Cited by 517Sleep and Work-Related FatigueWorkplace Health and Well-beingCircadian rhythm and melatonin

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Association Between Rotating Night Shift Work and Risk of Coronary Heart Disease Among Women

Open access

Vetter, Céline, Devore, Elizabeth E., Wegrzyn, Lani R., Massa, Jennifer, Speizer, Frank E., Kawachi, Ichiro, Rosner, Bernard, Stampfer, Meir J., Schernhammer, Eva S.·2016·JAMA

DOI 10.1001/jama.2016.4454PMC PMC5102147

Open this paper in CoChat — free account Open PDF

Abstract

Importance Prospective studies linking shift work to coronary heart disease (CHD) have been inconsistent and limited by short follow-up. Objective To determine whether rotating night shift work is associated with CHD risk. Design, Setting, and Participants Prospective cohort study of 189 158 initially healthy women followed up over 24 years in the Nurses’ Health Studies (NHS [1988-2012]: N = 73 623 and NHS2 [1989-2013]: N = 115 535). Exposures Lifetime history of rotating night shift work (≥3 night shifts per month in addition to day and evening shifts) at baseline (updated every 2 to 4 years in the NHS2). Main Outcomes and Measures Incident CHD; ie, nonfatal myocardial infarction, CHD death, angiogram-confirmed angina pectoris, coronary artery bypass graft surgery, stents, and angioplasty. Results During follow-up, 7303 incident CHD cases occurred in the NHS (mean age at baseline, 54.5 years) and 3519 cases in the NHS2 (mean age, 34.8 years). In multivariable-adjusted Cox proportional hazards models, increasing years of baseline rotating night shift work were associated with a significantly higher CHD risk in both cohorts. In the NHS, the age-standardized incidence rate (IR) for less than 5 years of rotating night shift work per 100 000 person-years was 435.1 (hazard ratio [HR], 1.02; 95% CI, 0.97-1.08); the IR for 5 to 9 years of rotating night shift work was 525.7 (HR, 1.12; 95% CI, 1.02-1.22); and the IR for 10 years or more of rotating night shift work was 596.9 (HR, 1.18; 95% CI, 1.10-1.26;P<.001 for trend) vs an IR of 425.5 in women who never worked rotating night shifts. In the NHS2, the IR for less than 5 years was 130.6 (HR, 1.05; 95% CI, 0.97-1.13); the IR for 5 to 9 years was 151.6 (HR,1.12; 95% CI, 0.99-1.26); and the IR for 10 years or more was 178.0 (HR, 1.15; 95% CI, 1.01-1.32;P = .01 for trend) vs an IR of 122.6 in women who never worked rotating night shifts. In the NHS, the association between duration of rotating night shift work and CHD was stronger in the first half of follow-up (IR for <5 years, 382.4; HR, 1.10 [95% CI, 1.01-1.21]; IR for 5-9 years, 483.1; HR, 1.19 [95% CI, 1.03-1.39]; and IR for ≥10 years, 494.4; HR, 1.27 [95% CI, 1.13-1.42];P<.001 for trend) than in the second half (IR for <5 years, 424.8; HR, 0.98 [95% CI, 0.92-1.05]; IR for 5-9 years, 520.7; HR, 1.08 [95% CI, 0.96-1.21]; IR for ≥10 years, 556.2; HR, 1.13 [95% CI, 1.04-1.24];P = .004 for trend;P = .02 for interaction), suggestive of waning risk after cessation of shift work. Longer time since quitting shift work was associated with decreased CHD risk among ever shift workers in the NHS2 (P<.001 for trend). Conclusions and Relevance Among women who worked as registered nurses, longer duration of rotating night shift work was associated with a statistically significant but small absolute increase in CHD risk. Further research is needed to explore whether the association is related to specific work hours and individual characteristics.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jama.2016.4454

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Association between Water Intake, Chronic Kidney Disease, and Cardiovascular Disease: A Cross-Sectional Analysis of NHANES Data
Sontrop, J. M., Dixon, S. N., Garg, A. X., Jiménez, I. B., Dohein, O., Huang, S. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,903
Reproducibility and validity of a semiquantitative food frequency questionnaire
WILLETT, W. C., SAMPSON, L., STAMPFER, M. J., ROSNER, B., BAIN, C., WITSCHI, J., HENNEKENS, C. H., & SPEIZER, F. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114086 · Cited by 4,274 · cited 3×
“Pack-years of smoking, median (IQR)c 18 (7-34) 18 (6-34) 20 (7-35) 24 (10-39) 10 (5-16) 9 (5-16) 10 (5-17) 11 (6-19)”
Self-citation
Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,090
Alternative Dietary Indices Both Strongly Predict Risk of Chronic Disease
Chiuve, S. E., Fung, T. T., Rimm, E. B., Hu, F. B., McCullough, M. L., Wang, M., Stampfer, M. J., & Willett, W. C. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.157222 · Cited by 1,951 · cited 3×
“Pack-years of smoking, median (IQR)c 18 (7-34) 18 (6-34) 20 (7-35) 24 (10-39) 10 (5-16) 9 (5-16) 10 (5-17) 11 (6-19)”
Self-citation
A Prospective Study of Obesity and Risk of Coronary Heart Disease in Women
Manson, J. E., Colditz, G. A., Stampfer, M. J., Willett, W. C., ROSNER, B. A., Monson, R. R., Speizer, F. E., & Hennekens, C. H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003293221303 · Cited by 1,403 · cited 4×
“≤6 6978 (23) 7506 (25) 1427 (29) 2901 (34) 8939 (20) 12 230 (22) 2542 (26) 1670 (28)”
InfluentialSelf-citation
Health disorders of shift workers
Knutsson, A. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg048 · Cited by 1,218 · cited 2×
“4); the interaction between shift work and BMI was not significant, (χ2(5) =10.”
BackgroundMethod
Reproducibility and validity of a self-administered physical activity questionnaire
WOLF, A. M., HUNTER, D. J., COLDITZ, G. A., MANSON, J. E., STAMPFER, M. J., CORSANO, K. A., ROSNER, B., KRISKA, A., & WILLETT, W. C. (1994) · International Journal of Epidemiology · doi:10.1093/ije/23.5.991 · Cited by 1,038 · cited 1×
“34,35 The exposure assessments lacked information on intensity of night shift work and physiological measures that may be affected by shift work.”
BackgroundSelf-citation
Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study of women
COLDITZ, G. A., MARTIN, P., STAMPFER, M. J., WILLETT, W. C., SAMPSON, L., ROSNER, B., HENNEKENS, C. H., & SPEIZER, F. E. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114319 · Cited by 992 · cited 1×
“34,35 The exposure assessments lacked information on intensity of night shift work and physiological measures that may be affected by shift work.”
BackgroundSelf-citation
Stress and Cardiovascular Disease: An Update on Current Knowledge
Steptoe, A., & Kivimäki, M. (2013) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031912-114452 · Cited by 879 · cited 6×
“Pack-years of smoking, median (IQR)c 18 (7-34) 18 (6-34) 20 (7-35) 24 (10-39) 10 (5-16) 9 (5-16) 10 (5-17) 11 (6-19)”
Influential

Flagged first, then by citations

Show all 39 references

Sorted by citations

Items 301–400 of 516

Fetal programming of adipose tissue function by gestational chronodisruption
Halabí, D., Ehrenfeld, P., Méndez, N., Hans, G. H. R., & Torres‐Farfan, C. (2020) · Sleep Science · doi:10.5935/1984-0063.20200014 · Cited by 8
Risk Perception & Risk-Reduction Behavior Model for Blue-Collar Workers: Adapted From the Health Promotion Model
Hwang, W. J., & Kim, M. J. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.538198 · Cited by 6
Myeloid inflammation thresholds stratify mortality risk in early-stage cardiovascular-kidney-metabolic syndrome: MLR-driven findings from NHANES
Qu, Y., Wang, L., Liu, L., & Sun, Y. (2025) · Immunologic Research · doi:10.1007/s12026-025-09707-5 · Cited by 4
“Missing covariate data were addressed through missing-indicator methods (dummy variables)[12].”
Association between night shift work and risk of osteoporosis and osteoporosis-related pathological fracture
Yang, D., Xiang, C., Wang, T., Guo, X., Ouyang, Z., & Wang, L. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1719807 · Cited by 4
Insomnia and Cardiovascular Disease: Untangling a Complex Relationship
Pengo, M. F., Javaheri, S., Maiolino, G., Redline, S. S., & Lombardi, C. (2026) · Journal of Sleep Research · doi:10.1111/jsr.70299 · Cited by 4
“Indeed, a rather large body of evidence suggests that night shift workers exhibit greater risk of developing ischemic heart disease and that such association can depend also on the duration of rotating night shift work (Vetter et al. 2016).”
Development of the Quality of Life Scale for Shift-working Nurses
Berşe, S., Çapuk, H., & Ağar, A. (2024) · Safety and Health at Work · doi:10.1016/j.shaw.2024.11.004 · Cited by 4
Endothelial Dysfunction and Hemostatic System Activation in Relation to Shift Workers, Social Jetlag, and Chronotype in Female Nurses
Saharov, G., Salti, B., Bareya, M., Keren‐Politansky, A., Fodi, M., Shochat, T., & Nadir, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020482 · Cited by 4
“Several studies have reported that the risks of developing ischemic stroke or coronary events are higher in shift workers as compared to day workers [1–3].”
Associations of Cardiac Ventricular Repolarization with Serum Adhesion Molecules and Cognitive Function in Older Adults: The MIND-China Study
Wang, C., Mao, M., Han, X., Hou, T., Wang, X., Han, Q., Dong, Y., Liu, R., Cong, L., Liu, C., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220874 · Cited by 4
“We created a dummy variable to indicate a group of individuals with missing values for each of covariates [26].”
Health Effects of Shift Work and Night Shift Work
Guénel, P., & Léger, D. (2023) · Handbook series in occupational health sciences · doi:10.1007/978-3-031-30492-7_19 · Cited by 4
Occupational Risk for Coronary Artery Disease in Shift Workers – A Systematic Review
d’Ettorre, G., Piscitelli, P., Pellicani, V., Tornese, R., Ceccarelli, G., d’Ettorre, G., & Torre, G. L. (2024) · La Medicina del Lavoro · doi:10.23749/mdl.v115i2.15532 · Cited by 4
“These findings are in line with the US Nurses’ Health Study in which the risk of CAD increased with longer duration of rotating shift-work [45]; particularly, after correction for confounders, the authors observed elevated risk for 5 years or more of shift work (multivariable HR for 5-9 years, 1.12…”
Influential
Assessment of Diet Quality Based on Selected Dietary Quality Indices and Consumption of Specific Food Items of Midwives Working on a Shift Schedule in Wroclaw, Poland
Gołąbek, K. D., Chmielewska, A., Karoluk, E., Kujawa, K., & Regulska−Ilow, B. (2024) · Nutrients · doi:10.3390/nu16152409 · Cited by 4
“Therefore, this type of work, especially over an extended period of time, may increase the risk of cardiovascular issues [2,3], colorectal cancer [4], or type 2 diabetes (T2D) [5].”
Background
Nurse night shift work and risk of gastrointestinal cancers
Guo, L., & Li, X. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1532623 · Cited by 5
“Moreover, working night shifts also raised the risk of coronary heart disease (CHD), but did not elevate the risk for stroke or heart failure (HF) (50).”
Emergency healthcare providers perception of workplace dangers in the polish Emergency Medical Service: a multi-centre survey study
Kłosiewicz, T., Zalewski, R., Dąbrowski, M., Kłosiewicz, K., Rut, A., Sip, M., Dabrowska, A. H., Mandecki, M., Stec, R., Nowicki, M. M., et al. (2019) · Disaster and Emergency Medicine Journal · doi:10.5603/demj.a2019.0030 · Cited by 4
“Among registered nurses, longer duration of rotating night shift work was associated with a significant but small absolute increase in CHD (chronic heart disease) risk [22].”
Background
Disturbances of Autonomic Regulation of Cardiovascular System at Different Working Regimes with Night Shifts
Merkulov, Y. A., Pyatkov, A. A., Gorokhova, S. G., Merkulova, D. M., & Atkov, O. Y. (2020) · Kardiologiia · doi:10.18087/cardio.2020.9.n1134 · Cited by 4
Electrocortical temporal complexity during wakefulness and sleep: an updated account
González, J., Cavelli, M., Mondino, A., Pascovich, C., Castro‐Zaballa, S., Rubido, N., & Torterolo, P. (2020) · Sleep Science · doi:10.5935/1984-0063.20200013 · Cited by 6
Sex and gender differences in sleep disorders: An overview
Shaib, F. H., & Attarian, H. P. (2023) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-323-88534-8.00036-5 · Cited by 6
Sudden cardiac death among workers: a systematic review and meta-analysis
Amantea, C., Pilia, E., Rossi, M. F., Corona, V. F., Amato, G., Ciccu, C., Gavi, F., Santoro, P. E., Borrelli, I., Ricciardi, W., et al. (2024) · Systematic Reviews · doi:10.1186/s13643-024-02504-5 · Cited by 4
“Long working hours, shift work [30], job strain [31], and work-related stress [32] have all been linked to an increased risk of cardio-vascular disease, including SCD. Long working hours and shift work, in particular, have been associated with disruptions in sleep patterns, increased levels of…”
Background
A Cross Talking between the Gut Microbiota and Metabolites of Participants in a Confined Environment
Song, X., Wang, Z., Xia, Y., Chen, Z., Wang, G., Yang, Y., Zhu, B., Ai, L., Xu, H., & Wang, C. (2024) · Nutrients · doi:10.3390/nu16111761 · Cited by 5
“Furthermore, disorders of gene expression involved in liver rhythm regulation, such as those of Bmal1 and Clock , were observed in high-energy diet models and are related to Bacteroides [35].”
Background
Sleep and maternal behavior in the postpartum rat after haloperidol and midazolam treatments
Peña, F., Rivas, M., González, J., Schwarzkopf, N., Torterolo, P., Ferreira, A., & Benedetto, L. (2020) · Sleep Science · doi:10.5935/1984-0063.20200019 · Cited by 4
Social modulation on daily variability in electric behavior
Gascue, V., da Silva, A. C. R., & Migliaro, A. (2020) · Sleep Science · doi:10.5935/1984-0063.20200012 · Cited by 6
Optimizing Wellness in Academic Emergency Medicine
Nordenholz, K. E., Alvarez, A., Lall, M. D., Stehman, C. R., Bitter, C. C., Hirsh, E., Manfredi, R. A., Sikora, R., Lu, D. W., Sánchez, L. D., et al. (2020) · Journal of Wellness · doi:10.18297/jwellness/vol2/iss2/8 · Cited by 4
“Shift work is associated with multiple chronic medical comorbidities and is potentially carcinogenic [98, 99].”
Background
Night work and risk of ischaemic heart disease and anti-hypertensive drug use: a cohort study of 145 861 Danish employees
Larsen, A. D., Rugulies, R., Hansen, J., Kolstad, H. A., Hansen, Å. M., Hannerz, H., & Garde, A. H. (2019) · European Journal of Public Health · doi:10.1093/eurpub/ckz189 · Cited by 4
Differences in impact of current and former shift work on cardiovascular risk factors, carotid atherosclerosis, and white matter integrity
Rimmele, D. L., Petersen, E. L., Affolderbach, S., Petersen, M., Cheng, B., Mayer, C., Nägele, F. L., Harth, V., Terschüren, C., Kühn, S., et al. (2024) · SLEEP Advances · doi:10.1093/sleepadvances/zpae056 · Cited by 3
The Effects of Night Shift Work on Women’s Health During the Climacteric: A Narrative Review
Saraiva, S. P., Marqueze, E. C., & Moreno, C. R. D. C. (2025) · Hygiene · doi:10.3390/hygiene5030026 · Cited by 3
“Occupational exposure to rotating or fixed night shifts increases the risk of coronary heart disease [14], affects reproductive health [15,16], contributes to metabolic disorders [17,18], and is linked to the development of tumors such as those associated with breast cancer [19,20].”
Nonlinear Association Between Calculated Globulin Levels and 28-Day Mortality in Patients with Sepsis: A Retrospective Cohort Study
She, X., Zhao, X., Yang, H., & Cui, X. (2025) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s532501 · Cited by 3
The effects of circadian rhythm on reproductive functions
Karabulut, S., & Oria, L. (2025) · Zygote · doi:10.1017/s0967199425100130 · Cited by 3
Associations between inflammatory indices derived from complete blood counts and mortality risk in diabetes and prediabetes patients: A cohort study from NHANES 1999--2018
She, X., Yang, J., Ren, B., Yang, X., Cheng, X., Tian, T., Shanshan, L. I. U., Zhao, X., Zhao, H., & Cui, X. (2026) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2026.113112 · Cited by 3
Impaired Responses to In Vitro Lipopolysaccharide-Induced Stimulation After Long-Term, Rotating Shift Work
Jackson, D. M., & Castañón‐Cervantes, O. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22050791 · Cited by 3
“…even for those workers in permanent night shifts who rotate back to diurnal sleep habits on days o ﬀ , but particularly for rotational shift workers, has been associated with chronic/partial sleep deprivation, increased stress, anxiety, and irregular menstrual cycles, among other conditions [5–10].”
Multi‐Wearable Approach for Monitoring Diurnal Light Exposure and Body Rhythms in Nightshift Workers
Hartmeyer, S. L., Phillips, N. E., Jassil, F. C., Joris, C., Dibner, C., Collet, T., & Andersen, M. (2025) · Acta Physiologica · doi:10.1111/apha.70069 · Cited by 3
Leveraging Microbiome Science From the Bedside to Bench and Back
Maki, K. A., Joseph, P. V., Ames, N. J., & Wallen, G. R. (2020) · Nursing Research · doi:10.1097/nnr.0000000000000475 · Cited by 3
Trabalho noturno e pressão arterial: um estudo com foco nas doses de exposição
Silva‐Costa, A., Braz, B. P., Griep, R. H., & Rotenberg, L. (2021) · Revista Brasileira de Saúde Ocupacional · doi:10.1590/2317-6369000023319 · Cited by 3
Evolution of work ability, quality of life and self-rated health in a police department after remodelling shift schedule
Garrido, M. V., Herold, R., Rohwer, E., Mache, S., Terschürenm, C., Preisser, A. M., & Harth, V. (2022) · BMC Public Health · doi:10.1186/s12889-022-14098-5 · Cited by 3
Association of shift work with hypercholesterolemia among nurses: A cross‐sectional and descriptive-analytical study
Solymanzadeh, F., Rokhafroz, D., Asadizaker, M., & Dastoorpoor, M. (2023) · Journal of Human Behavior in the Social Environment · doi:10.1080/10911359.2023.2208628 · Cited by 3
“Shift employees are exposed to risk factors for CVD, hypertension, obesity, hypercholesterolemia, and metabolic syndrome (Vetter et al., 2016).”
Background
Tackling Shift Work: Cardiovascular Health in the Auto Industry
Bunescu, M. G., Gheorman, V., Marcu, I. R., Lungulescu, C. V., & Dinescu, V. C. (2024) · Healthcare · doi:10.3390/healthcare12111097 · Cited by 3
“The increased CVD risk among night shift workers, particularly males, suggests that circadian rhythm disruptions contribute significantly to cardiovascular strain [22].”
Background
Predictive Factors and Risk Assessment for Hospitalization in Chest Pain Patients Admitted to the Emergency Department
Kagansky, N., Mazor, D., Wajdi, A., Yaron, Y. M., Sharfman, M., Ziv‐Baran, T., Kagansky, D., Pachys, G., Levy, Y., & Trotzky, D. (2024) · Diagnostics · doi:10.3390/diagnostics14232733 · Cited by 3
“This expedited care points to good triage in the ER focusing on high-risk patients [39].”
Cardiovascular Risk Factors in White Collar Workers Under Shift Work
Vangelova, K. K. (2017) · Acta Medica Bulgarica · doi:10.1515/amb-2017-0011 · Cited by 3
“Among women who worked as registered nurses, longer duration of rotating night shift work was associated with a statistically signifi cant but small absolute increase in Coronary Heart Disease (CHD) risk [10].”
Background
Margaret McCartney: Direct patient care should be rewarded and cherished
McCartney, M. (2018) · BMJ · doi:10.1136/bmj.k948 · Cited by 3
Hearts and Politics
Aiello, L. M., Quercia, D., & Roitmann, E. (2018) · International Conference on Digital Health · doi:10.1145/3194658.3194678 · Cited by 3
“Sleep deprivation also increases the chances of ailments such as hypertension [23], cancer [5], diabetes, and obesity [16], and, as such, increases mortality rates [7].”
Background
Heart Rate Variability in Obstetricians Working 14-Hour Call Compared to 24-Hour Call in Labour and Delivery
Thurman, R. H., Yoon, E. W., Murphy, K. E., Windrim, R. C., & Farrugia, M. M. (2017) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2017.05.009 · Cited by 3
Circadian Misalignment and Cardiovascular Risk
Ashby, T., & Louis, M. (2019) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2017.0070 · Cited by 3
Social jetlag: possibilities of micronutrient support
Shikh, E. V., Махова, А. А., Shikh, N. V., & NIKITIN, E. Y. (2022) · Voprosy Pitaniya · doi:10.33029/0042-8833-2022-91-3-85-95 · Cited by 6
The importance of sleep for governmental sectors, general population and industry – Asia–Pacific Economic Cooperation (APEC) Sleep Technology Agenda
Chiang, R. P., Lin, C., Li, Y., & Hsu, M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.10.002 · Cited by 3
The costs of care: An ethnography of care work in two residential homes for older people
Johnson, E. K. (2018) · ORCA Online Research @Cardiff (Cardiff University) · Cited by 3
Cardiometabolic consequences of circadian disruption
Zhu, B., Hanlon, E. C., Knutson, K. L., & Reutrakul, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00169-9 · Cited by 3
Chrononutritional Patterns: Examining the Interaction Between Shift Work, Eating Habits and Mealtimes in Shift Workers
Gonçalves, J. V. D. S., Gonzalez, T. N., Brito, A. S. D. A., Gadelha, G. O., dos Santos, E. D. S. G., Bezerra, P. C. D. L., Nehme, P., Moreno, C. R. D. C., & Vasconcelos, S. P. (2025) · American Journal of Health Promotion · doi:10.1177/08901171251336887 · Cited by 2
Associations Between Shift Work, Sociodemographic and Lifestyle Characteristics, Body Measurements, and MASLD
Tosoratto, J., López, P. J. T., López‐González, Á. A., Busquets-Cortés, C., de Hevia, J. O., & Ramírez‐Manent, J. I. (2025) · Life · doi:10.3390/life15060961 · Cited by 2
“These findings underscore the hypothesis that non-standard work schedules may contribute to adverse metabolic profiles, ultimately increasing the risk of MASLD [30,31].”
The positive association between evening or night work schedules and coronary heart disease or angina among U.S. adults: A cross-sectional study
Ding, J., Jia, Y., Ji, R., Zhang, H., Wang, Z., Song, X., Gao, J., & He, Q. (2025) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2025.101270 · Cited by 2
“Prior prospective cohort studies conducted by C ´ eline et al [10] and Kivim ¨ aki et al [11], each independently identified elevated CHD and angina risk among female nurses engaged in prolonged night shifts.”
Diurnal variation in neurovascular coupling and the impact of sleep quality: a UK Biobank study
Yang, S., & Webb, A. J. S. (2025) · SLEEP · doi:10.1093/sleep/zsaf256 · Cited by 2
Challenges of after-hours pediatric imaging
Aquino, M., Shah, J., & Kaplan, S. L. (2025) · Pediatric Radiology · doi:10.1007/s00247-025-06473-2 · Cited by 2
“For instance, a prospective study of over 180,000 nurses followed up over 24 years showed an increased risk of coronary heart disease with increasing years of night-shift-work (CI 1.04–1.24.04.24, P =0.004) [54].”
Influential
Circadian Disruption from Urban Night-Time Noise and Endocrine Health Risks in Shift Workers
Badea, D. O. (2025) · Noise and Health · doi:10.4103/nah.nah_183_25 · Cited by 2
“[37,41] Extending Circadian Models with Occupational Exposures Circadian regulation was firstly described as a response to light and darkness, and newer studies indicated that changes in sleep timing and core physiological rhythms can influence circadian phase.”
Chrononutrition interventions for mental health: addressing atypical depression, ultra-processed food use disorder, and circadian dysregulation
Cuaranta, I. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1603595 · Cited by 4
Metabolic risk stratification of night shift workers in a large retail workplace through clustering and SHAP interpretation
Lee, I., Hong, S., Jang, E., Lee, J., & Lee, J. S. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1704046 · Cited by 2
Circadian Rhythm Disorders: Focusing on Environmental Risk Factors, Interrelationship with Diseases, and Developing Chronotherapy
Li, S., Li, X., Nan, N., Zhang, Y., Yan, Z., Xu, M., Zhang, Y., Chen, R., & Qin, G. (2026) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/s44169-025-00108-1 · Cited by 1
“A prospective cohort study followed up 189,158 healthy women in the Nurses’ Health Studies for 24 years to assess their risk of developing CHD (Vetter et al. 2016).”
Influential
The mediating role of psychological resilience in the relationship between health anxiety and burnout among healthcare workers working in closed environments
ÇAĞATAY, A., & ÇAKMAK, İ. (2026) · BMC Health Services Research · doi:10.1186/s12913-026-14240-8 · Cited by 2
“Moreover, disruption of circadian rhythms due to limited daylight exposure has been linked to impaired sleep quality, affective dysregulation, and heightened vulnerability to stress-related outcomes in healthcare workers, which are well-established predictors of burnout [12].”
Low‐Dose Melatonin, Climacteric Symptoms and Sleep in Female Shift Workers: A Randomized Controlled Trial
Saraiva, S. P., D’Aurea, C. V. R., Luz, C. S. D. S., do Amaral, F. G., Cipolla‐Neto, J., Marqueze, E. C., & Moreno, C. R. D. C. (2026) · Journal of Pineal Research · doi:10.1111/jpi.70140 · Cited by 2
“Women working night shifts are at higher risk of developing chronic conditions, such as cardio-vascular diseases [27, 28], type 2 diabetes [29] and of adverse impact on outcomes of pregnancy, such as stillbirths, pre‐term delivery and small‐for‐gestational age babies [30].”
Navigating Nutrition in a 24/7 World: A Scoping Review of Dietary Intake and Chrononutrition Assessment in Shift Working Populations
Chatterjee, R., & Sahu, S. (2026) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.70272 · Cited by 2
Association of Choroidal Thickness with Sleep Deprivation in Night-shift Healthcare Workers
Shirzadi, K., & Torkashvand, A. (2021) · Annals of Military and Health Sciences Research · doi:10.5812/amh.113229 · Cited by 2
“This percentage is increasing due to societal and economic demands for 24hour availability in various settings (16).”
Background
Associations of WWC1 variants with Alzheimer's disease and vascular dementia among rural older adults in China: A population-based study
Wang, C., Han, X., Dong, Y., Liu, C., Wang, X., Hou, T., Tan, Q., Wang, Y., Du, Y., & Qiu, C. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.01.003 · Cited by 2
Genetic variants affect diurnal glucose levels throughout the day
Sinnott-Armstrong, N., Strausz, S. J., Urpa, L., Abner, E., Johnson, J. P., Valliere, J., Palumaa, T., FinnGen, Program, V. M. V., Palta, P., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72432-6 · Cited by 3
“In addition, previous research conducted by our team and others has demonstrated that the disruption of circadian rhythms, such as through night shift work, escalates the risk of cardiovascular diseases and T2DM 28,29 .”
Association Between Pericoronary Fat Attenuation Index as Evaluated by Coronary Artery CT Angiography and Clinical Interventions in Lipid Management Among Patients with Coronary Artery Disease
Feng, Y.-S., Sun, Z.-Y., Jiang, F., Ma, P., Liu, X.-R., Meng, Y., Liao, C., & Sun, G. (2024) · International Journal of General Medicine · doi:10.2147/ijgm.s468768 · Cited by 2
“19 Myocardial ischemia due to coronary artery stenosis is a major concern, and the Gensini score is used to assess the severity of CAD.”
Method
The Association Between Shift Work, Sleep Quality, and Health-Related Quality of Life Among Workers in the Logistics Industry
Xu, Q., Li, Y., Xu, Q., Wu, Y., Ling, C., Jordan, K. P., & Chen, Y. (2024) · Journal of Community Health · doi:10.1007/s10900-024-01426-6 · Cited by 2
Nurses’ Lifestyle Behaviors, Work‐Related Stress, and Cardiovascular Disease Risk
Al‐Dwaikat, T. N., Quran, H. K., Aldalaykeh, M., Abusalem, S., ALBashtawy, M., & Khatatbeh, H. (2025) · Nursing Forum · doi:10.1155/nuf/6387493 · Cited by 2
“Vetter et al. [21] found that nurses who work frequently on rotating shifts have an elevated risk of developing CVD.”
The roles of lifestyle factors and genetic risk in the association between night shift work and cholelithiasis: a prospective cohort study
He, W., Mi, N., Jin, K., Jin, B., Zhong, R., Liu, Z., Lin, Y., Yue, P., Xia, B., He, Q., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1573203 · Cited by 2
Timing matters: worker absenteeism in a weekly backward rotating shift model
Frick, B., Simmons, R., & Stein, F. (2020) · The European Journal of Health Economics · doi:10.1007/s10198-020-01232-6 · Cited by 2
Improved Sleep Quality and Work Performance Among Shift Workers Consuming a “Foods with Function Claims” Containing Asparagus Extract
Sakai, S., Nagata, M., Nagata, T., & Mori, K. (2021) · Journal of UOEH · doi:10.7888/juoeh.43.15 · Cited by 3
Risk of cardiovascular diseases and gastrointestinal tract disorders in relation to the impact of shift work among male workers of textile mills in Pali district of Rajasthan, India
Ranawat, R., & Srivastava, R. (2017) · Journal of Applied and Natural Science · doi:10.31018/jans.v9i3.1362 · Cited by 2
“According to Vetter et al. (2016), compared with women without a history of rotating night shift work, women who worked less than 5 years of shift work at baseline did not have a significantly increased CHD risk in age-adjusted analyses, but there was a significant association between longer…”
Background
Correlation Between Serum and Tear Fluid Interleukin 6 Levels in Day and Night Shift Health Care Workers
Hemalathaa, R., Rajendran, S., Divya, N., Keerthika, E., Tamil Selvi, B., Ananthi, N., & Brethis, C. S. (2024) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2938 · Cited by 2
“…that night shift health care workers are at risk of various systemic diseases, including metabolic syndrome and cardiovascular disease (CVD) 18,19 due to the prolonged disturbance in the circadian rhythm such as a sleep-wake cycle which leads to a higher incidence of morbidity 6,20-22 like…”
Background
Perceptions of the impact of non-standard work schedules on health in Australian graduates: an exploratory study
Crowther, M. E., Reynolds, A. C., Ferguson, S. A., & Adams, R. (2019) · Industrial Health · doi:10.2486/indhealth.2019-0036 · Cited by 2
The effect of health staff working the night shift on nutrition, anthropometric measurements, and the risk of cardiovascular disease: A sample from Samsun Province in Turkey
Uzdil, Z., Kaya, S., Kayacan, A. G., Özyıldırım, C., Kaya, P., & Ulus, C. A. (2020) · Progress in Health Sciences · doi:10.5604/01.3001.0014.6579 · Cited by 2
“In contrast, in a prospective cohort study, similar to our findings, it was reported that nurses working more than five years in shifts were at risk of cardiovascular diseases [22].”
Result
Association of shift work with cardiovascular disease risk among Chinese workers
Feng, X., Qiu, W., Cheng, M., Liang, R., Xu, T., Zhou, M., He, M., Zhang, X., Yuan, J., Wang, D., et al. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1917593 · Cited by 2
“Similar to our results, the Nurses’ Health Studies detected a significant association between shift work and the risk of coronary heart disease (CHD) among 189,158 nurses (Vetter et al. 2016).”
BackgroundResult
Shift Work and Cardiovascular Disease
GÜNDÜZ, S. Ş., & Vardar, S. A. (2021) · Sakarya Medical Journal · doi:10.31832/smj.939866 · Cited by 2
Night shift workers refer higher urinary symptoms with an impairment quality of life: a single cohort study
NUNZIO, C. D., NACCHIA, A., CICIONE, A., Angela, S. I. C. A., BALDASSARRI, V., VOGLINO, O., MANCINI, E., GUARNOTTA, G., TRUCCHI, A., & TUBARO, A. (2022) · Minerva Urology and Nephrology · doi:10.23736/s2724-6051.20.03735-2 · Cited by 2
Tales from the Night:
George, M. P., Kim, W. G., & Lee, E. Y. (2019) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2019.01.013 · Cited by 1
Use of Coronary Computed Tomography Angiography to Screen Hospital Employees with Cardiovascular Risk Factors
Li, P.-Y., Chen, R.-Y., Wu, F., Mar, G.-Y., Wu, M., & Wang, F.-W. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18105462 · Cited by 1
Health Problems of Women Working in Night Shift in India: A Review
Neha, N., & Uthkarsh, D. P. S. (2022) · International Journal of Medical Science and Clinical Research Studies · doi:10.47191/ijmscrs/v2-i3-02 · Cited by 1
Self-Similarity Analysis of Heartbeat Fluctuations in Sleep Among Female Shift Workers
Delgado-Aranda, R., Dorantes-Méndez, G., Bianchi, A. M., Kortelainen, J. M., & Méndez, M. O. (2024) · Fluctuation and Noise Letters · doi:10.1142/s0219477525500221 · Cited by 1
Association between serum homocysteine concentration level and tooth loss: a cross-sectional study from NHANES 2003–2006
Luo, S., Liu, Z., Gu, X., Li, X., Jiao, R., Sun, J., Ma, S., Zhu, H., Chen, Z., & Song, J. (2025) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-025-01588-w · Cited by 1
“Covariates were processed using dummy variable interpolation for the treatment, and the missing values were excluded from the final analysis[20] (the distribution of missing values refer to Supplementary Fig.”
Cardiovascular Disease in Tactical Athletes: A Focused Review on First Responders
Phillips, T. C., Husaini, M., Tayon, K. G., Kales, S. N., Smith, D. L., Elfessi, N. M., Petek, B. J., & Dineen, E. H. (2025) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-025-01078-2 · Cited by 1
“Shift workers, particularly night and rotating shifts, are at an increased risk of non-fatal cardiovascular events which increases with prolonged duration [47, 48].”
Circadian Disruptions and Their Impact on Inflammatory Pathways, Neuroendocrine Dysregulation, and Cardiovascular Risk: A Systematic Review and Meta-Analysis
Abdul-Rashid, H. A., Mushtaq, A., Raghib, S., Shaik, S. T., Maloth, A. K., Khan, A. A., Saad, S., Saad, M., Alaleeli, S. B. B., Gafoor, S. A., et al. (2025) · Indus journal of bioscience research. · doi:10.70749/ijbr.v3i2.754 · Cited by 2
An innovative approach based on health surveillance for the prevention and early detection of cardiovascular diseases in a large cohort of healthcare workers
Vimercati, L., Sponselli, S., Delvecchio, G., Giannelli, G., Caputi, A., Sole, S., Bianchi, F. P., Traversa, D., Zagaria, S., Bombini, G., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-93527-y · Cited by 2
Retrospective assessment of shift-work in epidemiological studies – Lessons learned
Rabstein, S., Pesch, B., Eisele, L., Marr, A., Moebus, S., Erbel, R., Schmidt, B., Dragano, N., Brüning, T., Behrens, T., et al. (2025) · Journal of Occupational and Environmental Hygiene · doi:10.1080/15459624.2025.2485089 · Cited by 1
“Shift-work, which refers to any work schedule that falls outside typical daytime work, has been associated with many diseases such as cancer, cardiovascular disease, and diabetes (Knutsson and Kempe 2014; Vetter et al. 2016; IARC Monographs Vol 124 group 2019).”
JCS/JCC/JACR/JATS 2024 guideline on cardiovascular practice with consideration for diversity, equity, and inclusion
Tsukada, Y. T., Aoki‐Kamiya, C., Mizuno, A., Nakayama, A., Ide, T., Aoyama, R., Honye, J., Hoshina, K., Ikegame, T., Inoue, K., et al. (2025) · Journal of Cardiology · doi:10.1016/j.jjcc.2025.03.002 · Cited by 2
Sleep Disturbances in Hospitalized Patients
Mechineni, A., LLOYD, T., Sahni, A., & Sharma, G. (2025) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2025.07.011 · Cited by 1
Impact of circadian-aligned meal timing and sleep rhythm on cardiovascular health: A comprehensive review
Fatima, G., Dhalla, N. S., & Khan, S. (2025) · Scripta Medica · doi:10.5937/scriptamed56-59779 · Cited by 1
Identification and Validation of RORC as a Circadian Rhythm-Related Biomarker in Gastric Cancer
Liu, X., Ren, B., Ma, W., Fu, L., Liu, S., & Sun, D. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s564102 · Cited by 1
“9 Such disruptions have been associated with an increased risk of metabolic syndrome, neurodegenerative diseases, and cancer.”
Chronic random sleep deprivation causes prolonged pain hypersensitivity via the anterior cingulate cortex
Nakano, K., Koga, K., Kadoya, M., Yamada, A., Kobayashi, K., Pickering, A. E., Koyama, H., & Furue, H. (2026) · iScience · doi:10.1016/j.isci.2026.114750 · Cited by 1
“37,38 Therefore, irregularity of sleep schedules could aggravate the chronic SD-induced mechanical hypersensitivity in RSD mice.”
Rotating night shift work, gestational diabetes and risk of type 2 diabetes among US nurses
Agarwal, I., Frankenfeld, C. L., Schernhammer, E. S., Strohmaier, S., Fleisch, A. F., Rich-Edwards, J. W., & Tobias, D. K. (2026) · Occupational and Environmental Medicine · doi:10.1136/oemed-2025-110594 · Cited by 1
Self-citation
The PER Gene Family: Pivotal Regulators Bridging Circadian Clock Disruption to Multifactorial Pathologies
Li, R., Gao, Q., Huang, Y., Pan, J.-A., Du, L., & Peng, X. (2026) · European Medical Journal · doi:10.33590/emj/v98iw0so · Cited by 1
Efficacy and Adherence to a Supervised Aerobic Exercise Training Intervention in Night‐Shift Hospital Nurses: A Randomized Controlled Trial
Brennan, A. M., Green, J. F., Carnero, E. Á., Sparks, L. M., Goodpaster, B. H., Robinson, P. S., & Erickson, M. L. (2026) · The FASEB Journal · doi:10.1096/fj.202504084rr · Cited by 1
How England got its name (1014-1030)
Beech, G. T. (2009) · Nouvelle revue d onomastique · doi:10.3406/onoma.2009.1506 · Cited by 1
XV Latin-American Symposium on Chronobiology
Silva, A., & Torterolo, P. (2020) · Sleep Science · doi:10.5935/1984-0063.20200005 · Cited by 2
Dysfunction of resolution receptor triggers cardiomyopathy of obesity and signs of non-resolving inflammation in heart failure
Kain, V., & Halade, G. V. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111521 · Cited by 1
Linking Organizational Stress and Burnout
Rua, O. L., Amorim, V., Lamas, M. C., & Lopes, B. D. S. (2023) · Advances in human resources management and organizational development book series · doi:10.4018/978-1-6684-7212-5.ch007 · Cited by 1
Health Effects of Shift Work and Night Shift Work
Guénel, P., & Léger, D. (2023) · Handbook series in occupational health sciences · doi:10.1007/978-3-030-94023-2_19-1 · Cited by 1
Evaluation of the Diurnal Cycle of Blood Pressure and Sleep in Shift Workers
Gupta, D., Mohan, L., Goel, A., & Kathrotia, R. (2023) · Cureus · doi:10.7759/cureus.48029 · Cited by 1
OS IMPACTOS DA ALTERAÇÃO DO SONO E REPOUSO EM TRABALHADORES DO TURNO NOTURNO SOB A ÓTICA DA ENFERMAGEM DO TRABALHO
Cunha, A. L. D., Ferreira, R. B., & Lopes, G. D. S. (2023) · Revista Contemporânea · doi:10.56083/rcv3n11-223 · Cited by 1
A Mixed-Methods, Multimedia Pilot Study to Investigate Sleep Irregularity Determinants Among Undergraduate Students
Marquardt, M. D., & Pontis, S. (2024) · American Journal of Health Promotion · doi:10.1177/08901171241240818 · Cited by 1
Time-Restricted Eating: A Circadian Intervention for the Prevention and Management of Metabolic Diseases in Animal Models and Humans
Deota, S., & Manoogian, E. N. C. (2024) · Springer eBooks · doi:10.1007/978-3-031-49622-6_3 · Cited by 1
Working Conditions in Complementary and Integrative Healthcare Professions
Whitley, M. D., Faydenko, J., Madigan, D., & Finnell, J. S. (2025) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000003251 · Cited by 1
Effect of Reading a Book on a Tablet Computer on Cerebral Blood Flow in the Prefrontal Cortex
Sugiura, A., Eto, T., Kinoshita, F., & Takada, H. (2018) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.73.39 · Cited by 1

Authors: Vetter, C., Devore, E. E., Wegrzyn, L. R., Massa, J., Speizer, F. E., Kawachi, I., Rosner, B., Stampfer, M. J., & Schernhammer, E. S.
Affiliations: Brigham and Women's Hospital (US)
Harvard University (US)
Corresponding author: Vetter, Céline
ORCID: Vetter, Céline
Wegrzyn, Lani R.
Massa, Jennifer
Kawachi, Ichiro
Rosner, Bernard
Stampfer, Meir J.
Schernhammer, Eva S.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2016-04-26
Volume: 315
Issue: 16
Pages: 1726
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2016.4454
PMC: PMC5102147
OpenAlex: W2342969444
Cited by: 517
References: 39
Citations by year: 2026: 42 · 2025: 61 · 2024: 59 · 2023: 51 · 2022: 64 · 2021: 53 · 2020: 57 · 2019: 44 · 2018: 44 · 2017: 27 · 2016: 13
FWCI: 60.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
UCL Discovery (University College London) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
National Heart, Lung, and Blood Institute (R01HL034594)
National Cancer Institute (UM1CA176726, UM1CA186107)
National Institute for Occupational Safety and Health (5R01OH009803, R01OH009803)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Workplace Health and Well-being
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: rotating night shift work, shift work, coronary artery disease, women, myocardial infarction, angina pectoris, coronary artery bypass grafting, Nurses' Health Study, cardiovascular risk, occupational exposure, coronary CT angiography, coronary artery calcification, coronary microvascular dysfunction
MeSH terms: Adult, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Middle Aged, Nurses, Personnel Staffing and Scheduling, Prospective Studies, Surveys and Questionnaires, Time Factors, United States, Work Schedule Tolerance, Incidence, Proportional Hazards Models, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association Between Rotating Night Shift Work and Risk of Coronary Heart Disease Among Women

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks