The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Association Between Rotating Night Shift Work and Risk of Coronary Heart Disease Among Women
Open accessAbstract
Importance Prospective studies linking shift work to coronary heart disease (CHD) have been inconsistent and limited by short follow-up. Objective To determine whether rotating night shift work is associated with CHD risk. Design, Setting, and Participants Prospective cohort study of 189 158 initially healthy women followed up over 24 years in the Nurses’ Health Studies (NHS [1988-2012]: N = 73 623 and NHS2 [1989-2013]: N = 115 535). Exposures Lifetime history of rotating night shift work (≥3 night shifts per month in addition to day and evening shifts) at baseline (updated every 2 to 4 years in the NHS2). Main Outcomes and Measures Incident CHD; ie, nonfatal myocardial infarction, CHD death, angiogram-confirmed angina pectoris, coronary artery bypass graft surgery, stents, and angioplasty. Results During follow-up, 7303 incident CHD cases occurred in the NHS (mean age at baseline, 54.5 years) and 3519 cases in the NHS2 (mean age, 34.8 years). In multivariable-adjusted Cox proportional hazards models, increasing years of baseline rotating night shift work were associated with a significantly higher CHD risk in both cohorts. In the NHS, the age-standardized incidence rate (IR) for less than 5 years of rotating night shift work per 100 000 person-years was 435.1 (hazard ratio [HR], 1.02; 95% CI, 0.97-1.08); the IR for 5 to 9 years of rotating night shift work was 525.7 (HR, 1.12; 95% CI, 1.02-1.22); and the IR for 10 years or more of rotating night shift work was 596.9 (HR, 1.18; 95% CI, 1.10-1.26;P<.001 for trend) vs an IR of 425.5 in women who never worked rotating night shifts. In the NHS2, the IR for less than 5 years was 130.6 (HR, 1.05; 95% CI, 0.97-1.13); the IR for 5 to 9 years was 151.6 (HR,1.12; 95% CI, 0.99-1.26); and the IR for 10 years or more was 178.0 (HR, 1.15; 95% CI, 1.01-1.32;P = .01 for trend) vs an IR of 122.6 in women who never worked rotating night shifts. In the NHS, the association between duration of rotating night shift work and CHD was stronger in the first half of follow-up (IR for <5 years, 382.4; HR, 1.10 [95% CI, 1.01-1.21]; IR for 5-9 years, 483.1; HR, 1.19 [95% CI, 1.03-1.39]; and IR for ≥10 years, 494.4; HR, 1.27 [95% CI, 1.13-1.42];P<.001 for trend) than in the second half (IR for <5 years, 424.8; HR, 0.98 [95% CI, 0.92-1.05]; IR for 5-9 years, 520.7; HR, 1.08 [95% CI, 0.96-1.21]; IR for ≥10 years, 556.2; HR, 1.13 [95% CI, 1.04-1.24];P = .004 for trend;P = .02 for interaction), suggestive of waning risk after cessation of shift work. Longer time since quitting shift work was associated with decreased CHD risk among ever shift workers in the NHS2 (P<.001 for trend). Conclusions and Relevance Among women who worked as registered nurses, longer duration of rotating night shift work was associated with a statistically significant but small absolute increase in CHD risk. Further research is needed to explore whether the association is related to specific work hours and individual characteristics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Long-term desynchronization of circadian rhythms is associated with adverse metabolic health effects, including weight gain, increased body fat, obesity, impaired glucose tolerance, insulin resistance, higher blood pressure, and elevated cholesterol levels, as well as elevated risk for cardiovascular diseases, diabetes, and metabolic syndrome (18, 47–54).”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [53]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sontrop, J. M., Dixon, S. N., Garg, A. X., Jiménez, I. B., Dohein, O., Huang, S. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,903
Reproducibility and validity of a semiquantitative food frequency questionnaire
WILLETT, W. C., SAMPSON, L., STAMPFER, M. J., ROSNER, B., BAIN, C., WITSCHI, J., HENNEKENS, C. H., & SPEIZER, F. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114086 · Cited by 4,274 · cited 3×
“Pack-years of smoking, median (IQR)c 18 (7-34) 18 (6-34) 20 (7-35) 24 (10-39) 10 (5-16) 9 (5-16) 10 (5-17) 11 (6-19)”
Self-citationHubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,090
Alternative Dietary Indices Both Strongly Predict Risk of Chronic Disease
Chiuve, S. E., Fung, T. T., Rimm, E. B., Hu, F. B., McCullough, M. L., Wang, M., Stampfer, M. J., & Willett, W. C. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.157222 · Cited by 1,951 · cited 3×
“Pack-years of smoking, median (IQR)c 18 (7-34) 18 (6-34) 20 (7-35) 24 (10-39) 10 (5-16) 9 (5-16) 10 (5-17) 11 (6-19)”
Self-citationA Prospective Study of Obesity and Risk of Coronary Heart Disease in Women
Manson, J. E., Colditz, G. A., Stampfer, M. J., Willett, W. C., ROSNER, B. A., Monson, R. R., Speizer, F. E., & Hennekens, C. H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003293221303 · Cited by 1,403 · cited 4×
“≤6 6978 (23) 7506 (25) 1427 (29) 2901 (34) 8939 (20) 12 230 (22) 2542 (26) 1670 (28)”
InfluentialSelf-citationHealth disorders of shift workers
Knutsson, A. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg048 · Cited by 1,218 · cited 2×
“4); the interaction between shift work and BMI was not significant, (χ2(5) =10.”
BackgroundMethodReproducibility and validity of a self-administered physical activity questionnaire
WOLF, A. M., HUNTER, D. J., COLDITZ, G. A., MANSON, J. E., STAMPFER, M. J., CORSANO, K. A., ROSNER, B., KRISKA, A., & WILLETT, W. C. (1994) · International Journal of Epidemiology · doi:10.1093/ije/23.5.991 · Cited by 1,038 · cited 1×
“34,35 The exposure assessments lacked information on intensity of night shift work and physiological measures that may be affected by shift work.”
BackgroundSelf-citationCOLDITZ, G. A., MARTIN, P., STAMPFER, M. J., WILLETT, W. C., SAMPSON, L., ROSNER, B., HENNEKENS, C. H., & SPEIZER, F. E. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114319 · Cited by 992 · cited 1×
“34,35 The exposure assessments lacked information on intensity of night shift work and physiological measures that may be affected by shift work.”
BackgroundSelf-citationStress and Cardiovascular Disease: An Update on Current Knowledge
Steptoe, A., & Kivimäki, M. (2013) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031912-114452 · Cited by 879 · cited 6×
“Pack-years of smoking, median (IQR)c 18 (7-34) 18 (6-34) 20 (7-35) 24 (10-39) 10 (5-16) 9 (5-16) 10 (5-17) 11 (6-19)”
Influential
Cited by
Sorted by citations
Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738
“Based on the prospective cohort study of the Nurses' Health Studies, a longer duration of rotating night work was associatedwith a small yet statistically significant absolute increase in the risk of coronary heart disease [136].”
BackgroundPhillips, A. J. K., Clerx, W. M., O’Brien, C. S., Sano, A., Barger, L. K., Picard, R. W., Lockley, S. W., Klerman, E. B., & Czeisler, C. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-03171-4 · Cited by 647
Torquati, L., Mielke, G. I., Brown, W. J., & Kolbe-Alexander, T. (2018) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.3700 · Cited by 510
“Indeed, the studies that presented estimates for CHD and CVD mortality were published in recent years (2010–2016) and thus most of these (16, 18, 38) were not included by Vyas et al (7), which may explain some of the different results.”
BackgroundInfluentialChronotypes in the US–influence of age and sex
Fischer, D., Lombardi, D. A., Marucci-Wellman, H., & Roenneberg, T. (2017) · PLOS ONE · doi:10.1371/journal.pone.0178782 · Cited by 502
Disturbance of the Circadian System in Shift Work and Its Health Impact
Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211064218 · Cited by 580
“…risk of cardiometabolic disorders (Brum et al., 2015; Kecklund and Axelsson, 2016), including metabolic syndrome (Khosravipour et al., 2021; Wang et al., 2021), type 2 diabetes (Vetter et al., 2018; Gao et al., 2020), and cardiovascular heart diseases (Vetter et al., 2016; Kervezee et al., 2020).”
BackgroundCircadian rest-activity pattern changes in aging and preclinical Alzheimer disease
Musiek, E. S., Bhimasani, M., Zangrilli, M. A., Morris, J. C., Holtzman, D. M., & Ju, Y.-E. S. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.4719 · Cited by 465
Sleep Irregularity and Risk of Cardiovascular Events
Huang, T., Mariani, S., & Redline, S. S. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.054 · Cited by 387
“Elevated CVD risk has been observed among rotating night shift workers or frequent intercontinental travelers, including flight crews (9,10,34,35).”
BackgroundCircadian rhythms and disorders of the timing of sleep
Meyer, N., Harvey, A. G., Lockley, S. W., & Dijk, D.-J. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00877-7 · Cited by 346
Impact of Circadian Disruption on Cardiovascular Function and Disease
Chellappa, S. L., Vujović, N., Williams, J. S., & Scheer, F. A. J. L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.008 · Cited by 346
“Epidemiological data show an association between shift work and cardiovascular disease [6], and controlled experimental human studies indicate that circadian misalignment (typical in shift workers) adversely affects cardiovascular risk factors.”
BackgroundMcHill, A. W., & Wright, K. P. (2017) · Obesity Reviews · doi:10.1111/obr.12503 · Cited by 330
“Night shift workers have a higher risk of gastrointestinal disorders, (74–76) obesity (77,78), cardiovascular disease (79) and diabetes (80,81).”
BackgroundShan, Z., Li, Y., Zong, G., Guo, Y., Li, J., Manson, J. E., Hu, F. B., Willett, W. C., Schernhammer, E. S., & Bhupathiraju, S. N. (2018) · BMJ · doi:10.1136/bmj.k4641 · Cited by 317
Self-citationMelnyk, B. M., Orsolini, L., Tan, A., Arslanian‐Engoren, C., Melkus, G. D., Dunbar‐Jacob, J. M., Rice, V. H., Millán, A., Dunbar, S. B., Braun, L. T., et al. (2017) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001198 · Cited by 296
“Further, nurses who work night and evening shifts have increased all-cause mortality as well as increased mortality from cardiovascular disease, diabetes, Alzheimer disease and dementia.(9,10)Shift work among nurses also is associated with menstrual cycle”
BackgroundInteraction between circadian rhythms and stress
Koch, C. E., Leinweber, B., Drengberg, B. C., Blaum, C. M., & Oster, H. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.09.001 · Cited by 281
“…a higher incidence of obesity, diabetes type II and related metabolic disturbances (Karlsson et al., 2003; Pan et al., 2011; Proper et al., 2016), along with hypertension (Kubo et al., 2013), coronary heart disease (Vetter et al., 2016), and ischemic stroke (Vyas et al., 2012) in shift workers.”
Wang, N., Sun, Y. B., Zhang, H., Wang, B., Chen, C., Wang, Y., Chen, J., Tan, X. W., Zhang, J., Xia, F., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab505 · Cited by 228
“Differences in study design, sample sizes, and changes in work intensity over time (healthy worker effect) may partly explain the non-linear relationship, which were also found in previous studies.(12,27) Few studies provide information on the association .”
ResultValidation of the Sleep Regularity Index in Older Adults and Associations with Cardiometabolic Risk
Lunsford‐Avery, J. R., Engelhard, M., Návar, A. M., & Kollins, S. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-32402-5 · Cited by 222
Moreno, C. R. D. C., Marqueze, E. C., Sargent, C., Wright, K. P., Ferguson, S. A., & Tucker, P. (2019) · Industrial Health · doi:10.2486/indhealth.sw-1 · Cited by 246
Dasgupta, S., van Maanen, N., Gosling, S. N., Piontek, F., Otto, C., & Schleussner, C. (2021) · The Lancet Planetary Health · doi:10.1016/s2542-5196(21)00170-4 · Cited by 221
“47–50 These issues need to be carefully considered along with the technical aspects of how to model adaptation in future studies on labour productivity and supply.”
BackgroundShift Work, Chronotype, and Melatonin Rhythm in Nurses
Razavi, P., Devore, E. E., Bajaj, A., Lockley, S. W., Figueiro, M. G., Ricchiuti, V., Gauderman, W. J., Hankinson, S. E., Willett, W. C., & Schernhammer, E. S. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1018 · Cited by 178
“HRT use, N (%) 4 (9) 4 (5) Sleeping pill use, N (%) 14 (30) 39 (46) NSAID use, N (%) 13 (28) 35 (42)”
Self-citationRotating night shift work and colorectal cancer risk in the nurses’ health studies
Papantoniou, K., Devore, E. E., MASSA, J. S., Strohmaier, S., Vetter, C., Yang, L., Shi, Y. X., Giovannucci, E. L., Speizer, F. E., & Schernhammer, E. S. (2018) · International Journal of Cancer · doi:10.1002/ijc.31655 · Cited by 158
“A similar pattern of increased risk during the first half of follow-up and decreased risk over the second half was also observed for breast cancer and coronary heart disease in this cohort.(25,26) In the younger and mostly premenopausal, NHS2 cohort no overall association was observed with shift work history.”
BackgroundSelf-citationCircadian rhythm phase shifts caused by timed exercise vary with chronotype
Thomas, J. M., Kern, P. A., Bush, H., McQuerry, K., Black, W. S., Clasey, J. L., & Pendergast, J. S. (2020) · JCI Insight · doi:10.1172/jci.insight.134270 · Cited by 160
“, >5 years) markedly increases the risk of heart disease, breast cancer, and type 2 diabetes compared to acute exposure (49-51).”
BackgroundChronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice
Inokawa, H., Umemura, Y. M., Shimba, A., Kawakami, E., Koike, N., Tsuchiya, Y., Ohashi, M., Minami, Y., Cui, G., Asahi, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59541-y · Cited by 137
Wang, D., Ruan, W., Chen, Z., Peng, Y., & Li, W. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318783892 · Cited by 135
Timing of food intake: identifying contributing factors to design effective interventions
Dashti, H. S., Scheer, F. A. J. L., Saxena, R., & Garaulet, M. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy131 · Cited by 121
“Although less accurate, this may also be made possible by attaining self-reported chronotype (105).”
BackgroundDaily circadian misalignment impairs human cognitive performance task-dependently
Chellappa, S. L., Morris, C. J., & Scheer, F. A. J. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-20707-4 · Cited by 128
Sun, S., Cao, W., Ge, Y., Ran, J., Sun, F., Zeng, Q., Guo, M., Huang, J., Lee, R. S.-Y., Tian, L., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa846 · Cited by 127
“We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of the association between outdoor light at night at the residence and risk of CHD.”
ResultInfluentialCharlot, A., Hutt, F., Sabatier, E., & Zoll, J. (2021) · Nutrients · doi:10.3390/nu13051405 · Cited by 125
“Shift work is associated with a higher risk of coronary heart diseases and vascular events such as myocardial infarction or ischemic stroke, in comparison to day work [77,78].”
BackgroundCircadian rhythm and disease: Relationship, new insights, and future perspectives
Neves, A. R., Albuquerque, T., Quintela, T., & Costa, D. R. B. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30815 · Cited by 128
“3.3.1 | Neurodegenerative diseases Preliminary studies suggested that rhythm disruptions can be a risk factor for Alzheimer's disease (AD) development (J. L. Wang et al., 2015; Wu et al., 2019) and Parkinson's disease (PD) (Leng et al., 2020; Li et al., 2017; Videnovic & Golombek, 2017).”
BackgroundInfluentialShift work and overall and cause-specific mortality in the Danish nurse cohort
̧rgensen, J. T. J., Karlsen, S., Stayner, L. T., Andersen, J., & Andersen, Z. J. (2016) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3612 · Cited by 107
Härmä, M., Karhula, K., Puttonen, S., Ropponen, A., Koskinen, A., Ojajärvi, A., & Mika Kivimaki, B. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12658 · Cited by 106
“Prospective studies have linked shift work to increased risk of occupational accidents (Wagstaff & Sigstad Lie, 2011), cardiovascular disease (Vetter et al., 2016; Vyas et al., 2012) and type 2 diabetes (Knutsson & Kempe, 2014).”
BackgroundRitonja, J. A., Aronson, K. J., Matthews, R. W., Boivin, D. B., & Kantermann, T. (2019) · Industrial Health · doi:10.2486/indhealth.sw-5 · Cited by 107
Arousal From Sleep and Sympathetic Excitation During Wakefulness
Taylor, K. S., Murai, H., Millar, P. J., Haruki, N., Kimmerly, D. S., Morris, B. L., TOMLINSON, G. A., Bradley, T. D., & Floras, J. S. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08212 · Cited by 102
Gumz, M. L., Shimbo, D., Abdalla, M., Balijepalli, R. C., Benedict, C., Chen, Y., Earnest, D. J., Gamble, K. L., Garrison, S., Gong, M. C., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19372 · Cited by 105
Self-citationMeal timing, aging, and metabolic health
Kessler, K., & Pivovarova-Ramich, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081911 · Cited by 95
Time restricted eating: A dietary strategy to prevent and treat metabolic disturbances
Schuppelius, B., Peters, B., Ottawa, A., & Pivovarova-Ramich, O. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.683140 · Cited by 93
Rumanova, V. S., Okuliarová, M., & Zeman, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155478 · Cited by 100
“The negative consequences of exposure to light at inappropriate times of the day can especially be observed in long-term shift-workers, who may suffer from metabolic diseases [24,25], cardiovascular diseases [26,27] and cancer [28,29].”
BackgroundCircadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis
Man, A. W. C., Li, H., & Xia, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020676 · Cited by 96
“Longitudinal studies have shown that shift workers are at higher risk for metabolic and cardiovascular complications [1,2].”
BackgroundCircadian Synchrony: Sleep, Nutrition, and Physical Activity
Healy, K. L., Morris, A. R., & Liu, A. C. (2021) · Frontiers in Network Physiology · doi:10.3389/fnetp.2021.732243 · Cited by 98
“Shift work is classified as a carcinogen, and the risk of cancer, as well as heart disease, further increases with the time spent carrying out shift work (Schernhammer et al., 2001; Megdal et al., 2005; Davis and Mirick, 2006; Vetter et al., 2016; Yousef et al., 2020).”
Bagheri Hosseinabadi, M., Ebrahimi, M. H., Khanjani, N., Biganeh, J., Mohammadi, S., & Abdolahfard, M. (2019) · Journal of Clinical Nursing · doi:10.1111/jocn.14778 · Cited by 87
Strohmaier, S., Devore, E. E., Zhang, Y., & Schernhammer, E. S. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1102-5 · Cited by 89
Self-citationThe Relationship Between Shift Work and Men’s Health
Deng, N., Kohn, T. P., Lipshultz, L. I., & Pastuszak, A. W. (2018) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.11.009 · Cited by 83
A novel method to visualise and quantify circadian misalignment
Fischer, D. R., Vetter, C., & Roenneberg, T. (2016) · Scientific Reports · doi:10.1038/srep38601 · Cited by 82
Self-citationThe circadian system, sleep, and the health/disease balance: a conceptual review
Roenneberg, T., Foster, F., & Klerman, E. B. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13621 · Cited by 81
Schilperoort, M., van den Berg, R., Bosmans, L. A., van Os, B. W., Dollé, M. E. T., Smits, N. A. M., Guichelaar, T., van Baarle, D., Koemans, L., Berbée, J. F. P., et al. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12614 · Cited by 79
The changing microbial landscape of Western society: Diet, dwellings and discordance
Broussard, J. L., & Devkota, S. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.07.007 · Cited by 76
Su, F., Huang, D., Wang, H., & Yang, Z. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.08.017 · Cited by 78
Cardiovascular Disease Burden and Socioeconomic Correlates: Findings From the Jackson Heart Study
Min, Y., Anugu, P., Butler, K. R., Hartley, T. A., Mwasongwe, S. E., Norwood, A. F., Sims, M., Wang, W., Winters, K. P., & Correa, A. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004416 · Cited by 72
Yang, L., Luo, Y., He, L., Yin, J., Li, T., Liu, S., Li, D., Cheng, X., & Bai, Y. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.025936 · Cited by 71
Meal timing and its role in obesity and associated diseases
Peters, B., Vahlhaus, J., & Pivovarova-Ramich, O. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359772 · Cited by 72
Circadian Disruption and Consequences on Innate Immunity and Inflammatory Response
Jerigová, V. Š., Zeman, M., & Okuliarová, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213722 · Cited by 65
Li, X., Cao, Y., Xu, X., Wang, C., Ni, Q., Lv, X., Yang, C., Zhang, Z., Qi, X., & Song, G. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319026 · Cited by 65
Sűdy, Á. R., Ella, K., Bódizs, R., & Káldi, K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00950 · Cited by 65
“Both epidemiological and laboratory studies indicate that severe forms of circadian misalignment such as shift work or jetlag adversely affect the circulatory system and therefore increase the risk of the development of cardiovascular diseases (Knutsson, 2003; Grimaldi et al., 2016; Morris et al., 2016; Vetter et al.,…”
BackgroundKhaing, N. E. E., Abuduxike, G., Posadzki, P., Divakar, U., Visvalingam, N., Nazeha, N., Dunleavy, G., Christopoulos, G. I., Soh, C. K., Järbrink, K., et al. (2018) · Tunnelling and Underground Space Technology · doi:10.1016/j.tust.2018.11.022 · Cited by 64
Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism
Hunter, A. L., Pelekanou, C. E., Adamson, A., Downton, P., Barron, N. J., Cornfield, T., Poolman, T. M., Humphreys, N., Cunningham, P. S., Hodson, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005330117 · Cited by 54
“In modern human society, shift work and social jetlag drive desynchrony between internal clock cycles and the external environment, including food availability, and are associated with metabolic disease (49, 50).”
BackgroundZheng, R., Xin, Z., Li, M., Wang, T., Xu, M., Lu, J., Dai, M., Zhang, D., Chen, Y., Wang, S., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05819-x · Cited by 62
“Night-shift workers exposed to higher levels of LAN were found to be at higher risks of disrupted circadian rhythms and CHD [9, 10].”
BackgroundInfluentialKim, S., Jang, E.-C., Kwon, S.-C., Han, W., Kang, M.-S., Nam, Y.-H., & Lee, Y.-J. (2016) · Annals of Occupational and Environmental Medicine · doi:10.1186/s40557-016-0135-y · Cited by 61
“, a dose-response relationship between the duration of shift work and the risk of CHD was observed; moreover, after shift work ceased, the risk of CHD decreased over time [49].”
BackgroundShift work of nursing professionals and blood pressure, burnout and common mental disorders
Nascimento, J. O. V., dos Santos, J., Meira, K. C., Pierin, Â. M. G., & Souza‐Talarico, J. N. (2019) · Revista da Escola de Enfermagem da USP · doi:10.1590/s1980-220x2018002103443 · Cited by 61
Rotating Night Shift Work and Healthy Aging After 24 Years of Follow-up in the Nurses' Health Study
Shi, H., Huang, T., Schernhammer, E. S., Sun, Q., & Wang, M. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.10450 · Cited by 67
Self-citationThe Effect of Circadian and Sleep Disruptions on Obesity Risk
Noh, J. H. (2018) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2018.27.2.78 · Cited by 63
Larsen, A. D., Ropponen, A., Hansen, J., Hansen, Å. M., Kolstad, H. A., Koskinen, A., Härmä, M., & Garde, A. H. (2020) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2020.103639 · Cited by 59
Reed, J. L., Prince, S. A., Pipe, A., Attallah, S., Adamo, K. B., Tulloch, H. E., Manuel, D. G., Mullen, K., Fodor, G. J., & Reid, R. D. (2018) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2018.02.001 · Cited by 58
Impact of Shift Work on the Circadian Timing System and Health in Women
Kervezee, L., Shechter, A., & Boivin, D. B. (2018) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2018.04.003 · Cited by 60
Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure
Eckle, T. D. L. G., Bertazzo, J., Khatua, T. N., Tabatabaei, S. R. F., Bakhtiari, N. M., Walker, L. A., & Martino, T. A. (2024) · Circulation Research · doi:10.1161/circresaha.123.323522 · Cited by 57
“…and gut microbiome composition, 43 all of which play critical roles in post-MI cardiac repair and the progression of HF. Interestingly, despite CLOCK’s involvement in obesity and metabolic functions, Clock Δ 19/ Δ 19 mice resist developing heart disease when challenged with a chronic high-fat diet.”
BackgroundThe Case for Permanent Residency for Frontline Workers
Gerver, M. (2021) · American Political Science Review · doi:10.1017/s0003055421000708 · Cited by 54
“Firefighters, soldiers, and even nurses who work night shifts often assume substantial risks while helping citizens (Vetter et al. 2016), as do some nonmigrants abroad.”
BackgroundHo, F. K. W., Celis-Morales, C. A., Gray, S. R., Demou, E., Mackay, D., Welsh, P. I., Katikireddi, S. V., Sattar, N. A., & Pell, J. P. (2021) · International Journal of Epidemiology · doi:10.1093/ije/dyab144 · Cited by 54
“8 However, the mechanisms by which shift work may cause CVD are still elusive.”
BackgroundZhang, H., Wang, J., Zhang, S., Tong, S., Hu, J., Che, Y., Zhuo, L., Wang, P., Geng, R., Zhou, Y., et al. (2023) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-023-02014-2 · Cited by 59
“In the Nurses’ Health Study (NHS), a longer rotating night shift work was associated with the risk of coronary heart disease and type 2 diabetes (Shan et al. 2018; Vetter et al. 2016).”
BackgroundInfluentialSleep and circadian rhythms: pillars of health—a Keystone Symposia report
Cable, J., Schernhammer, E. S., Hanlon, E. C., Vetter, C., Cedernaes, J., Makarem, N., Dashti, H. S., Shechter, A., Depner, C. M., Ingiosi, A. M., et al. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14661 · Cited by 51
Self-citationCircadian rhythms in cardiovascular (dys)function: approaches for future therapeutics
Lecacheur, M., Ammerlaan, D. J. M., & Dierickx, P. (2024) · npj Cardiovascular Health · doi:10.1038/s44325-024-00024-8 · Cited by 63
McHill, A. W., Hull, J. T., & Klerman, E. B. (2022) · Nutrients · doi:10.3390/nu14091800 · Cited by 61
The effects of phytochemicals on circadian rhythm and related diseases
Xu, T., & Lu, B. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1493678 · Cited by 53
“Epidemiological evidence shows that shift-work is a risk factor for coronary heart disease (CHD) (Vetter et al. 2016; Havakuk et al. 2018), stroke (Li, Huang, Tan, Yang, and Tang 2016; Brown et al.”
BackgroundInfluentialNight shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator?
Wang, F., Zhang, L., Wu, S. Y., Li, W., Sun, M., Feng, W., Ding, D., Wong, S. Y. S., Zhu, P., Evans, G. J., et al. (2018) · Occupational and Environmental Medicine · doi:10.1136/oemed-2018-105273 · Cited by 50
Shift work and ischaemic heart disease: meta-analysis and dose–response relationship
Cheng, M., He, H., Wang, D., Xu, L., Wang, B., Ho, K. M., & Chen, W. (2019) · Occupational Medicine · doi:10.1093/occmed/kqz020 · Cited by 49
Effect of night-shift work on cortisol circadian rhythm and melatonin levels
Brum, M. C. B., Senger, M. B., Schnorr, C. C., Ehlert, L. R., & Rodrigues, T. D. C. (2022) · Sleep Science · doi:10.5935/1984-0063.20220034 · Cited by 47
“In addition, it is implicated in higher rates of metabolic disorders and cardiovascular diseases 2-5 .”
BackgroundNapping on night‐shifts among nursing staff: A mixed‐methods systematic review
Li, H., Shao, Y., Xing, Z., Li, Y., Wang, S., Zhang, M., Ying, J., Shi, Y., & Sun, J. (2018) · Journal of Advanced Nursing · doi:10.1111/jan.13859 · Cited by 47
Shift work and incidence of dementia: A Danish Nurse Cohort study
Jørgensen, J. T., Hansen, J., Westendorp, R. G. J., Nabe‐Nielsen, K., Stayner, L. T., Simonsen, M. K., & Andersen, Z. J. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12126 · Cited by 47
Fritz, J., Phillips, A., Hunt, L., Imam, A., Reid, K., Perreira, K., Mossavar-Rahmani, Y., Daviglus, M., Sotres-Alvarez, D., Zee, P., et al. (2020) · Sleep · doi:10.1093/sleep/zsaa218 · Cited by 36
“Exposure to rotating shift work schedules, which results in irregular sleep schedules and circadian disruption [14], increases the risk of diabetes and GMDs, suggesting regular sleep schedules may be important for metabolic health [15, 16].”
BackgroundSelf-citationVidafar, P., Gooley, J. J., Burns, A. C., Rajaratnam, S. M. W., Rueger, M., Van Reen, E., Czeisler, C. A., Lockley, S. W., & Cain, S. W. (2018) · Sleep · doi:10.1093/sleep/zsy098 · Cited by 46
Extracellular Vesicles: Potential Participants in Circadian Rhythm Synchronization
Tao, S., & Guo, S. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.26518 · Cited by 44
“of malignant tumours, diabetes, and cardiomyopathy [19-25].”
Crowther, M. E., Ferguson, S. A., Vincent, G. E., & Reynolds, A. C. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3010009 · Cited by 42
Shift work disorder, mental health and burnout among nurses: A cross‐sectional study
Cheng, H. L., Guangbi, L., Yang, J., Wang, Q., & Yang, H. L. (2022) · Nursing Open · doi:10.1002/nop2.1521 · Cited by 54
“SWD may induce a variety of undesirable health outcomes, such as type 2 diabetes (Anothaisintawee et al., 2016), coronary artery disease (Vetter et al., 2016), abdominal obesity (Sun et al., 2018), breast cancer (Straif et al., 2007), nurses who work shifts and long hours are at risk of fatigue,…”
BackgroundMentzelou, M., Papadopoulou, S. Κ., Papandreou, D., Spanoudaki, M., Dakanalis, A., Vasios, G. K., Voulgaridou, G., Pavlidou, E., Mantzorou, M., & Giaginis, C. (2023) · Metabolites · doi:10.3390/metabo13030370 · Cited by 46
The Impact of the Circadian Genes CLOCK and ARNTL on Myocardial Infarction
Škrlec, I., Milić, J., & Steiner, R. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020484 · Cited by 41
Association between circadian disruption and diseases: A narrative review
Hou, Y., Liu, L.-M., Chen, X., Li, Q., & Li, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118512 · Cited by 48
Cho, H., Sagherian, K., & Steege, L. M. B. (2021) · Workplace Health & Safety · doi:10.1177/2165079920987543 · Cited by 45
“Night shift nurses experience sleep loss, sleepiness, fatigue, and performance decrements and are at high risk for sickness absences, adverse health outcomes, and drowsy driving incidents (Akerstedt & Wright, 2009; Dall’Ora et al., 2020; Geiger-Brown et al., 2012; Scott et al., 2007; Vetter et al., 2016).”
BackgroundReid, K. J., Weng, J. F., Ramos, A. R., Zee, P. C., Daviglus, M. L., Mossavar‐Rahmani, Y., Sotres‐Alvarez, D., Gallo, L. C., Chirinos, D. A., & Patel, S. R. (2018) · SLEEP · doi:10.1093/sleep/zsy131 · Cited by 42
Loef, B., van Baarle, D., van der Beek, A. J., Beekhof, P., van Kerkhof, L. W., & Proper, K. I. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211557 · Cited by 39
Circadian influence on inflammatory response during cardiovascular disease
Aziz, I. S., McMahon, A. M., Friedman, D., Rabinovich-Nikitin, I., Kirshenbaum, L. A., & Martino, T. A. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.11.007 · Cited by 40
Lu, Y., Ma, X., Zhou, X., & Wang, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-12393-0 · Cited by 38
Circadian Rhythms in AD Pathogenesis: a Critical Appraisal
Musiek, E. S. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0072-5 · Cited by 37
Capodilupo, E. R., & Miller, D. J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256063 · Cited by 39
“These benefits are understood to be related to the circadian rhythm; shifting sleep timing decouples the circadian rhythm from the sleep/wake rhythm [11, 12], contributing to adverse health outcomes such as higher rates of cardiovascular disease [13] and breast cancer [14].”
BackgroundAssociation between shift work and risk of metabolic syndrome: A systematic review and meta-analysis
Yang, X., Di, W., Zeng, Y., Liu, D., Han, M., Qie, R., Huang, S., Zhao, Y., Feng, Y., Hu, D., et al. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.06.007 · Cited by 36
Short Sleep, Insomnia, and Cardiovascular Disease
Hsieh, C. G., & Martin, J. L. (2019) · Current Sleep Medicine Reports · doi:10.1007/s40675-019-00157-8 · Cited by 36
Patterson, P. D., Mountz, K. A., Budd, C. T., Bubb, J. L., Hsin, A. U., Weaver, M. D., Turner, R. L., Platt, T. E., Guyette, F. X., Martin‐Gill, C., et al. (2020) · Sleep Health · doi:10.1016/j.sleh.2020.03.006 · Cited by 36
McMullan, C. J., Rimm, E. B., Schernhammer, E. S., & Forman, J. P. (2016) · Heart · doi:10.1136/heartjnl-2016-310098 · Cited by 35
Self-citationAssessment and Management of Sleep Disturbance in Cirrhosis
Formentin, C., Garrido, M., & Montagnese, S. (2018) · Current Hepatology Reports · doi:10.1007/s11901-018-0390-1 · Cited by 35
Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia
Tsuzuki, K., Shimizu, Y., Suzuki, J., Pu, Z., Yamaguchi, S., Fujikawa, Y., Kato, K., Ohashi, K., Takefuji, M., Bando, Y., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.020896 · Cited by 35
Working against the biological clock: a review for the Occupational Physician
Copertaro, A., & Bracci, M. (2019) · Industrial Health · doi:10.2486/indhealth.2018-0173 · Cited by 35
Amano, H., Fukuda, Y., Yokoo, T., & Yamaoka, K. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.42036 · Cited by 33
Night shift work and cardiovascular disease biomarkers in female nurses
Johnson, C. Y., Tanz, L. J., Lawson, C. C., Schernhammer, E. S., Vetter, C., & Rich-Edwards, J. W. (2019) · American Journal of Industrial Medicine · doi:10.1002/ajim.23079 · Cited by 37
Self-citationLi, X., Li, L., Yang, L., Yang, J., & Lu, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-95207-z · Cited by 33
Work Exposures and Development of Cardiovascular Diseases: A Systematic Review
Anfossi, C. M., Ahumada, M., Fredes, C. T., Rojas, F. P., Ross, J., Head, J. A., & Britton, A. R. (2022) · Annals of Work Exposures and Health · doi:10.1093/annweh/wxac004 · Cited by 33
Metadata
- Authors
- Vetter, C., Devore, E. E., Wegrzyn, L. R., Massa, J., Speizer, F. E., Kawachi, I., Rosner, B., Stampfer, M. J., & Schernhammer, E. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Vetter, Céline
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2016-04-26
- Volume
- 315
- Issue
- 16
- Pages
- 1726
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC5102147
- OpenAlex
- W2342969444
- Cited by
- 517
- References
- 39
- Citations by year
- 2026: 42 · 2025: 61 · 2024: 59 · 2023: 51 · 2022: 64 · 2021: 53 · 2020: 57 · 2019: 44 · 2018: 44 · 2017: 27 · 2016: 13
- FWCI
- 60.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Heart, Lung, and Blood Institute (R01HL034594)
- National Cancer Institute (UM1CA176726, UM1CA186107)
- National Institute for Occupational Safety and Health (5R01OH009803, R01OH009803)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Workplace Health and Well-being
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- rotating night shift work, shift work, coronary artery disease, women, myocardial infarction, angina pectoris, coronary artery bypass grafting, Nurses' Health Study, cardiovascular risk, occupational exposure, coronary CT angiography, coronary artery calcification, coronary microvascular dysfunction
- MeSH terms
- Adult, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Middle Aged, Nurses, Personnel Staffing and Scheduling, Prospective Studies, Surveys and Questionnaires, Time Factors, United States, Work Schedule Tolerance, Incidence, Proportional Hazards Models, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
