Defining and Measuring Functional Recovery from Depression
Abstract
Depression is associated with significant functional impairment and reduced quality of life. Disruptions occur both globally as well as in specific functional areas such as work, interpersonal relationships and cognitive function. From both a clinical and research perspective, much focus has been given to the resolution of symptoms associated with depression, while relatively little attention has been given to functional improvements. Definitions of remission in depression are most frequently based on achieving a cut-off score on clinical rating scales of depressive symptoms. Research in this area has sparsely included psychosocial function or health-related quality of life as a primary outcome measure in clinical trials. However, the need to fully understand the impact of depression and its treatments on functioning is great, given the existing evidence of the profound effect that depression has on function. Even mild depressive symptoms and subsyndromal depression result in functional impairment and reduced quality of life, and untreated residual depressive symptomatology can result in an increased likelihood for relapse of the fully symptomatic disorder (i.e. major depressive disorder). Therefore, clinicians and researchers alike need to broaden the focus of treatment to encompass not only the specific symptoms of depression, but the functional consequences as well. Many tools have been developed to assess function and quality of life, both globally as well as within speci…
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Improvement in cognitive function significantly influences functional recovery from a major depressive episode.
“Moreover, it has been proposed that improvement in cognitive function significantly influences functional recovery from an MDE (Jaeger et al., 2006; Greer et al., 2010).”
From A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults (2014) · cites this paper as Greer et al., 2010
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- Authors
- Greer, T. L., Kurian, B. T., & Trivedi, M. H.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Trivedi, Madhukar H.
- Venue
- CNS Drugs
- Published
- 2010-04
- Volume
- 24
- Issue
- 4
- Pages
- 267-284
- ISSN
- 1172-7047 (ISSN-L)
- OpenAlex
- W2037304868
- Cited by
- 222
- References
- 22
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 11 · 2023: 18 · 2022: 10 · 2021: 13 · 2020: 11 · 2019: 10 · 2018: 16 · 2017: 14 · 2016: 25 · 2015: 25 · 2014: 14 · 2013: 12 · 2012: 7
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Drugs (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Texas Southwestern Medical Center
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- depression, functional recovery, functional disability, health-related quality of life, psychosocial functioning, remission, residual depressive symptoms, relapse, mild depressive symptoms, subthreshold depression, treatment outcome measures, cognitive impairment, somatic symptoms, fatigue, insomnia
- MeSH terms
- Adaptation, Psychological, Antidepressive Agents, Cognition Disorders, Depression, Fatigue, Humans, Pain, Quality of Life, Sleep Wake Disorders, Social Behavior, Task Performance and Analysis
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