Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial
Open accessAbstract
IMPORTANCE: Breast cancer is the leading cause of female cancer burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that the Mediterranean diet may reduce the risk of breast cancer. OBJECTIVE: To evaluate the effect of 2 interventions with Mediterranean diet vs the advice to follow a low-fat diet (control) on breast cancer incidence. DESIGN, SETTING, AND PARTICIPANTS: The PREDIMED study is a 1:1:1 randomized, single-blind, controlled field trial conducted at primary health care centers in Spain. From 2003 to 2009, 4282 women aged 60 to 80 years and at high cardiovascular disease risk were recruited after invitation by their primary care physicians. INTERVENTIONS: Participants were randomly allocated to a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURES: Breast cancer incidence was a prespecified secondary outcome of the trial for women without a prior history of breast cancer (n = 4152). RESULTS: After a median follow-up of 4.8 years, we identified 35 confirmed incident cases of breast cancer. Observed rates (per 1000 person-years) were 1.1 for the Mediterranean diet with extra-virgin olive oil group, 1.8 for the Mediterranean diet with nuts group, and 2.9 for the control group. The multivariable-adjusted hazard ratios vs the control group were 0.32 (95% CI, 0.13-0.79) for the Mediterranean diet with extra-virgin olive oil group and 0.59 (95% CI, 0.26-1.35) for the Mediterranean diet with nuts group. In analyses with yearly cumulative updated dietary exposures, the hazard ratio for each additional 5% of calories from extra-virgin olive oil was 0.72 (95% CI, 0.57-0.90). CONCLUSIONS AND RELEVANCE: This is the first randomized trial finding an effect of a long-term dietary intervention on breast cancer incidence. Our results suggest a beneficial effect of a Mediterranean diet supplemented with extra-virgin olive oil in the primary prevention of breast cancer. These results come from a secondary analysis of a previous trial and are based on few incident cases and, therefore, need to be confirmed in longer-term and larger studies. TRIAL REGISTRATION: ISRCTN.org Identifier: ISRCTN35739639.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the PREDIMED study, after a mean follow-up of 4.8 years, breast cancer rates were lower in the intervention groups with EVOO or nuts than in the control group with a low-fat diet; after multivariate adjustment, the EVOO group had a significantly lower risk of developing breast cancer, with a 28% lower risk for every 5% additional calories from EVOO.
“Data from the PREDIMED study showed that after a mean follow-up of 4.8 years, the observed rates of breast cancer were lower in the intervention groups with EVOO or with nuts than in the control group with a low-fat diet. After multivariate adjustment, the group supplementing MD with EVOO had a significantly lower risk of developing breast cancer than the control group; for every 5% additional”
From Mediterranean Diet and Obesity-related Disorders: What is the Evidence? (2022) · cites this paper as [148]
In substudies using the PRIDIMED database, the incidence of type 2 diabetes, peripheral artery disease, atrial fibrillation, and breast cancer, but not the incidence of heart failure, was significantly reduced in individuals randomized to the Mediterranean diet.
“The incidence of type 2 diabetes, peripheral artery disease, atrial fibrillation, breast cancer, but not the incidence of heart failure, was significantly reduced in individuals randomized to the Mediterranean diet (25–27).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [26]
In the PREDIMED trial, after a median follow-up of 4.8 years in 4282 postmenopausal women, breast cancer incidence rates per 1000 person-years were 1.1 for the EVOO-enriched MedDiet group, 1.8 for the nuts-enriched MedDiet group, and 2.9 for the control group.
“After a median follow-up of 4.8 years, on 4282 postmenopausal women, 35 incident cases of breast cancer were identified. The observed incidence rates (per 1000 person-years) of breast cancer were 1.1 for the EVOO-enriched MedDiet group, 1.8 for the nuts-enriched MedDiet group, and 2.9 for the control group [159].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [159]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257 · see citing works
Self-citationRetractedCancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
Ferlay, J., Steliarova‐Foucher, E., Lortet‐Tieulent, J., Rosso, S., Coebergh, J. W. W., Comber, H., Forman, D., & Bray, F. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2012.12.027 · Cited by 5,243 · see citing works
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1800389 · Cited by 3,616 · see citing works
Self-citationMediterranean diet pyramid: a cultural model for healthy eating
Willett, W., Sacks, F., Trichopoulou, A., Drescher, G., Ferro-Luzzi, A., Helsing, E., & Trichopoulos, D. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1402s · Cited by 2,461 · see citing works
Modern Epidemiology 3rd edition
Rothman, K. J., Lash, T. L., & Greenland, S. (1986) · Cited by 1,736 · see citing works
Schröder, H., Fitó, M., Estruch, R., Martínez-González, M. A., Corella, D., Salas-Salvadó, J., Lamuela-Raventós, R., Ros, E., Salaverría, I., Fiol, M., et al. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135566 · Cited by 1,624 · see citing works
Self-citationFernández-Ballart, J. D., Piñol, J. L., Zazpe, I., Corella, D., Carrasco, P., Toledo, E., Perez-Bauer, M., Martínez-González, M. Á., Salas-Salvadó, J., & Martín-Moreno, J. M. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509993837 · Cited by 898 · see citing works
Self-citationPrentice, R. L., Caan, B., Chlebowski, R. T., Patterson, R., Kuller, L. H., Ockene, J. K., Margolis, K. L., Limacher, M. C., Manson, J. E., Parker, L. M., et al. (2006) · JAMA · doi:10.1001/jama.295.6.629 · Cited by 828 · see citing works
Chlebowski, R. T., Blackburn, G. L., Thomson, C. A., Nixon, D. W., Shapiro, A. C., Hoy, M. K., Goodman, M. T., Giuliano, A. E., KARANJA, N. M., McAndrew, P. F., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj494 · Cited by 824 · see citing works
Cohort Profile: Design and methods of the PREDIMED study
Martinez-Gonzalez, M. A., Corella, D., Salas-Salvado, J., Ros, E., Covas, M. I., Fiol, M., Warnberg, J., Aros, F., Ruiz-Gutierrez, V., Lamuela-Raventos, R. M., et al. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyq250 · Cited by 671 · see citing works
Self-citationValidation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish Men
Elosua, R., Marrugat, J., Molina, L., Pons, S., & Pujol, E. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116966 · Cited by 499 · see citing works
Mediterranean diet and cardiovascular health: teachings of the PREDIMED study
Ros, E., Martínez-González, M. A., Estruch, R., Salas-Salvadó, J., Fitó, M., Martínez, J. A., & Corella, D. (2014) · Advances in Nutrition · doi:10.3945/an.113.005389 · Cited by 393 · see citing works
Self-citationCancer and Mediterranean dietary traditions.
Trichopoulou, A., Lagiou, P., Kuper, H., & Trichopoulos, D. (2000) · PubMed · Cited by 390 · see citing works
Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish Women
ELOSUA, R., GARCIA, M., AGUILAR, A., MOLINA, L., COVAS, M.-I., & MARRUGAT, J. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200008000-00011 · Cited by 377 · see citing works
Mediterranean Dietary Pattern in a Randomized Trial
de Lorgeril, M., Salen, P., Martin, J., Monjaud, I., Boucher, P., & Mamelle, N. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.11.1181 · Cited by 364 · see citing works
Fung, T. T., Hu, F. B., McCullough, M. L., Newby, P. K., Willett, W. C., & Holmes, M. D. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.2.466 · Cited by 321 · see citing works
Self-citationΨαλτοπούλου, Θ., Kosti, R. I., Haidopoulos, D. A., Dimopoulos, M. A., & Panagiotakos, D. B. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-127 · Cited by 283 · see citing works
Schwingshackl, L., & Hoffmann, G. (2014) · International Journal of Cancer · doi:10.1002/ijc.28824 · Cited by 269 · see citing works
Buckland, G., Travier, N., Cottet, V., González, C. A., Luján‐Barroso, L., Agudo, A., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Peeters, P. H., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.27958 · Cited by 238 · see citing works
Self-citationThiébaut, A. C. M., Kipnis, V., Chang, S., Subar, A. F., Thompson, F. E., Rosenberg, P. S., Hollenbeck, A. R., Leitzmann, M., & Schatzkin, A. G. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk094 · Cited by 213 · see citing works
Mitjavila, M. T., Fandos, M., Salas‐Salvadó, J., Covas, M., Borrego, S., Estruch, R., Lamuela-Raventós, R. M., Corella, D., Martínez‐González, M. Á., Sánchez, J. M., et al. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.002 · Cited by 200 · see citing works
Self-citationZazpe, I., Sanchez-Tainta, A., Estruch, R., Lamuela-Raventos, R. M., Schröder, H., Salas-Salvado, J., Corella, D., Fiol, M., Gomez-Gracia, E., Aros, F., et al. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.04.011 · Cited by 193 · see citing works
Self-citationMeta-analyses of lignans and enterolignans in relation to breast cancer risk
Buck, K., Zaineddin, A. K., Vrieling, A., Linseisen, J., & Chang-Claude, J. C. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28573 · Cited by 182 · see citing works
A comparison of two dietary instruments for evaluating the fat–breast cancer relationship
Freedman, L. S., Potischman, N. A., Kipnis, V., Midthune, D., Schatzkin, A. G., Thompson, F. E., Troiano, R. P., Prentice, R. L., Patterson, R. E., Carroll, R. J., et al. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl085 · Cited by 162 · see citing works
Warleta, F., Campos, M., Allouche, Y., Sánchez‐Quesada, C., Ruíz-Mora, J., Beltrán, G., & Gaforio, J. J. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.01.031 · Cited by 153 · see citing works
Mediterranean diet and cancer: epidemiological evidence and mechanism of selected aspects
Grosso, G., Buscemi, S., Galvano, F., Mistretta, A., Marventano, S., Vela, V. L., Drago, F., Gangi, S., Basile, F., & Biondi, A. (2013) · BMC Surgery · doi:10.1186/1471-2482-13-s2-s14 · Cited by 149 · see citing works
Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells
Warleta, F., Sánchez‐Quesada, C., Campos, M., Allouche, Y., Beltrán, G., & Gaforio, J. J. (2011) · Nutrients · doi:10.3390/nu3100839 · Cited by 145 · see citing works
Casaburi, I., Puoci, F., Chimento, A., Sirianni, R., Ruggiero, C., Avena, P., & Pezzi, V. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200503 · Cited by 139 · see citing works
Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells
Elamin, M. H., Daghestani, M. H., Omer, S. A., et al. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.12.009 · Cited by 134 · see citing works
Akl, M. R., Ayoub, N. M., Mohyeldin, M. M., Busnena, B. A., Foudah, A. I., Liu, Y., & Sayed, K. A. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097622 · Cited by 129 · see citing works
Dietary Fat Intake and Development of Specific Breast Cancer Subtypes
Sieri, S., Chiodini, P., Agnoli, C., Pala, V. M., Berrino, F., Trichopoulou, A., Benetou, V., Vasilopoulou, E., Sánchez, M., Chirlaque, M., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju068 · Cited by 128 · see citing works
Menéndez, J. A., Papadimitropoulou, A., Vellón, L., & Lupu, R. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2005.10.016 · Cited by 117 · see citing works
Mediterranean Dietary Pattern and Risk of Breast Cancer
Couto, E., Sandin, S., Löf, M., Ursin, G., Adami, H., & Weiderpass, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055374 · Cited by 104 · see citing works
Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells
Hassan, Z. K., Elamin, M. H., Omer, S. A., et al. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.11.6739 · Cited by 94 · see citing works
Postmenopausal breast cancer is associated with high intakes of ω6 fatty acids (Sweden)
Wirfält, E., Mattisson, I., Gullberg, B., et al. (2002) · Cancer Causes & Control · doi:10.1023/a:1021922917489 · Cited by 93 · see citing works
Cade, J. E., Taylor, E. F., Burley, V. J., & Greenwood, D. C. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.69 · Cited by 92 · see citing works
Tognon, G., Nilsson, L. M., Lissner, L., Johansson, I., Hallmans, G., Lindahl, B., & Winkvist, A. (2012) · Journal of Nutrition · doi:10.3945/jn.112.160499 · Cited by 92 · see citing works
Buckland, G., Travier, N., Agudo, A., Fonseca‐Nunes, A., Navarro, C., Λάγιου, Π., Demetriou, C. A., Amiano, P., Dorronsoro, M., Chirlaque, M., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27516 · Cited by 49 · see citing works
Fat Intake and Breast Cancer Revisited
Smith‐Warner, S. A., & Stampfer, M. J. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk124 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- International Agency for Research on Cancer. Latest world cancer statistics. global cancer burden rises to 14.1 million new cases in 2012: marked increase in breast cancers must be addressed. In: WHO International Agency for Research on Cancer, ed. Lyon, France and Geneva, Switzerland: International Agency for Research on Cancer and World Health Organization; 2013: 1.
- Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008.
- Menendez JA, Papadimitropoulou A, Vellon L, Lupu R. A genomic explanation connecting "Mediterranean diet," olive oil and cancer. Eur J Cancer. 2006;42(15):2425-2432.
Cited by
Sorted by citations
Facing up to the global challenges of ageing
Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature · doi:10.1038/s41586-018-0457-8 · Cited by 1,475 · see citing works
American Cancer Society guideline for diet and physical activity for cancer prevention
Rock, C. L., Thomson, C., Gansler, T., Gapstur, S. M., McCullough, M. L., Patel, A. V., Andrews, K. S., Bandera, E. V., Spees, C. K., Robien, K., et al. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21591 · Cited by 789 · see citing works
Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms
Tosti, V., Bertozzi, B., & Fontana, L. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx227 · Cited by 762 · see citing works
Mendonça, R. D. D., Pimenta, A. M., Gea, A., de la Fuente-Arrillaga, C., Martinez-Gonzalez, M. A., Lopes, A. C. S., & Bes-Rastrollo, M. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.135004 · Cited by 618 · see citing works
Adherence to Mediterranean Diet and Risk of Cancer: An Updated Systematic Review and Meta-Analysis
Schwingshackl, L., Schwedhelm, C., Galbete, C., & Hoffmann, G. (2017) · Nutrients · doi:10.3390/nu9101063 · Cited by 632 · see citing works
The obese adipose tissue microenvironment in cancer development and progression
Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542 · see citing works
Dietary patterns and cancer risk
Steck, S. E., & Murphy, E. A. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0227-4 · Cited by 292 · see citing works
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works
“However, stronger evidence for primary chemoprevention of breast malignancies with frequent consumption of EVOO is provided by a prespecified outcome of the PREvención con DIeta MEDiterránea (PREDIMED) trial [159].”
BackgroundThe Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?
Mazzocchi, A., Leone, L., Agostoni, C., & Pali-Schöll, I. (2019) · Nutrients · doi:10.3390/nu11122941 · Cited by 252 · see citing works
Galbete, C., Schwingshackl, L., Schwedhelm, C., Boeing, H., & Schulze, M. B. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0427-3 · Cited by 212 · see citing works
The Effects of the Mediterranean Diet on Health and Gut Microbiota
Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2023) · Nutrients · doi:10.3390/nu15092150 · Cited by 213 · see citing works
Mediterranean Diet and Obesity-related Disorders: What is the Evidence?
Muscogiuri, G., Verde, L., Sulu, C., Katsiki, N., Hassapidou, M., Frias-Toral, E., Cucalón, G., Pazderska, A., Yumuk, V. D., Colao, A., et al. (2022) · Current Obesity Reports · doi:10.1007/s13679-022-00481-1 · Cited by 207 · see citing works
Gaforio, J. J., Visioli, F., Alarcón-de-la-Lastra, C., Castañer, O., Delgado-Rodríguez, M., Fitó, M., Hernández, A. F., Huertas, J. R., Martínez-González, M. A., Menendez, J. A., et al. (2019) · Nutrients · doi:10.3390/nu11092039 · Cited by 187 · see citing works
Self-citationRadd-Vagenas, S., Duffy, S. L., Naismith, S. L., Brew, B. J., Flood, V. M., & Fiatarone Singh, M. A. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx070 · Cited by 176 · see citing works
Bloomfield, H. E., Koeller, E., Greer, N., MacDonald, R., Kane, R., & Wilt, T. J. (2016) · Annals of Internal Medicine · doi:10.7326/m16-0361 · Cited by 159 · see citing works
Sánchez-Sánchez, M. L., García-Vigara, A., Hidalgo-Mora, J. J., García-Pérez, M.-Á., Tarín, J., & Cano, A. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.03.008 · Cited by 137 · see citing works
Impact of Mediterranean Diet on Cancer: Focused Literature Review
(2017) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20050 · Cited by 47 · see citing works
The Rise and Fall of the Mediterranean Diet and Related Nutrients in Preventing Diabetes
Mirabelli, M., & Brunetti, A. (2022) · Nutrients · doi:10.3390/nu14020379 · Cited by 8 · see citing works
- Authors
- Toledo, E., Salas-Salvadó, J., Donat-Vargas, C., Buil-Cosiales, P., Estruch, R., Ros, E., Corella, D., Fitó, M., Hu, F. B., Arós, F., Gómez-Gracia, E., Romaguera, D., Ortega-Calvo, M., Serra-Majem, L., Pintó, X., Schröder, H., Basora, J., Sorlí, J. V., Bulló, M., Serra-Mir, M., & Martínez-González, M. A.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
- Department of Preventive Medicine and Public Health, University of Navarra–School of Medicine, Pamplona, Navarra, Spain
- Servicio Navarro de Salud-Osasunbidea, Pamplona, Navarra, Spain
- Universitat de València (ES)
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- JAMA Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2015-11-01
- Volume
- 175
- Issue
- 11
- Pages
- 1752
- ISSN
- 2168-6106 (ISSN-L)
- OpenAlex
- W2155215362
- Cited by
- 528
- References
- 39
- Citations by year
- 2026: 31 · 2025: 35 · 2024: 42 · 2023: 53 · 2022: 53 · 2021: 74 · 2020: 56 · 2019: 44 · 2018: 60 · 2017: 43 · 2016: 31 · 2015: 6
- FWCI
- 49.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Hispana (submittedVersion, cc-by-nc-nd)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, public-domain)
- Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion)
- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion, cc-by-nc-nd)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
- Funders
- Loma Linda University
- Generalitat Valenciana (ACOMP/2013/159, ACOMP/2013/165)
- National Institutes of Health (RTIC RD 06/0045, PI10/02658, RTIC G03/140, PI10/01407, PI0105/2007, PI07/0240)
- Instituto de Salud Carlos III (PI040233, AGL2010-22319-C03, PI1002658, RTIC G03/140, PI11/00049, 06/0045, RD06/0045, PI11/, PI07/0240, AGL2010‐22319‐C03‐03, PI050976, 1R01HL118264-01, RTIC RD06/0045, G03/140, PI1001407, PI0105/2007, PI11/02505)
- European Regional Development Fund (06/0045, PI10/01407, PI07/0240, PI11/02505, RTIC G03/140, (RD 06/0045, AGL2010-22319-C03-03, PI10/02658, G03/140, PI11/00049)
- National Heart, Lung, and Blood Institute (R01HL118264)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Keywords
- Mediterranean diet, breast cancer incidence, extra virgin olive oil, mixed nuts, dietary fat reduction, cardiovascular risk, PREDIMED trial, older women, dietary intervention, secondary prevention of cardiovascular disease
- MeSH terms
- Olive Oil, Aged, Breast Neoplasms, Cardiovascular Diseases, Dietary Fats, Female, Follow-Up Studies, Humans, Middle Aged, Nuts, Primary Prevention, Time, Incidence, Treatment Outcome, Diet, Mediterranean, Risk Reduction Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
