No association between semaglutide and postoperative pneumonia in people with diabetes undergoing elective surgery
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There are conflicting data on the magnitude of the risks of pulmonary aspiration with peri-operative GLP-1 RA use.
“There are, however, conflicting data on the magnitude of these risks [41].”
There are conflicting data on the magnitude of perioperative risks of GLP-1 RA.
“There are, however, conflicting data on the magnitude of these risks.34”
From Evaluation of safety of preoperative GLP-1 receptor agonists in patients undergoing elective surgery: a systematic review, meta-analysis and meta-regression (2025) · cites this paper as [34]
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Cites
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Marso, S. P., Bain, S. C., Consoli, A., Eliaschewitz, F. G., Jódar, E., Leiter, L. A., Lingvay, I., Rosenstock, J., Seufert, J., Warren, M. L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1607141 · Cited by 6,900 · see citing works
Silveira, S. Q., da Silva, L. M., de Campos Vieira Abib, A., de Moura, D. T. H., de Moura, E. G. H., Santos, L. B., Ho, A. M.-H., Nersessian, R. S. F., Lima, F. L. M., Silva, M. V., et al. (2023) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2023.111091 · Cited by 259 · see citing works
Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report
Klein, S. R., & Hobai, I. A. (2023) · Canadian Journal of Anesthesia/Journal canadien d'anesthésie · doi:10.1007/s12630-023-02440-3 · Cited by 207 · see citing works
Van de Putte, P., Vernieuwe, L., Jerjir, A., Verschueren, L., Tacken, M., & Perlas, A. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aew435 · Cited by 176 · see citing works
Hashash, J. G., Thompson, C. C., & Wang, A. Y. (2024) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.11.002 · Cited by 140 · see citing works
Sherwin, M., Hamburger, J., Katz, D., & DeMaria, S. (2023) · Canadian Journal of Anesthesia/Journal canadien d'anesthésie · doi:10.1007/s12630-023-02549-5 · Cited by 132 · see citing works
van Zuylen, M. L., Siegelaar, S. E., Plummer, M. P., Deane, A. M., Hermanides, J., & Hulst, A. H. (2024) · British Journal of Anaesthesia · doi:10.1016/j.bja.2024.01.001 · Cited by 132 · see citing works
Yeo, Y. H., Gaddam, S., Ng, W. H., Huang, P.-C., Mohamed, G., Samaan, J., Yi-Jin Hsieh, T., Lee, G. Y., Watson, R., Mathur, R., et al. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.03.015 · Cited by 128 · see citing works
Gastric emptying in diabetes: an overview.
Horowitz, M., Wishart, J. M., Jones, K. L., & Hebbard, G. S. (1996) · PubMed · Cited by 126 · see citing works
Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis
Warner, M. A. A., Meyerhoff, K. L., Warner, M. E., Posner, K. L., Stephens, L. S., & Domino, K. B. (2021) · Anesthesiology · doi:10.1097/aln.0000000000003831 · Cited by 115 · see citing works
Preoperative GLP-1 Receptor Agonist Use and Risk of Postoperative Respiratory Complications
Dixit, A. A., Bateman, B. T., Hawn, M. T., Odden, M. C., & Sun, E. C. (2024) · JAMA · doi:10.1001/jama.2024.5003 · Cited by 94 · see citing works
Anesthesia Considerations for a Patient on Semaglutide and Delayed Gastric Emptying
Fujino, E., Cobb, K. W., Schoenherr, J. W., Gouker, L. N., & Lund, E. T. (2023) · Cureus · doi:10.7759/cureus.42153 · Cited by 80 · see citing works
Hulst, A. H., Polderman, J. A. W., Siegelaar, S. E., van Raalte, D. H., DeVries, J. H., Preckel, B., & Hermanides, J. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.10.023 · Cited by 68 · see citing works
Klonoff, D. C., Kim, S. H., Galindo, R. J., Joseph, J. I., Garrett, V., Gombar, S., Aaron, R. E., Tian, T., & Kerr, D. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15636 · Cited by 58 · see citing works
Postoperative Pneumonia and Aspiration Pneumonia Following Elderly Hip Fractures
Ahn, J., Chang, J. S., & Kim, J. W. (2022) · The journal of nutrition health & aging · doi:10.1007/s12603-022-1821-9 · Cited by 47 · see citing works
Risk factors for fatal outcome in surgical patients with postoperative aspiration pneumonia
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“3 However, case reports have described intraoperative aspiration in appropriately fasted patients on semaglutide, 4 – 6 and small studies in people (mostly without diabetes) who used semaglutide found a three-to sevenfold increase in visible stomach contents on ultrasonography or during endoscopy…”
Should glucagon‐like peptide‐1 receptor agonist treatment be withheld in preoperative management?
Bloomgarden, Z. T. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13469 · Cited by 14 · see citing works
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El‐Boghdadly, K., Dhesi, J., Fabb, P., Levy, N., Lobo, D. N., McKechnie, A., Mustafa, O., Newland‐Jones, P., Patel, A., Pournaras, D. J., et al. (2025) · Anaesthesia · doi:10.1111/anae.16541 · Cited by 147 · see citing works
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Castrillon, J., Rele, S., Sumithran, P., Hii, M., Thuraisingam, S., Spelman, T., Phan, T., Choong, P., Dowsey, M., & Shadbolt, C. (2025) · Anaesthesia · doi:10.1111/anae.16601 · Cited by 65 · see citing works
Kamarajah, S. K., Gudiozzi, N., Findlay, J. M., Lee, M. J., Pinkney, T., & Markar, S. R. (2025) · eClinicalMedicine · doi:10.1016/j.eclinm.2025.103408 · Cited by 29 · see citing works
- Authors
- Welk, B., McClure, J. A., Carter, B., Clarke, C., Dubois, L., & Clemens, K. K.
- Affiliations
- Western University (CA)
- London Health Sciences Centre (CA)
- Institute for Clinical Evaluative Sciences (CA)
- Corresponding author
- Welk, Blayne
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2024-06-11
- Volume
- 26
- Issue
- 9
- Pages
- 4105-4110
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W4399545973
- Cited by
- 16
- References
- 18
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 1
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Obesity and Metabolism (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Ontario Ministry of Health and Long-Term Care
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Keywords
- semaglutide, postoperative pneumonia, diabetes mellitus, elective surgery, GLP-1 receptor agonists, surgical outcomes
- MeSH terms
- Semaglutide, Aged, Diabetes Mellitus, Type 2, Glucagon-Like Peptides, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Pneumonia, Postoperative Complications, Elective Surgical Procedures
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