Cited by 230Nutrition and Health StudiesVitamin C and Antioxidants ResearchPediatric health and respiratory diseases

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Effect of Daily Vitamin E and Multivitamin-Mineral Supplementation on Acute Respiratory Tract Infections in Elderly Persons: A Randomized Controlled Trial

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Graat, Judith M., Schouten, Evert G., Kok, Frans J.·2002·JAMA

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Abstract

Context Immune response in elderly individuals has been reported to improve after micronutrient supplementation. However, efficacy trials evaluating infectious diseases as outcomes are scarce and inconclusive. Objective To investigate the effect of daily multivitamin-mineral and vitamin E supplementation on incidence and severity of acute respiratory tract infections in elderly individuals. Design A randomized, double blind, placebo-controlled, 2 x 2 factorial trial. Setting and participants A total of 652 noninstitutionalized individuals aged 60 years or older enrolled from 2 community-based sampling strategies in the Wageningen area of the Netherlands, conducted from 1998 to 2000. At baseline, 6% of participants had suboptimal ascorbic acid and 1.3% had suboptimal alpha-tocopherol plasma concentration. Intervention Physiological doses of multivitamin-minerals, 200 mg of vitamin E, both, or placebo. Main outcome measures Incidence and severity of self-reported acute respiratory tract infections at 15 months, as assessed by a nurse (telephone contact), home visits, and microbiological and serological testing in subsets of patients. Results During a median observation period of 441 days, 443 (68%) of 652 participants recorded 1024 respiratory tract infection episodes. The incidence rate ratio of acute respiratory tract infection for multivitamin-mineral supplementation was 0.95 (95% confidence interval, 0.75-1.15; P =.58) and for vitamin E supplementation, 1.12 (95% confidence…

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RETRACTED: Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects
Chandra, R. K. (1992) · The Lancet · doi:10.1016/0140-6736(92)93151-c · Cited by 523
Retracted
Preparation and Properties of a Cholesterol Oxidase from Nocardia sp. and Its Application to the Enzymatic Assay of Total Cholesterol in Serum
Richmond, W. (1973) · Clinical Chemistry · doi:10.1093/clinchem/19.12.1350 · Cited by 1,593
The aging immune system: primer and prospectus
Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165 · cited 2×
“Acute symptoms were defined as follows (1) sudden onset, (2) a pattern that differed from any usual symptoms, and (3) 1 or more of the respiratory tract symptoms like rhinitis, sore throat, or cough persisted for at least 2 days.”
Background
Vitamin E Supplementation and In Vivo Immune Response in Healthy Elderly Subjects: A Randomized Controlled Trial
Meydani, S. N. (1997) · JAMA · doi:10.1001/jama.1997.03540410058031 · Cited by 545
Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant
Bowry, V. W., Ingold, K. U., & Stocker, R. (1992) · Biochemical Journal · doi:10.1042/bj2880341 · Cited by 511
Vitamin E: non-antioxidant roles
Azzi, A., & Stocker, A. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00006-0 · Cited by 483
Acute respiratory illness in the community: frequency of illness and the agents involved
Monto, A. S., & Sullivan, K. M. (1993) · Epidemiology and Infection · doi:10.1017/s0950268800050779 · Cited by 458
Acute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden
Nicholson, K. G., Kent, J., Hammersley, V., & Cancio, E. (1997) · BMJ · doi:10.1136/bmj.315.7115.1060 · Cited by 381
Impact of Trace Elements and Vitamin Supplementation on Immunity and Infections in Institutionalized Elderly Patients
Girodon, F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.7.748 · Cited by 292
Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase.
Hess, D., Keller, H., Oberlin, B., Bonfanti, R., & Schüep, W. (1991) · PubMed · Cited by 283

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Authors: Graat, J. M., Schouten, E. G., & Kok, F. J.
Affiliations: Wageningen University & Research (NL)
ORCID: Kok, Frans J.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2002-08-14
Volume: 288
Issue: 6
Pages: 715
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.288.6.715
OpenAlex: W2132119356
Cited by: 230
References: 32
Citations by year: 2026: 3 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 16 · 2020: 16 · 2019: 3 · 2018: 9 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 16
FWCI: 16.38
Type: journal article
Language: en
Open access: green
research.wur.nl
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric health and respiratory diseases
Keywords: vitamin E supplementation, multivitamin-mineral supplementation, acute respiratory infections, older adults, micronutrient supplementation, infection incidence, infection severity, vitamin C, vitamin E, alpha-tocopherol, disease duration, fever, activity limitation, community-dwelling older adults, factorial trial, subgroup analysis
MeSH terms: Acute Disease, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Minerals, Respiratory Tract Infections, Severity of Illness Index, Vitamin E, Vitamins, Incidence, Treatment Failure, Dietary Supplements

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Effect of Daily Vitamin E and Multivitamin-Mineral Supplementation on Acute Respiratory Tract Infections in Elderly Persons: A Randomized Controlled Trial

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