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Cited by 136Hormonal and reproductive studiesDoping in SportsAdrenal Hormones and Disorders

Oral Androstenedione Administration and Serum Testosterone Concentrations in Young Men

Leder, Benjamin Z.·2000·JAMA
DOI 10.1001/jama.283.6.779
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Abstract

CONTEXT: Androstenedione, a steroid hormone and the major precursor to testosterone, is available without prescription and is purported to increase strength and athletic performance. The hormonal effects of androstenedione, however, are unknown. OBJECTIVE: To determine if oral administration of androstenedione increases serum testosterone levels in healthy men. DESIGN: Open-label randomized controlled trial conducted between October 1998 and April 1999. SETTING: General clinical research center of a tertiary-care, university-affiliated hospital. PARTICIPANTS: Forty-two healthy men aged 20 to 40 years. INTERVENTION: Subjects were randomized to receive oral androstenedione (either 100 mg/d [n = 15] or 300 mg/d [n = 14]) or no androstenedione (n = 13) for 7 days. MAIN OUTCOME MEASURES: Changes in serum testosterone, androstenedione, estrone, and estradiol levels, measured by frequent blood sampling, compared among the 3 treatment groups. RESULTS: Mean (SE) changes in the area under the curve (AUC) for serum testosterone concentrations were -2% (7%), -4% (4%), and 34% (14%) in the groups receiving 0, 100, and 300 mg/d of androstenedione, respectively. When compared with the control group, the change in testosterone AUC was significant for the 300-mg/d group (P<.001) but not for the 100-mg/d group (P = .48). Baseline testosterone levels, drawn 24 hours after androstenedione administration, did not change. Mean (SE) changes in the AUC for serum estradiol concentrations were 4% (6%), 42% (12%), and 128% (24%) in the groups receiving 0, 100, and 300 mg/d of androstenedione, respectively. When compared with the control group, the change in the estradiol AUC was significant for both the 300-mg/d (P<.001) and 100-mg/d (P = .002) groups. There was marked variability in individual responses for all measured sex steroids. CONCLUSIONS: Our data suggest that oral androstenedione, when given in dosages of 300 mg/d, increases serum testosterone and estradiol concentrations in some healthy men.

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Authors
Leder, B. Z.
Affiliations
Massachusetts General Hospital (US)
Corresponding author
Leder, Benjamin Z.
ORCID
Leder, Benjamin Z.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2000-02-09
Volume
283
Issue
6
Pages
779
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.283.6.779
OpenAlex
W2153302571
Cited by
135
References
21
Citations by year
2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 6
FWCI
10.68
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (K24DK02759, 5 R29 DK443341, K24DK002759)
  • National Center for Research Resources (M01RR001066, RR-1066)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Social Sciences › Sociology and Political Science › Doping in Sports
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
androstenedione, testosterone, estradiol, estrone, young men, dose-response relationship, over-the-counter supplements, anabolic steroids, athletic performance improvement, over-the-counter drug regulation
MeSH terms
Administration, Oral, Adult, Androstenedione, Estradiol, Estrone, Humans, Male, Testosterone, Area Under Curve

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