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Emergence of a Novel SARS-CoV-2 Variant in Southern California
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Abstract
This research describes findings of sequencing and phylogenetic analyses of SARS-CoV-2 isolates from symptomatic patients cared for at Cedar-Sinai Medical Center in November-December 2020 during a regional surge in cases and hospitalizations.
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“The Epsilon (GH/452R.V1) variant first identified in California, the USA in 2021, showed a 20% increase in transmission possibly attributed to the L452R and D614G substitutions in the spike protein [36].”
From Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe (2022) · cites this paper as [36]
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Metadata
- Authors
- Zhang, W., Davis, B. D., Chen, S. S., Sincuir Martinez, J. M., Plummer, J. T., & Vail, E.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California
- Corresponding author
- Plummer, Jasmine T.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2021-04-06
- Volume
- 325
- Issue
- 13
- Pages
- 1324
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC7879386
- OpenAlex
- W3127156551
- Cited by
- 371
- References
- 10
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 19 · 2023: 21 · 2022: 86 · 2021: 232
- FWCI
- 28.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- JAMA (publishedVersion, other-oa)
- medRxiv (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- SARS-CoV-2, COVID-19 pandemic, novel variants, viral variant emergence, phylogenetic analysis, viral genome sequencing, symptomatic patients, Southern California
- MeSH terms
- COVID-19, SARS-CoV-2, California, Humans, Mutation, Sequence Analysis, RNA, Spike Glycoprotein, Coronavirus
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