The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Childhood Adversity, Monoamine Oxidase A Genotype, and Risk for ConductDisorder
Abstract
BACKGROUND: Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder. OBJECTIVE: To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys. DESIGN: Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline. SETTING: A community-based sample of twin boys. PARTICIPANTS: Five hundred fourteen male twins aged 8 to 17 years. MAIN OUTCOME MEASURE: Conduct disorder. RESULTS: There was a main effect of adversity but not of monoamine oxidase A on risk for conduct disorder. Low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment. Neither a passive nor an evocative genotype-environment correlation accounted for the interaction. CONCLUSION: This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys.
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In the citing paper
“A functional polymorphism in the monoamine oxidase A (MAOA) gene has been found to moderate the effects of a risk environment on the development of antisocial behavior (Caspi et al., 2002;Foley et al., 2004).”
From Heritability for adolescent antisocial behavior differs with socioeconomic status: gene–environment interaction (2006) · cites this paper as Foley et al., 2004
In the citing paper
“Further research has replicated and extended the finding by noting that parent neglect as well as abuse in conjunction with the polymorphism increase risk for conduct problems and violence (Foley et al. 2004, Jaffee et al. 2005).”
From Mediators and Mechanisms of Change in Psychotherapy Research (2007) · cites this paper as Foley et al. 2004
In the citing paper
“The association between maltreatment and mental health problems was significantly stronger in the group of males with a genotype conferring low versus high MAO-A activity.”
From Human Aggression Across the Lifespan (2011) · cites this paper as Foley et al., 2004
In the citing paper
“So far, there have only been a few replications of this important finding (Foley et al., 2004; Kim-Cohen et al., 2006; Nilsson et al., 2006).”
From Human Aggression Across the Lifespan (2011) · cites this paper as Foley et al., 2004
Citations
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Metadata
- Authors
- Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., & Riley, B.
- Affiliations
- Virginia Commonwealth University (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2004-07-01
- Volume
- 61
- Issue
- 7
- Pages
- 738
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2147817341
- Cited by
- 564
- References
- 33
- Citations by year
- 2026: 4 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 12 · 2019: 6 · 2018: 15 · 2017: 13 · 2016: 26 · 2015: 26 · 2014: 33 · 2013: 33 · 2012: 32
- FWCI
- 69.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH57761, MH45268, R01MH045268, P30MH057761)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- conduct disorder, monoamine oxidase A, childhood adversity, gene-environment interaction, antisocial behavior, interparental violence, parental neglect, inconsistent discipline, risk factors
- MeSH terms
- Adolescent, Antisocial Personality Disorder, Child, Child Abuse, Diseases in Twins, Genotype, Humans, Life Change Events, Male, Monoamine Oxidase, Risk Factors, Sex Factors, Social Environment, Virginia, Child of Impaired Parents, Domestic Violence, Conduct Disorder, Genetic Predisposition to Disease
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