Cited by 497Coffee research and impactsPharmacogenetics and Drug MetabolismGenetic Associations and Epidemiology

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Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction

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Cornelis, Marilyn C., El-Sohemy, Ahmed, Kabagambe, Edmond K., Campos, Hannia·2006·JAMA

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Abstract

CONTEXT: The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers. OBJECTIVE: To determine whether CYP1A2 genotype modifies the association between coffee consumption and risk of acute nonfatal MI. DESIGN, SETTING, AND PARTICIPANTS: Cases (n = 2014) with a first acute nonfatal MI and population-based controls (n = 2014) living in Costa Rica between 1994 and 2004, matched for age, sex, and area of residence, were genotyped by restriction fragment-length polymorphism polymerase chain reaction. A food frequency questionnaire was used to assess the intake of caffeinated coffee. MAIN OUTCOME MEASURE: Relative risk of nonfatal MI associated with coffee intake, calculated using unconditional logistic regression. RESULTS: Fifty-five percent of cases (n = 1114) and 54% of controls (n = 1082) were carriers of the slow *1F allele. For carriers of the slow *1F allele, the multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of nonfatal MI associated with consuming less than 1, 1, 2 to 3, and 4 or more cups of coffee per day were 1.00 (reference), 0.99 (0.69-1.44), 1.36 (1.01-1.83), and 1.64 (1.14-2.34), respectively. Corresponding ORs (95% CIs) for individuals with the rapid *1A/*1A genotype were 1.00, 0.75 (0.51-1.12), 0.78 (0.56-1.09), and 0.99 (0.66-1.48) (P = .04 for gene x coffee interaction). For individuals younger than the median age of 59 years, the ORs (95% CIs) associated with consuming less than 1, 1, 2 to 3, or 4 or more cups of coffee per day were 1.00, 1.24 (0.71-2.18), 1.67 (1.08-2.60), and 2.33 (1.39-3.89), respectively, among carriers of the *1F allele. The corresponding ORs (95% CIs) for those with the *1A/*1A genotype were 1.00, 0.48 (0.26-0.87), 0.57 (0.35-0.95), and 0.83 (0.46-1.51). CONCLUSION: Intake of coffee was associated with an increased risk of nonfatal MI only among individuals with slow caffeine metabolism, suggesting that caffeine plays a role in this association.

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Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents.
Tunstall-Pedoe, H., Kuulasmaa, K., Amouyel, P., Arveiler, D., Rajakangas, A.-M., & Pająk, A. (1994) · Circulation · doi:10.1161/01.cir.90.1.583 · Cited by 2,260
Effects of caffeine on human health
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003) · Food Additives and Contaminants · doi:10.1080/0265203021000007840 · Cited by 1,199
Functional significance of a C–>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
Sachse, C., Brockmöller, J., Bauer, S., & Roots, I. (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00898.x · Cited by 751
How introns influence and enhance eukaryotic gene expression
Hir, H. L., Nott, A., & Moore, M. J. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00052-5 · Cited by 734
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
Butler, M. A., Iwasaki, M., Guengerich, F. P., & Kadlubar, F. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7696 · Cited by 638
Adenosine and Adenosine Receptors in the Cardiovascular System: Biochemistry, Physiology, and Pharmacology
Shryock, J. C., & Belardinelli, L. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00256-7 · Cited by 578
Caffeine as a psychomotor stimulant: mechanism of action
Fisone, G., Borgkvist, A., & Usiello, A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3269-3 · Cited by 558
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Sanghera, D. K., Bejar, C., Sapkota, B. R., Wander, G. S., & Ralhan, S. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-33981-z · Cited by 14
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Karjalainen, M. J., Neuvonen, P. J., & Backman, J. T. (2008) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0456-4 · Cited by 14
“been associated with an increased incidence of myocardial infaction, which was suggested to be caused by impaired caffeine metabolism [9].”
Background
Catechol- O -Methyltransferase Genotype Is Associated with Self-Reported Increased Heart Rate Following Caffeine Consumption
Brathwaite, J. M., Costa, L. A. D., & El‐Sohemy, A. (2011) · Journal of Caffeine Research · doi:10.1089/jcr.2011.0015 · Cited by 13
Design and rationale of TROCADERO: A TRial Of Caffeine to Alleviate DyspnEa Related to ticagrelOr
Lindholm, D. P., Storey, R. F., Christersson, C., Halvorsen, S., Grove, E. L., Braun, O. Ö., Varenhorst, C., & James, S. K. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.06.014 · Cited by 13
Molecular Genetic Markers as a Basis for Personalized Medicine / MOLEKULARNO-GENETIČKI MARKERI KAO OSNOV ZA PERSONALIZOVANU MEDICINU
Pavlović, S., Zukić, B., & Maja, S.-P. (2013) · Journal of Medical Biochemistry · doi:10.2478/jomb-2013-0035 · Cited by 11
“Predictive genetic tests can indicate that a person needs to modify the diet, to avoid the harmful effects of nutrients, for example gluten (for celiac disease) (74), lactose (for adult hypolactasia) (75), caffeine (for hypersensitivity) (76, 77) or fat (for obesity) (78–82).”
Background
Narrative Review: Impact of Genetic Variability of CYP1A2 , ADORA2A , and AHR on Caffeine Consumption and Response
Tennent, R., Ali, A., Wham, C. A., & Rutherfurd-Markwick, K. J. (2020) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2020.0016 · Cited by 13
Pharmacogenetics/Pharmacogenomics of Drug-Metabolizing Enzymes and Transporters
Arbitrio, M., Scionti, F., Martino, M. T. D., Pensabene, L., Tassone, P., & Tagliaferri, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00013-x · Cited by 12
Pharmacogenetic Research Activity in Central America and the Caribbean: A Systematic Review
Céspedes-Garro, C., Naranjo, M.-E. G., Rodrigues‐Soares, F., LLerena, A., Duconge-Soler, J., Jaime, L. K. M., Roblejo, H., Fariñas, H., Campos, M. D. L. A., Ramírez, R., et al. (2016) · Pharmacogenomics · doi:10.2217/pgs-2016-0053 · Cited by 12
The effects of coffee intake on coronary heart disease: Ongoing controversy
Celık, T., Iyısoy, A., & Amasyalı, B. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.12.112 · Cited by 12
Tea Consumption and New-Onset Acute Kidney Injury: The Effects of Milk or Sweeteners Addition and Caffeine/Coffee
Liu, M., Yang, S., Ye, Z., Zhang, Y., Zhang, Y., He, P., Zhou, C., Hou, F. F., & Qin, X. (2023) · Nutrients · doi:10.3390/nu15092201 · Cited by 11
Identification of the susceptible genes and mechanism underlying the comorbid presence of coronary artery disease and rheumatoid arthritis: a network modularization analysis
Zhang, S., Niu, Q., Lin, T., Liu, S., Wang, P., Xu, H., Li, B., & Zhang, H. (2023) · BMC Genomics · doi:10.1186/s12864-023-09519-7 · Cited by 11
Coffee consumption and risk of type 2 diabetes
Palatini, P. (2014) · Diabetologia · doi:10.1007/s00125-014-3425-3 · Cited by 11
“These data suggest that, in participants with the fast CYP1A2 *1A/*1A genotype, the harmful effects of caffeine on glucose metabolism are less marked and are outweighed by the favourable action of polyphenols or other bioactive agents [7, 9, 10].”
Influential
Caffeine reduces the sensitivity of vasodilator MPI for the detection of myocardial ischaemia: Pro
Reyes, E. (2016) · Journal of Nuclear Cardiology · doi:10.1007/s12350-015-0371-5 · Cited by 11
Moderate coffee consumption is associated with lower risk of mortality in prior Acute Coronary Syndrome patients: a prospective analysis in the ERICO cohort
Miranda, A. M., Goulart, A. C., Benseñor, I. M., Lotufo, P. A., & Marchioni, D. M. L. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1862069 · Cited by 11
“One study (Cornelis et al. 2006) found that coffee drinking increased the risk of MI only in carriers of the 1 F allele.”
Background
Caffeine and rheumatoid arthritis: A complicated relationship
Ingegnoli, F., Cavalli, S., Giudice, L., & Caporali, R. F. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103117 · Cited by 11
The magical smell and taste: Can coffee be good to patients with cardiometabolic disease?
Ribeiro, M. M., Alvarenga, L., Cardozo, L., Kemp, J. A., Lima, L. S., de Almeida, J. S., Leal, V. D. O., Stenvinkel, P., Shiels, P. G., & Mafra, D. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2106938 · Cited by 14
“The change in this allele directly interferes with caffeine metabolization, and "slow" metabo-lisers may be associated with a greater risk of myocardial infarction and hypertension, indicating a decrease of coffee consumption (Palatini et al. 2009; Cornelis et al. 2006).”
Background
Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank
Tang, L., Yang, L., Chen, W., Li, C., Zeng, Y., Yang, H., Hu, Y., Qu, Y., Song, H., Zeng, X., et al. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002234 · Cited by 11
“Meanwhile, the genetic polymorphisms affecting caffeine metabolism are also associated with increased risk of several health impairments, including hypertension, impaired fasting glucose, and myocardial infarction.([17-19]) Therefore, it is worth examining whether the effect of coffee on incident CKD is independent of…”
Background
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Larsson, S. C., Wolk, A., Håkansson, N., & Bäck, M. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.01.016 · Cited by 11
Addiction to Caffeine and Other Xanthines
Favrod-Coune, T., & Broers, B. (2020) · Springer eBooks · doi:10.1007/978-3-030-36391-8_16 · Cited by 11
Relationship of coffee consumption with a decline in kidney function among patients with type 2 diabetes: The Fukuoka Diabetes Registry
Komorita, Y., Ohkuma, T., Iwase, M., Fujii, H., Ide, H., Oku, Y., Higashi, T., Oshiro, A., Sakamoto, W., Yoshinari, M., et al. (2022) · Journal of Diabetes Investigation · doi:10.1111/jdi.13769 · Cited by 12
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
Frishman, W. H. (2007) · Yearbook of Medicine · doi:10.1016/s0084-3873(08)70204-9 · Cited by 11
Coffee intake and hypertension in Korean adults: results from KNHANES 2012–2016
Shah, S., Cho, I., Lee, W., Pyun, W. B., & Ha, E. (2023) · Clinical Hypertension · doi:10.1186/s40885-023-00239-4 · Cited by 10
Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine
Bochud, M., Burnier, M., & Guessous, I. (2011) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/187569211798377135 · Cited by 11
“In a matched case-control study (N=4,028) of subjects living in Costa Rica, an increased risk of myocardial infarction with increasing coffee consumption has been reported among carriers of the CYP1A2 C variant [56].”
Background
Coffee Consumption and Cardiovascular Diseases – Has the Time Come to Change Dietary Advice? A Mini Review
Wierzejska, R. E. (2016) · Polish Journal of Food and Nutrition Sciences · doi:10.1515/pjfns-2015-0048 · Cited by 10
Smoking habits and the risk of non-fatal acute myocardial infarction in Costa Rica
Rossi, M., Negri, E., Vecchia, C. L., & Campos, H. (2011) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/1741826710389381 · Cited by 12
“hypercholesterolemia and current abdominal obesity, and the intakes of alcohol and coffee.(26,27) History of diabetes, hypertension and hypercholesterolemia was self-reported, so adjustment for these covariates may not be optimal.”
BackgroundResult
The metabolic nature of individuality
Dragsted, L. O. (2020) · Nature Food · doi:10.1038/s43016-020-0104-z · Cited by 10
Coffee, Myocardial Infarction, and CYP Nomenclature
Ingelman‐Sundberg, M., Sim, S. C., & Nebert, D. W. (2006) · JAMA · doi:10.1001/jama.296.7.764-b · Cited by 10
Coffee and sleep: Benefits and risks
Davisaraei, Y. B., Nateghi, S., Rashidipour, H., Raise‐Abdullahi, P., & Rashidy‐Pour, A. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.014 · Cited by 13
The impact of genetic variability on the relationship between caffeine and cardiometabolic outcomes: A systematic review
Virgili, J., Motitis, P., Julal, G., Mavrommatis, Y., & Pilić, L. (2023) · Nutrition Bulletin · doi:10.1111/nbu.12606 · Cited by 13
Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition
Iglesias‐Carres, L., & Neilson, A. P. (2021) · Food & Function · doi:10.1039/d1fo02782d · Cited by 9
Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia
Eichelberger, K. Y., Baker, A., Woodham, P. C., Haeri, S., Strauss, R. A., & Stuebe, A. M. (2015) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000001041 · Cited by 9
Coffee Consumption and Coronary Heart Diseases: A Mini-Review
Shateri, Z., & Djafarian, K. (2016) · Journal of Clinical Nutrition & Dietetics · doi:10.4172/2472-1921.100010 · Cited by 9
Coffee and mental disorders: How caffeine affects anxiety and depression
Meamar, M., Raise‐Abdullahi, P., Rashidy‐Pour, A., & Raeis-Abdollahi, E. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.015 · Cited by 13
Association of coffee consumption and caffeine metabolism with arrhythmias and cardiac morphology: An observational, genetic, and Mendelian randomization study
Zheng, J., Chen, H., Yang, Q., Zhou, Z., Yang, C., Huang, J., Tu, Q., Wu, H., Qiu, P., Huang, W., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.11.047 · Cited by 11
The impact of (poly)phenol-rich foods and extracts on flow-mediated dilation (FMD): a narrative review
Murphy, B., Neill, H. R., Magee, N., Rosbotham, E. J., Pourshahidi, L. K., Richardson, P., Pouchieu, C., Gaudout, D., Ray, S., Bresciani, L., et al. (2025) · Food & Function · doi:10.1039/d5fo01106j · Cited by 8
The Role of Xenobiotic Caffeine on Cardiovascular Health: Promises and Challenges
Campagna, R., & Vignini, A. (2025) · Journal of Xenobiotics · doi:10.3390/jox15020051 · Cited by 8
“Cornelis et al. investigated whether the CYP1A2 genotype influences the association between coffee intake and risk of acute nonfatal myocardial infarction [49].”
Influential
Allele Frequency and Genotype Distribution of 9 SNPs in the Kazakh Population
Romanova, A. A. (2014) · Journal of Pharmacogenomics & Pharmacoproteomics · doi:10.4172/2153-0645.1000129 · Cited by 8
“*Different sources with a population sample of more than 100 people (including HapMap data) [3-8,10-12,20-48].”
Background
Genetic test for the prescription of diets in support of physical activity.
Naureen, Z., Miggiano, G. A. D., Aquilanti, B., Velluti, V., Matera, G., Gagliardi, L., Zulian, A., Romanelli, R., & Bertelli, M. (2020) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v91i13-s.10584 · Cited by 11
“One of those studies analyzed the involvement of genetic variants in the gene CYP1A2 encoding a caffeine-metabolizing enzyme in CVD (27).”
BackgroundInfluential
Quantitation of phenanthrene dihydrodiols in the urine of smokers and non-smokers by gas chromatography-negative ion chemical ionization-tandem mass spectrometry
Luo, K., Hochalter, J. B., Carmella, S. G., & Hecht, S. S. (2020) · Journal of Chromatography B · doi:10.1016/j.jchromb.2020.122023 · Cited by 8
Influence of dietary total antioxidant capacity on the association between smoking and hypertension in Brazilian graduates (CUME project)
Sabião, T. D. S., Bressan, J., Pimenta, A. M., Hermsdorff, H. H. M., de Oliveira, F. L. P., Mendonça, R. D. D., Carraro, J. C. C., & de Aguiar, A. S. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.05.025 · Cited by 8
Cytochrome P450 and ischemic heart disease: current concepts and future directions
Rowland, A., & Mangoni, A. A. (2013) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.859675 · Cited by 8
“By contrast, other studies considered a wider range of clinical and demographic confounders [146-148,151,152,157-159,161].”
BackgroundResult
Coffee Intake and obesity
Pimentel, G. D., Micheletti, T. O., Fernandes, R. C., & Nehlig, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816093-0.00024-0 · Cited by 8
Cytochrome P450 1A2 Polymorphisms, Coffee Consumption and Impaired Glucose Metabolism in Japanese Men
Tajima, M. K. O. (2013) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.1000119 · Cited by 9
“Coffee consumption was associated with an increased risk of myocardial infarction among carriers of the inactive allele (C allele) of CYP1A2*1F in the former study [27].”
Background
Integrated Analysis of Genomic and Genome-Wide Association Studies Identified Candidate Genes for Nutrigenetic Studies in Flavonoids and Vascular Health: Path to Precision Nutrition for (Poly)phenols
Ruskovska, T., Postolov, F., & Milenković, D. (2024) · Nutrients · doi:10.3390/nu16091362 · Cited by 7
“These studies identified caffeine as a key factor for increased risk only for individuals with slow caffeine metabolism [45] that is associated with the − 163A > C (rs762551) single nucleotide polymorphism of the Cytochrome P450 Family 1 Subfamily A Member 2 ( CYP1A2 ) gene.”
Background

Authors: Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H.
Affiliations: University of Toronto (CA)
Harvard University (US)
ORCID: Cornelis, Marilyn C.
Kabagambe, Edmond K.
Campos, Hannia
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2006-03-08
Volume: 295
Issue: 10
Pages: 1135
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.295.10.1135
OpenAlex: W1972508135
Cited by: 490
References: 52
Citations by year: 2026: 22 · 2025: 26 · 2024: 26 · 2023: 21 · 2022: 20 · 2021: 21 · 2020: 24 · 2019: 24 · 2018: 30 · 2017: 30 · 2016: 21 · 2015: 22 · 2014: 28 · 2013: 22 · 2012: 24
FWCI: 16.50
Type: journal article
Language: en
Open access: green
jamanetwork.com
Licence: other-oa
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Investigative News in Education (Universidad de Costa Rica) (submittedVersion)
Funders: Harvard University
Universidad de Costa Rica
National Heart, Lung, and Blood Institute (HL 60692, HL 071888, R01HL071888, R01HL060692)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: coffee consumption, myocardial infarction, caffeine metabolism, gene-environment interaction, cardiovascular risk, Costa Rica, young adults, hormone replacement therapy
MeSH terms: Aged, Catchment Area, Health, Coffee, Costa Rica, Female, Genotype, Humans, Male, Middle Aged, Myocardial Infarction, Polymorphism, Restriction Fragment Length, Risk Factors, Logistic Models, Polymerase Chain Reaction, Cytochrome P-450 CYP1A2, Amino Acid Substitution

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Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction

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