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Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan
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ApoE3 or apoE4 competes with Aβ for the association with cell-surface HSPGs.
“Indeed, apoE3 or apoE4 competes with Aβ for the association with cell-surface HSPGs (23).”
From APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1 (2019) · cites this paper as [23]
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Metadata
- Authors
- Fu, Y., Zhao, J., Atagi, Y., Nielsen, H. M., Liu, C.-C., Zheng, H., Shinohara, M., Kanekiyo, T., & Bu, G.
- Venue
- Molecular Neurodegeneration
- Published
- 2016-05-05
- Volume
- 11
- Issue
- 1
- ISSN
- 1750-1326
- PMC
- PMC4857252
- Cited by
- 69
- References
- 26
- Language
- en
- Funders
- National Institutes of Health (R01AG035355, P01AG030128)
- Alzheimer’s Association
- Alzheimer’s Association NIRG
- Mayo Clinic CRM Career Development Award
- National Natural Science Foundation of China (81500917)
- The Science Fund for Distinguished Young Scholars from the Fourth Affiliated Hospital of Harbin Medical University (HYDSYJQ201501)
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