Community-Acquired Methicillin-Resistant <EMPH TYPE="ITAL">Staphylococcus aureus</EMPH> in Children With No Identified Predisposing Risk
Abstract
Context Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections in children have occurred primarily in individuals with recognized predisposing risks. Community-acquired MRSA infections in the absence of identified risk factors have been reported infrequently. Objectives To determine whether community-acquired MRSA infections in children with no identified predisposing risks are increasing and to define the spectrum of disease associated with MRSA isolation. Design Retrospective review of medical records. Patients Hospitalized children with S aureus isolated between August 1988 and July 1990 (1988-1990) and between August 1993 and July 1995 (1993-1995). Setting The University of Chicago Children's Hospital. Main outcome measures Prevalence of community-acquired MRSA over time, infecting vs colonizing isolates, and risk factors for disease. Results The number of children hospitalized with community-acquired MRSA disease increased from 8 in 1988-1990 to 35 in 1993-1995. Moreover, the prevalence of community-acquired MRSA without identified risk increased from 10 per 100000 admissions in 1988-1990 to 259 per 100000 admissions in 1993-1995 (P Conclusions These findings demonstrate that the prevalence of community-acquired MRSA among children without identified risk factors is increasing.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The prevalence of community-acquired MRSA is increasing among young children, and intrafamilial transmission of isolates has been documented.
“The prevalence of CA-MRSA is increasing among young children, and intrafamilial transmission of isolates has been documented (11,12);”
From Postpartum Mastitis and Community-acquired Methicillin-resistant<i>Staphylococcus aureus</i> (2007) · cites this paper as [11]
Cited by
Sorted by citations
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192 · see citing works
Waves of resistance: Staphylococcus aureus in the antibiotic era
Chambers, H. F., & DeLeo, F. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2200 · Cited by 2,718 · see citing works
Methicillin-Resistant <i>S. aureus</i> Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285 · see citing works
David, M. Z., & Daum, R. S. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00081-09 · Cited by 1,972 · see citing works
Inadequate Antimicrobial Treatment of Infections
Kollef, M. H., Sherman, G., Ward, S., & Fraser, V. J. (1999) · Chest · doi:10.1378/chest.115.2.462 · Cited by 1,805 · see citing works
Liu, C., Bayer, A., Cosgrove, S. E., Daum, R. S., Fridkin, S. K., Gorwitz, R. J., Kaplan, S. L., Karchmer, A. W., Levine, D. P., Murray, B. E., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir034 · Cited by 1,599 · see citing works
Methicillin-Resistant <i>Staphylococcus aureus</i> Disease in Three Communities
Fridkin, S. K., Hageman, J. C., Morrison, M., Sanza, L. T., Como-Sabetti, K., Jernigan, J. A., Harriman, K., Harrison, L. H., Lynfield, R., & Farley, M. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043252 · Cited by 1,493 · see citing works
Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat
Zetola, N., Francis, J. S., Nuermberger, E. L., & Bishai, W. R. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70112-2 · Cited by 791 · see citing works
Prevalence of <i>Staphylococcus aureus</i> Nasal Colonization in the United States, 2001–2002
Kuehnert, M. J., Kruszon‐Moran, D., Hill, H. A., McQuillan, G., McAllister, S. K., Fosheim, G., McDougal, L. K., Chaitram, J., Jensen, B., Fridkin, S. K., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/499632 · Cited by 659 · see citing works
Voyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563 · see citing works
Oliveira, D. C., Tomasz, A., & de Lencastre, H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00227-x · Cited by 494 · see citing works
Frazee, B. W., Lynn, J., Charlebois, E. D., Lambert, L., Lowery, D., & Perdreau-Remington, F. (2005) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2004.10.011 · Cited by 494 · see citing works
Basis of Virulence in Community-Associated Methicillin-Resistant <i>Staphylococcus aureus</i>
Otto, M. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134309 · Cited by 457 · see citing works
Neutrophils in innate host defense against Staphylococcus aureus infections
Rigby, K. M., & DeLeo, F. R. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0295-3 · Cited by 400 · see citing works
Groom, A. V. (2001) · JAMA · doi:10.1001/jama.286.10.1201 · Cited by 360 · see citing works
Fridkin, S. K., Hageman, J., McDougal, L. K., Mohammed, J., Jarvis, W. R., Perl, T. M., Tenover, F. C., & the Vancomycin‐Intermediate Staphylococcus aureus Epidemiology Study Group (2003) · Clinical Infectious Diseases · doi:10.1086/346207 · Cited by 344 · see citing works
Eady, E. A., & Cove, J. H. (2003) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200304000-00007 · Cited by 329 · see citing works
Methicillin-resistant–<i>Staphylococcus aureus</i>Hospitalizations, United States
Kuehnert, M. J., Hill, H. A., Kupronis, B. A., Tokars, J. I., Solomon, S. L., & Jernigan, D. B. (2005) · Emerging Infectious Diseases · doi:10.3201/eid1106.040831 · Cited by 287 · see citing works
Methicillin-resistant<i>Staphylococcus aureus</i>in Community-acquired Skin Infections
Moran, G. J., Amii, R. N., Abrahamian, F. M., & Talan, D. A. (2005) · Emerging Infectious Diseases · doi:10.3201/eid1106.040641 · Cited by 278 · see citing works
Host defense and pathogenesis in Staphylococcus aureus infections
DeLeo, F. R., Diep, B. A., & Otto, M. (2009) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2008.10.003 · Cited by 269 · see citing works
“Two reports in the late 1990s marked the beginning of a new era in MRSA epidemiology.(7,8) Isolates”
BackgroundEleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look
Davydov, M., & Krikorian, A. D. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00181-1 · Cited by 256 · see citing works
Madhi, S. A., Petersen, K., Madhi, A., Khoosal, M., & Klugman, K. P. (2000) · Clinical Infectious Diseases · doi:10.1086/313925 · Cited by 254 · see citing works
Charlebois, E. D., Bangsberg, D. R., Moss, N. J., Moore, M. R., Moss, A. R., Chambers, H. F., & Perdreau-Remington, F. (2002) · Clinical Infectious Diseases · doi:10.1086/338069 · Cited by 245 · see citing works
Liu, C., Graber, C. J., Karr, M., Diep, B. A., Basuino, L., Schwartz, B. S., Enright, M. C., O’Hanlon, S. J., Thomas, J. C., Perdreau‐Remington, F., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/587893 · Cited by 205 · see citing works
Gorwitz, R. J. (2008) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31815819bb · Cited by 164 · see citing works
Chavez-Bueno, S., Bozdogan, B., Katz, K., Bowlware, K. L., Cushion, N., Cavuoti, D., Ahmad, N., McCracken, G. H., & Appelbaum, P. C. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.6.2283-2288.2005 · Cited by 124 · see citing works
Barbosa-Cesnik, C., Schwartz, K., & Foxman, B. (2003) · JAMA · doi:10.1001/jama.289.13.1609 · Cited by 105 · see citing works
A Postinfluenza Model of<i>Staphylococcus aureus</i>Pneumonia
Lee, M., Arrecubieta, C., Martin, F. J., Prince, A., Borczuk, A. C., & Lowy, F. D. (2010) · The Journal of Infectious Diseases · doi:10.1086/650204 · Cited by 90 · see citing works
Methicillin-Resistant Staphylococcus aureus Infection in the Texas Prison System
Baillargeon, J., Kelley, M. F., Leach, C. T., Baillargeon, G., & Pollock, B. H. (2004) · Clinical Infectious Diseases · doi:10.1086/383146 · Cited by 88 · see citing works
Postpartum Mastitis and Community-acquired Methicillin-resistant<i>Staphylococcus aureus</i>
Reddy, P., Qi, C., Zembower, T., Noskin, G. A., & Bolon, M. (2007) · Emerging Infectious Diseases · doi:10.3201/eid1302.060989 · Cited by 69 · see citing works
Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system
Farrand, A. J., Reniere, M. L., Ingmer, H., Frees, D., & Skaar, E. P. (2013) · Journal of Bacteriology · doi:10.1128/jb.00505-13 · Cited by 56 · see citing works
Reduction of Methicillin-Resistant<i>Staphylococcus aureus</i>Infection among Veterans in Atlanta
Stenehjem, E., Stafford, C., & Rimland, D. (2013) · Infection Control & Hospital Epidemiology · doi:10.1086/668776 · Cited by 14 · see citing works
- Authors
- Herold, B. C.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Herold, Betsy C.
- ORCID
- Herold, Betsy C.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1998-02-25
- Volume
- 279
- Issue
- 8
- Pages
- 593
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2097879657
- Cited by
- 1,412
- References
- 0
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 18 · 2023: 14 · 2022: 12 · 2021: 26 · 2020: 23 · 2019: 17 · 2018: 20 · 2017: 29 · 2016: 35 · 2015: 46 · 2014: 53 · 2013: 80 · 2012: 58
- FWCI
- 26.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Blowitz-Ridgeway Foundation
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Medicine › Infectious Diseases › Otolaryngology and Infectious Diseases
- Keywords
- community-acquired MRSA, methicillin-resistant Staphylococcus aureus, children, MRSA prevalence, MRSA colonization, MRSA infection, antimicrobial resistance, risk factors, hospitalized children
- MeSH terms
- Child, Child, Preschool, DNA, Bacterial, Female, Genes, Bacterial, Hospitalization, Humans, Infant, Male, Microbial Sensitivity Tests, Retrospective Studies, Risk Factors, Staphylococcal Infections, Staphylococcus aureus, Prevalence, Methicillin Resistance, Polymerase Chain Reaction, Electrophoresis, Gel, Pulsed-Field, Community-Acquired Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
