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Cited by 230Nutrition and Health StudiesVitamin C and Antioxidants ResearchPediatric health and respiratory diseases

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Effect of Daily Vitamin E and Multivitamin-Mineral Supplementation on Acute Respiratory Tract Infections in Elderly Persons: A Randomized Controlled Trial

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Graat, Judith M., Schouten, Evert G., Kok, Frans J.·2002·JAMA
DOI 10.1001/jama.288.6.715
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Abstract

Context Immune response in elderly individuals has been reported to improve after micronutrient supplementation. However, efficacy trials evaluating infectious diseases as outcomes are scarce and inconclusive. Objective To investigate the effect of daily multivitamin-mineral and vitamin E supplementation on incidence and severity of acute respiratory tract infections in elderly individuals. Design A randomized, double blind, placebo-controlled, 2 x 2 factorial trial. Setting and participants A total of 652 noninstitutionalized individuals aged 60 years or older enrolled from 2 community-based sampling strategies in the Wageningen area of the Netherlands, conducted from 1998 to 2000. At baseline, 6% of participants had suboptimal ascorbic acid and 1.3% had suboptimal alpha-tocopherol plasma concentration. Intervention Physiological doses of multivitamin-minerals, 200 mg of vitamin E, both, or placebo. Main outcome measures Incidence and severity of self-reported acute respiratory tract infections at 15 months, as assessed by a nurse (telephone contact), home visits, and microbiological and serological testing in subsets of patients. Results During a median observation period of 441 days, 443 (68%) of 652 participants recorded 1024 respiratory tract infection episodes. The incidence rate ratio of acute respiratory tract infection for multivitamin-mineral supplementation was 0.95 (95% confidence interval, 0.75-1.15; P =.58) and for vitamin E supplementation, 1.12 (95% confidence…

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Metadata

Authors
Graat, J. M., Schouten, E. G., & Kok, F. J.
Affiliations
Wageningen University & Research (NL)
ORCID
Kok, Frans J.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2002-08-14
Volume
288
Issue
6
Pages
715
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.288.6.715
OpenAlex
W2132119356
Cited by
230
References
32
Citations by year
2026: 3 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 16 · 2020: 16 · 2019: 3 · 2018: 9 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 16
FWCI
16.38
Type
journal article
Language
en
Open access
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric health and respiratory diseases
Keywords
vitamin E supplementation, multivitamin-mineral supplementation, acute respiratory infections, older adults, micronutrient supplementation, infection incidence, infection severity, vitamin C, vitamin E, alpha-tocopherol, disease duration, fever, activity limitation, community-dwelling older adults, factorial trial, subgroup analysis
MeSH terms
Acute Disease, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Minerals, Respiratory Tract Infections, Severity of Illness Index, Vitamin E, Vitamins, Incidence, Treatment Failure, Dietary Supplements

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