Cited by 2,155Heart Failure Treatment and ManagementBlood Pressure and Hypertension StudiesCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

The Progression From Hypertension to Congestive Heart Failure

Levy, Daniel·1996·JAMA: The Journal of the American Medical Association

DOI 10.1001/jama.1996.03530440037034

Open this paper in CoChat — free account

Abstract

OBJECTIVES: - To study the relative and population-attributable risks of hypertension for the development of congestive heart failure (CHF), to assess the time course of progression from hypertension to CHF, and to identify risk factors that contribute to the development of overt heart failure in hypertensive subjects. DESIGN: - Inception cohort study. SETTING: - General community. PARTICIPANTS: - Original Framingham Heart Study and Framingham Offspring Study participants aged 40 to 89 years and free of CHF. To reflect more contemporary experience, the starting point of this study was January 1, 1970. EXPOSURE MEASURES: - Hypertension (blood pressure of at least 140 mm Hg systolic or 90 mm Hg diastolic or current use of medications for treatment of high blood pressure) and other potential CHF risk factors were assessed at periodic clinic examinations. OUTCOME MEASURE: - The development of CHF. RESULTS: - A total of 5143 eligible subjects contributed 72422 person-years of observation. During up to 20.1 years of follow-up (mean, 14.1 years), there were 392 new cases of heart failure; in 91% (357/392), hypertension antedated the development of heart failure. Adjusting for age and heart failure risk factors in proportional hazards regression models, the hazard for developing heart failure in hypertensive compared with normotensive subjects was about 2-fold in men and 3-fold in women. Multivariable analyses revealed that hypertension had a high population-attributable risk for CHF, accounting for 39% of cases in men and 59% in women. Among hypertensive subjects, myocardial infarction, diabetes, left ventricular hypertrophy, and valvular heart disease were predictive of increased risk for CHF in both sexes. Survival following the onset of hypertensive CHF was bleak; only 24% of men and 31% of women survived 5 years. CONCLUSIONS: - Hypertension was the most common risk factor for CHF, and it contributed a large proportion of heart failure cases in this population-based sample. Preventive strategies directed toward earlier and more aggressive blood pressure control are likely to offer the greatest promise for reducing the incidence of CHF and its associated mortality.

Integrity signals

Registry

Crossref · 10.1001/jama.1996.03530440037034

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
The SOLVD Investigators* (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250501 · Cited by 8,029
The environment and disease: association or causation?
Hill, A. B. (2015) · Journal of the Royal Society of Medicine · doi:10.1177/0141076814562718 · Cited by 7,804
Analysis of Survival Data
Cox, D. R., & Oakes, D. (2018) · Chapman & Hall/CRC eBooks · doi:10.1201/9781315137438 · Cited by 6,269
Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction: Results of the Survival and Ventricular Enlargement Trial
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
Swedberg, K. B., & KJEKSHUS, J. K. (1988) · The American Journal of Cardiology · doi:10.1016/s0002-9149(88)80087-0 · Cited by 3,762
Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions
(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725
The natural history of congestive heart failure: the Framingham study
McKee, P. A., Castelli, W. P., McNamara, P. M., & Kannel, W. B. (1971) · New England Journal of Medicine · doi:10.1056/nejm197112232852601 · Cited by 3,448
A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure
Cohn, J. N., Johnson, G., Ziesche, S., Cobb, F., Francis, G., Tristani, F., Smith, R., Dunkman, W. B., Loeb, H., Wong, M., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250502 · Cited by 2,833
Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure
Cohn, J. N., Archibald, D. G., Ziesche, S., Franciosa, J. A., Harston, W. E., Tristani, F. E., Dunkman, W. B., Jacobs, W., Francis, G. S., Flohr, K. H., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606123142404 · Cited by 2,400
The epidemiology of heart failure: The Framingham Study
Ho, K. K. L., Pinsky, J. L., Kannel, W. B., & Levy, D. A. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90455-a · Cited by 2,246
Self-citation

Show all 46 references

Sorted by citations

Items 501–600 of 999

Diagnosis and Management of Left Ventricular Diastolic Dysfunction in the Hypertensive Patient
Galderisi, M. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.235 · Cited by 52
Central arterial pulse wave augmentation is greater in girls than boys, independent of height
Ayer, J. G., Harmer, J. A., Marks, G. B., Avolio, A. P., & Celermajer, D. S. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283332286 · Cited by 52
Subclinical Abnormalities in Sarcoplasmic Reticulum Ca2+ Release Promote Eccentric Myocardial Remodeling and Pump Failure Death in Response to Pressure Overload
Sedej, S., Schmidt, A. G., Denegri, M., Walther, S., Matovina, M., Arnstein, G., Gutschi, E.-M., Windhager, I., Ljubojević-Holzer, S., Negri, S., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.010 · Cited by 52
Prevention of relapse in patients with congestive heart failure: the role of precipitating factors
Feenstra, J., Grobbee, D. E., Jonkman, F. A. M., Hoes, A. W., & Stricker, B. H. C. (1998) · Heart · doi:10.1136/hrt.80.5.432 · Cited by 52
“Recent data from the Framingham study underscore the importance of hypertension as a major risk factor for CHF.”
Method
Clinical implications of apoptosis in hypertensive heart disease
Fortuño, M. A., González, A., Ravassa, S., López, B., & Díez, J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00025.2003 · Cited by 52
Current Understanding of Molecular Pathophysiology of Heart Failure With Preserved Ejection Fraction
Budde, H., Hassoun, R., Mügge, A., Kov́acs, Á., & Hamdani, N. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.928232 · Cited by 56
“Although a LV EF of ˃49% is considered normal in HF, patients with HFpEF presented LV functional variety with an EF spectrum between 50–85% (Levy et al., 1996; Yancy et al., 2013; Ponikowski et al., 2016).”
Background
The Link between Prostanoids and Cardiovascular Diseases
Beccacece, L., Abondio, P., Bini, C., Pelotti, S., & Luiselli, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044193 · Cited by 51
“PGE2 and EP receptors thus play an important role in the pathogenesis of hypertension and possibly of myocardial ischemia and heart failure [186].”
Background
Priming with synthetic oligonucleotides attenuates pressure overload-induced inflammation and cardiac hypertrophy in mice
Velten, M., Duerr, G. D., Pessies, T., Schild, J., Lohner, R., Mersmann, J., Dewald, O., Zacharowski, K. D., Klaschik, S., Hilbert, T., et al. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs280 · Cited by 51
Air Pollution and Emergency Department Visits for Hypertension in Edmonton and Calgary, Canada: A Case-Crossover Study
Brook, R. D., & Kousha, T. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpu302 · Cited by 50
ABC of heart failure: Aetiology
Lip, G. Y. H. (2000) · BMJ · doi:10.1136/bmj.320.7227.104 · Cited by 51
Load Versus Humoral Activation in the Genesis of Early Hypertensive Heart Disease
Hart, C. Y. T., Meyer, D., Tazelaar, H. D., Grande, J. P., Burnett, J. C. J., Housmans, P. R., & Redfield, M. M. (2001) · Circulation · doi:10.1161/01.cir.104.2.215 · Cited by 51
“Adult male dogs (20 to 26 kg) were studied (1) 5 weeks after sham surgeries (controls, n56), (2) 5 weeks after renal wrap (HTN-5wk, n57), and (3) 12 weeks after renal wrap (HTN-12wk, n55).”
Method
Use of cyclo‐oxygenase 2 inhibitors (COX‐2) and prescription non‐steroidal anti‐inflammatory drugs (NSAIDS) in UK and USA populations. Implications for COX‐2 cardiovascular profile
Arellano, F. M., Yood, M. U., Wentworth, C. E., Oliveria, S. A., Rivero‐Ferrer, E., Verma, A., & Rothman, K. J. (2006) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1343 · Cited by 51
“This effect is closely linked to the capacity of these drugs to induce hypertension(38) and increase SBP due to salt and water retention.(39) In our studies between 15% and 33% of patients had a history of hypertension and between 1% and 6% of CHF.”
Background
From Hypertension to Heart Failure: Role of Nitric Oxide–Mediated Endothelial Dysfunction and Emerging Insights from Myocardial Contrast Echocardiography
Lapu-Bula, R., & Ofili, E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.014 · Cited by 50
VENTRICULAR REMODELING
Goldstein, S., Ali, A. S., & Sabbah, H. N. (1998) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70039-4 · Cited by 51
DASH Eating Pattern Is Associated with Favorable Left Ventricular Function in the Multi-Ethnic Study of Atherosclerosis
Nguyen, H., Bertoni, A. G., Nettleton, J. A., Bluemke, D. A., Levitan, E. B., & Burke, G. L. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720466 · Cited by 51
The imminent epidemic of atrial fibrillation and its concomitant diseases – Myocardial infarction and heart failure - A cause for concern
Börschel, C. S., & Schnabel, R. B. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.11.123 · Cited by 52
Sex and Heart Failure with Preserved Ejection Fraction: From Pathophysiology to Clinical Studies
Tadic, M. V., Cuspidi, C., Plein, S., Belyavskiy, E., Heinzel, F. R., & Galderisi, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060792 · Cited by 52
“reported similar findings, and calculated that hypertension increased the risk of HF three-fold in women, compared with two-fold in men [28].”
Result
SGLT2 Inhibitors and Their Antiarrhythmic Properties
Kolesnik, E., Scherr, D., Rohrer, U., Benedikt, M., Manninger, M., Sourij, H., & von Lewinski, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031678 · Cited by 56
“This is of importance since elevated blood pressure is a known risk factor for the development of congestive heart failure [30].”
Background
Arginine vasopressin receptor signaling and functional outcomes in heart failure
Wasilewski, M. A., Myers, V. D., Recchia, F. A., Feldman, A. M., & Tilley, D. G. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.07.021 · Cited by 50
“Since HTN is the most prevalent and preventable risk factor for HF development and HTN contributions to a large proportion of HF cases [1, 94, 95], a better understanding the role of V1AR in HTN may provide insights about the management of HTN-induced HF.”
Congestive Heart Failure in Elderly Patients
Senni, M., & Redfield, M. M. (1997) · Mayo Clinic Proceedings · doi:10.4065/72.5.453 · Cited by 50
Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis
Kiriazis, H. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00487-4 · Cited by 50
Isolated Systolic Hypertension: an Important Cardiovascular Risk Factor
HIMMELMANN, T. H. A. (1998) · Blood Pressure · doi:10.1080/080370598437222 · Cited by 50
Guest Editorial: What Is the Appropriate Treatment of Hypertension in Elders?
Aronow, W. S. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.8.m483 · Cited by 50
Differential Prognostic Effect of Systolic Blood Pressure on Mortality According to Left-Ventricular Function in Patients with Acute Heart Failure
Núñez, J. E., Núñez, E., Fonarow, G. C., Sanchís, J., Bodı́, V., Bertomeu‐González, V., Miñana, G., Merlos, P., Bertoméu, V., Redón, J., et al. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp176 · Cited by 49
“Hypertension is one of the main risk factors involved in the pathogenesis of cardiovascular (CV) diseases.(1) In fact, hypertension is the major population-attributable risk factor for heart failure (HF),(2) and lowering blood pressure in patients with hypertension”
Background
Racial Differences in Incident Heart Failure During Antihypertensive Therapy
Okin, P. M., Kjeldsen, S. E., Dahlöf, B., & Devereux, R. B. (2011) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.110.960112 · Cited by 50
Treatment of prehypertension: lifestyle and/or medication
Collier, S. R., & Landram, M. J. (2012) · Vascular Health and Risk Management · doi:10.2147/vhrm.s29138 · Cited by 54
“35 At the forefront of BP research is the need to develop studies aimed at elucidating the time point at which human arterial health is compromised, and to develop meaningful studies that lead to prevention of prehypertension and avoidance of progression to the need for pharmacological intervention.”
The Perspectives of Health Care Professionals on Providing End of Life Care and Palliative Care for Patients With Chronic Heart Failure: An Integrative Review
Singh, G. K., Davidson, P. M., Macdonald, P. S., & Newton, P. J. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.10.009 · Cited by 49
Guía de práctica clínica de la Sociedad Europea de Cardiología (ESC) para el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica (2008)
(2008), G. D. T. D. L. E. P. E. D. Y. T. D. L. I. C. A. Y. C., & Desarrollada en colaboración con la Heart Failure Association (HFA) de la ESC y aprobada por la European Society of Intensive Care Medicine (ESICM) (2008) · Revista Española de Cardiología · doi:10.1016/s0300-8932(08)75740-3 · Cited by 50
Characterization of High-Salt and High-Fat Diets on Cardiac and Vascular Function in Mice
Yu, Q., Larson, D. F., Slayback, D. L., Lundeen, T. F., Baxter, J. H., & WATSON, R. R. (2004) · Cardiovascular Toxicology · doi:10.1385/ct:4:1:37 · Cited by 49
“One-month-old C57BL/6J mice were fed one of the following diets for 3 mo: (1) control diet consisting of a high fat–high simple carbohydrate (HFHSC); (2) 8% NaCl diet (HS); or (3) HFHSC diet supplemented with 1% NaCl (HFHS).”
BackgroundMethod
Heart transplantation in diabetic recipients: a decade review of 161 patients at columbia presbyterian
Morgan, J. A., John, R., Weinberg, A. D., Colletti, N. J., MANCINI, D. M., & Edwards, N. M. (2004) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2003.11.063 · Cited by 49
Blood pressure, hypertension, and the risk of heart failure: a systematic review and meta-analysis of cohort studies
Baffour, P. K., Jahangiry, L., Jain, S., Sen, A., & Aune, D. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad344 · Cited by 48
Heart Failure in Non-Caucasians, Women, and Older Adults: A White Paper on Special Populations From the Heart Failure Society of America Guideline Committee
Colvin, M. M., Sweitzer, N. K., Albert, N. M., Krishnamani, R., Rich, M. W., Stough, W. G., Walsh, M. N., Canary, C. A. W., Allen, L. A., Bonnell, M. R., et al. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.05.013 · Cited by 50
Prevention, Diagnosis, and Treatment of Hypertensive Heart Disease
Georgiopoulou, V. V., Kalogeropoulos, A. P., Raggi, P., & Butler, J. (2010) · Cardiology Clinics · doi:10.1016/j.ccl.2010.07.005 · Cited by 50
Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice
Watson, P. A., Birdsey, N., Huggins, G. S., Svensson, E., Heppe, D. B., & Knaub, L. A. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00394.2010 · Cited by 48
Intradialytic Hypotension and Cardiac Remodeling: A Vicious Cycle
Chao, C., Huang, J., & Yen, C. (2015) · BioMed Research International · doi:10.1155/2015/724147 · Cited by 48
Smokeless tobacco (snus) and risk of heart failure: results from two Swedish cohorts
Arefalk, G., Hergens, M.-P., Ingelsson, E., Ärnlöv, J., Michaëlsson, K., Lind, L., Ye, W., Nyrén, O., Lambe, M., & Sundström, J. (2012) · European Journal of Preventive Cardiology · doi:10.1177/1741826711420003 · Cited by 54
Calcium and phosphate impact cardiovascular risk
Heine, G. H., Nangaku, M., & Fliser, D. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs353 · Cited by 49
Dose–Response Relationship of Total and Leisure Time Physical Activity to Risk of Heart Failure
Andersen, K., Mariosa, D., Adami, H., Held, C., Ingelsson, E., Lagerros, Y. T., Nyrén, O., Ye, W., Bellocco, R., & Sundström, J. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.001010 · Cited by 47
Endothelial dysfunction in hypertension: The role of arginase
Danielle, L. M. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/199 · Cited by 48
Hypertension and heart failure: a dysfunction of systole, diastole or both?
Yip, G. W., Fung, J. W. H., Tan, Y. T., & Sanderson, J. E. (2008) · Journal of Human Hypertension · doi:10.1038/jhh.2008.141 · Cited by 48
Progressive Diastolic Dysfunction in the Female mRen(2).Lewis Rat: Influence of Salt and Ovarian Hormones
Groban, L., Yamaleyeva, L. M., Westwood, B. M., Houle, T. T., Lin, M., Kitzman, D. W., & Chappell, M. C. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.1.3 · Cited by 48
“Body weight was significantly increased in OVX rats compared to their respective NS and HS cohorts (Estrogen: F(1,21)1⁄4 38.”
BackgroundInfluential
Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development
Burton, P. B. J. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1231 · Cited by 48
“Cardiac hypertrophy is the physiological response to pressure overload but becomes pathological when it exceeds normal limits, resulting in loss of contractile performance and ultimately in heart failure([7]).”
Background
Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction
Lau, E. S., Roshandelpoor, A., Zarbafian, S., Wang, D., Guseh, J. S., Allen, N. B., Varadarajan, V., Nayor, M. G., Shah, R. V., Lima, J. A. C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43363-3 · Cited by 50
Serum Levels of Large Tenascin-C Variants, Matrix Metalloproteinase-9, and Tissue Inhibitors of Matrix Metalloproteinases in Concentric Versus Eccentric Left Ventricular Hypertrophy
Franz, M., Berndt, A., Altendorf-Hofmann, A., Fiedler, N., Richter, P., Schumm, J., Fritzenwanger, M., Figulla, H. R., & Brehm, B. R. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp128 · Cited by 47
Effects of Estrogen, an ERα Agonist and Raloxifene on Pressure Overload Induced Cardiac Hypertrophy
Westphal, C., Schubert, C., Prelle, K., Penkalla, A., Fliegner, D., Petrov, G., & Regitz‐Zagrosek, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050802 · Cited by 50
“Women with HF exhibit more often diastolic dysfunction with small ventricles and thickened walls [6,7], whereas men suffer mainly from systolic dysfunction [8,9].”
Background
Limited bedside echocardiography by emergency physicians for diagnosis of diastolic heart failure
Ünlüer, E. E., Bayata, S., Postacı, N., Yeşil, M., Yavaşỉ, Ö., Kara, P. H., Vandenberk, N., & Akay, S. (2011) · Emergency Medicine Journal · doi:10.1136/emj.2011.111229 · Cited by 47
Blood pressure control
Black, H. R. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00320-8 · Cited by 47
Reducing dietary sodium and decreases in cardiovascular disease in Canada
Penz, E. D., Joffres, M. R., & Campbell, N. R. C. (2008) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(08)70625-1 · Cited by 47
“Based on Framingham data, it was assumed in the present model that 70% of myocardial infarctions, 84% of strokes and 91% of heart failure events occur in hypertensive patients (12-14).”
Method
Heart Failure and its Treatment in Women
Regitz‐Zagrosek, V., & Lehmkuhl, E. (2005) · Herz · doi:10.1007/s00059-005-2718-1 · Cited by 47
“Männer [weiß]) [13]; PAR: „population attributable risk“; HTN: Hypertonie; MI: Myokardinfarkt; AP: Angina pectoris; VHD: Herzklappenerkrankungen; LVH: linksventrikuläre Hypertrophie; DM: Diabetes mellitus.”
BackgroundInfluential
Sex Differences in Long-Term Outcomes Following Acute Heart Failure Hospitalization: Findings from the Get with the Guidelines-Heart Failure Registry
Keshvani, N., Shah, S. V., Ayodele, I., Chiswell, K., Alhanti, B., Allen, L. A., Greene, S. J., Yancy, C. W., Alonso, W., Spall, H. G. C. V., et al. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.3003 · Cited by 49
Long term health care consumption and cost expenditure in systolic heart failure
Mejhert, M., Lindgren, P., Schill, O., Edner, M., Persson, H., & Kahan, T. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.11.015 · Cited by 46
“However, a documented history of ischemic heart disease was present in 67% and of hypertension in 31% (see Table 1), indicating that these were the two most common aetiologies for heart failure, which is in good agreement with other findings [20,21].”
Result
Comparison of angiotensin II type 1-receptor blockers to regress pressure overload-induced cardiac hypertrophy in mice
Li, L., Zhou, N., Gong, H., Wu, J., Lin, L., Komuro, I., Ge, J., & Zou, Y. (2010) · Hypertension Research · doi:10.1038/hr.2010.182 · Cited by 46
Insuficiência cardíaca descompensada
Mangini, S., Pires, P. V., Marcondes‐Braga, F. G., & Bacal, F. (2013) · Einstein (São Paulo) · doi:10.1590/s1679-45082013000300022 · Cited by 54
EPIDEMIOLOGY AND RISK FACTORS FOR HEART FAILURE IN THE ELDERLY
Schocken, D. D. (2000) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70020-3 · Cited by 46
Enhanced cardiovascular morbidity and mortality during rhythm control treatment in persistent atrial fibrillation in hypertensives: data of the RACE study
Rienstra, M., van Veldhuisen, D. J., Crijns, H. J. G. M., Gelder, I. C. V., & for the RACE investigators (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl436 · Cited by 46
“07 Duration present episode of AF (days) 34 (1-392) 31 (1-399) 0.”
Ostial Renal Artery Stenosis Angioplasty: Immediate and Mid-term Angiographic and Clinical Results
Hoffman, O., Carreres, T., Sapoval, M. R., Auguste, M. C., Beyssen, B. M., Raynaud, A. C., & Gaux, J. (1998) · Journal of Vascular and Interventional Radiology · doi:10.1016/s1051-0443(98)70484-1 · Cited by 46
Telomere Shortening in Hypertensive Heart Disease Depends on Oxidative DNA Damage and Predicts Impaired Recovery of Cardiac Function in Heart Failure
Brandt, M., Doerschmann, H., Khraisat, S., Knopp, T., Ringen, J., Kalinovic, S., Garlapati, V. S., Siemer, S., Molitor, M., Göbel, S., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18935 · Cited by 47
Heart Failure Diagnosis in the General Community – Who, how and When? A Clinical Consensus Statement of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
Docherty, K. F., Lam, C. S. P., Rakisheva, A., Coats, A. J. S., Greenhalgh, T., Metra, M., Petrie, M. C., & Rosano, G. M. C. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.2946 · Cited by 58
“29”
Modest Elevation in BNP in Asymptomatic Hypertensive Patients Reflects Sub-Clinical Cardiac Remodeling, Inflammation and Extracellular Matrix Changes
Phelan, D. M. J., Watson, C. J., Martos, R., Collier, P. H., Patle, A. K., Donnelly, S. C., Ledwidge, M. T., Baugh, J. A., & McDonald, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049259 · Cited by 45
“It plays a major etiological role in the development of HF and ischaemic heart disease, with even modest increases in blood pressure contributing to the long term risk [9,22].”
Background
Heart Failure with Preserved Ejection Fraction: Hypertension, Diabetes, Obesity/Sleep Apnea, and Hypertrophic and Infiltrative Cardiomyopathy
Desai, A. S., & Fang, J. C.-T. (2008) · Heart Failure Clinics · doi:10.1016/j.hfc.2007.11.001 · Cited by 45
Potential Reduction of Interstitial Myocardial Fibrosis With Renal Denervation
Doltra, A., Messroghli, D., Stawowy, P., Hassel, J., Gebker, R., Leppänen, O., Gräfe, M., Schneeweis, C., Schnackenburg, B., Fleck, E., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001353 · Cited by 45
Impact of Baseline Systolic Blood Pressure on Long-Term Outcomes in Patients With Advanced Chronic Systolic Heart Failure (Insights from the BEST Trial)
Desai, R. V., Banach, M., Ahmed, M. I., Mujib, M. U., Aban, I., Love, T. E., White, M., Fonarow, G. C., DEEDWANIA, P. C., Aronow, W. S., et al. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.02.032 · Cited by 45
Epidemiology of Hypertension in the Elderly
Mosley, W. J., & Lloyd‐Jones, D. M. (2009) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.01.002 · Cited by 45
Effects of Fixed-Dose Isosorbide Dinitrate/Hydralazine on Diastolic Function and Exercise Capacity in Hypertension-Induced Diastolic Heart Failure
Wilson, R. M., Silva, D. S. D., Sato, K., Izumiya, Y., & Sam, F. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.134932 · Cited by 45
“following: (1) a reduction in SBP despite the presence of”
Background
The Emerging Importance of Genetics in Epidemiologic Research II. Issues in Study Design and Gene Mapping
Ellsworth, D. L., & Manolio, T. A. (1999) · Annals of Epidemiology · doi:10.1016/s1047-2797(98)00064-7 · Cited by 45
Irbesartan
Markham, A., Spencer, C. M., & Jarvis, B. (2000) · Drugs · doi:10.2165/00003495-200059050-00014 · Cited by 45
P‐Wave Indices, Distribution and Quality Control Assessment (from the Framingham Heart Study)
Magnani, J. W., Mazzini, M. J., SULLIVAN, L. M., Williamson, M. A., Ellinor, P. T., & Benjamin, E. J. (2010) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2009.00343.x · Cited by 44
Community screening for left ventricular hypertrophy in patients with hypertension using hand-held echocardiography
Senior, R., Galasko, G. I. W., Hickman, M., Jeetley, P., & Lahiri, A. (2004) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2003.09.013 · Cited by 44
P‐Wave Indices: Derivation of Reference Values from the Framingham Heart Study
Magnani, J. W., Johnson, V. M., SULLIVAN, L. M., Lubitz, S. A., Schnabel, R. B., Ellinor, P. T., & Benjamin, E. J. (2010) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2010.00390.x · Cited by 44
“0) Systolic blood pressure, mmHg 119 (11) 121 (11) 117 (11) Diastolic blood pressure, mmHg 74 (8) 75 (8) 74 (8) Total/high-density lipoprotein cholesterol ratio 4.”
A Disintegrin and Metalloprotease-17 Regulates Pressure Overload–Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1
Dong, F., Takawale, A. R., Shen, M., Samokhvalov, V., Basu, R., Patel, V. B., Wang, X., Fernández-Patrón, C., Seubert, J. M., Oudit, G. Y., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07566 · Cited by 44
“Hypertension is by far the most common antecedent condition in patients with heart failure and drives adverse myocardial remodeling and pathological hypertrophy.(2,35) In this study, we report a unique function for ADAM17 in regulating myocardial hypertrophy in response to mechanical stress by proteolytic cleavage of…”
Background
Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans
Koentges, C., Pepin, M. E., Muesse, C., Pfeil, K., Alvarez, S. V. V., Hoppe, N., Hoffmann, M. M., Odening, K. E., Sossalla, S. T., Zirlik, A., et al. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0666-6 · Cited by 44
“cardiac-related morbidity and mortality [18, 36].”
Background
2018 Korean society of hypertension guidelines for the management of hypertension: part III-hypertension in special situations
Kim, K., Ihm, S., Kim, G., Kim, H. C., Kim, J. H., Lee, H., Lee, J. H., Park, J. M., Park, S., Pyun, W. B., et al. (2019) · Clinical Hypertension · doi:10.1186/s40885-019-0123-y · Cited by 45
The Impact of Sex on Left Ventricular Cardiac Adaptations to Endurance Training: a Systematic Review and Meta-analysis
Díaz-Cañestro, C., & Montero, D. (2020) · Sports Medicine · doi:10.1007/s40279-020-01294-9 · Cited by 44
Race- and Sex-Specific Population Attributable Fractions of Incident Heart Failure
Sinha, A., Ning, H., Carnethon, M. R., Allen, N. B., Wilkins, J. T., Lloyd‐Jones, D. M., & Khan, S. S. (2021) · Circulation Heart Failure · doi:10.1161/circheartfailure.120.008113 · Cited by 43
Effects of exercise and cardiac rehabilitation on cardiovascular outcomes
Ades, P. A., Green, N. M., & Coello, C. E. (2003) · Cardiology Clinics · doi:10.1016/s0733-8651(03)00056-0 · Cited by 44
“Hypertension is a well-established risk factor for the development and progression of coronary artery disease, cerebrovascular disease, renovascular disease, and chronic heart failure [75].”
Background
Socioeconomic Factors as Predictors of Incident Heart Failure
Ingelsson, E., LIND, L., Ärnlöv, J., & Sundström, J. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.05.010 · Cited by 44
Heart Failure in Older Adults
Rich, M. W. (2006) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.05.012 · Cited by 44
CYP3A5 polymorphism, amlodipine and hypertension
Zhang, Y.-P., Zuo, X.-C., Huang, Z.-J., Cai, J.-J., Wen, J., Duan, D. D., & Yuan, H. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.67 · Cited by 45
Effect of post-discharge follow-up care on re-admissions among US veterans with congestive heart failure: a rural-urban comparison
Muus, K. J., Knudson, A. D., Klug, M. G., Gokun, J., Vaughan‐Sarrazin, M., & Kaboli, P. J. (2010) · Rural and Remote Health · doi:10.22605/rrh1447 · Cited by 44
Chronic Intake of a Phytochemical-Enriched Diet Reduces Cardiac Fibrosis and Diastolic Dysfunction Caused by Prolonged Salt-Sensitive Hypertension
Seymour, E., Singer, A. A. M., Bennink, M. R., Parikh, R. V., Kirakosyan, A., Kaufman, P. B., & Bolling, S. F. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.10.1034 · Cited by 43
“More than 90% of heart failure cases are preceded by prolonged hypertension (2).”
Background
Geographic Disparities in Heart Failure Hospitalization Rates Among Medicare Beneficiaries
Casper, M. L., Nwaise, I. A., Croft, J. B., Hong, Y., Fang, J., & Greer, S. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.021 · Cited by 43
Homocysteine and Heart Failure: An Overview
Vizzardi, E., Bonadei, I., Zanini, G., Frattini, S., Fiorina, C., Raddino, R., & Cas, L. (2009) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/157489009787259991 · Cited by 45
“Elevated homocysteine concentration is a risk factor for coronary atherosclerosis and myocardial infarction the latter being a key antecedent of CHF [59].”
Background
Chronic heart failure and exercise
Kokkinos, P. F., Choucair, W. K., Graves, P. R. T., Papademetriou, V., & Ellahham, S. (2000) · American Heart Journal · doi:10.1067/mhj.2000.106916 · Cited by 43
Morbidity and mortality in diabetic patients following cardiac transplantation
Lang, C. C., Beniaminovitz, A., Edwards, N. M., & MANCINI, D. M. (2003) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(02)00567-3 · Cited by 43
Valsartan: a novel angiotensin Type 1 receptor antagonist
Thürmann, P. (2000) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.1.2.337 · Cited by 43
“High blood pressure remains a serious health problem leading to heart disease, stroke, end stage renal failure and retinopathy [1,2].”
Background
Differential sex-dependent susceptibility to diastolic dysfunction and arrhythmia in cardiomyocytes from obese diabetic heart failure with preserved ejection fraction model
Hernández, J. M., Shen, E. Y., Ko, C. Y., Hourani, Z., Spencer, E. R., Smoliarchuk, D., Bossuyt, J., Granzier, H. L. M., Bers, D. M., & Hegyi, B. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae070 · Cited by 42
“7 Hypertension increases HF risk by three-fold in women compared with two-fold in men, 8 and diabetes mellitus increases HF risk by five-fold in women compared with 2.4-fold in men.”
Influential
Clinical Trials in Patients with Heart Failure and Preserved Left Ventricular Ejection Fraction
Cleland, J. G. F., Pellicori, P., & Dierckx, R. (2014) · Heart Failure Clinics · doi:10.1016/j.hfc.2014.04.011 · Cited by 44
Deregulation of RGS2 in cardiovascular diseases
Xiao, R.-P. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s84 · Cited by 42
“The Role of RGS2 and Cardiovascular Disease 3.1 Deregulation of RGS2 in the vascular system and hypertension Hypertension is a major risk factor for ischemic heart diseases and a strong predictor of hospitalization for congestive heart failure (CHF) (46).”
Influential
Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway
Shen, C., Wang, C., Fan, F., Yang, Z., Cao, Q., Liu, X., Sun, X., Zhao, X., Wang, P., Ma, X., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.07.014 · Cited by 41
Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats
Seymour, E., Bennink, M. R., & Bolling, S. F. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.01.008 · Cited by 42
“Over 90% of heart failure cases are preceded by prolonged hypertension[2].”
Background
Clinical Characteristics, Management, and Outcomes of Hospitalized Heart Failure in a Chinese Population—The Hong Kong Heart Failure Registry
Hai, J. J., Chan, P., Huang, D., Ho, M.-H., Ho, C. W., Cheung, E. H.-L., Lau, C., Tse, H., & Siu, C. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2016.03.007 · Cited by 40
Genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors
Conen, D., Schön, T., Aeschbacher, S., Paré, G., Frehner, W., Risch, M., & Risch, L. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2013.13728 · Cited by 41
Cardio-centric hemodynamic management improves spinal cord oxygenation and mitigates hemorrhage in acute spinal cord injury
Williams, A. M., Manouchehri, N., Erskine, E., Tauh, K., So, K., Shortt, K., Webster, M., Fisk, S., Billingsley, A., Munro, A. I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18905-8 · Cited by 44
Home-measured blood pressure is more strongly associated with electrocardiographic left ventricular hypertrophy than is clinic blood pressure: the Finn-HOME study
Niiranen, T., Jula, A., Kantola, I. M., Karanko, H., & Reunanen, A. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002192 · Cited by 41
Clinical Significance of Minor Nonspecific ST-Segment and T-Wave Abnormalities in Asymptomatic Subjects: A Systematic Review
Kumar, A., & Lloyd‐Jones, D. M. (2007) · Cardiology in Review · doi:10.1097/01.crd.0000249382.65955.14 · Cited by 42
“Age-related changes in autonomic function, with higher levels of circulating catecholamine levels in elderly subjects, may also contribute to the higher prevalence of minor NSSTTA in the elderly.38,43 The association between minor NSSTTA and CHF incidence in the elderly, an association observed only in subjects withou…”
BackgroundInfluential
Renal Artery Stenosis: Epidemiology, Clinical Manifestation, and Percutaneous Endovascular Therapy
Zeller, T. (2005) · Journal of Interventional Cardiology · doi:10.1111/j.1540-8183.2005.00092.x · Cited by 42
Hospitalized Congestive Heart Failure after Renal Transplantation in the United States
Abbott, K. C., Hypolite, I. O., Hshieh, P., Cruess, D. F., Taylor, A. J., & Agodoa, L. Y. C. (2002) · Annals of Epidemiology · doi:10.1016/s1047-2797(01)00272-1 · Cited by 42
Ionizing radiation and genetic risks
Sankaranarayanan, K., Chakraborty, R., & Boerwinkle, E. (1999) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(98)00017-9 · Cited by 42
RSSDI Guidelines for the management of hypertension in patients with diabetes mellitus
Kumar, V., Agarwal, S., Saboo, B., & Makkar, B. M. (2022) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-022-01143-7 · Cited by 47
“High blood pressure can also lead to high prevalence of atrial fibrillation [62], ventricular arrhythmias [63], and a sixfold greater risk of myocardial infarction [64], and subsequent heart failure with reduced ejection fraction (HFrEF).”
Background
Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions
van Ommen, A. M. L. N., Canto, E. D., Cramer, M. J., Rutten, F. H., Onland‐Moret, N. C., & den Ruijter, H. M. (2022) · BMC Medicine · doi:10.1186/s12916-022-02650-4 · Cited by 43
“Hypertension Women with hypertension have higher HF risk [23], HF risk increases at SBP ≥ 110 mmHg in women [24]”
Background

Authors: Levy, D.
Affiliations: Framingham Heart Study (US)
Corresponding author: Levy, Daniel
ORCID: Levy, Daniel
Venue: JAMA: The Journal of the American Medical Association
Publisher: American Medical Association (AMA)
Published: 1996-05-22
Volume: 275
Issue: 20
Pages: 1557
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1996.03530440037034
OpenAlex: W2023515446
Cited by: 2,155
References: 46
Citations by year: 2026: 32 · 2025: 62 · 2024: 62 · 2023: 85 · 2022: 82 · 2021: 73 · 2020: 71 · 2019: 86 · 2018: 70 · 2017: 75 · 2016: 68 · 2015: 98 · 2014: 86 · 2013: 102 · 2012: 108
FWCI: 27.57
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc038038-022)
National Heart, Lung, and Blood Institute (N01-HC-38038)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: hypertension, congestive heart failure, population attributable risk, heart failure risk factors, myocardial infarction, diabetes mellitus, left ventricular hypertrophy, valvular heart disease, blood pressure control, Framingham Heart Study, Framingham Offspring Study
MeSH terms: Adult, Aged, Diastole, Female, Heart Failure, Humans, Hypertension, Longitudinal Studies, Male, Middle Aged, Risk Factors, Systole, Cohort Studies, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Hypertrophy, Left Ventricular, Disease Progression, Ventricular Dysfunction, Left

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Progression From Hypertension to Congestive Heart Failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks