Functional, Global and Cognitive Decline Correlates to Accumulation of Alzheimers Pathology in MCI and AD
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BACKGROUND: Cognitive, global and functional instruments have been extensively investigated for correlations with neuropathological changes such as neurofibrillary tangles (NFTs), plaques, and synapse loss in the brain. OBJECTIVE: Our objective is to correlate the functional, global and cognitive decline assessed clinically with the neuropathological changes observed in a large prospectively characterized cohort of mild cognitive impairment (MCI) and Alzheimer's disease (AD). METHODS: We examined 150 subjects (16 MCI and 134 AD) that were prospectively assessed and longitudinally followed to autopsy. MCI subjects clinically met Petersen criteria for single or multi-domain amnestic MCI. AD subjects clinically met NINCDS-ADRDA criteria for probable or possible AD. All subjects received the Functional Assessment Staging (FAST), the Global Deterioration Scale (GDS), and the Mini Mental State Examination (MMSE) ante-mortem. Plaque and tangle counts were gathered for hippocampus, entorhinal cortex, frontal, temporal and parietal cortices. Braak staging was performed as well. RESULTS: The GDS, FAST and MMSE correlated with plaque counts in all regions. The GDS, FAST and MMSE correlated with tangle counts in in all regions. The three instruments also correlated with the Braak score. The MMSE and GDS correlate better than the FAST in most regions. CONCLUSIONS: Accumulation of neuropathology appears to correlate with functional, global, and cognitive decline as people progress from MCI through AD.
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Duyckaerts et al and Sabbagh et al independently arrived at the conclusion that the density of NFTs in selected cerebral cortical fields significantly (p < 0.01) correlated with Blessed or Mini-Mental State Examination scores.
“Duyckaerts et al (287) and Sabbagh et al (252) independently arrived at the conclusion that the density of NFTs in selected cerebral cortical fields significantly (p < 0.01) correlated with Blessed or Mini-Mental State Examination scores (297).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [252]
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- Authors
- Sabbagh, M. N., Cooper, K., DeLange, J., Stoehr, J. D., Thind, K., Lahti, T., Reisberg, B., Sue, L., Vedders, L., Fleming, S. R., & Beach, T. G.
- Affiliations
- Banner Sun Health Research Institute (US)
- New York University (US)
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-06-01
- Volume
- 7
- Issue
- 4
- Pages
- 280-286
- ISSN
- 1567-2050 (ISSN-L)
- PMC
- PMC3138789
- OpenAlex
- W2101956359
- Cited by
- 79
- References
- 46
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 1 · 2019: 6 · 2018: 10 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 4 · 2013: 6 · 2012: 10
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Alzheimer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30 AG 08051, R01AG003051, R01 AG 03051, P30s AG 019610, P30AG008051, P30AG019610)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, mild cognitive impairment, neurofibrillary tangles, amyloid plaques, synaptic loss, functional decline, cognitive decline, Global Deterioration Scale, Mini-Mental State Examination, Braak staging, hippocampus, entorhinal cortex, longitudinal follow-up
- MeSH terms
- Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Cognition Disorders, Disability Evaluation, Female, Hippocampus, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Predictive Value of Tests, Prognosis, Prospective Studies, Severity of Illness Index, Cohort Studies, Neurofibrillary Tangles, Disease Progression, Entorhinal Cortex, Plaque, Amyloid
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