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Cited by 320Reproductive tract infections researchNeonatal and Maternal InfectionsOcular Infections and Treatments

Prospective study of perinatal transmission of Chlamydia trachomatis.

Schachter, Julius·1986·JAMA: The Journal of the American Medical Association
DOI 10.1001/jama.1986.03370240044034
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Abstract

During a five-year period, 262 (4.7%) of 5,531 pregnant women had positive cervical cultures for Chlamydia trachomatis, and 131 of their infants were followed up prospectively to ascertain the outcome of chlamydial exposure during the birth process. Culture-confirmed inclusion conjunctivitis of the newborn was seen in 23 (18%) of the infants. Chlamydial pneumonia was diagnosed in 21 (16%) of the infants at risk. Chlamydia trachomatis was recovered from 47 of the infants (36%), while 79 (60%) showed serologic evidence of infection. Subclinical rectal and vaginal infections were detected in 14% of infants at risk. In our population, 2.8% of newborn infants show serologic evidence of perinatal chlamydial infection and 1.4% develop either chlamydial pneumonia or conjunctivitis. Incidence rates of this magnitude indicate the need for programs aimed at preventing perinatal transmission of C trachomatis.

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Crossref · 10.1001/jama.1986.03370240044034

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  • Genital infection with T. vaginalis or rectal or genital infection with C. trachomatis among young children might be the result of perinatally acquired infection and has, in certain cases of chlamydial infection, persisted for as long as 2-3 years.

    “For example, genital infection with T. vaginalis (1442) or rectal or genital infection with C. trachomatis among young children might be the result of perinatally acquired infection and has, in certain cases of chlamydial infection, persisted for as long as 2–3 years (1443–1445), although perinatal chlamydial infection is now uncommon because of prenatal screening and treatment of pregnant women.”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1445]

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Authors
Schachter, J.
Affiliations
University of California, San Francisco (US)
Corresponding author
Schachter, Julius
Venue
JAMA: The Journal of the American Medical Association
Publisher
American Medical Association (AMA)
Published
1986-06-27
Volume
255
Issue
24
Pages
3374
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.1986.03370240044034
OpenAlex
W2089207400
Cited by
320
References
19
Citations by year
2026: 2 · 2025: 9 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 3 · 2018: 10 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 11 · 2013: 8 · 2012: 11
FWCI
13.79
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Eye Institute (EY 02216)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
  • Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords
Chlamydia trachomatis, perinatal transmission, chlamydial infection in pregnancy, neonates, inclusion conjunctivitis, chlamydial pneumonia, serologic evidence of infection, incidence, prevention
MeSH terms
Antibodies, Bacterial, Chlamydia Infections, Chlamydia trachomatis, Conjunctivitis, Inclusion, Erythromycin, Female, Humans, Immunoglobulin G, Immunoglobulin M, Infant, Infant, Newborn, Ophthalmia Neonatorum, Pneumonia, Pregnancy, Pregnancy Complications, Infectious, Prospective Studies

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