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Predictors of Mortality in Eating Disorders
Abstract
Background Anorexia nervosa, but not bulimia nervosa, has one of the highest mortality rates among psychiatric disorders. However, potential predictors of mortality, such as comorbid psychiatric illnesses, remain unclear. We sought to determine mortality ratios and predictors of fatal outcome in women diagnosed as having anorexia or bulimia nervosa. Methods Women (N = 246) diagnosed as having either DSM-IV anorexia nervosa (n = 136) or bulimia nervosa (n = 110) between January 1, 1987, and December 31, 1991, participated in a prospective longitudinal study. Vital status was determined by ongoing contact and a National Death Index search as of December 1998 (overall ascertainment, 99.8%) and telephone contact as of October 2000 (ascertainment, 95.0%). Results Eleven women died. Standardized mortality ratios were elevated for all causes of mortality (11.6; 95% confidence interval, 5.5-21.3) and suicide (56.9; 95% confidence interval, 15.3-145.7) in anorexia nervosa but not for death (1.3; 95% confidence interval, 0.0-7.2) in bulimia nervosa. Predictors of mortality in anorexia nervosa included severity of alcohol use disorder during follow-up (P Conclusions Physicians treating patients with anorexia nervosa should carefully assess patterns of alcohol use during the course of care because one third of women who had alcoholism and died had no history of alcohol use disorder at intake.
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Anorexia Nervosa is associated with a high suicide rate.
“Consider also that Anorexia Nervosa is associated with a high suicide rate (Keel, Dorer, Eddy, Franko, Charatan, & Herzog, 2003).”
From The interpersonal theory of suicide. (2010) · cites this paper as Keel, Dorer, Eddy, Franko, Charatan, & Herzog, 2003
Citations
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“Inpatient treatment is used less for bulimia nervosa than for anorexia nervosa.(11,12) Thus, methodologic differences in treatment settings through which patients are ascertained may represent actual differences in illness severity that result in disparate mortality rates for anorexia and bulimia nervosa.”
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“The authors would like to acknowledge Ashley A. Moskovich, M.A., and Lisa K. Honeycutt, M.A., for their contribution to this manuscript. uthor M anuscript A uthor M anuscript A uthor M anuscript & Gao, 2005; Herzog et al., 2000; Keel et al., 2003).”
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Metadata
- Authors
- Keel, P. K., Dorer, D. J., Eddy, K. T., Franko, D., Charatan, D. L., & Herzog, D. B.
- Affiliations
- Harvard University (US)
- Corresponding author
- Keel, Pamela K.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2003-02-01
- Volume
- 60
- Issue
- 2
- Pages
- 179
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2160248121
- Cited by
- 396
- References
- 2
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 12 · 2023: 9 · 2022: 14 · 2021: 5 · 2020: 19 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 20 · 2015: 20 · 2014: 20 · 2013: 37 · 2012: 35
- FWCI
- 22.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH061836, R01 MH 38333-06A4, R01 MH 61836-02, R01MH038333)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- anorexia nervosa, bulimia nervosa, eating disorders, mortality, suicide, standardized mortality ratio, alcoholism, comorbidities, women
- MeSH terms
- Alcoholism, Anorexia Nervosa, Feeding and Eating Disorders, Bulimia, Cause of Death, Female, Follow-Up Studies, Humans, Longitudinal Studies, Probability, Prospective Studies, Comorbidity, Life Tables, Diagnosis, Dual (Psychiatry)
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