holmes, A., Grootoonk, S., Seaward, J., McKenna, P., Chua, S. E., Schnorr, L., et al. (1995) · Nature · doi:10.1038/378176a0 · Cited by 906 · cited 4×
“resonance imaging studies have given additional support,(82,83) as have PET studies.(21,46,84) We have re-”
BackgroundInfluentialAndreasen, N. C., O'Leary, D. S., Cizadlo, T., Arndt, S., Rezai, K., Ponto, L. L., Watkins, G. L., & Hichwa, R. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9985 · Cited by 625
Self-citationRemembering the past: two facets of episodic memory explored with positron emission tomography
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1576 · Cited by 593
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Cited by
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review
Cisler, J. M., & Koster, E. H. W. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.11.003 · Cited by 1,753
The Neurodevelopmental Hypothesis of Schizophrenia, Revisited
Fatemi, S. H., & Folsom, T. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn187 · Cited by 860
The role of the cerebellum in schizophrenia
Andreasen, N. C., & Pierson, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.003 · Cited by 669
Self-citationStability and Course of Neuropsychological Deficits in Schizophrenia
Heaton, R. K., Gladsjo, J. A., Palmer, B. W., Kuck, J., Marcotte, T. D., & Jeste, D. V. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.1.24 · Cited by 618
Metadata
- Authors
- Andreasen, N. C.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1999-09-01
- Volume
- 56
- Issue
- 9
- Pages
- 781
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2039238247
- Cited by
- 610
- References
- 5
- FWCI
- 15.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Andreasen, N. C. (1999). A Unitary Model of Schizophrenia: Bleuler's "Fragmented Phrene" as Schizencephaly. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.56.9.781
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
