Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works

Phases of Aβ-deposition in the human brain and its relevance for the development of AD

Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022 · see citing works

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611 · see citing works

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526 · see citing works

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works

A Stable Nonfluorescent Derivative of Resorufin for the Fluorometric Determination of Trace Hydrogen Peroxide: Applications in Detecting the Activity of Phagocyte NADPH Oxidase and Other Oxidases

Zhou, M., Diwu, Z. J., Panchuk-Voloshina, N., & Haugland, R. P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2391 · Cited by 1,400 · see citing works

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294 · see citing works

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268 · see citing works

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038 · see citing works

Intraneuronal Aβ42 Accumulation in Human Brain

Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., et al. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64700-1 · Cited by 991 · see citing works

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

Klein, W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01749-5 · Cited by 989 · see citing works

Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

Gravina, S. A., Ho, L., Eckman, C. B., Long, K. E., Otvos, L., Younkin, L. H., Suzuki, N., & Younkin, S. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7013 · Cited by 676 · see citing works

Neuropathologic changes in Alzheimer's disease.

Wenk, G. L. (2003) · PubMed · Cited by 554 · see citing works

Clearing the brain's amyloid cobwebs

Selkoe, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00475-5 · Cited by 541 · see citing works

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

Hashimoto, M., Rockenstein, E. M., Crews, L. A., & Masliah, E. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:4:1-2:21 · Cited by 498 · see citing works

The importance of neuritic plaques and tangles to the development and evolution of AD

Tiraboschi, P., Hansen, L. A., Thal, L. J., & Corey-Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000129697.01779.0a · Cited by 477 · see citing works

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer’s disease

D'Andrea, M. R., Nagele, R. G., Wang, H., Peterson, P. A., & Lee, D. H. S. (2001) · Histopathology · doi:10.1046/j.1365-2559.2001.01082.x · Cited by 390 · see citing works

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide

Yasojima, K., Akiyama, H., McGeer, E. G., & McGeer, P. L. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01675-x · Cited by 357 · see citing works

Physical, morphological and functional differences between ph 5.8 and 7.4 aggregates of the Alzheimer's amyloid peptide Abeta.

Wood, S. J., Maleeff, B., Hart, T., & Wetzel, R. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0133 · Cited by 337 · see citing works

Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease.

Joachim, C. L., Morris, J. H., & Selkoe, D. J. (1989) · PubMed · Cited by 336 · see citing works

Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

Wirths, O., Multhaup, G., Czech, C., Blanchard, V., Moussaoui, S., Tremp, G., Pradier, L., Beyreuther, K., & Bayer, T. A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01876-6 · Cited by 336 · see citing works

Age- and region-dependent alterations in Aβ-degrading enzymes: implications for Aβ-induced disorders

Caccamo, A., Oddo, S., Sugarman, M. C., Akbari, Y., & LaFerla, F. M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.013 · Cited by 299 · see citing works

Fluorometric method for the enzymatic determination of cholesterol

Amundson, D. M., & Zhou, M. (1999) · Journal of Biochemical and Biophysical Methods · doi:10.1016/s0165-022x(98)00036-0 · Cited by 282 · see citing works

Intraneuronal Aβ42 accumulation in Down syndrome brain: Original Articles

Mori, C., Spooner, E. T., Wisniewski, K. E., Wisniewski, T. M., Yamaguchi, H., Saido, T. C., Tolan, D. R., Selkoe, D. J., & Lemere, C. A. (2002) · Amyloid · doi:10.3109/13506120208995241 · Cited by 255 · see citing works

Intracellular Accumulation of Amyloidogenic Fragments of Amyloid-β Precursor Protein in Neurons with Niemann-Pick Type C Defects Is Associated with Endosomal Abnormalities

Jin, L., Maezawa, I., Vincent, I. J., & Bird, T. D. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63185-9 · Cited by 212 · see citing works

Aβ-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

Eckman, C. B., & Eckman, E. A. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051101 · Cited by 201 · see citing works

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

Wirths, O., Breyhan, H., Cynis, H., Schilling, S., Demuth, H.-U., & Bayer, T. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0557-5 · Cited by 174 · see citing works

The Amyloid β Peptide (Aβ 1 - 40 ) Is Thermodynamically Soluble at Physiological Concentrations

Sengupta, P., Garai, K., Sahoo, B., Shi, Y., Callaway, D. J. E., & Maiti, S. (2003) · Biochemistry · doi:10.1021/bi0341410 · Cited by 166 · see citing works

Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains

Welander, H., Frånberg, J., Graff, C., Sundström, E., Winblad, B. G., & Tjernberg, L. O. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06170.x · Cited by 147 · see citing works

Parenchymal and vascular Aβ‐deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease

Thal, D. R., Griffin, W. S. T., & Braak, H. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00411.x · Cited by 134 · see citing works

Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

Christensen, D. Z., Kraus, S. L., Flohr, A., Cotel, M.-C., Wirths, O., & Bayer, T. A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0451-6 · Cited by 126 · cited 1× · see citing works

Aβ-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

Eckman, E. A., & Eckman, C. B. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331101 · Cited by 116 · see citing works

The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils.

Nordstedt, C., Näslund, J., Tjernberg, L. O., Karlström, A. R., Thyberg, J., & Terenius, L. Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47347-4 · Cited by 103 · see citing works

Cerebellar diffuse amyloid plaques are derived from dendritic Aβ42 accumulations in Purkinje cells

Wang, H.-Y., D’Andrea, M. R., & Nagele, R. G. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00279-2 · Cited by 80 · see citing works

Intracellular A-Beta Amyloid, A Sign for Worse Things to Come?

Echeverrı́a, V., & Cuello, A. C. (2002) · Molecular Neurobiology · doi:10.1385/mn:26:2-3:299 · Cited by 75 · see citing works

Amyloid β-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain

Aoki, M., Volkmann, I., Tjernberg, L. O., Winblad, B., & Bogdanovic, N. (2008) · NeuroReport · doi:10.1097/wnr.0b013e328302c858 · Cited by 53 · see citing works

Protein markers for Alzheimer disease in the frontal cortex and cerebellum

Verdile, G., Gnjec, A., Miklossy, J., Fonte, J., Veurink, G., Bates, K. A., Kakulas, B. A., Mehta, P. D., Milward, E. A., Tan, N., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000141848.45315.a6 · Cited by 32 · see citing works

Ex Situ Atomic Force Microscopy Analysis of β-Amyloid Self-Assembly and Deposition on a Synthetic Template

Ha, C., & Park, C. B. (2006) · Langmuir · doi:10.1021/la0601511 · Cited by 30 · see citing works

A Resorufin-Based Fluorescent Assay for Quantifying NADH

Batchelor, R. H., & Zhou, M. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5596 · Cited by 19 · see citing works

Metabolites of Cerebellar Neurons and Hippocampal Neurons Play Opposite Roles in Pathogenesis of Alzheimer's Disease

Du, J., Sun, B., Chen, K., Zhang, L., Liu, S., Gu, Q., Li, F., Zhao, N., & Wang, Z. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005530 · Cited by 15 · see citing works

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works

Alzheimer’s disease: Clinical trials and drug development

Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P., & Kivipelto, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70119-8 · Cited by 1,217 · see citing works

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

Gouras, G. K., Tampellini, D., Takahashi, R. H., & Capetillo-Zarate, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0679-9 · Cited by 372 · see citing works

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

Thibaudeau, T. A., Anderson, R. T., & Smith, D. M. (2018) · Nature Communications · doi:10.1038/s41467-018-03509-0 · Cited by 356 · see citing works

Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer’s disease

Drummond, E., Nayak, S., Faustin, A., Pires, G., Hickman, R. A., Askenazi, M., Cohen, M., Haldiman, T., Kim, C., Han, X., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1691-0 · Cited by 239 · see citing works

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

Schedin‐Weiss, S., Inoue, M., Hromádková, L., Teranishi, Y., Yamamoto, N. G., Wiehager, B., Bogdanović, N., Winblad, B. G., Matton, A., Frykman, S., et al. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0279-1 · Cited by 237 · see citing works

Amyloid precursor protein processing and bioenergetics

Wilkins, H., & Swerdlow, R. H. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.009 · Cited by 222 · see citing works

Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system

Xia, M., Yang, L., Sun, G., Qi, S., & Li, B. (2017) · Psychopharmacology · doi:10.1007/s00213-016-4473-9 · Cited by 149 · see citing works

Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer's Disease: From Pathogenesis to Biomarkers

Ferreiro, E. B., Baldeiras, I., Ferreira, I. L., Costa, R. O., Rego, A. C., Pereira, C., & Oliveira, C. R. (2012) · International Journal of Cell Biology · doi:10.1155/2012/735206 · Cited by 152 · see citing works

Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot

Hampel, H. J., Lista, S., & Khachaturian, Z. S. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.2116 · Cited by 138 · see citing works

Intracellular Accumulation of Amyloid- (A ) Protein Plays a Major Role in A -Induced Alterations of Glutamatergic Synaptic Transmission and Plasticity

Ripoli, C., Cocco, S., Puma, D. D. L., Piacentini, R., Mastrodonato, A., Scala, F., Puzzo, D., D’Ascenzo, M., & Grassi, C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1201-14.2014 · Cited by 122 · see citing works

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study

Iulita, M. F., Allard, S. T. M., Richter, L., Munter, L. M., Ducatenzeiler, A., Weise, C., Carmo, S. D., Klein, W. L., Multhaup, G., & Cuello, A. C. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-61 · Cited by 102 · see citing works

Intraneuronal Aβ accumulation and neurodegeneration: Lessons from transgenic models

Wirths, O., & Bayer, T. A. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.02.001 · Cited by 91 · see citing works

Proteomic analysis of neurons microdissected from formalin-fixed, paraffin-embedded Alzheimer’s disease brain tissue

Drummond, E. S., Nayak, S., Ueberheide, B., & Wisniewski, T. (2015) · Scientific Reports · doi:10.1038/srep15456 · Cited by 78 · see citing works

Amyloid and Alzheimer's Disease: Inside and Out

Tam, J. H. K., & Pasternak, S. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100013408 · Cited by 64 · see citing works

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice

Sivilia, S., Lorenzini, L., Giuliani, A., Gusciglio, M., Fernández, M., Baldassarro, V. A., Mangano, C., Ferraro, L., Pietrini, V., Baroc, M. F., et al. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-44 · Cited by 70 · see citing works

Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapses

Yu, Y., Jans, D. C., Winblad, B. G., Tjernberg, L. O., & Schedin‐Weiss, S. (2018) · Life Science Alliance · doi:10.26508/lsa.201800028 · Cited by 58 · see citing works

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse

Schedin-Weiss, S., Caesar, I., Winblad, B., Blom, H., & Tjernberg, L. O. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0296-5 · Cited by 58 · see citing works

Amyloid-Beta Mediates Homeostatic Synaptic Plasticity

Galanis, C., Fellenz, M., Becker, D., Bold, C. S., Lichtenthaler, S. F., Müller, U., Deller, T., & Vlachos, A. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1820-20.2021 · Cited by 53 · see citing works

Amyloid load and translocator protein 18 kDa in APPswePS1-dE9 mice: a longitudinal study

Sérrière, S., Tauber, C., Vercouillie, J., Mothes, C., Pruckner, C., Guilloteau, D., Kassiou, M., Doméné, A., Garreau, L., Page, G., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.11.023 · Cited by 49 · see citing works

Excitability and Synaptic Alterations in the Cerebellum of APP/PS1 Mice

Hoxha, E., Boda, E., Montarolo, F., Parolisi, R., & Tempia, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034726 · Cited by 49 · see citing works

Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology

Suelves, N., Saleki, S., Ibrahim, T., Palomares, D., Moonen, S., Koper, M. J., Vrancx, C., Vadukul, D. M., Papadopoulos, N., Viceconte, N., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01578-x · Cited by 43 · see citing works

Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions

Rönnbäck, A., Sagelius, H., Bergstedt, K. D., Näslund, J., Westermark, G. T., Winblad, B., & Graff, C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.012 · Cited by 43 · see citing works

Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures

Mota, S. I., Ferreira, I. L., Pereira, C., Oliveira, C. R., & Rego, A. C. (2012) · Current Alzheimer Research · doi:10.2174/156720512802455322 · Cited by 40 · see citing works

Critical role of intraneuronal Aβ in Alzheimer's disease: Technical challenges in studying intracellular Aβ

Gouras, G. K., Willén, K., & Tampellini, D. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.06.004 · Cited by 39 · see citing works

Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease

Jęśko, H. M., Wencel, P. L., Lukiw, W. J., & Strosznajder, R. P. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1040-x · Cited by 39 · see citing works

Analysis of microdissected neurons by 18O mass spectrometry reveals altered protein expression in Alzheimer's disease

Hashimoto, M., Bogdanović, N., Nakagawa, H., Volkmann, I., Aoki, M., Winblad, B. G., Sakai, J., & Tjernberg, L. O. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01441.x · Cited by 38 · see citing works

Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice

Huang, J., WU, J., Xiang, S., Sheng, S., Jiang, Y., Yang, Z., & Hua, F. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4496 · Cited by 37 · see citing works

Exploring the Role of Monoamine Oxidase Activity in Aging and Alzheimer’s Disease

Rahman, M. S., Uddin, M. S., Rahman, M. A., Samsuzzaman, M., Behl, T., Hafeez, A., Perveen, A., Barreto, G. E., & Ashraf, G. M. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210612051713 · Cited by 36 · see citing works

Impairments of long‐term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APP swe/ PS 1dE9 double transgenic mice

Kuwabara, Y., Ishizeki, M., Watamura, N., Toba, J., Yoshii, A., Inoue, T., & Ohshima, T. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12728 · Cited by 34 · see citing works

A disposable electrochemical sensor for amyloid-β42 protein based on molecular imprinted polymers with nitrogen doped carbon dots-graphene nanohybrid

Pakapongpan, S., Poo‐arporn, Y., Ninket, S., & Poo-arporn, R. P. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.111559 · Cited by 31 · see citing works

Heterogeneous Association of Alzheimer’s Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses

Willén, K. I., Sroka-Oleksiak, A., Takahashi, R. H., & Gouras, G. K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170262 · Cited by 27 · see citing works

Potential Novel Approaches to Understand the Pathogenesis and Treat Alzheimer’s Disease

Drummond, E., Goñi, F., Liu, S., Prelli, F., Scholtzova, H., & Wısnıewskı, T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179909 · Cited by 26 · see citing works

Oligomeric amyloid-β induces early and widespread changes to the proteome in human iPSC-derived neurons

Sackmann, C., & Hallbeck, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-63398-6 · Cited by 27 · see citing works

AβPP Accumulation and/or Intraneuronal Amyloid-β Accumulation? The 3xTg-AD Mouse Model Revisited

Wirths, O., Dins, A., & Bayer, T. A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111529 · Cited by 26 · see citing works

Mechanistic perspectives on differential mitochondrial-based neuroprotective effects of several carnitine forms in Alzheimer’s disease in vitro model

Mota, S. I., Pita, I. R., Águas, R., Tagorti, S., Virmani, A., Pereira, F. C., & Rego, A. C. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03104-1 · Cited by 26 · see citing works

Cerebellar Amyloid-β Plaques: Disturbed Cortical Circuitry in AβPP/PS1 Transgenic Mice as a Model of Familial Alzheimer's Disease

Lomoio, S., López‐González, I., Aso, E., Carmona, M., Torrejón-Escribano, B., Scherini, E., & Ferrer, I. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-112198 · Cited by 26 · see citing works

Alternations of central insulin‐like growth factor‐1 sensitivity in APP/PS1 transgenic mice and neuronal models

Zhang, B., Tang, X. C., & Zhang, H. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23201 · Cited by 26 · see citing works

Activity-independent release of the amyloid β-peptide from rat brain nerve terminals

Lundgren, J. L., Ahmed, S., Winblad, B. G., Gouras, G. K., Tjernberg, L. O., & Frykman, S. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.02.050 · Cited by 18 · see citing works

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer‐linked mutations

Wanngren, J., Lara, P., Öjemalm, K., Maioli, S., Moradi, N., Chen, L., Tjernberg, L. O., Lundkvist, J., Nilsson, I., & Karlström, H. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.04.006 · Cited by 16 · see citing works

Data-driven modeling of mitochondrial dysfunction in Alzheimer's disease

Toglia, P. T., Demuro, A., Mak, D. D., & Ullah, G. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.09.003 · Cited by 15 · see citing works

Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products

van Husen, L. S., Schedin‐Weiss, S., Trung, M. N., Kazmi, M. A., Winblad, B. G., Sakmar, T. P., Elsässer, S. J., & Tjernberg, L. O. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190898 · Cited by 15 · see citing works

A Super-Resolved View of the Alzheimer’s Disease-Related Amyloidogenic Pathway in Hippocampal Neurons

Yu, Y., Gao, Y., Winblad, B. G., Tjernberg, L. O., & Schedin‐Weiss, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215008 · Cited by 14 · see citing works

Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models

Cuello, A. C., Allard, S., & Ferretti, M. T. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.05.020 · Cited by 14 · see citing works

Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons

Gao, Y., Wennmalm, S., Winblad, B. G., Schedin‐Weiss, S., & Tjernberg, L. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094530 · Cited by 11 · see citing works

Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2)

Frykman, S., Inoue, M., Ikeda, A., Teranishi, Y., Kihara, T., Lundgren, J. L., Yamamoto, N. G., Bogdanović, N., Winblad, B. G., Schedin‐Weiss, S., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.140 · Cited by 11 · see citing works

The workflow from post-mortem human brain sampling to cell microdissection: a Brain Net Europe study

Meyronet, D., Dorey, A., Massoma, P., Rey, C., Alix, E., Silva, K., Perrin, C., Quadrio, I., Perret‐Liaudet, A., Streichenberger, N., et al. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1378-4 · Cited by 11 · see citing works

Pathology Associated with AAV Mediated Expression of Beta Amyloid or C100 in Adult Mouse Hippocampus and Cerebellum

Drummond, E., Muhling, J., Martins, R. N., Wijaya, L. K., Ehlert, E., & Harvey, A. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059166 · Cited by 10 · see citing works

Neural stem cells isolated from amyloid precursor protein-mutated mice for drug discovery

Baldassarro, V. A. (2013) · World Journal of Stem Cells · doi:10.4252/wjsc.v5.i4.229 · Cited by 10 · see citing works

γ‐secretase complexes containing caspase‐cleaved presenilin‐1 increase intracellular Aβ42/Aβ40 ratio

Hedskog, L., Petersen, C. H., Svensson, A., Welander, H., Tjernberg, L. O., Karlström, H., & Ankarcrona, M. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01208.x · Cited by 10 · see citing works

Localized Proteomics of Individual Neurons Isolated from Formalin-Fixed, Paraffin-Embedded Tissue Sections Using Laser Capture Microdissection

Drummond, E., Nayak, S., Ueberheide, B. M., & Wısnıewskı, T. (2017) · Neuromethods · doi:10.1007/978-1-4939-7119-0_18 · Cited by 10 · see citing works

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

Röntgen, A., Toprakcioglu, Z., & Vendruscolo, M. (2025) · FEBS Letters · doi:10.1002/1873-3468.70118 · Cited by 8 · see citing works

Mechanism of Cellular Formation and In Vivo Seeding Effects of Hexameric β-Amyloid Assemblies

Vrancx, C., Vadukul, D. M., Suelves, N., Contino, S., D’Auria, L., Perrin, F., Pesch, V. V., Hanseeuw, B. J., Quinton, L., & Kienlen‐Campard, P. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02567-8 · Cited by 9 · see citing works

Intraneuronal Aβ accumulation causes tau hyperphosphorylation via endolysosomal leakage

Gao, Y., Wang, L., Doeswijk, T., Winblad, B. G., Schedin‐Weiss, S., & Tjernberg, L. O. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70091 · Cited by 6 · see citing works

A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer’s Disease

Hashimoto, M., Yamazaki, A., Ohno, A., Kimura, T., Winblad, B. G., & Tjernberg, L. O. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190700 · Cited by 7 · see citing works

Clinical Trials and Drug Development

Mahipal, A. (2014) · Cancer Control · doi:10.1177/107327481402100301 · Cited by 8 · see citing works

Altered APP trafficking drives amyloidogenic processing in primary neurons from the AppNL-F knock-in mouse model of Alzheimer's disease

Yu, Y., Zhou, R. Z., Nilsson, P., Winblad, B. G., Tjernberg, L. O., & Schedin‐Weiss, S. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107129 · Cited by 5 · see citing works

A closer look at pathogenic amyloid-β in Alzheimer’s disease using cryo-electron microscopy: a narrative review

Gao, Y., Schedin‐Weiss, S., & Tjernberg, L. O. (2024) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-24-00014 · Cited by 5 · see citing works

Uncovering the Early Events Associated with Oligomeric Aβ-Induced Src Activation

Mota, S. I., Fão, L., Coelho, P., & Rego, A. C. (2023) · Antioxidants · doi:10.3390/antiox12091770 · Cited by 5 · see citing works

Aβ40 Oligomers Promote Survival and Early Neuronal Differentiation of Dentate Gyrus-Isolated Precursor Cells Through Activation of the Akt Signaling Pathway

Silva‐Lucero, M., Gomez‐Virgilio, L., Ortíz‐López, L., Ramírez-Rodríguez, G. B., & Meraz‐Ríos, M. A. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00253-6 · Cited by 2 · see citing works

Small Molecule Decoy of Amyloid-β Aggregation Blocks Activation of Microglia-Like Cells

Oasa, S., Chen, G., Schultzberg, M., & Terenius, L. Y. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231399 · Cited by 2 · see citing works

Stimulating Neuroprotective and Regenerative Mechanisms in Alzheimer Disease

Lilja, A. M. (2013) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.8515

Amyloid Basis of Alzheimer’s Disease

D’Andrea, M. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804256-4.00001-2

Immunocytochemical Detection of Intraneuronal Aβ Peptides in Mouse Models of Alzheimer’s Disease

Wirths, O., & Saul, A. (2015) · Neuromethods · doi:10.1007/978-1-4939-2313-7_10

En recuerdo de Mario Benedetti

Ramos, A. O. (2009) · Abaco: Revista de cultura y ciencias sociales

N-truncated Aβ4-x peptides in Alzheimer's disease: generation, degradation, and relationship with neuropathological hallmarks

Zampar, S. (2021) · doi:10.53846/goediss-9004

Photo-Secondary Metabolites as a Potential Therapeutic Gateway for Alzheimer’s Disease Management

Kathiresan, D. S., Puthamohan, V. M., Ganesan, S., & Arun Nagendran., N. (2026) · Springer eBooks · doi:10.1007/978-981-95-4751-7_10

Etude des mécanismes physiοpathοlοgiques de la maladie d'Alzheimer : appοrt de l'étude des variants du gène SΟRL1

Castelot, R. (2024) · theses.fr (ABES) · doi:10.70675/c2a7ce1ez8caaz4593zbb3azae8add8055b5

Neuronal maturation is altered during pre-pathological stages in the App NL-F mouse model of Alzheimer's disease

Doeswijk, T., Axenhus, M., Malik, S. C., Winblad, B. G., Tjernberg, L. O., & Schedin‐Weiss, S. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261491991

P1‐256: A highly sensitive ELISA reveals intracellular accumulation of Aβ42 in microdissected human Purkinje neurons from Alzheimer brains

Tjernberg, L. O., Hashimoto, M., Bogdanović, N., Volkmann, I., Aoki, M., & Winblad, B. G. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.05.808

Amyloid β-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain

Aoki, M., Volkmann, I., Tjernberg, L. O., Winblad, B., & Bogdanovic, N. (2008) · NeuroReport · doi:10.1097/wnr.0b013e328302c858 · Cited by 53 · see citing works

P1‐480: Amyloid β‐peptide levels in laser capture microdissected CA1 pyramidal neurons of Alzheimer's brain

Aoki, M., Volkmann, I., Tjernberg, L. O., Winblad, B. G., & Bogdanović, N. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.1063

高感度ELISAを用いたヒト単離ニューロンの解析で明らかとなったAβ42の細胞内濃度上昇とアルツハイマー病の神経病理との関連性

ハシモト, マ., & 橋本, 雅. (n.d.) · OUKA (Osaka University Knowledge Archive) (Osaka University)

Significance of intracellular A beta 42 accumulation in Alzheimer s disease

Tabira, T. (2002) · Frontiers in bioscience · doi:10.2741/tabira · Cited by 60 · see citing works