Cited by 1,268Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Näslund, Jan·2000·JAMA

DOI 10.1001/jama.283.12.1571

Open this paper in CoChat — free account

Abstract

CONTEXT: Alzheimer disease (AD) is characterized neuropathologically by the presence of amyloid beta-peptide (Abeta)-containing plaques and neurofibrillary tangles composed of abnormal tau protein. Considerable controversy exists as to whether the extent of accumulation of Abeta correlates with dementia and whether Abeta alterations precede or follow changes in tau. OBJECTIVES: To determine whether accumulation of Abeta correlates with the earliest signs of cognitive deterioration and to define the relationship between Abeta accumulation and early tau changes. DESIGN, SETTING, AND PATIENTS: Postmortem cross-sectional study of 79 nursing home residents with Clinical Dementia Rating (CDR) scale scores of 0.0 to 5.0 who died between 1986 and 1997, comparing the levels of Abeta variants in the cortices of the subjects with no (CDR score, 0.0 [n = 16]), questionable (CDR score, 0.5 [n = 11]), mild (CDR score, 1.0 [n = 22]), moderate (CDR score, 2.0 [n = 15]), or severe (CDR score, 4.0 or 5.0 [n = 15]) dementia. MAIN OUTCOME MEASURES: Levels of total Abeta peptides with intact or truncated amino termini and ending in either amino acid 40 (A(beta)x-40) or 42 (A(beta)x-42) in 5 neocortical brain regions as well as levels of tau protein undergoing early conformational changes in frontal cortex, as a function of CDR score. RESULTS: The levels of both A(beta)x-40 and A(beta)x-42 were elevated even in cases classified as having questionable dementia (CDR score = 0.5), and increases of both peptides correlated with progression of dementia. Levels of the more fibril-prone A(beta)x-42 peptide were higher than those of A(beta)x-40 in nondemented cases and remained higher throughout progression of disease in all regions examined. Finally, increases in A(beta)x-40 and A(beta)x-42 precede significant tau pathology at least in the frontal cortex, an area chosen for examination because of the absence of neuritic changes in the absence of disease. CONCLUSIONS: In this study, levels of total A(beta)x-40 and A(beta)x-42 were elevated early in dementia and levels of both peptides were strongly correlated with cognitive decline. Of particular interest, in the frontal cortex, Abeta was elevated before the occurrence of significant tau pathology. These results support an important role for Abeta in mediating initial pathogenic events in AD dementia and suggest that treatment strategies targeting the formation, accumulation, or cytotoxic effects of Abeta should be pursued.

Integrity signals

Registry

Crossref · 10.1001/jama.283.12.1571

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
Jarrett, J. T., & Lansbury, P. T. (1993) · Cell · doi:10.1016/0092-8674(93)90635-4 · Cited by 2,178
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370
Mechanisms of Neuronal Degeneration in Alzheimer's Disease
Yankner, B. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80115-4 · Cited by 953
Alzheimer's Disease--Genotypes, Phenotype, and Treatments
Selkoe, D. J. (1997) · Science · doi:10.1126/science.275.5300.630 · Cited by 879
Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
Haass, C., & Selkoe, D. J. (1993) · Cell · doi:10.1016/0092-8674(93)90312-e · Cited by 686
Tau protein pathology in neurodegenerative diseases
Spillantini, M. G., & Goedert, M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01337-x · Cited by 683
Neurochemical Correlates of Dementia Severity in Alzheimer's Disease: Relative Importance of the Cholinergic Deficits
Bierer, L. M., Haroutunian, V. H., Gabriel, S., Knott, P. J., Carlin, L. S., Purohit, D. P., Perl, D. P., Schmeidler, J., Kanof, P. D., & Davis, K. L. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020749.x · Cited by 580

Show all 28 references

Sorted by citations

Items 401–500 of 1,000

Insulin inhibits amyloid β-induced cell death in cultured human brain pericytes
Rensink, A. A. M., Otte‐Höller, I., de Boer, R., Bosch, R. R., ten Donkelaar, H. J., de Waal, R. M. W., Verbeek, M. M., & Kremer, B. P. H. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00039-3 · Cited by 82
Murine models of Alzheimer's disease and their use in developing immunotherapies
Wısnıewskı, T., & Sigurdsson, E. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.05.004 · Cited by 84
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
Klunk, W. E., Mathis, C. A., Price, J. C., Lopresti, B. J., & DeKosky, S. T. (2006) · Brain · doi:10.1093/brain/awl281 · Cited by 80
Can exercise training teach us how to treat Alzheimer's disease?
Huuha, A. M., Norevik, C. S., Moreira, J. B. N., Kobro-Flatmoen, A., Scrimgeour, N., Kivipelto, M., Van Praag, H., Ziaei, M., Sando, S. B., Wisløff, U., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101559 · Cited by 79
Functional, Global and Cognitive Decline Correlates to Accumulation of Alzheimers Pathology in MCI and AD
Sabbagh, M. N., Cooper, K., DeLange, J., Stoehr, J. D., Thind, K., Lahti, T., Reisberg, B., Sue, L., Vedders, L., Fleming, S. R., et al. (2010) · Current Alzheimer Research · doi:10.2174/156720510791162340 · Cited by 79
APP transgenic mice: their use and limitations
Balducci, C., & Forloni, G. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8141-7 · Cited by 79
A lysosome-targeting dual-functional fluorescent probe for imaging intracellular viscosity and beta-amyloid
Tan, H.-Y., Qiu, Y.-T., Sun, H., Yan, J., & Zhang, L. (2019) · Chemical Communications · doi:10.1039/c9cc00113a · Cited by 79
The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer’s disease
Karl, T., Garner, B., & Cheng, D. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000247 · Cited by 83
Neurotoxic β-amyloid oligomers cause mitochondrial dysfunction—the trigger for PANoptosis in neurons
Meng, X., Song, Q., Liu, Z., Liu, X., Wang, Y., & Liu, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1400544 · Cited by 84
β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR‐α, PPAR‐γ and TRPV1, but not CB1 or CB2 receptors
Benito, C., Tolón, R. M., Castillo, A. I., Ruiz‐Valdepeñas, L., Martínez-Orgado, J. A., Fernández, J., Vázquez, C., Cravatt, B. F., & Romero, J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01889.x · Cited by 81
Biochemical Characterization of Aβ and Tau Pathologies in Mild Cognitive Impairment and Alzheimer's Disease
Tremblay, C., Pilote, M., Phivilay, A., Émond, V., Bennett, D. A., & Calon, F. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12411 · Cited by 78
Change in plasma Aβ peptides and onset of dementia in adults with Down syndrome
Schupf, N., Zigman, W. B., Tang, M. X., Pang, D. I., Mayeux, R. P., Mehta, P. D., & Silverman, W. P. (2010) · Neurology · doi:10.1212/wnl.0b013e3181fb448b · Cited by 81
Virtual Screening for β-Secretase (BACE1) Inhibitors Reveals the Importance of Protonation States at Asp32 and Asp228
Polgár, T., & Keserű, G. M. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm049133b · Cited by 78
Using model membranes for the study of amyloid beta:lipid interactions and neurotoxicity
Vestergaard, M. C. M., Hamada, T., & Takagi, M. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21731 · Cited by 79
Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer’s disease in mice
El‐Shiekh, R. A., Ashour, R. M. S., El-Haleim, E. A. A., Ahmed, K. A., & Abdel-Sattar, E. A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110303 · Cited by 78
Secretion and Intracellular Generation of Truncated Aβ in β-Site Amyloid-β Precursor Protein-cleaving Enzyme Expressing Human Neurons
Lee, E. B., Skovronsky, D., Abtahian, F., Doms, R. W., & Lee, V. M. ‐. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210105200 · Cited by 78
Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model
Cushman-Nick, M., Bonini, N. M., & Shorter, J. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003781 · Cited by 80
Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-β levels in female rats
Berry, A. S., Tomidokoro, Y., Ghiso, J. A., & Thornton, J. E. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.02.006 · Cited by 79
Oligomers of the amyloid-β protein disrupt working memory: Confirmation with two behavioral procedures
Poling, A. D., Morgan-Paisley, K., Panos, J., Kim, E., O‘Hare, E., Cleary, J. P., Lesné, S., Ashe, K. H., Porritt, M., & Baker, L. E. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.001 · Cited by 77
Sex-Dependent Alterations in Social Behaviour and Cortical Synaptic Activity Coincide at Different Ages in a Model of Alzheimer’s Disease
Bories, C., Guitton, M. J., Julien, C., Tremblay, C., Vandal, M., Msaid, M., Koninck, Y. D., & Calon, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046111 · Cited by 80
An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide
Bolognin, S., Blanchard, J., Wang, X., Basurto‐Islas, G., Tung, Y. C., Kohlbrenner, E., Grundke, I., & Iqbal, K. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0908-x · Cited by 80
Green tea catechin leads to global improvement among Alzheimer's disease-related phenotypes in NSE/hAPP-C105 Tg mice
Lim, H. J., Shim, S. B., Jee, S. W., Lee, S. H., Lim, C. J., Hong, J. T., Sheen, Y. Y., & Hwang, D. Y. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.10.005 · Cited by 77
Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria
Godoy, J. A., Lindsay, C. B., Quintanilla, R. A., Carvajal, F. J., Cerpa, W. F., & Inestrosa, N. C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0203-x · Cited by 78
Cholinesterase inhibitors, β-amyloid precursor protein and amyloid β-peptides in Alzheimer's disease
Lahiri, D. K., Farlow, M. R., Hintz, N., Utsuki, T., & Greig, N. H. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.00309.x · Cited by 77
Small-molecule BACE1 inhibitors: a patent literature review (2006 – 2011)
Probst, G. D., & Xu, Y. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.681302 · Cited by 76
Risk Factors for Alzheimer’s Disease: Role of Multiple Antioxidants, Non-Steroidal Anti-inflammatory and Cholinergic Agents Alone or in Combination in Prevention and Treatment
Prasad, K. N., Cole, W. C., & Prasad, K. C. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719249 · Cited by 76
Membrane‐bound tetramer and trimer Aβ oligomeric species correlate with toxicity towards cultured neurons
Jana, M. K., Cappai, R., Pham, C. L. L., & Ciccotosto, G. D. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13443 · Cited by 76
Synthesis and Structure−Affinity Relationships of Novel Dibenzylideneacetone Derivatives as Probes for β-Amyloid Plaques
Cui, M., Ono, M., Kimura, H., Liu, B., & Saji, H. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101404k · Cited by 76
β-Amyloid Protein Structure Determines the Nature of Cytokine Release From Rat Microglia
Lindberg, C., Selenica, M. B., Westlind‐Danielsson, A., & Schultzberg, M. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:27:1:001 · Cited by 76
Current pharmacotherapy and putative disease-modifying therapy for Alzheimer’s disease
Kulshreshtha, A., & Piplani, P. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2625-7 · Cited by 76
Rodent Models of Amyloid-Beta Feature of Alzheimer’s Disease: Development and Potential Treatment Implications
Poon, C. H., Wang, Y., Fung, M., Zhang, C., & Lim, L. W. (2020) · Aging and Disease · doi:10.14336/ad.2019.1026 · Cited by 76
Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
Sowade, R. F., & Jahn, T. R. (2017) · Nature Communications · doi:10.1038/s41467-017-00579-4 · Cited by 78
Intracellular A-Beta Amyloid, A Sign for Worse Things to Come?
Echeverría, V., & Cuello, A. C. (2002) · Molecular Neurobiology · doi:10.1385/mn:26:2-3:299 · Cited by 81
Advances in microfluidics-based experimental methods for neuroscience research
Park, J. W., Kim, H. J., Kang, M. W., & Jeon, N. L. (2013) · Lab on a Chip · doi:10.1039/c2lc41081h · Cited by 77
Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease
Kobro‐Flatmoen, A., Nagelhus, A., & Witter, M. P. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.012 · Cited by 78
Doxycycline for Alzheimer’s Disease: Fighting β-Amyloid Oligomers and Neuroinflammation
Balducci, C., & Forloni, G. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00738 · Cited by 74
Importance of Bioactive Substances in Sheep’s Milk in Human Health
Flis, Z., & Molik, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094364 · Cited by 74
Plasma Aβ42 correlates positively with increased body fat in healthy individuals
Balakrishnan, K., Verdile, G., Mehta, P. D., Beilby, J. P., Nolan, D. A., Galvao, D. A., Newton, R. U., Gandy, S., & Martins, R. N. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8305 · Cited by 76
Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models
Bouter, Y., López‐Noguerola, J. S., Tucholla, P., Crespi, G. A. N., Parker, M. W., Wiltfang, J., Miles, L. A., & Bayer, T. A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1489-x · Cited by 74
A Darwinian-evolutionary concept of age-related diseases
Wick, G., Berger, P., Jansen‐Dürr, P., & Grubeck‐Loebenstein, B. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00161-4 · Cited by 74
Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer’s disease models
Shim, H. S., Horner, J. W., Wu, C.-J., Li, J., Lan, Z. D., Jiang, S., Xu, X., Hsu, W.-H., Zal, T., Flores, I. I., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00146-z · Cited by 73
Exposure to low-dose ambient fine particulate matter PM2.5 and Alzheimer’s disease, non-Alzheimer’s dementia, and Parkinson’s disease in North Carolina
Rhew, S. H., Kravchenko, J. S., & Lyerly, H. K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253253 · Cited by 77
Trajectory of Cognitive Decline as a Predictor of Psychosis in Early Alzheimer Disease in the Cardiovascular Health Study
Emanuel, J. E., López, O. L., Houck, P. R., Becker, J. T., Weamer, E. A., DeMichele‐Sweet, M. A. A., Kuller, L. H., & Sweet, R. A. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181e446c8 · Cited by 73
A Method for Evaluating the Level of Soluble β‐Amyloid(1–40/1–42) in Alzheimer’s Disease Based on the Binding of Gelsolin to β‐Amyloid Peptides
Yu, Y., Zhang, L., Li, C., Sun, X., Tang, D., & Shi, G. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201405001 · Cited by 74
Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly
Malek-Ahmadi, M., Perez, S. E., Chen, K., & Mufson, E. J. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160365 · Cited by 73
Dementia: Alzheimer pathology and vascular factors: From mutually exclusive to interaction
van Norden, A. G. W., van Dijk, E. J., de Laat, K. F., Scheltens, P., Olde-Rikkert, M. G. M., & de Leeuw, F. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.07.003 · Cited by 75
Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system
Zheng, L. P., Cedazo-Mı́nguez, Á., Hallbeck, M., Jerhammar, F., Marcusson, J. O., & Terman, A. (2012) · Translational Neurodegeneration · doi:10.1186/2047-9158-1-19 · Cited by 73
Beta-amyloid peptide - nicotinic acetylcholine receptor interaction: the two faces of health and disease
Kelly, T. D. (2007) · Frontiers in bioscience · doi:10.2741/2445 · Cited by 72
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro
Balleza‐Tapia, H., Crux, S., Andrade‐Talavera, Y., Dolz-Gaitón, P., Papadia, D., Chen, G., Johansson, J., & Fisahn, A. (2018) · eLife · doi:10.7554/elife.37703 · Cited by 72
Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment
Grundman, M., Jack, C. R., Petersen, R. C., Kim, H. T., Taylor, C., Datvian, M., Weiner, M., DeCarli, C. S., DeKosky, S. T., van Dyck, C. H., et al. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:3:241 · Cited by 77
Oxidative protein damage and the proteasome
Grimm, S., Höhn, A., & Grune, T. (2010) · Amino Acids · doi:10.1007/s00726-010-0646-8 · Cited by 73
Changes in PGC‐1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model
Panes-Fernández, J., Godoy, P. A., Silva-Grecchi, T., Celis, M. T., Ramírez-Molina, O., Gavilán, J., Muñoz-Montesino, C., Castro, P. A., Moraga‐Cid, G., Yévenes, G. E., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00709 · Cited by 71
Beta‐amyloid protein (25–35) disrupts hippocampal network activity: Role of Fyn‐kinase
Peña‐Ortega, F., Ordaz, B., Balleza‐Tapia, H., Bernal‐Pedraza, R., Márquez‐Ramos, A., Carmona‐Aparicio, L., & Giòrdano, M. (2009) · Hippocampus · doi:10.1002/hipo.20592 · Cited by 71
Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan
Fu, Y., Zhao, J., Atagi, Y., Nielsen, H. M., Liu, C.-C., Zheng, H., Shinohara, M., Kanekiyo, T., & Bu, G. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0099-y · Cited by 69
Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease
Olajide, O. J., Suvanto, M. E., & Chapman, C. A. (2021) · Biology Open · doi:10.1242/bio.056796 · Cited by 77
Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing
Dolan, D., Troncoso, J., Resnick, S. M., Crain, B. J., Zonderman, A. B., & O'Brien, R. J. (2010) · Brain · doi:10.1093/brain/awq141 · Cited by 70
Deferoxamine enhances alternative activation of microglia and inhibits amyloid beta deposits in APP/PS1 mice
Zhang, Y., & He, M. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.019 · Cited by 71
Biomarkers for early diagnosis of Alzheimer disease: ‘ALZheimer ASsociated gene’– a new blood biomarker?
Jellinger, K. A., Janetzky, B., Attems, J., & Kienzl, E. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00313.x · Cited by 72
Pathological Determinants of the Transition to Clinical Dementia in Alzheimer's Disease
Royall, D. R., Palmer, R. F., Mulroy, A. R., Polk, M. J., Román, G. C., David, J. P., & Delacourte, A. (2002) · Experimental Aging Research · doi:10.1080/03610730252800166 · Cited by 71
Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology
Hashimoto, M., Bogdanovic, N., Volkmann, I., Aoki, M., Winblad, B., & Tjernberg, L. O. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0661-6 · Cited by 69
Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw
Hwang, D. Y., Cho, J. S., Lee, S. H., Chae, K. R., Lim, H. J., Min, S. H., Seo, S. J., Song, Y. S., Song, C. W., Paik, S. G., et al. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2003.09.021 · Cited by 69
Cortical α7 Nicotinic Acetylcholine Receptor and β-Amyloid Levels in Early Alzheimer Disease
Ikonomović, M. D., Wecker, L., Abrahamson, E. E., Wuu, J., Counts, S., Ginsberg, S. D., Mufson, E. J., & DeKosky, S. T. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.46 · Cited by 72
The hypothalamus as the primary brain region of metabolic abnormalities in APP/PS1 transgenic mouse model of Alzheimer's disease
Zheng, H. X., Zhou, Q., Du, Y., Li, C., Xu, P., Li, L., Xiao, J., & Gao, H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.10.028 · Cited by 71
Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Aβ peptide
Buxbaum, J. D., Geoghagen, N. S. M., & Friedhoff, L. T. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3207 · Cited by 69
The Protease Inhibitor, MG132, Blocks Maturation of the Amyloid Precursor Protein Swedish Mutant Preventing Cleavage by β-Secretase
Steinhilb, M. L., Turner, R. S., & Gaut, J. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008793200 · Cited by 69
Broad-Spectrum Effects of 4-Aminopyridine to Modulate Amyloid β1–42-Induced Cell Signaling and Functional Responses in Human Microglia
Franciosi, S., Ryu, J. K., Choi, H. B., Radov, L. A., Kim, S. U., & McLarnon, J. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2490-06.2006 · Cited by 69
A amyloid deposition in the language system and how the brain responds
Nelissen, N., Vandenbulcke, M., Fannes, K., Verbruggen, A., Peeters, R. R., Dupont, P. J., Laere, K. V., Bormans, G. M., & Vandenberghe, R. R. (2007) · Brain · doi:10.1093/brain/awm133 · Cited by 70
Clinical Validity of Aß-Protein Deposition Staging in Brain Aging and Alzheimer Disease
Gold, G., Kövari, E., Corte, G., Herrmann, F. R., Canuto, A., Bussière, T., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.10.946 · Cited by 67
Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions
Villemagne, V. L., & Okamura, N. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.09.002 · Cited by 70
Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats
Stefanova, N. A., Muraleva, N. A., Korbolina, E. E., Владимировна, К. Е., Maksimova, K. Y., & Kolosova, N. G. (2014) · Oncotarget · doi:10.18632/oncotarget.2751 · Cited by 66
Autophagy Modulation for Alzheimer’s Disease Therapy
Zhu, X., Yu, J., Jiang, T., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8457-z · Cited by 66
Prion neurodegeneration
Mallucci, G. R. (2009) · Prion · doi:10.4161/pri.3.4.9981 · Cited by 66
Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue
Lemoine, L., Saint‐Aubert, L., Marutle, A., Antoni, G., Eriksson, J., Ghetti, B. F., Okamura, N., Nennesmo, I., Gillberg, P.-G., & Nordberg, A. K. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0220-4 · Cited by 65
Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease
Funalot, B., Ouimet, T., Clapéron, A., Fallet‐Bianco, C., Delacourte, A., Epelbaum, J., Subkowski, T., Léonard, N., Codron, V., David, J. P., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001584 · Cited by 65
Glucocorticoids Facilitate Astrocytic Amyloid-β Peptide Deposition by Increasing the Expression of APP and BACE1 and Decreasing the Expression of Amyloid-β-Degrading Proteases
Wang, Y., Li, M., Tang, J., Song, M., Xu, X., Xiong, J., Li, J., & Bai, Y. (2011) · Endocrinology · doi:10.1210/en.2011-0145 · Cited by 66
Disaggregation of Amyloid Plaque in Brain of Alzheimer’s Disease Transgenic Mice with Daily Subcutaneous Administration of a Tetravalent Bispecific Antibody That Targets the Transferrin Receptor and the Abeta Amyloid Peptide
Sumbria, R. K., Hui, E. K., Lu, J. Z., Boado, R. J., & Pardridge, W. M. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400348n · Cited by 65
Total saponins from Rhizoma Anemarrhenae ameliorate diabetes-associated cognitive decline in rats: Involvement of amyloid-beta decrease in brain
Liu, Y., Zhu, X., Lü, Q., Wang, J., Li, W., Wei, Y., & Yin, X. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.11.004 · Cited by 65
Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics
Cocciolo, A., Domenico, F. D., Coccia, R., Fiorini, A., Cai, J., Pierce, W. M. J., Mecocci, P., Butterfield, D. A., & Marzia Perluigi, A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.596 · Cited by 65
Assessments of the accumulation severities of amyloid β-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
Zhou, X., Li, X., Björkdahl, C., Sjögren, M. J. C., Alafuzoff, I. I., Soininen, H. S., Grundke, I., Iqbal, K., Winblad, B. G., & Pei, J.-J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.01.006 · Cited by 65
Trehalose against Alzheimer's Disease: Insights into a Potential Therapy
Khalifeh, M., Read, M. I., Barreto, G. E., & Sahebkar, A. (2020) · BioEssays · doi:10.1002/bies.201900195 · Cited by 67
Amyloid and Alzheimer's Disease: Inside and Out
Tam, J. H. K., & Pasternak, S. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100013408 · Cited by 64
Polyfluorinated Bis-styrylbenzene β-Amyloid Plaque Binding Ligands
Flaherty, D. P., Walsh, S. M., Kiyota, T., Dong, Y., Ikezu, T., & Vennerstrom, J. L. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070085f · Cited by 64
Reducing Amyloid-Related Alzheimer's Disease Pathogenesis by a Small Molecule Targeting Filamin A
Wang, H.-Y., Bakshi, K. P., Frankfurt, M., Stucky, A., Goberdhan, M., Shah, S. M., & Burns, L. H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0354-12.2012 · Cited by 64
Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease
Cheng, D., Logge, W., Low, J. K., Garner, B., & Karl, T. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.008 · Cited by 69
Extracellular chaperones modulate the effects of Alzheimer’s patient cerebrospinal fluid on Aβ1-42 toxicity and uptake
Yerbury, J. J., & Wilson, M. R. (2009) · Cell Stress and Chaperones · doi:10.1007/s12192-009-0122-0 · Cited by 65
Amyloid imaging: Past, present and future perspectives
Villemagne, V. L. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.005 · Cited by 68
μ-Amyloid Peptide-induced Apoptosis Regulated by a Novel Protein Containing a G Protein Activation Module
Kajkowski, E. M., Lo, C. F., Ning, X., Walker, S., Sofia, H. J., Wang, W., Edris, W., Chanda, P., Wagner, E., Vile, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011161200 · Cited by 63
Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide
Tamagnini, F., Scullion, S., Brown, J. T., & Randall, A. D. (2014) · Hippocampus · doi:10.1002/hipo.22403 · Cited by 66
Spontaneous in Vitro Formation of Supramolecular β-Amyloid Structures, “βamy Balls”, by β-Amyloid 1−40 Peptide
Westlind‐Danielsson, A., & Arnerup, G. (2001) · Biochemistry · doi:10.1021/bi010375c · Cited by 63
Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier
Pardridge, W. M. (2023) · Frontiers in Drug Delivery · doi:10.3389/fddev.2023.1227816 · Cited by 62
Gonadotropins and Cognition in Older Women
Rodrigues, M. A., Verdile, G., Foster, J. K., Hogervorst, E., Joesbury, K. A., Dhaliwal, S. S., Corder, E. H., Laws, S. M., Hone, E., Prince, R. L., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13304 · Cited by 64
A Mathematical Model of the Impact of Novel Treatments on the AβBurden in the Alzheimer's Brain, CSF and Plasma
Craft, D. (2002) · Bulletin of Mathematical Biology · doi:10.1006/bulm.2002.0304 · Cited by 64
Increased susceptibility to Aβ toxicity in neuronal cultures derived from familial Alzheimer’s disease (PSEN1-A246E) induced pluripotent stem cells
Armijo, E., González, C., Shahnawaz, M., Flores, A., Davis, B. R., & Soto, C. A. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.060 · Cited by 61
Amyloid Imaging with PET in Early Alzheimer Disease Diagnosis
Rowe, C. C., & Villemagne, V. L. (2013) · Medical Clinics of North America · doi:10.1016/j.mcna.2012.12.017 · Cited by 62
Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures
Couturier, J., Paccalin, M., Morel, M., Terro, F., Milin, S., Pontcharraud, R., Fauconneau, B., & Page, G. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-72 · Cited by 65
Endocytic pathways mediating oligomeric Aβ42 neurotoxicity
Yu, C., Nwabuisi‐Heath, E., Laxton, K., & LaDu, M. J. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-19 · Cited by 63
The Role of Neurotrophins in Brain Aging: A Perspective in Honor of Regino Perez-Polo
Cotman, C. W. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6960-y · Cited by 61
Stabilization of discordant helices in amyloid fibril‐forming proteins
Päiviö, A., Nordling, E., Kallberg, Y., Thyberg, J., & Johansson, J. (2004) · Protein Science · doi:10.1110/ps.03442404 · Cited by 61
Gadolinium-based contrast agents targeted to amyloid aggregates for the early diagnosis of Alzheimer's disease by MRI
Bort, G., Catoen, S., Borderies, H., Kebsi, A., Ballet, S., Louin, G., Port, M., & Ferroud, C. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.10.016 · Cited by 62
The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain
McDonald, J. M., Cairns, N. J., Taylor‐Reinwald, L., Holtzman, D. M., & Walsh, D. M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.02.041 · Cited by 61

Authors: Näslund, J.
Affiliations: Rockefeller University (US)
Corresponding author: Näslund, Jan
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2000-03-22
Volume: 283
Issue: 12
Pages: 1571
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.283.12.1571
OpenAlex: W2000706612
Cited by: 1,268
References: 28
Citations by year: 2026: 9 · 2025: 14 · 2024: 32 · 2023: 23 · 2022: 28 · 2021: 32 · 2020: 31 · 2019: 29 · 2018: 34 · 2017: 29 · 2016: 57 · 2015: 56 · 2014: 60 · 2013: 59 · 2012: 65
FWCI: 40.95
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-02219, AG 05138, P50AG005138, AG 14996, P01AG002219)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta, Alzheimer's disease, cognitive decline, dementia progression, tau protein, amyloid-beta 42, Aβ40, frontal cortex, Clinical Dementia Rating, postmortem brain, neocortex, nursing home residents, amyloid plaques, neurofibrillary tangles
MeSH terms: Aged, Aged, 80 and over, Brain, Cognition Disorders, Cross-Sectional Studies, Dementia, Enzyme-Linked Immunosorbent Assay, Female, Frontal Lobe, Humans, Immunoenzyme Techniques, Male, Immunoblotting, Amyloid beta-Peptides, tau Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks