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Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction
Open accessAbstract
CONTEXT: The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers. OBJECTIVE: To determine whether CYP1A2 genotype modifies the association between coffee consumption and risk of acute nonfatal MI. DESIGN, SETTING, AND PARTICIPANTS: Cases (n = 2014) with a first acute nonfatal MI and population-based controls (n = 2014) living in Costa Rica between 1994 and 2004, matched for age, sex, and area of residence, were genotyped by restriction fragment-length polymorphism polymerase chain reaction. A food frequency questionnaire was used to assess the intake of caffeinated coffee. MAIN OUTCOME MEASURE: Relative risk of nonfatal MI associated with coffee intake, calculated using unconditional logistic regression. RESULTS: Fifty-five percent of cases (n = 1114) and 54% of controls (n = 1082) were carriers of the slow *1F allele. For carriers of the slow *1F allele, the multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of nonfatal MI associated with consuming less than 1, 1, 2 to 3, and 4 or more cups of coffee per day were 1.00 (reference), 0.99 (0.69-1.44), 1.36 (1.01-1.83), and 1.64 (1.14-2.34), respectively. Corresponding ORs (95% CIs) for individuals with the rapid *1A/*1A genotype were 1.00, 0.75 (0.51-1.12), 0.78 (0.56-1.09), and 0.99 (0.66-1.48) (P = .04 for gene x coffee interaction). For individuals younger than the median age of 59 years, the ORs (95% CIs) associated with consuming less than 1, 1, 2 to 3, or 4 or more cups of coffee per day were 1.00, 1.24 (0.71-2.18), 1.67 (1.08-2.60), and 2.33 (1.39-3.89), respectively, among carriers of the *1F allele. The corresponding ORs (95% CIs) for those with the *1A/*1A genotype were 1.00, 0.48 (0.26-0.87), 0.57 (0.35-0.95), and 0.83 (0.46-1.51). CONCLUSION: Intake of coffee was associated with an increased risk of nonfatal MI only among individuals with slow caffeine metabolism, suggesting that caffeine plays a role in this association.
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“The Panel notes that, although this case-control study suggests that polymorphisms of the CYP1A2 gene may affect the risk of MI in relation to caffeine consumption, which may be further affected by polymorphisms of the serotonin receptor gene HTR2A, the results have not yet been replicated and the hypothesis has not been tested in prospective cohort studies.”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Cornelis et al., 2006
In the citing paper
“In total, 55 % of cases (n = 1 114) and 54 % of controls (n = 1 082) were carriers of the slow *1F allele, for which the multivariate-adjusted odds ratios (ORs) and 95 % CIs for non-fatal MI associated with the consumption of less than one, one, two to three and four or more cups of coffee per day were 1.00 (reference), 0.99 (0.69-1.44), 1.36 (1.01-1.83)and 1.64 (1.14-2.34),respectively.Cor”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Cornelis et al., 2006
In the citing paper
“A study by Cornelis MC et al.47 showed that CYP1A2 genotype was an effect modifier between coffee consumption and risk of myocardial infarction: coffee consumption was related to higher risk of myocardial infarction for the slow caffeine metabolizer, and was not related to myocardial infarction for the fast caffeine metabolizer.”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [47]
In the citing paper
“However, this analysis was based on a case-control study conducted in Costa Rico and the results have not been replicated in prospective cohort studies yet.”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [47]
Citations
Cites
Willett, W. C. (1998) · doi:10.1093/acprof:oso/9780195122978.001.0001 · Cited by 4,541
Tunstall-Pedoe, H., Kuulasmaa, K., Amouyel, P., Arveiler, D., Rajakangas, A.-M., & Pająk, A. (1994) · Circulation · doi:10.1161/01.cir.90.1.583 · Cited by 2,260
Effects of caffeine on human health
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003) · Food Additives and Contaminants · doi:10.1080/0265203021000007840 · Cited by 1,199
Sachse, C., Brockmöller, J., Bauer, S., & Roots, I. (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00898.x · Cited by 751
How introns influence and enhance eukaryotic gene expression
Hir, H. L., Nott, A., & Moore, M. J. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00052-5 · Cited by 734
Butler, M. A., Iwasaki, M., Guengerich, F. P., & Kadlubar, F. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7696 · Cited by 638
Shryock, J. C., & Belardinelli, L. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00256-7 · Cited by 578
Caffeine as a psychomotor stimulant: mechanism of action
Fisone, G., Borgkvist, A., & Usiello, A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3269-3 · Cited by 558
Nakajima, M., Yokoi, T., Mizutani, M., Kinoshitah, M., Funayama, M., & Kamataki, T. (1999) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022352 · Cited by 345
Gu, L., Gonzalez, F. J., KALOW, W., & Tang, B. K. (1992) · Pharmacogenetics · doi:10.1097/00008571-199204000-00004 · Cited by 326
Cited by
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Items 101–200 of 497
Guessous, I., Dobrinas, M., Kutalik, Z., Pruijm, M., Ehret, G., Maillard, M., Bergmann, S., Beckmann, J. S., Cusi, D., Rizzi, F., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds137 · Cited by 70
“Finally, the effect of coffee compounds other than caffeine on CYP1A2 is unlikely given that caffeine is the only known coffee compound to be detoxified by CYP1A2 (50).”
BackgroundAging and cardiovascular diseases: the role of gene-diet interactions
Corella, D., & Ordovás, J. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.08.002 · Cited by 83
Spence, J. D. (2018) · Stroke and Vascular Neurology · doi:10.1136/svn-2017-000130 · Cited by 74
“Some evidence that caffeine in coffee may be harmful came from a study in which slow metabolisers of caffeine (because of a variant of the CYP1A2 genotype) appeared to have increased the risk of myocardial infarction.(43) A recent meta-analysis indicates that consuming 3–5 cups per day of coffee reduces cardiovascular…”
BackgroundGenetic determinants of blood pressure responses to caffeine drinking
Renda, G., Zimarino, M., Antonucci, I., Tatasciore, A., Ruggieri, B., Bucciarelli, T., Prontera, T., Stuppia, L., & Caterina, R. D. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.018267 · Cited by 69
Sartini, M., Bragazzi, N. L., Spagnolo, A. M., Schinca, E., Ottria, G., Dupont, C., & Cristina, M. L. (2019) · Nutrients · doi:10.3390/nu11030694 · Cited by 68
“Other biological events or diseases have been found to be characterized by a complex gene–caffeine interaction, such as variability in the cardiovascular response to caffeine [41], coffee consumption and the risk of developing neurodegenerative disorders [42], epithelial ovarian cancer [43], breast cancer [44], or myo…”
Carman, A. J., Dacks, P. A., Lane, R. F., Shineman, D. W., & Fillit, H. M. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0021-7 · Cited by 75
Efficacy and safety of ingredients found in preworkout supplements
Eudy, A. E., Gordon, L. L., Hockaday, B. C., Lee, D. A., Lee, V., Luu, D., Martinez, C. A., & Ambrose, P. J. (2013) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp120118 · Cited by 72
“Slow metabolizers of caffeine who drink the caffeine equivalent of more than two cups of coffee per day may have a higher risk of experiencing coronary or arrhythmic events.(24) However, the purported performance-enhancing effects of caffeine may occur and peak at different levels of caffeine ingestion.”
BackgroundLee, Y., Lai, C., Ordovás, J. M., & Parnell, L. D. (2011) · Journal of Data Mining in Genomics & Proteomics · doi:10.4172/2153-0602.1000106 · Cited by 67
“The case of CYP1A2 variants, caffeine intake and myocardial infarction, where an association was not observed until dual stratification of genotype and caffeine intake was considered [54], illustrates a potential shortcoming of such studies, but does suggest that still many other GxE interactions may be described with…”
BackgroundBlood Pressure in Relation to Coffee and Caffeine Consumption
Guessous, I., Eap, C. B., & Bochud, M. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0468-2 · Cited by 69
Hallström, H., Melhus, H., Glynn, A. W., Lind, L., Syvänen, A., & Michaëlsson, K. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-12 · Cited by 66
“However, in a study of coffee intake, CYP1A2 genotype and risk of myocardial infarction coffee was associated with an increased risk of nonfatal myocardial infarction only in participants regarded as slow metabolizers of caffeine [26].”
BackgroundInfluentialThe effect of caffeine on intraocular pressure: a systematic review and meta-analysis
Li, M., Wang, M., Guo, W., Wang, J., & Sun, X. (2010) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-010-1455-1 · Cited by 66
“It had been found that in homozygotes of CYP1A2*1F alleles, who were “slow” caffeine metabolizers, caffeine intake was associated with nonfatal myocardial infarction [41].”
BackgroundCoffee Consumption and Risk of Cardiovascular Events After Acute Myocardial Infarction
Silletta, M. G., Marfisi, R., Levantesi, G., Boccanelli, A., Chieffo, C., Franzosi, M., Geraci, E., Maggioni, A. P., Nicolosi, G. L., Schweiger, C., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712976 · Cited by 65
Turati, F., Galeone, C., La Vecchia, C., Garavello, W., & Tavani, A. (2011) · Annals of Oncology · doi:10.1093/annonc/mdq603 · Cited by 64
“Studies included in these meta-analyses did not consider genetic variants associated with coffee drinking, such as CYP1A2, which is responsible for more than 95% of caffeine metabolism [38].”
Palatini, P., Benetti, E., Mos, L., Garavelli, G., Mazzer, A., Cozzio, S., Fania, C., & Casiglia, E. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-9990-z · Cited by 63
“As the clinical effects of coffee drinking may depend on the genetic background of an individual, another purpose of the present analysis was to ascertain the effect of regular coffee intake on fasting glucose within subjects stratified by CYP1A2 genotype, which has been shown to modulate the association of coffee use…”
BackgroundCarswell, A. T., Howland, K., Martinez-Gonzalez, B., Baron, P., & Davison, G. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04384-8 · Cited by 61
Association between caffeine intake and risk of Parkinson's disease among fast and slow metabolizers
Tan, E., Chua, E., Fook-Chong, S. M. C., Teo, Y., Yih, Y., Tan, L. C. S., & Zhao, Y. (2007) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3282f09265 · Cited by 61
Schliep, K. C., Schisterman, E. F., Mumford, S. L., Pollack, A. Z., Zhang, C., Ye, A., Stanford, J. B., Hammoud, A. O., Porucznik, C. A., & Wactawski‐Wende, J. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.021287 · Cited by 62
“Polymorphisms of CYP1A2 have been linked to variability in caffeine clearance (24) and serum E2 concentrations (25) and have been shown to modify relations between caffeine intake and adverse health outcomes (26, 27).”
BackgroundPharmacogenetics of Drug Metabolism
Desta, Z., & Flockhart, D. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802101-9.00018-1 · Cited by 62
Barreto, G., Grecco, B. H., Merola, P., Reis, C. E. G., Gualano, B., & Saunders, B. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04571-7 · Cited by 66
Houston, M. C. (2018) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944717743920 · Cited by 62
A Comprehensive Overview of the Risks and Benefits of Coffee Consumption
Pourshahidi, L. K., Navarini, L., Petracco, M., & Strain, J. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12206 · Cited by 64
Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era
Cassotta, M., Forbes-Hernández, T. Y., Cianciosi, D., Elexpuru-Zabaleta, M., Cano, S. S., Azpíroz, I. D., Bullón, B., Regolo, L., Álvarez-Suárez, J. M., Giampieri, F., et al. (2021) · Nutrients · doi:10.3390/nu13030763 · Cited by 60
“One example of how nutrigenomics and NGS technologies has been employed to elucidate the involvement of precise dietary factors results from an investigation on coffee and heart disease [44].”
BackgroundCoffee consumption and cardiometabolic health: a comprehensive review of the evidence
Ungvari, Z. I., & Kunutsor, S. K. (2024) · GeroScience · doi:10.1007/s11357-024-01262-5 · Cited by 69
“…the associations are less prominent in never smokers compared with former and current smokers, others have shown stronger associations among never and past smokers than among current smokers, and still others have shown similar associations among never, former and current smokers [82, 87, 89, 181].”
BackgroundResultInfluentialLandberg, R., Manach, C., Kerckhof, F., Minihane, A. M., Saleh, R. N. M., de Roos, B., Tomás-Barberán, F. A., Morand, C., & de Wiele, T. V. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02095-1 · Cited by 57
Wang, T., Huang, T., Kang, J. H., Zheng, Y., Jensen, M. K., Wiggs, J. L., Pasquale, L. R., Fuchs, C. S., Campos, H., Rimm, E. B., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0862-0 · Cited by 60
“Such heterogeneous associations might be attributed, at least partly, to the modification effects of divergent genetic predispositions, as observed in previous studies showing coffee-gene interactions on other health outcomes [8, 9].”
ResultImpact of Coffee Consumption on Cardiovascular Health
Mendoza, M. F., Sulague, R. M., Posas-Mendoza, T., & Lavie, C. J. (2023) · Ochsner Journal · doi:10.31486/toj.22.0073 · Cited by 54
“This function of phytoestrogen may explain the lack of protective effect of coffee for atherosclerotic calcification in males.26 Cornelis et al (2006) shed some light on why these studies commonly reported a dose-dependent J- or U-shaped curve.27 According to their study, the increased risk of…”
BackgroundGenetic susceptibility to caffeine intake and metabolism: a systematic review
Low, J. J.-L., Tan, B. J., Yi, L., Zhou, Z., & Tan, E. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05737-z · Cited by 70
“…in “slow metabolizers”, caffeine intake was also previously shown to be associated with higher risk of myocardial infarction and when more than 3 cups of coffee per day was consumed, there was a higher risk of albuminuria, hyperfiltration and hypertension, compared to “fast metabolizers” [102–104].”
BackgroundPolymorphisms, diet and nutrigenomics
Bonetti, G., Kiani, A. K., Donato, K., Kaftalli, J., Herbst, K. L., Stuppia, L., Fioretti, F., Nodari, S., Perrone, M. A., Chiurazzi, P., et al. (2022) · Journal of preventive medicine and hygiene · doi:10.15167/2421-4248/jpmh2022.63.2s3.2754 · Cited by 68
Methylxanthines and Human Health: Epidemiological and Experimental Evidence
Beaudoin, M., & Graham, T. E. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_21 · Cited by 54
Nutrition, genetic variation and male fertility
Vanderhout, S. M., Panah, M. R., García‐Bailo, B., Grace-Farfaglia, P., Samsel, K., Dockray, J., Jarvi, K. A., & El‐Sohemy, A. (2021) · Translational Andrology and Urology · doi:10.21037/tau-20-592 · Cited by 54
“Caffeine CYP1A2: rs7662551 (65) Sperm motility, count and morphology improved at”
BackgroundInfluentialHigh-Dose Adenosine Overcomes the Attenuation of Myocardial Perfusion Reserve Caused by Caffeine
Reyes, E., Loong, C. Y., Harbinson, M., Donovan, J., Anagnostopoulos, C., & Underwood, S. R. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.052 · Cited by 52
“In addition, caffeine levels in plasma after coffee ingestion can vary widely owing to interindividual differences in caffeine metabolism (9,17), which is the most likely explanation for the observed variability in serum caffeine concentrations despite standard brewing of the same coffee brand.”
BackgroundHapponen, P., Voutilainen, S., Tuomainen, T., & Salonen, J. T. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000117 · Cited by 52
“Recently Cornelis and co-workers determined whether CYP1A2 genotype modifies the association between intake of caffeinated coffee and the risk of nonfatal myocardial infarction [32].”
BackgroundNielsen, D. E., Shih, S., & El‐Sohemy, A. (2014) · Lifestyle Genomics · doi:10.1159/000365508 · Cited by 52
Ntzani, E., Rizos, E. C., & Ioannidis, J. P. A. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwk085 · Cited by 53
“Moreover, several other associations have been postulated in the recent literature in prestigious journals, and they await further replication (11, 12, 29).”
BackgroundPalacios, N., Weisskopf, M. G., Simon, K., Gao, X., Schwarzschild, M. A., & Ascherio, A. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.02.012 · Cited by 51
“[23] reported that this polymorphism modified the relationship between coffee intake and risk of myocardial infarction (MI).”
BackgroundEspresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort
Grioni, S., Agnoli, C., Sieri, S., Pala, V. M., Ricceri, F., Masala, G., Saieva, C., Panico, S., Mattiello, A., Chiodini, P., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126550 · Cited by 49
“In a case-control study, high coffee intake was associated with increased risk of non-fatal myocardial infarction only in individuals with the CYP1A2 1F allele [36], suggesting that caffeine is involved in the coffee-CHD association.”
BackgroundCaffeine and Blood Pressure Response: Sex, Age, and Hormonal Status
Farag, N. H., Whitsett, T. L., McKey, B. S., Wilson, M. F., Vincent, A. S., Everson‐Rose, S. A., & Lovallo, W. R. (2010) · Journal of Women s Health · doi:10.1089/jwh.2009.1664 · Cited by 49
“Persons possessing a slow metabolic profile, and consequently experiencing longer and greater caffeine exposure, have been shown to have a greater prevalence of hypertension 38 and myocardial infarction 39 associated with habitual caffeine intake with a graded dose-response effect.”
CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction
Mahdavi, S., Palatini, P., & El‐Sohemy, A. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.47868 · Cited by 48
Effects of Caffeine and Coffee Consumption on Cardiovascular Disease and Risk Factors
Mattioli, A. V. (2007) · Future Cardiology · doi:10.2217/14796678.3.2.203 · Cited by 48
“A recent interesting study showed that among patients with a CYP1A2 genotype predicting slow caffeine metabolism, the intake of coffee, even two to three cups/day, was associated with an increased risk of nonfatal myocardial infarction, suggesting that caffeine does play a role in this association [25].”
BackgroundBågeman, E., Ingvar, C., Rose, C., & Jernström, H. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0555 · Cited by 48
“Although coffee induces, and is metabolized by, the CYP1A2 enzyme (9), no association between the inducible CYP1A2*1F genotype (10) and coffee consumption has been observed in the general population (11).”
BackgroundDenden, S., Bouden, B., Khelil, A. H., Chibani, J. B., & Hamdaoui, M. H. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15027487 · Cited by 48
“Finally, 12 studies were included in the meta-analysis (Nordmark et al., 2002; Sata et al., 2005; Cornelis et al., 2006; Kotsopoulos et al., 2007; Tan et al., 2007; Jernström et al., 2008; Djordjevic et al., 2010; Popat et al., 2011; Kohno et al., 2013; Lowcock et al., 2013; Tian et al., 2013; Dik et al., 2014) (Figur…”
BackgroundCaffeine toxicity in forensic practice: possible effects and under-appreciated sources
Musgrave, I., Farrington, R., Hoban, C. L., & Byard, R. W. (2016) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-016-9786-9 · Cited by 48
“In these people, caffeine consumption is correlated with higher incidences of ischemic heart disease [19] and hypertension [20], both of which are disorders associated with sudden and unexpected death, and therefore frequently encountered in medicolegal cases.”
BackgroundIntrauterine exposure to caffeine and inattention/overactivity in children
Bekkhus, M., Skjøthaug, T., Nordhagen, R., & BORGE, A. I. H. (2010) · Acta Paediatrica · doi:10.1111/j.1651-2227.2010.01744.x · Cited by 47
“handling of caffeine metabolism, thus mothers may be characterized as ‘slow metabolizers’ and are unable to acetylate the primary caffeine metabolite, paraxanthine (29).”
BackgroundSaid, M. A., van de Vegte, Y. J., Verweij, N., & van der Harst, P. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016808 · Cited by 47
“Caffeine from coffee 0 (0-0) 15 (6-60) 120 (85-120) 180 (170-180) 240 (240-240) 300 (255-300) 360 (340-360) 480 (425-595)”
Coffee drinking timing and mortality in US adults
Wang, X., Ma, H., Sun, Q., Li, J., Heianza, Y., van Dam, R. M., Hu, F. B., Rimm, E. B., Manson, J. E., & Qi, L. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehae871 · Cited by 50
“…factors may modify the association between coffee intake, especially heavy coffee intake, and health outcomes, including smoking, 5,6 decaffeinated coffee intake, 5 genetically determined caffeine metabolism rate, 6,8,9 and sweeteners added to coffee, 10,11 as well as the coffee brewing method.”
The impact of CYP allelic variation on antidepressant metabolism: a review
Black, J. L., O’Kane, D. J., & Mrazek, D. A. (2007) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.3.1.21 · Cited by 44
“(2007) 3(1) demethylation of caffeine, a property that has been controversially linked to heart disease [5].”
BackgroundAlGrain, H. A., Thomas, R. M., Carrillo, A. E., Ryan, E. J., Kim, C.-H., Lettan, R. B. I., & Ryan, E. J. (2015) · Journal of Caffeine Research · doi:10.1089/jcr.2015.0029 · Cited by 44
Herber-Gast, G.-C. M., van Essen, H., Verschuren, W. M. M., Stehouwer, C. D. A., Gansevoort, R. T., Bakker, S. J. L., & Spijkerman, A. M. W. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.112755 · Cited by 44
Polonikov, A., Bushueva, O. Y., Булгакова, И. В., Freidin, M. B., Churnosov, M. I., Solodilova, M. A., Дмитриевич, Ш. Я., & Ivanov, V. P. (2016) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000261 · Cited by 44
Komorita, Y., Iwase, M., Fujii, H., Ohkuma, T., Ide, H., Jodai, T., Yoshinari, M., Oku, Y., Higashi, T., Nakamura, U., et al. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001252 · Cited by 44
Coffee and health: explaining conflicting results in hypertension
Hamer, M. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002076 · Cited by 43
Coffee reduces the risk of death after acute myocardial infarction
Brown, O. I., Allgar, V. L., & Wong, K. (2016) · Coronary Artery Disease · doi:10.1097/mca.0000000000000397 · Cited by 41
Bidel, S., & Tuomilehto, J. O. (2010) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2013.09.02.99 · Cited by 41
Zergui, A., Boudalia, S., Ababou, A., & Marlie-Landy, J. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03582-7 · Cited by 40
“On the other hand, excessive coffee consumption could cause myocardial and cerebral infarction [9], insomnia [10], and cardiovascular complications [11].”
BackgroundLowcock, E. C., Cotterchio, M., Anderson, L. N., Boucher, B. A., & El‐Sohemy, A. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.768348 · Cited by 40
“CYP1A2 genotype has been shown to modify the associations between caffeine/coffee and health outcomes such as hypertension (32), myocardial infarction (33), and ovarian cancer (34).”
BackgroundPalatini, P., Fania, C., Mos, L., Garavelli, G., Mazzer, A., Cozzio, S., Saladini, F., & Casiglia, E. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.03.006 · Cited by 40
“As shown by us (18,19) and others (49), the effects of coffee on the risk of adverse outcomes may vary according to CYP1A2 polymorphism that has important influences on caffeine metabolism (50).”
BackgroundCorella, D., Coltell, Ó., Mattingley, G., Sorlí, J. V., & Ordovás, J. M. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1311208 · Cited by 41
Gender Differences in Coffee Consumption and Its Effects in Young People
Demura, S., Aoki, H., Mizusawa, T., Soukura, K., Noda, M., & Sato, T. (2013) · Food and Nutrition Sciences · doi:10.4236/fns.2013.47096 · Cited by 39
“On the other hand, the risk of myocardial infarction and glaucoma are increased by coffee consumption [22, 23].”
BackgroundPerera, V., Gross, A. S., Polasek, T. M., Yan, Q., Rao, G. G., Forrest, A., Xu, J., & McLachlan, A. J. (2013) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2013.795540 · Cited by 39
“These studies include associations between CYP1A2 genetic variants and parameters such as coffee intake [135,150-152], clinical outcomes (e.”
BackgroundHilli, J., Korhonen, T., Turpeinen, M., Hokkanen, J., Mattila, S., & Laine, K. (2008) · The Journal of Clinical Pharmacology · doi:10.1177/0091270008318669 · Cited by 38
“In the literature, carriers of the variant CYP1A2*1F allele have been designated as slow caffeine metabolizers, whereas subjects homozygous for the wild-type CYP1A2*1A allele have been designated as rapid caffeine metabolizers.(42) Our finding of the higher 6-OH-melatonin concentrations in the representatives of the w…”
BackgroundMatthaei, J., Tzvetkov, M. V., Strube, J., Sehrt, D. B., Sachse-Seeboth, C., Hjelmborg, J., Möller, S., Halekoh, U., Hofmann, U., Schwab, M. G., et al. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.444 · Cited by 38
Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine’s Effect on Postprandial Glycaemia
Banks, N. F., Tomko, P. M., Colquhoun, R. J., Muddle, T. W. D., Emerson, S. R., & Jenkins, N. D. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-46931-0 · Cited by 44
Rosuvastatin Increases Extracellular Adenosine Formation in Humans In Vivo
Meijer, P., Oyen, W. J. G., Dekker, D., van den Broek, P. H. H., Wouters, C. W., Boerman, O. C., Scheffer, G. J., Smits, P., & Rongen, G. A. P. J. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179622 · Cited by 38
Daimiel, L., Vargas, T., & de Molina, A. R. (2012) · Electrophoresis · doi:10.1002/elps.201200084 · Cited by 39
Biomarkers of dairy intake and the risk of heart disease
Aslibekyan, S. W., Campos, H., & Baylín, A. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.02.003 · Cited by 38
Hamer, M., Williams, E. D., Vuononvirta, R., Gibson, E. L., & Steptoe, A. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000249696.19360.be · Cited by 37
Caffeine intake reduces incident atrial fibrillation at a population level
Casiglia, E., Tikhonoff, V., Albertini, F., Gasparotti, F., Mazza, A., Montagnana, M., Danese, E., Benati, M., Spinella, P., & Palatini, P. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318772945 · Cited by 37
Genetic Biomarkers of Metabolic Detoxification for Personalized Lifestyle Medicine
Aronica, L., Ordovás, J. M., Volkov, A., Lamb, J. J., Stone, P. M., Minich, D. M., Leary, M., Class, M., Metti, D., Larson, I. A., et al. (2022) · Nutrients · doi:10.3390/nu14040768 · Cited by 36
Soares, R. N., Schneider, A., Valle, S. C., & Schenkel, P. C. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.03.002 · Cited by 35
The Effect of Caffeine on Performance in Collegiate Tennis Players
Klein, C. S., Clawson, A. J., Martin, M., Saunders, M. J., Flohr, J. A., Bechtel, M. K., Dunham, W., Hancock, M., & Womack, C. J. (2012) · Journal of Caffeine Research · doi:10.1089/jcr.2012.0019 · Cited by 35
Human in vivo research on the vascular effects of adenosine
Riksen, N. P., Rongen, G. A. P. J. M., Yellon, D. M., & Smits, P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.053 · Cited by 34
Coffee Consumption and Risk of Type 2 Diabetes and Heart Disease
Campos, H., & Baylín, A. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00297.x · Cited by 35
Karjalainen, M. J., Neuvonen, P. J., & Backman, J. T. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.011965 · Cited by 35
“, 2006b), and according to recent findings, intake of caffeine may be associated with an increased risk of myocardial infarction among individuals with “slow caffeine metabolism” (Cornelis et al., 2006).”
BackgroundRenda, G., Committeri, G., Zimarino, M., Nicola, M. D., Tatasciore, A., Ruggieri, B., Ambrosini, E., Viola, V., Antonucci, I., Stuppia, L., et al. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.03.001 · Cited by 39
“, 2009) and myocardial infarction (Cornelis et al., 2006) compared with rapid caffeine metabolizers (carrying the wild-type A21A allele).”
BackgroundTea and coffee consumption in relation to DNA methylation in four European cohorts
Ek, W. E., Tobi, E. W., Ahsan, M., Lampa, E., Ponzi, E., Kyrtopoulos, S. Α., Georgiadis, P., Lumey, L. H., Heijmans, B. T., Botsivali, M., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx194 · Cited by 35
“On the other hand, coffee consumption has also been associated with an increased risk of high blood pressure (8,9), different types of cancer (10,11) and myocardial infarction (12).”
Canonico, M., Bouaziz-Amar, É., Carcaillon‐Bentata, L., Verstuyft, C., Guiochon‐Mantel, A., Becquemont, L., & Scarabin, P. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0450 · Cited by 35
“specific mutation effect are somewhat controversial (10), this”
BackgroundRichardson, T., Baker, J. N., Thomas, P., Meckes, C., Rozkovec, A., & Kerr, D. E. (2009) · QJM · doi:10.1093/qjmed/hcp072 · Cited by 34
“Reduction in HRV occurs immediately following acute myocardial infarction and can remain suppressed for days to months.(9) Attenuated HRV post-STEMI is likely to reflect a decrease in vagal activity thereby leading to”
BackgroundInfluentialNegaresh, R., Coso, J. D., Mokhtarzade, M., Lima‐Silva, A. E., Baker, J. S., Willems, M. E. T., Talebvand, S., Khodadoost, M., & Farhani, F. (2018) · European Journal of Sport Science · doi:10.1080/17461391.2018.1534990 · Cited by 34
Ye, Y., Saïd, G., Lin, Y., Manickavasagam, S., Hughes, M. G., McAdoo, D. J., Perez‐Polo, R. J., & Birnbaum, Y. (2008) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-008-6105-z · Cited by 34
“studied 2,014 cases with first acute nonfatal myocardial infarction and compared them to 2,014 age, gender, and area of residence matched controls and reported that intake of coffee is correlated with an increased risk of myocardial infarction only among individuals with a CYP1A2 genotype associated with slow caffeine…”
ResultTam, T. W., Liu, R., Arnason, J. T., Krantis, A., Staines, W. A., Haddad, P. S., & Foster, B. C. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.07.036 · Cited by 33
Food Supply Chain Safety Research Trends From 1997 to 2020: A Bibliometric Analysis
Luo, J., Leng, S., & Bai, Y. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2021.742980 · Cited by 33
“, 2006 (27) Journal of the American Medical Association 296 21.”
BackgroundMo, L., Xie, W., Pu, X.-Q., & Ouyang, D. (2018) · Oncotarget · doi:10.18632/oncotarget.23947 · Cited by 31
“[23] found that the positive association between coffee consumption and nonfatal MI was only significant in subjects with slow caffeine metabolism, suggesting that caffeine is a key in this association.”
BackgroundRuggiero, E., Castelnuovo, A. F. D., Costanzo, S., Persichillo, M., Curtis, A. D., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L., & Bonaccio, M. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa365 · Cited by 31
Effect of Caffeine on Vigilance and Cognitive Performance During Extended Wakefulness
Kilpeläinen, A. A., Huttunen, K. H., Lohi, J. J., & Lyytinen, H. (2010) · International Journal of Aviation Psychology · doi:10.1080/10508411003617847 · Cited by 30
Robertson, T. M., Clifford, M. N., Penson, S., Williams, P., & Robertson, M. D. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518000260 · Cited by 31
“Associations between coffee drinking and increased risk of myocardial infarction((15)), hypertension((16,17)) and IFG((18))”
BackgroundThe Coffee Paradox in Stroke: Increased Consumption Linked with Fewer Strokes
Liebeskind, D. S., Sanossian, N., Fu, K. A., Wang, H.-J., & Arab, L. (2016) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000035 · Cited by 30
Zaharieva, D. P., Miadovnik, L. A., Rowan, C. P., Gumieniak, R. J., Jamnik, V., & Riddell, M. C. (2015) · Diabetic Medicine · doi:10.1111/dme.12857 · Cited by 30
Caffeine in Food and Dietary Supplements: Examining Safety
Institute of Medicine (2014) · National Academies Press eBooks · doi:10.17226/18607 · Cited by 32
Miranda, A. M., Steluti, J., Norde, M. M., Fisberg, R. M., & Marchioni, D. M. L. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.07.033 · Cited by 29
Bachmann, K. A. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-369521-5.00008-7 · Cited by 29
Cornelis, M. C. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398397-8.00012-5 · Cited by 27
Genetic Risk Prediction: Individualized Variability in Susceptibility to Toxicants
Nebert, D. W., Zhang, G., & Vesell, E. S. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140241 · Cited by 26
Battram, D. S., Graham, T. E., & Dela, F. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.130526 · Cited by 27
“…compilation C© 2007 The Physiological Society and uncharacteristic effects of adenosine/caffeine and isoproterenol/adrenaline are at present unknown, Cornelis et al. (2006) have demonstrated that the elevated risk of heart disease with chronic caffeinated coffee ingestion is dependent on an…”
BackgroundLee, J., Lee, J.-E., & Kim, Y. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0232-y · Cited by 27
“Some evidence suggests that the rate of caffeine metabolism differs between races [45, 46].”
BackgroundHellstrom, H. R. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.05.031 · Cited by 27
Giersch, G. E. W., Boyett, J. C., Hargens, T. A., Luden, N. D., Saunders, M. J., Daley, H., Hughey, C. A., El‐Sohemy, A., & Womack, C. J. (2018) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2017.0028 · Cited by 27
“12 Due to the similarities in metabolism in all C allele carriers, 7,13 this grouping is consistent with prior research.”
InfluentialJenkins, D. J. A., Josse, A. R., Dorian, P., Burr, M. L., Labelle, R., Kendall, C. W. C., & Cunnane, S. C. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719713 · Cited by 26
“studies, emerging data on the influence of genes on the metabolism of nutrients and food components in relation to CHD is making this line of research increasingly relevant [103].”
Lim, D., Chang, J.-U., Ahn, J., & Kim, J. (2020) · Processes · doi:10.3390/pr8040438 · Cited by 26
“Genetic variation, especially CYP1A2 allele [91], can affect the clearance rate for caffeine among and within individuals and can vary up to 40-fold [92].”
BackgroundGkouskou, K. K., Georgiopoulos, G. A., Vlastos, I. M., Lazou, E., Chaniotis, D. I., Papaioannou, T. G., Mantzoros, C. S., Sanoudou, D., & Eliopoulos, A. G. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00972-6 · Cited by 31
“Indeed, when 14 cpw were used as a cutoff for coffee consumption [28], BMI was found decreased by −5.”
MethodRoa‐Díaz, Z. M., Teuscher, J., Gamba, M., Bundo, M., Grisotto, G., Wehrli, F., Gamboa-Delgado, E. M., Rojas, L. Z., Gómez‐Ochoa, S. A., Verhoog, S., et al. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02808-1 · Cited by 28
“04) interaction between coffee consumption and CYP1A2 variants on MI risk [34].”
Background
Metadata
- Authors
- Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H.
- Affiliations
- University of Toronto (CA)
- Harvard University (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2006-03-08
- Volume
- 295
- Issue
- 10
- Pages
- 1135
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1972508135
- Cited by
- 490
- References
- 52
- Citations by year
- 2026: 22 · 2025: 26 · 2024: 26 · 2023: 21 · 2022: 20 · 2021: 21 · 2020: 24 · 2019: 24 · 2018: 30 · 2017: 30 · 2016: 21 · 2015: 22 · 2014: 28 · 2013: 22 · 2012: 24
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- green
- jamanetwork.com
- Licence
- other-oa
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Investigative News in Education (Universidad de Costa Rica) (submittedVersion)
- Funders
- Harvard University
- Universidad de Costa Rica
- National Heart, Lung, and Blood Institute (HL 60692, HL 071888, R01HL071888, R01HL060692)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- coffee consumption, myocardial infarction, caffeine metabolism, gene-environment interaction, cardiovascular risk, Costa Rica, young adults, hormone replacement therapy
- MeSH terms
- Aged, Catchment Area, Health, Coffee, Costa Rica, Female, Genotype, Humans, Male, Middle Aged, Myocardial Infarction, Polymorphism, Restriction Fragment Length, Risk Factors, Logistic Models, Polymerase Chain Reaction, Cytochrome P-450 CYP1A2, Amino Acid Substitution
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