Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection
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Abstract
Deep mutational scanning shows that the mRNA-1273 RBD-binding antibody response is less affected by single viral mutations than the infection response.
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mRNA vaccines have recently been successfully used against COVID-19, validating the platform and showing that mRNA vaccines can prevent infectious diseases in the future.
“Furthermore, mRNA vaccines have recently been successfully used against COVID-19, validating the platform and showing that mRNA vaccines can prevent infectious diseases in the future (Greaney et al., 2021).”
From A novel Toxoplasma gondii TGGT1_316290 mRNA-LNP vaccine elicits protective immune response against toxoplasmosis in mice (2023) · cites this paper as Greaney et al., 2021
The Introduction (page unavailable) says two mRNA COVID-19 vaccines received US emergency-use approval and cites preliminary evidence of substantial protection against infection and severe disease. It does not say that this success validates the mRNA platform or establishes that mRNA vaccines can prevent other infectious diseases in the future. (LLM, conf=0.84)
Experimental — accuracy not yet measuredL452R has resulted in 3-fold to 10-fold reduced susceptibility to about one third of convalescent and vaccinee plasma samples.
“L452R has resulted in 3-fold to 10-fold reduced susceptibility to about one third of convalescent and vaccinee plasma samples”
From The biological and clinical significance of emerging SARS-CoV-2 variants (2021) · cites this paper as [164]
The levels of neutralizing mAbs elicited by the mRNA vaccines has been high and in most persons are likely to be maintained for many months above the levels required for protection against even the most resistant circulating variants.
“The levels of neutralizing mAbs elicited by the mRNA vaccines has been high and in most persons are likely to be maintained for many months above the levels required for protection against even the most resistant circulating variants 164,239,240 .”
From The biological and clinical significance of emerging SARS-CoV-2 variants (2021) · cites this paper as [164]
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Self-citationLee, D. B., Kim, H., Jeong, J. H., Jang, U. S., Jang, Y., Roh, S., Jeon, H., Kim, E. J., Han, S. Y., Maeng, J. Y., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208425120 · Cited by 22 · see citing works
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
Lee, J., Stewart, C., Schäfer, A., Leaf, E. M., Park, Y.-J., Asarnow, D., Powers, J. M., Treichel, C., Sprouse, K. R., Corti, D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49656-5 · Cited by 23 · see citing works
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- Authors
- Greaney, A. J., Loes, A. N., Gentles, L. E., Crawford, K. H. D., Starr, T. N., Malone, K. D., Chu, H. Y., & Bloom, J. D.
- Affiliations
- University of Washington (US)
- Howard Hughes Medical Institute (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Bloom, Jesse D.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2021-06-30
- Volume
- 13
- Issue
- 600
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8369496
- OpenAlex
- W3169651048
- Cited by
- 244
- References
- 53
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 29 · 2023: 52 · 2022: 79 · 2021: 49 · 2020: 1
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science Translational Medicine (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by)
- Funders
- National Institutes of Health (UM1AI148373, UM1AI148576, UM1AI148684, NIH P51 OD011132, AI149644, R01AI127893, S10OD028685, T32AI083203, F30AI149928)
- National Institute of Allergy and Infectious Diseases (UM1AI148373, R01AI141707, R01AI127893, T32AI083203, F30AI149928, UM1AI148576, UM1AI148684, NIH AID AI149644)
- Howard Hughes Medical Institute
- ASCRS Research Foundation (R01AI141707, R01AI127893, T32AI083203, F30AI149928, INV-004949, INV-016575, S10OD028685, DRG-2381-19, RNA-1273, UM1AI148373, UM1AI148576, UM1AI148684, NIH P51 OD011132, NIH AID AI149644, HHSN272201500002C)
- Bill and Melinda Gates Foundation (INV-004949, INV-016575)
- Gates Foundation (INV-004949, INV-016575)
- Damon Runyon Cancer Research Foundation (DRG-2381-19)
- Department of Health and Human Services (HHSN272201500002C)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- SARS-CoV-2, mRNA-1273 vaccine, COVID-19 vaccination, natural infection, receptor binding domain, spike protein, neutralizing antibodies, epitope specificity, viral evolution, antigenic drift, deep mutational scanning, convalescent sera
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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