Acute effect of coffee on aortic stiffness and wave reflections in healthy individuals: differential effect according to habitual consumption
Abstract
The acute effect of coffee on arterial stiffness and its dependence on habitual consumption was studied in 24 volunteers on four separate occasions during which subjects received: (a) coffee espresso, (b) decaffeinated coffee espresso, (c) caffeine alone and (d) placebo (hot water). The increase in carotid femoral pulse wave velocity (PWV), augmentation index (AIx) and augmented pressure (AP) of the aortic pressure waveform after coffee consumption was more pronounced in non-habitual (n = 13) compared to habitual drinkers (n = 11), (differences of maximal changes between groups in PWV, AIx, AP responses by 0.39 m/s, 4.5% and 1.9 mmHg, respectively, for coffee; and by 0.34 m/s, 5.3% and 2.1 mmHg, respectively, for decaffeinated coffee; all p < .05). Caffeine increased PWV, as well as AIx and AP but differences in responses between the two groups were not significant. Both caffeinated and decaffeinated coffee consumption is associated with a more potent effect on arterial stiffness in non-habitual than habitual coffee consumers, whereas caffeine induces comparable changes in both groups.
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Caffeine alone negatively impacts the cardiovascular system via measures of pulse wave reflection.
“the literature suggests that caffeine alone negatively impacts the cardiovascular system via measures of PWR,10,15,19”
From The Effects of Caffeine and Resistance Exercise on Pulse Wave Reflection in Resistance-Trained Women (2025) · cites this paper as [10]
In response to an acute bout of resistance exercise, measures of pulse wave reflection are significantly increased.
“In response to an acute bout of resistance exercise (RE) measures of PWR are significantly increased.9–12”
From The Effects of Caffeine and Resistance Exercise on Pulse Wave Reflection in Resistance-Trained Women (2025) · cites this paper as [10]
Augmentations in measures of pulse wave reflection have been shown to last upwards of 3 hours post caffeine ingestion.
“Augmentations in measures of PWR have been shown to last upwards of 3 hours post caffeine ingestion.10,15,19”
From The Effects of Caffeine and Resistance Exercise on Pulse Wave Reflection in Resistance-Trained Women (2025) · cites this paper as [10]
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- Authors
- Ioakeimidis, N., Tzifos, V., Vlachopoulos, C., Terentes-Printzios, D., Georgakopoulos, C., & Tousoulis, D.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Henry Dunant Hospital (GR)
- Corresponding author
- Vlachopoulos, Charalambos
- ORCID
- Venue
- International Journal of Food Sciences and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2018-01-10
- Volume
- 69
- Issue
- 7
- Pages
- 870-881
- ISSN
- 0963-7486 (ISSN-L)
- 1465-3478
- OpenAlex
- W2784159980
- Cited by
- 19
- References
- 41
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 1
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Food Sciences and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- coffee, aortic stiffness, arterial stiffness, pulse wave velocity, wave reflection, augmentation index, caffeine, decaffeinated coffee, espresso, aortic pressure waveform
- MeSH terms
- Adult, Aorta, Caffeine, Coffee, Female, Humans, Male, Single-Blind Method, Cross-Over Studies, Young Adult, Vascular Stiffness, Pulse Wave Analysis
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